Human Phenotype Ontology 
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Involuntary movements (HP:0004305)help
Parent Node:
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Tremor (HP:0001337)help
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Resting tremor (HP:0002322)help
Term ID: 2322
Name: Resting tremor
Synonym: Parkinsonian tremor; Rest tremor; Resting tremor; Tremor at rest
Definition: A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.
Comments:
Reference: HP:0002322
Genes and Diseases:
 
       Child Nodes:
........expandPill-rolling tremor (HP:0025387) help

 Sister Nodes: 
..expandAction tremor (HP:0002345) help
..expandRubral tremor (HP:0030665) help
..expandTremor by anatomical site (HP:0030188) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002322HP:0002322Resting tremor0ADCY5 CL E G H111236OMIM:606703Dyskinesia, familial, with facial myokymiaHP:0040283 - Occasional25
HP:0002322HP:0002322Resting tremor0ADCY5 CL E G H111236ORPHA:324588Familial dyskinesia and facial myokymiaHP:0040282 - Frequent25
HP:0002322HP:0002322Resting tremor0ADH1C CL E G H126251OMIM:168600Parkinson disease, late-onset.4
HP:0002322HP:0002322Resting tremor0ALDH18A1 CL E G H58329722OMIM:601162Spastic paraplegia 9A, autosomal dominant89
HP:0002322HP:0002322Resting tremor0ATP13A2 CL E G H2340030213OMIM:617225SPASTIC PARAPLEGIA 78, AUTOSOMAL RECESSIVE; SPG78100
HP:0002322HP:0002322Resting tremor0ATP1A3 CL E G H478801ORPHA:71517Rapid-onset dystonia-parkinsonismHP:0040283 - Occasional150
HP:0002322HP:0002322Resting tremor0ATP6AP2 CL E G H1015918305OMIM:300911Parkinsonism with spasticity, X-linked.36
HP:0002322HP:0002322Resting tremor0ATP6AP2 CL E G H1015918305ORPHA:363654X-linked parkinsonism-spasticity syndromeHP:0040281 - Very frequent36
HP:0002322HP:0002322Resting tremor0ATXN2 CL E G H631110555OMIM:168600Parkinson disease, late-onset.11
HP:0002322HP:0002322Resting tremor0ATXN8OS CL E G H631510561OMIM:168600Parkinson disease, late-onset.1
HP:0002322HP:0002322Resting tremor0CACNA1G CL E G H89131394ORPHA:458803Spinocerebellar ataxia type 42HP:0040283 - Occasional32
HP:0002322HP:0002322Resting tremor0CDKL5 CL E G H679211411ORPHA:3095Atypical Rett syndrome405
HP:0002322HP:0002322Resting tremor0CHCHD2 CL E G H5114221645OMIM:616710Parkinson disease 22, autosomal dominant.3
HP:0002322HP:0002322Resting tremor0COQ2 CL E G H2723525223ORPHA:227510Multiple system atrophy, cerebellar typeHP:0040283 - Occasional54
HP:0002322HP:0002322Resting tremor0COQ2 CL E G H2723525223ORPHA:98933Multiple system atrophy, parkinsonian typeHP:0040282 - Frequent54
HP:0002322HP:0002322Resting tremor0CYP27A1 CL E G H15932605ORPHA:909Cerebrotendinous xanthomatosisHP:0040283 - Occasional114
HP:0002322HP:0002322Resting tremor0DNAJC13 CL E G H2331730343ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent2
HP:0002322HP:0002322Resting tremor0DNAJC6 CL E G H982915469ORPHA:391411Atypical juvenile parkinsonismHP:0040281 - Very frequent6
HP:0002322HP:0002322Resting tremor0DNAJC6 CL E G H982915469OMIM:615528Parkinson disease 19a, juvenile-onset6
HP:0002322HP:0002322Resting tremor0DNMT1 CL E G H17862976ORPHA:314404Autosomal dominant cerebellar ataxia-deafness-narcolepsy syndromeHP:0040283 - Occasional145
HP:0002322HP:0002322Resting tremor0EIF4G1 CL E G H19813296ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent2
HP:0002322HP:0002322Resting tremor0EIF4G1 CL E G H19813296OMIM:614251Parkinson disease 18.2
HP:0002322HP:0002322Resting tremor0FMR1 CL E G H23323775OMIM:300623Fragile X tremor/ataxia syndrome30
HP:0002322HP:0002322Resting tremor0FTL CL E G H25123999ORPHA:157846NeuroferritinopathyHP:0040284 - Very rare33
HP:0002322HP:0002322Resting tremor0GABBR2 CL E G H95684507ORPHA:3095Atypical Rett syndrome5
HP:0002322HP:0002322Resting tremor0GBA1 CL E G H26294177ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent
HP:0002322HP:0002322Resting tremor0GBA1 CL E G H26294177OMIM:168600Parkinson disease, late-onset.
HP:0002322HP:0002322Resting tremor0GCH1 CL E G H26434193OMIM:128230Dystonia, DOPA-responsive, with or without hyperphenylalaninemia86
HP:0002322HP:0002322Resting tremor0GIGYF2 CL E G H2605811960ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent8
HP:0002322HP:0002322Resting tremor0GIGYF2 CL E G H2605811960OMIM:607688PARKINSON DISEASE 11, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO; PARK118
HP:0002322HP:0002322Resting tremor0GLUD2 CL E G H27474336OMIM:168600Parkinson disease, late-onset.1
HP:0002322HP:0002322Resting tremor0KCNN2 CL E G H37816291OMIM:619725NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT VARIABLE MOVEMENT OR BEHAVIORAL ABNORMALITIES; NEDMAB
HP:0002322HP:0002322Resting tremor0LRRK2 CL E G H12089218618ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent221
HP:0002322HP:0002322Resting tremor0LRRK2 CL E G H12089218618OMIM:607060Parkinson disease 8, autosomal dominant.221
HP:0002322HP:0002322Resting tremor0MAN1B1 CL E G H112536823ORPHA:397941MAN1B1-CDGHP:0040284 - Very rare93
HP:0002322HP:0002322Resting tremor0MAPT CL E G H41376893OMIM:168600Parkinson disease, late-onset.140
HP:0002322HP:0002322Resting tremor0MECP2 CL E G H42046990ORPHA:3095Atypical Rett syndrome950
HP:0002322HP:0002322Resting tremor0MECP2 CL E G H42046990OMIM:300055Mental retardation, X-linked, syndromic 13950
HP:0002322HP:0002322Resting tremor0MECP2 CL E G H42046990ORPHA:3077X-linked intellectual disability-psychosis-macroorchidism syndromeHP:0040283 - Occasional950
HP:0002322HP:0002322Resting tremor0MICU1 CL E G H103671530ORPHA:401768Proximal myopathy with extrapyramidal signsHP:0040282 - Frequent14
HP:0002322HP:0002322Resting tremor0NR4A2 CL E G H49297981OMIM:61991127
HP:0002322HP:0002322Resting tremor0NR4A2 CL E G H49297981OMIM:168600Parkinson disease, late-onset.27
HP:0002322HP:0002322Resting tremor0NTNG1 CL E G H2285423319ORPHA:3095Atypical Rett syndrome1
HP:0002322HP:0002322Resting tremor0OPA3 CL E G H802078142ORPHA:67036Autosomal dominant optic atrophy and cataractHP:0040283 - Occasional163
HP:0002322HP:0002322Resting tremor0PARK7 CL E G H1131516369OMIM:606324PARKINSON DISEASE 7, AUTOSOMAL RECESSIVE EARLY-ONSET; PARK723
HP:0002322HP:0002322Resting tremor0PINK1 CL E G H6501814581OMIM:605909Parkinson disease 6, autosomal recessive early-onset.55
HP:0002322HP:0002322Resting tremor0PLA2G6 CL E G H83989039OMIM:612953Parkinson disease 14, autosomal recessive133
HP:0002322HP:0002322Resting tremor0PODXL CL E G H54209171ORPHA:391411Atypical juvenile parkinsonismHP:0040281 - Very frequent6
HP:0002322HP:0002322Resting tremor0POLG CL E G H54289179ORPHA:254892Autosomal dominant progressive external ophthalmoplegiaHP:0040282 - Frequent464
HP:0002322HP:0002322Resting tremor0POLG CL E G H54289179OMIM:157640Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1.464
HP:0002322HP:0002322Resting tremor0POLG2 CL E G H112329180ORPHA:254892Autosomal dominant progressive external ophthalmoplegiaHP:0040282 - Frequent45
HP:0002322HP:0002322Resting tremor0PSAP CL E G H56609498OMIM:619491PARKINSON DISEASE 24, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO; PARK2481
HP:0002322HP:0002322Resting tremor0RAB39B CL E G H11644216499OMIM:311510Waisman syndrome.34
HP:0002322HP:0002322Resting tremor0RRM2B CL E G H5048417296ORPHA:254892Autosomal dominant progressive external ophthalmoplegiaHP:0040282 - Frequent125
HP:0002322HP:0002322Resting tremor0SLC25A4 CL E G H29110990ORPHA:254892Autosomal dominant progressive external ophthalmoplegiaHP:0040282 - Frequent68
HP:0002322HP:0002322Resting tremor0SMC1A CL E G H824311111ORPHA:3095Atypical Rett syndrome135
HP:0002322HP:0002322Resting tremor0SNCA CL E G H662211138ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent65
HP:0002322HP:0002322Resting tremor0SNCA CL E G H662211138OMIM:168601Parkinson disease 1, autosomal dominant.65
HP:0002322HP:0002322Resting tremor0SNCAIP CL E G H962711139OMIM:168600Parkinson disease, late-onset.35
HP:0002322HP:0002322Resting tremor0SYNJ1 CL E G H886711503ORPHA:391411Atypical juvenile parkinsonismHP:0040281 - Very frequent9
HP:0002322HP:0002322Resting tremor0TAF1 CL E G H687211535ORPHA:53351X-linked dystonia-parkinsonismHP:0040282 - Frequent21
HP:0002322HP:0002322Resting tremor0TBP CL E G H690811588OMIM:168600Parkinson disease, late-onset.7
HP:0002322HP:0002322Resting tremor0TRNT CL E G H45767499OMIM:168600Parkinson disease, late-onset.
HP:0002322HP:0002322Resting tremor0TWNK CL E G H566521160ORPHA:254892Autosomal dominant progressive external ophthalmoplegiaHP:0040282 - Frequent113
HP:0002322HP:0002322Resting tremor0UQCRC1 CL E G H738412585OMIM:619279PARKINSONISM WITH POLYNEUROPATHY; PKNPY
HP:0002322HP:0002322Resting tremor0VPS13A CL E G H232301908ORPHA:2388ChoreoacanthocytosisHP:0040283 - Occasional130
HP:0002322HP:0002322Resting tremor0VPS13C CL E G H5483223594OMIM:616840Parkinson disease 23, autosomal recessive early-onset8
HP:0002322HP:0002322Resting tremor0VPS35 CL E G H5573713487ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent37
HP:0002322HP:0002322Resting tremor0VPS35 CL E G H5573713487OMIM:614203Parkinson disease 17.37
HP:0002322HP:0025387Pill-rolling tremor1CDKL5 CL E G H679211411ORPHA:3095Atypical Rett syndromeHP:0040283 - Occasional405
HP:0002322HP:0025387Pill-rolling tremor1DNAJC6 CL E G H982915469OMIM:615528Parkinson disease 19a, juvenile-onset6
HP:0002322HP:0025387Pill-rolling tremor1GABBR2 CL E G H95684507ORPHA:3095Atypical Rett syndromeHP:0040283 - Occasional5
HP:0002322HP:0025387Pill-rolling tremor1MECP2 CL E G H42046990ORPHA:3095Atypical Rett syndromeHP:0040283 - Occasional950
HP:0002322HP:0025387Pill-rolling tremor1NTNG1 CL E G H2285423319ORPHA:3095Atypical Rett syndromeHP:0040283 - Occasional1
HP:0002322HP:0025387Pill-rolling tremor1PLA2G6 CL E G H83989039OMIM:612953Parkinson disease 14, autosomal recessive133
HP:0002322HP:0025387Pill-rolling tremor1SMC1A CL E G H824311111ORPHA:3095Atypical Rett syndromeHP:0040283 - Occasional135


Genes (55) :ADCY5 ADH1C ALDH18A1 ATP13A2 ATP1A3 ATP6AP2 ATXN2 ATXN8OS CACNA1G CDKL5 CHCHD2 COQ2 CYP27A1 DNAJC13 DNAJC6 DNMT1 EIF4G1 FMR1 FTL GABBR2 GBA1 GCH1 GIGYF2 GLUD2 KCNN2 LRRK2 MAN1B1 MAPT MECP2 MICU1 NR4A2 NTNG1 OPA3 PARK7 PINK1 PLA2G6 PODXL POLG POLG2 PSAP RAB39B RRM2B SLC25A4 SMC1A SNCA SNCAIP SYNJ1 TAF1 TBP TRNT TWNK UQCRC1 VPS13A VPS13C VPS35

Diseases (44) :OMIM:606703 ORPHA:324588 OMIM:168600 OMIM:601162 OMIM:617225 ORPHA:71517 OMIM:300911 ORPHA:363654 ORPHA:458803 ORPHA:3095 OMIM:616710 ORPHA:227510 ORPHA:98933 ORPHA:909 ORPHA:411602 ORPHA:391411 OMIM:615528 ORPHA:314404 OMIM:614251 OMIM:300623 ORPHA:157846 OMIM:128230 OMIM:607688 OMIM:619725 OMIM:607060 ORPHA:397941 OMIM:300055 ORPHA:3077 ORPHA:401768 OMIM:619911 ORPHA:67036 OMIM:606324 OMIM:605909 OMIM:612953 ORPHA:254892 OMIM:157640 OMIM:619491 OMIM:311510 OMIM:168601 ORPHA:53351 OMIM:619279 ORPHA:2388 OMIM:616840 OMIM:614203
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.