Human Phenotype Ontology 
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Onset (HP:0003674)help
Parent Node:
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Adult onset (HP:0003581)help
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Late onset (HP:0003584)help
Term ID: 3584
Name: Late onset
Synonym:
Definition: A type of adult onset with onset of symptoms after the age of 60 years.
Comments:
Reference: HP:0003584
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandMiddle age onset (HP:0003596) help
..expandYoung adult onset (HP:0011462) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003584HP:0003584Late onset0AAGAB CL E G H7971925662OMIM:148600Palmoplantar keratoderma, punctate type IA.7
HP:0003584HP:0003584Late onset0ABCA7 CL E G H1034737OMIM:608907Alzheimer disease 9, susceptibility to3
HP:0003584HP:0003584Late onset0ABCC8 CL E G H683359OMIM:125853Diabetes mellitus, noninsulin-dependent.245
HP:0003584HP:0003584Late onset0ACTC1 CL E G H70143OMIM:612098Cardiomyopathy, familial hypertrophic, 11208
HP:0003584HP:0003584Late onset0ADH1C CL E G H126251OMIM:168600Parkinson disease, late-onset4
HP:0003584HP:0003584Late onset0AKT2 CL E G H208392OMIM:125853Diabetes mellitus, noninsulin-dependent.12
HP:0003584HP:0003584Late onset0ANLN CL E G H5444314082OMIM:616032Focal segmental glomerulosclerosis 86
HP:0003584HP:0003584Late onset0ANXA11 CL E G H311535OMIM:617839Amyotrophic lateral sclerosis 23
HP:0003584HP:0003584Late onset0APOE CL E G H348613OMIM:104310Alzheimer disease 2.39
HP:0003584HP:0003584Late onset0APOE CL E G H348613OMIM:603075Macular degeneration, age-related, 139
HP:0003584HP:0003584Late onset0ATN1 CL E G H18223033OMIM:125370Dentatorubral-Pallidoluysian atrophy naito-oyanagi disease haw river syndrome ataxia, chorea, seizures, and dementia16
HP:0003584HP:0003584Late onset0ATXN2 CL E G H631110555OMIM:168600Parkinson disease, late-onset11
HP:0003584HP:0003584Late onset0ATXN2 CL E G H631110555OMIM:183090Spinocerebellar ataxia 211
HP:0003584HP:0003584Late onset0ATXN8OS CL E G H631510561OMIM:168600Parkinson disease, late-onset1
HP:0003584HP:0003584Late onset0BAG3 CL E G H9531939OMIM:613881Cardiomyopathy, dilated, 1hh204
HP:0003584HP:0003584Late onset0BAP1 CL E G H8314950OMIM:614327Tumor predisposition syndrome184
HP:0003584HP:0003584Late onset0BEAN1 CL E G H14622724160OMIM:117210Spinocerebellar ataxia 31HP:0040282 - Frequent1
HP:0003584HP:0003584Late onset0BLVRA CL E G H6441062OMIM:614156Hyperbiliverdinemia2
HP:0003584HP:0003584Late onset0CAPN3 CL E G H8251480OMIM:618129Muscular dystrophy, limb-girdle, autosomal dominant 4323
HP:0003584HP:0003584Late onset0CAV1 CL E G H8571527OMIM:615343Pulmonary hypertension, primary, 311
HP:0003584HP:0003584Late onset0CCNF CL E G H8991591OMIM:619141FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 5; FTDALS5
HP:0003584HP:0003584Late onset0CFHR1 CL E G H30784888OMIM:603075Macular degeneration, age-related, 1
HP:0003584HP:0003584Late onset0CFHR3 CL E G H1087816980OMIM:603075Macular degeneration, age-related, 1
HP:0003584HP:0003584Late onset0CHCHD10 CL E G H40091615559OMIM:615911Frontotemporal dementia and/or amyotrophic lateral sclerosis 211
HP:0003584HP:0003584Late onset0CLEC3B CL E G H712311891OMIM:619977
HP:0003584HP:0003584Late onset0CLN6 CL E G H549822077OMIM:204300Ceroid lipofuscinosis, neuronal, 4A, autosomal recessive143
HP:0003584HP:0003584Late onset0CYLD CL E G H15402584OMIM:619132FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 8; FTDALS8126
HP:0003584HP:0003584Late onset0DSC2 CL E G H18243036OMIM:610476Arrhythmogenic right ventricular dysplasia, familial, 11268
HP:0003584HP:0003584Late onset0DSG2 CL E G H18293049OMIM:610193Arrhythmogenic right ventricular dysplasia, familial, 10358
HP:0003584HP:0003584Late onset0ELOVL4 CL E G H678514415OMIM:133190Spinocerebellar ataxia 3462
HP:0003584HP:0003584Late onset0ENPP1 CL E G H51673356OMIM:125853Diabetes mellitus, noninsulin-dependent.151
HP:0003584HP:0003584Late onset0EPCAM CL E G H407211529OMIM:613244Colorectal cancer, hereditary nonpolyposis, type 8170
HP:0003584HP:0003584Late onset0ERBB4 CL E G H20663432OMIM:615515Amyotrophic lateral sclerosis 1915
HP:0003584HP:0003584Late onset0FBLN5 CL E G H105163602OMIM:608895Macular degeneration, age-related, 363
HP:0003584HP:0003584Late onset0FLNC CL E G H23183756OMIM:617047Cardiomyopathy, familial hypertrophic, 26197
HP:0003584HP:0003584Late onset0FMR1 CL E G H23323775OMIM:300623Fragile X tremor/ataxia syndrome30
HP:0003584HP:0003584Late onset0GANAB CL E G H231934138OMIM:600666Polycystic kidney disease 36
HP:0003584HP:0003584Late onset0GBA1 CL E G H26294177OMIM:168600Parkinson disease, late-onset
HP:0003584HP:0003584Late onset0GCK CL E G H26454195OMIM:125853Diabetes mellitus, noninsulin-dependent.237
HP:0003584HP:0003584Late onset0GLUD2 CL E G H27474336OMIM:168600Parkinson disease, late-onset1
HP:0003584HP:0003584Late onset0GPD2 CL E G H28204456OMIM:125853Diabetes mellitus, noninsulin-dependent.3
HP:0003584HP:0003584Late onset0GYG1 CL E G H29924699OMIM:616199Polyglucosan body myopathy 218
HP:0003584HP:0003584Late onset0HAVCR2 CL E G H8486818437OMIM:618398T-CELL LYMPHOMA, SUBCUTANEOUS PANNICULITIS-LIKE
HP:0003584HP:0003584Late onset0HMCN1 CL E G H8387219194OMIM:603075Macular degeneration, age-related, 1262
HP:0003584HP:0003584Late onset0HMGA1 CL E G H31595010OMIM:125853Diabetes mellitus, noninsulin-dependent.1
HP:0003584HP:0003584Late onset0HNF1A CL E G H692711621OMIM:125853Diabetes mellitus, noninsulin-dependent.161
HP:0003584HP:0003584Late onset0HNF1B CL E G H692811630OMIM:125853Diabetes mellitus, noninsulin-dependent.90
HP:0003584HP:0003584Late onset0HNF4A CL E G H31725024OMIM:125853Diabetes mellitus, noninsulin-dependent.138
HP:0003584HP:0003584Late onset0HTRA1 CL E G H56549476OMIM:616779Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 234
HP:0003584HP:0003584Late onset0IGF2BP2 CL E G H1064428867OMIM:125853Diabetes mellitus, noninsulin-dependent.1
HP:0003584HP:0003584Late onset0IL6 CL E G H35696018OMIM:125853Diabetes mellitus, noninsulin-dependent.2
HP:0003584HP:0003584Late onset0IMPG2 CL E G H5093918362OMIM:616152Macular dystrophy, vitelliform, 5120
HP:0003584HP:0003584Late onset0IRS1 CL E G H36676125OMIM:125853Diabetes mellitus, noninsulin-dependent.5
HP:0003584HP:0003584Late onset0IRS2 CL E G H86606126OMIM:125853Diabetes mellitus, noninsulin-dependent.3
HP:0003584HP:0003584Late onset0JAK2 CL E G H37176192OMIM:263300Polycythemia vera57
HP:0003584HP:0003584Late onset0KCNE2 CL E G H99926242OMIM:611493ATRIAL FIBRILLATION, FAMILIAL, 4; ATFB443
HP:0003584HP:0003584Late onset0KCNJ11 CL E G H37676257OMIM:125853Diabetes mellitus, noninsulin-dependent.127
HP:0003584HP:0003584Late onset0KLKB1 CL E G H38186371OMIM:612423PREKALLIKREIN DEFICIENCY8
HP:0003584HP:0003584Late onset0KRT18 CL E G H38756430OMIM:215600Cirrhosis, familial19
HP:0003584HP:0003584Late onset0LAMA4 CL E G H39106484OMIM:615235Cardiomyopathy, dilated, 1jj279
HP:0003584HP:0003584Late onset0LDB3 CL E G H1115515710OMIM:609452Myopathy, myofibrillar, 4.286
HP:0003584HP:0003584Late onset0LIPC CL E G H39906619OMIM:125853Diabetes mellitus, noninsulin-dependent.35
HP:0003584HP:0003584Late onset0LMX1B CL E G H40106654OMIM:256020NAIL-PATELLA-LIKE RENAL DISEASE165
HP:0003584HP:0003584Late onset0LRRK2 CL E G H12089218618OMIM:607060Parkinson disease 8, autosomal dominant221
HP:0003584HP:0003584Late onset0MAFA CL E G H38969223145OMIM:147630Insulinomatosis and diabetes mellitus
HP:0003584HP:0003584Late onset0MAPK8IP1 CL E G H94796882OMIM:125853Diabetes mellitus, noninsulin-dependent.1
HP:0003584HP:0003584Late onset0MAPT CL E G H41376893OMIM:168600Parkinson disease, late-onset140
HP:0003584HP:0003584Late onset0MAPT CL E G H41376893OMIM:601104Supranuclear palsy, progressive, 1140
HP:0003584HP:0003584Late onset0MARS1 CL E G H41416898OMIM:616280Charcot-Marie-Tooth disease, axonal, type 2U
HP:0003584HP:0003584Late onset0MME CL E G H43117154OMIM:617018SPINOCEREBELLAR ATAXIA 43; SCA4318
HP:0003584HP:0003584Late onset0MTNR1B CL E G H45447464OMIM:125853Diabetes mellitus, noninsulin-dependent.4
HP:0003584HP:0003584Late onset0MYBPC3 CL E G H46077551OMIM:615396Left ventricular noncompaction 101143
HP:0003584HP:0003584Late onset0MYH6 CL E G H46247576OMIM:613251Cardiomyopathy, familial hypertrophic, 14452
HP:0003584HP:0003584Late onset0MYPN CL E G H8466523246OMIM:615248Cardiomyopathy, dilated, 1kk217
HP:0003584HP:0003584Late onset0NEK1 CL E G H47507744OMIM:617892Amyotrophic lateral sclerosis, susceptibility to, 24101
HP:0003584HP:0003584Late onset0NEUROD1 CL E G H47607762OMIM:125853Diabetes mellitus, noninsulin-dependent.32
HP:0003584HP:0003584Late onset0NEXN CL E G H9162429557OMIM:613122Cardiomyopathy, dilated, 1cc167
HP:0003584HP:0003584Late onset0NR4A2 CL E G H49297981OMIM:168600Parkinson disease, late-onset27
HP:0003584HP:0003584Late onset0OPTN CL E G H1013317142OMIM:613435Amyotrophic lateral sclerosis 1262
HP:0003584HP:0003584Late onset0PABPN1 CL E G H81068565OMIM:164300Oculopharyngeal muscular dystrophy10
HP:0003584HP:0003584Late onset0PAX4 CL E G H50788618OMIM:125853Diabetes mellitus, noninsulin-dependent.55
HP:0003584HP:0003584Late onset0PDGFRB CL E G H51598804OMIM:615007Basal ganglia calcification, idiopathic, 428
HP:0003584HP:0003584Late onset0PDX1 CL E G H36516107OMIM:125853Diabetes mellitus, noninsulin-dependent.30
HP:0003584HP:0003584Late onset0PPARG CL E G H54689236OMIM:125853Diabetes mellitus, noninsulin-dependent.42
HP:0003584HP:0003584Late onset0PPP1R3A CL E G H55069291OMIM:125853Diabetes mellitus, noninsulin-dependent.12
HP:0003584HP:0003584Late onset0PSEN2 CL E G H56649509OMIM:613697Cardiomyopathy, dilated, 1V59
HP:0003584HP:0003584Late onset0PTPN1 CL E G H57709642OMIM:125853Diabetes mellitus, noninsulin-dependent.1
HP:0003584HP:0003584Late onset0RETN CL E G H5672920389OMIM:125853Diabetes mellitus, noninsulin-dependent.1
HP:0003584HP:0003584Late onset0RPS14 CL E G H620810387OMIM:153550Chromosome 5q deletion syndrome
HP:0003584HP:0003584Late onset0RYR2 CL E G H626210484OMIM:600996Arrhythmogenic right ventricular dysplasia, familial, 21103
HP:0003584HP:0003584Late onset0SEC23B CL E G H1048310702OMIM:224100Anemia, dyserythropoietic congenital, type II60
HP:0003584HP:0003584Late onset0SFTPA1 CL E G H65350910798OMIM:619611INTERSTITIAL LUNG DISEASE 1; ILD119
HP:0003584HP:0003584Late onset0SLC2A2 CL E G H651411006OMIM:125853Diabetes mellitus, noninsulin-dependent.71
HP:0003584HP:0003584Late onset0SLC30A8 CL E G H16902620303OMIM:125853Diabetes mellitus, noninsulin-dependent.3
HP:0003584HP:0003584Late onset0SNCAIP CL E G H962711139OMIM:168600Parkinson disease, late-onset35
HP:0003584HP:0003584Late onset0TARDBP CL E G H2343511571OMIM:612069Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia65
HP:0003584HP:0003584Late onset0TBP CL E G H690811588OMIM:168600Parkinson disease, late-onset7
HP:0003584HP:0003584Late onset0TBP CL E G H690811588OMIM:607136Spinocerebellar ataxia 177
HP:0003584HP:0003584Late onset0TCF7L2 CL E G H693411641OMIM:125853Diabetes mellitus, noninsulin-dependent.4
HP:0003584HP:0003584Late onset0THSD1 CL E G H5590117754OMIM:618734ANEURYSM, INTRACRANIAL BERRY, 12; ANIB122
HP:0003584HP:0003584Late onset0THSD4 CL E G H7987525835OMIM:619825AORTIC ANEURYSM, FAMILIAL THORACIC 12; AAT122
HP:0003584HP:0003584Late onset0TIA1 CL E G H707211802OMIM:619133AMYOTROPHIC LATERAL SCLEROSIS 26 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA; ALS265
HP:0003584HP:0003584Late onset0TMEM43 CL E G H7918828472OMIM:619832AUDITORY NEUROPATHY, AUTOSOMAL DOMINANT 3; AUNA3171
HP:0003584HP:0003584Late onset0TNNC1 CL E G H713411943OMIM:611879CARDIOMYOPATHY, DILATED, 1Z; CMD1Z73
HP:0003584HP:0003584Late onset0TPM1 CL E G H716812010OMIM:611878Cardiomyopathy, dilated, 1Y230
HP:0003584HP:0003584Late onset0TRNT CL E G H45767499OMIM:168600Parkinson disease, late-onset
HP:0003584HP:0003584Late onset0UQCRC1 CL E G H738412585OMIM:619279PARKINSONISM WITH POLYNEUROPATHY; PKNPY
HP:0003584HP:0003584Late onset0VCL CL E G H741412665OMIM:613255Cardiomyopathy, familial hypertrophic, 15248
HP:0003584HP:0003584Late onset0WFS1 CL E G H746612762OMIM:125853Diabetes mellitus, noninsulin-dependent.389


Genes (105) :AAGAB ABCA7 ABCC8 ACTC1 ADH1C AKT2 ANLN ANXA11 APOE ATN1 ATXN2 ATXN8OS BAG3 BAP1 BEAN1 BLVRA CAPN3 CAV1 CCNF CFHR1 CFHR3 CHCHD10 CLEC3B CLN6 CYLD DSC2 DSG2 ELOVL4 ENPP1 EPCAM ERBB4 FBLN5 FLNC FMR1 GANAB GBA1 GCK GLUD2 GPD2 GYG1 HAVCR2 HMCN1 HMGA1 HNF1A HNF1B HNF4A HTRA1 IGF2BP2 IL6 IMPG2 IRS1 IRS2 JAK2 KCNE2 KCNJ11 KLKB1 KRT18 LAMA4 LDB3 LIPC LMX1B LRRK2 MAFA MAPK8IP1 MAPT MARS1 MME MTNR1B MYBPC3 MYH6 MYPN NEK1 NEUROD1 NEXN NR4A2 OPTN PABPN1 PAX4 PDGFRB PDX1 PPARG PPP1R3A PSEN2 PTPN1 RETN RPS14 RYR2 SEC23B SFTPA1 SLC2A2 SLC30A8 SNCAIP TARDBP TBP TCF7L2 THSD1 THSD4 TIA1 TMEM43 TNNC1 TPM1 TRNT UQCRC1 VCL WFS1

Diseases (70) :OMIM:148600 OMIM:608907 OMIM:125853 OMIM:612098 OMIM:168600 OMIM:616032 OMIM:617839 OMIM:104310 OMIM:603075 OMIM:125370 OMIM:183090 OMIM:613881 OMIM:614327 OMIM:117210 OMIM:614156 OMIM:618129 OMIM:615343 OMIM:619141 OMIM:615911 OMIM:619977 OMIM:204300 OMIM:619132 OMIM:610476 OMIM:610193 OMIM:133190 OMIM:613244 OMIM:615515 OMIM:608895 OMIM:617047 OMIM:300623 OMIM:600666 OMIM:616199 OMIM:618398 OMIM:616779 OMIM:616152 OMIM:263300 OMIM:611493 OMIM:612423 OMIM:215600 OMIM:615235 OMIM:609452 OMIM:256020 OMIM:607060 OMIM:147630 OMIM:601104 OMIM:616280 OMIM:617018 OMIM:615396 OMIM:613251 OMIM:615248 OMIM:617892 OMIM:613122 OMIM:613435 OMIM:164300 OMIM:615007 OMIM:613697 OMIM:153550 OMIM:600996 OMIM:224100 OMIM:619611 OMIM:612069 OMIM:607136 OMIM:618734 OMIM:619825 OMIM:619133 OMIM:619832 OMIM:611879 OMIM:611878 OMIM:619279 OMIM:613255
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.