Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal lung morphology (HP:0002088)

Parent Node:
Abnormal pleura morphology (HP:0002103)

..Starting node
..Pleuritis (HP:0002102)

Term ID:

2102

Name:

Pleuritis

Synonym:

Inflammation of tissues lining lungs and chest; Pleurisy

Definition:

Inflammation of the pleura.

Comments:

Reference:

HP:0002102

Genes and Diseases:

Child Nodes:

Sister Nodes:

Hemothorax (HP:0012151)

Neoplasia of the pleura (HP:0100527)

Pleural cyst (HP:0025422)

Pleural effusion (HP:0002202)

Pleural lymphangiectasia (HP:0006531)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002102	HP:0002102	Pleuritis	0	C4A CL E G H	720	1323	ORPHA:117	Behçet disease	HP:0040283 - Occasional	1
HP:0002102	HP:0002102	Pleuritis	0	CCR1 CL E G H	1230	1602	ORPHA:117	Behçet disease	HP:0040283 - Occasional
HP:0002102	HP:0002102	Pleuritis	0	CTLA4 CL E G H	1493	2505	ORPHA:900	Granulomatosis with polyangiitis	HP:0040283 - Occasional	10
HP:0002102	HP:0002102	Pleuritis	0	CTLA4 CL E G H	1493	2505	OMIM:152700	Systemic lupus erythematosus	.	10
HP:0002102	HP:0002102	Pleuritis	0	DNASE1 CL E G H	1773	2956	OMIM:152700	Systemic lupus erythematosus	.	3
HP:0002102	HP:0002102	Pleuritis	0	ERAP1 CL E G H	51752	18173	ORPHA:117	Behçet disease	HP:0040283 - Occasional	1
HP:0002102	HP:0002102	Pleuritis	0	FAS CL E G H	355	11920	ORPHA:117	Behçet disease	HP:0040283 - Occasional	59
HP:0002102	HP:0002102	Pleuritis	0	FCGR2A CL E G H	2212	3616	OMIM:152700	Systemic lupus erythematosus	.	6
HP:0002102	HP:0002102	Pleuritis	0	FCGR2B CL E G H	2213	3618	OMIM:152700	Systemic lupus erythematosus	.	2
HP:0002102	HP:0002102	Pleuritis	0	HLA-B CL E G H	3106	4932	ORPHA:117	Behçet disease	HP:0040283 - Occasional	4
HP:0002102	HP:0002102	Pleuritis	0	HLA-DPA1 CL E G H	3113	4938	ORPHA:900	Granulomatosis with polyangiitis	HP:0040283 - Occasional
HP:0002102	HP:0002102	Pleuritis	0	HLA-DPB1 CL E G H	3115	4940	ORPHA:900	Granulomatosis with polyangiitis	HP:0040283 - Occasional	1
HP:0002102	HP:0002102	Pleuritis	0	IFNGR1 CL E G H	3459	5439	ORPHA:117	Behçet disease	HP:0040283 - Occasional	60
HP:0002102	HP:0002102	Pleuritis	0	IL10 CL E G H	3586	5962	ORPHA:117	Behçet disease	HP:0040283 - Occasional	2
HP:0002102	HP:0002102	Pleuritis	0	IL12A CL E G H	3592	5969	ORPHA:117	Behçet disease	HP:0040283 - Occasional
HP:0002102	HP:0002102	Pleuritis	0	IL12A-AS1 CL E G H	101928376	49094	ORPHA:117	Behçet disease	HP:0040283 - Occasional
HP:0002102	HP:0002102	Pleuritis	0	IL23R CL E G H	149233	19100	ORPHA:117	Behçet disease	HP:0040283 - Occasional	1
HP:0002102	HP:0002102	Pleuritis	0	IRF4 CL E G H	3662	6119	ORPHA:3452	Whipple disease	HP:0040282 - Frequent	1
HP:0002102	HP:0002102	Pleuritis	0	KLRC4 CL E G H	8302	6377	ORPHA:117	Behçet disease	HP:0040283 - Occasional
HP:0002102	HP:0002102	Pleuritis	0	MEFV CL E G H	4210	6998	ORPHA:117	Behçet disease	HP:0040283 - Occasional	281
HP:0002102	HP:0002102	Pleuritis	0	MEFV CL E G H	4210	6998	ORPHA:342	Familial Mediterranean fever	HP:0040282 - Frequent	281
HP:0002102	HP:0002102	Pleuritis	0	MEFV CL E G H	4210	6998	OMIM:249100	Familial Mediterranean fever, AR		281
HP:0002102	HP:0002102	Pleuritis	0	MEFV CL E G H	4210	6998	OMIM:134610	FAMILIAL MEDITERRANEAN FEVER, AUTOSOMAL DOMINANT		281
HP:0002102	HP:0002102	Pleuritis	0	NOD2 CL E G H	64127	5331	OMIM:617321	YAO SYNDROME; YAOS		187
HP:0002102	HP:0002102	Pleuritis	0	PRG4 CL E G H	10216	9364	ORPHA:2848	Camptodactyly-arthropathy-coxa-vara-pericarditis syndrome		6
HP:0002102	HP:0002102	Pleuritis	0	PRTN3 CL E G H	5657	9495	ORPHA:900	Granulomatosis with polyangiitis	HP:0040283 - Occasional
HP:0002102	HP:0002102	Pleuritis	0	PTPN22 CL E G H	26191	9652	ORPHA:900	Granulomatosis with polyangiitis	HP:0040283 - Occasional	3
HP:0002102	HP:0002102	Pleuritis	0	PTPN22 CL E G H	26191	9652	OMIM:152700	Systemic lupus erythematosus	.	3
HP:0002102	HP:0002102	Pleuritis	0	STAT4 CL E G H	6775	11365	ORPHA:117	Behçet disease	HP:0040283 - Occasional	2
HP:0002102	HP:0002102	Pleuritis	0	TLR4 CL E G H	7099	11850	ORPHA:117	Behçet disease	HP:0040283 - Occasional	3
HP:0002102	HP:0002102	Pleuritis	0	TNFRSF1A CL E G H	7132	11916	OMIM:142680	Periodic fever, familial, autosomal dominant		131
HP:0002102	HP:0002102	Pleuritis	0	TNFRSF1A CL E G H	7132	11916	ORPHA:32960	Tumor necrosis factor receptor 1 associated periodic syndrome	HP:0040282 - Frequent	131
HP:0002102	HP:0002102	Pleuritis	0	TREX1 CL E G H	11277	12269	OMIM:152700	Systemic lupus erythematosus	.	56
HP:0002102	HP:0002102	Pleuritis	0	UBAC2 CL E G H	337867	20486	ORPHA:117	Behçet disease	HP:0040283 - Occasional

Genes (28) :C4A CCR1 CTLA4 DNASE1 ERAP1 FAS FCGR2A FCGR2B HLA-B HLA-DPA1 HLA-DPB1 IFNGR1 IL10 IL12A IL12A-AS1 IL23R IRF4 KLRC4 MEFV NOD2 PRG4 PRTN3 PTPN22 STAT4 TLR4 TNFRSF1A TREX1 UBAC2

Diseases (11) :ORPHA:117 ORPHA:900 OMIM:152700 ORPHA:3452 ORPHA:342 OMIM:249100 OMIM:134610 OMIM:617321 ORPHA:2848 OMIM:142680 ORPHA:32960

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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