Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Human Phenotype Ontology

Grandparent Node:
Abnormality of the endocrine system (HP:0000818)

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Parent Node:
Abnormal circulating hormone concentration (HP:0003117)

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..Starting node
..Increased serum serotonin (HP:0003144)

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Term ID:

3144

Name:

Increased serum serotonin

Synonym:

Increased serum serotonin

Definition:

A increased concentration of serotonin in the blood.

Comments:

Reference:

Genes and Diseases:

Child Nodes:

Sister Nodes:

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Abnormal adiponectin level (HP:0030684)

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Abnormal circulating adrenocorticotropin concentration (HP:0011043)

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Abnormal circulating androgen level (HP:0030347)

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Abnormal circulating antimullerian hormone concentration (HP:0031101)

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Abnormal circulating estrogen level (HP:0025132)

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Abnormal circulating gonadotropin concentration (HP:0030338)

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Abnormal circulating inhibin level (HP:0031099)

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Abnormal circulating insulin concentration (HP:0040214)

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Abnormal circulating leptin concentration (HP:0004361)

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Abnormal circulating osteocalcin level (HP:0031427)

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Abnormal circulating pregnenolone concentration (HP:0031187)

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Abnormal circulating progesterone level (HP:0031212)

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Abnormal circulating thyroid hormone concentration (HP:0031508)

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Abnormal glucagon level (HP:0030687)

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Abnormal gonadotropin-releasing hormone concentration (HP:0500012)

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Abnormal serum insulin-like growth factor 1 level (HP:0030352)

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Abnormality of circulating catecholamine level (HP:0012099)

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Abnormality of circulating glucocorticoid level (HP:0012111)

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Decreased circulating dehydroepiandrosterone concentration (HP:0031214)

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Decreased circulating dehydroepiandrosterone-sulfate concentration (HP:0031215)

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Decreased circulating parathyroid hormone level (HP:0031817)

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Decreased response to growth hormone stimulation test (HP:0000824)

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Elevated circulating parathyroid hormone level (HP:0003165)

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Elevated vascular endothelial growth factor level (HP:0031052)

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Fasting hypoglycemia (HP:0003162)

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Increased pituitary glycoprotein hormone alpha subunit level (HP:0031208)

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obsolete Increased serum 1,25-dihydroxyvitamin D3 (HP:0003152)

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Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	Onset	HGMD variants	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003144	HP:0003144	Increased serum serotonin	0	ATRX CL E G H	546	886	ORPHA:100075	Neuroendocrine tumor of stomach	HP:0040284 - Very rare			169
HP:0003144	HP:0003144	Increased serum serotonin	0	CDKN1A CL E G H	1026	1784	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare			2
HP:0003144	HP:0003144	Increased serum serotonin	0	CDKN1B CL E G H	1027	1785	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare			102
HP:0003144	HP:0003144	Increased serum serotonin	0	CDKN2B CL E G H	1030	1788	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare			1
HP:0003144	HP:0003144	Increased serum serotonin	0	CDKN2C CL E G H	1031	1789	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare
HP:0003144	HP:0003144	Increased serum serotonin	0	DAXX CL E G H	1616	2681	ORPHA:100075	Neuroendocrine tumor of stomach	HP:0040284 - Very rare
HP:0003144	HP:0003144	Increased serum serotonin	0	MECP2 CL E G H	4204	6990	OMIM:300496	Autism susceptibility, X-linked 3	HP:0040282 - Frequent			950
HP:0003144	HP:0003144	Increased serum serotonin	0	MEN1 CL E G H	4221	7010	ORPHA:652	Multiple endocrine neoplasia type 1	HP:0040284 - Very rare			462
HP:0003144	HP:0003144	Increased serum serotonin	0	NLGN3 CL E G H	54413	14289	OMIM:300425	Autism susceptibility, X-linked 1	HP:0040282 - Frequent			24
HP:0003144	HP:0003144	Increased serum serotonin	0	NLGN4X CL E G H	57502	14287	OMIM:300495	Autism, susceptibility to, X-linked 2	HP:0040282 - Frequent			57
HP:0003144	HP:0003144	Increased serum serotonin	0	SDHD CL E G H	6392	10683	ORPHA:100093	Carcinoid syndrome	HP:0040283 - Occasional			129
HP:0003144	HP:0003144	Increased serum serotonin	0	SHROOM4 CL E G H	57477	29215	ORPHA:85288	X-linked intellectual disability, Stocco Dos Santos type	HP:0040283 - Occasional			42
HP:0003144	HP:0003144	Increased serum serotonin	0	SNRPN CL E G H	6638	11164	OMIM:209850	Autism susceptibility 1	HP:0040282 - Frequent			37

Genes (13) :ATRX CDKN1A CDKN1B CDKN2B CDKN2C DAXX MECP2 MEN1 NLGN3 NLGN4X SDHD SHROOM4 SNRPN

Diseases (8) :ORPHA:100075 ORPHA:652 OMIM:300496 OMIM:300425 OMIM:300495 ORPHA:100093 ORPHA:85288 OMIM:209850

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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