Human Phenotype Ontology 
Grandparent Node:
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Abnormality of skin adnexa physiology (HP:0025276)help
Parent Node:
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Hypohidrosis or hyperhidrosis (HP:0007550)help
..Starting node
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Hypohidrosis (HP:0000966)help
Term ID: 966
Name: Hypohidrosis
Synonym: Decreased ability to sweat; Decreased sweating; Inadequate sweating; Oligohidrosis; Sweating, decreased
Definition: Abnormally diminished capacity to sweat.
Comments:
Reference: HP:0000966
Genes and Diseases:
 
       Child Nodes:
........expandDecreased sweating due to autonomic dysfunction (HP:0007480) help

 Sister Nodes: 
..expandHyperhidrosis (HP:0000975) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0000966HP:0000966Hypohidrosis0ABCA12 CL E G H2615479394ORPHA133614637607800
HP:0000966HP:0000966Hypohidrosis0ABCA12 CL E G H2615479394ORPHA136114637607800
HP:0000966HP:0000966Hypohidrosis0ALOX12B CL E G H24279394ORPHA1291430603741
HP:0000966HP:0000966Hypohidrosis0ALOX12B CL E G H24279394ORPHA1285430603741
HP:0000966HP:0000966Hypohidrosis0ALOX12B CL E G H242242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM1291430603741
HP:0000966HP:0000966Hypohidrosis0ALOX12B CL E G H242242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM1285430603741
HP:0000966HP:0000966Hypohidrosis0ALOXE3 CL E G H5934479394ORPHA120213743607206
HP:0000966HP:0000966Hypohidrosis0ALOXE3 CL E G H5934479394ORPHA120913743607206
HP:0000966HP:0000966Hypohidrosis0ALOXE3 CL E G H59344242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM120213743607206
HP:0000966HP:0000966Hypohidrosis0ALOXE3 CL E G H59344242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM120913743607206
HP:0000966HP:0000966Hypohidrosis0ALOXE3 CL E G H59344606545Autosomal recessive congenital ichthyosis 3606545C1847849OMIM120213743607206
HP:0000966HP:0000966Hypohidrosis0ALOXE3 CL E G H59344606545Autosomal recessive congenital ichthyosis 3606545C1847849OMIM120913743607206
HP:0000966HP:0000966Hypohidrosis0ARX CL E G H170302452ORPHA162418060300382
HP:0000966HP:0000966Hypohidrosis0ARX CL E G H170302452ORPHA156518060300382
HP:0000966HP:0000966Hypohidrosis0CASK CL E G H8573300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia300749C2677903OMIM15831497300172
HP:0000966HP:0000966Hypohidrosis0CASK CL E G H8573300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia300749C2677903OMIM16331497300172
HP:0000966HP:0000966Hypohidrosis0CERS3 CL E G H20421979394ORPHA116623752615276
HP:0000966HP:0000966Hypohidrosis0CERS3 CL E G H20421979394ORPHA116023752615276
HP:0000966HP:0000966Hypohidrosis0CLCF1 CL E G H235291545Corsello Opitz syndromeORPHA12817412607672
HP:0000966HP:0000966Hypohidrosis0CLDN10 CL E G H9071617671HELIX SYNDROME617671C4522164OMIM1892033617579
HP:0000966HP:0000966Hypohidrosis0CLDN10 CL E G H9071617671HELIX SYNDROME617671C4522164OMIM1862033617579
HP:0000966HP:0000966Hypohidrosis0COG6 CL E G H57511614576Congenital disorder of glycosylation type 2L614576C3553230OMIM128118621606977
HP:0000966HP:0000966Hypohidrosis0COG6 CL E G H57511614576Congenital disorder of glycosylation type 2L614576C3553230OMIM129718621606977
HP:0000966HP:0000966Hypohidrosis0COG6 CL E G H57511615328Shaheen syndrome615328C3809160OMIM129718621606977
HP:0000966HP:0000966Hypohidrosis0COG6 CL E G H57511615328Shaheen syndrome615328C3809160OMIM128118621606977
HP:0000966HP:0000966Hypohidrosis0COL11A1 CL E G H1301560ORPHA113392186120280
HP:0000966HP:0000966Hypohidrosis0COL11A1 CL E G H1301560ORPHA110282186120280
HP:0000966HP:0000966Hypohidrosis0CRLF1 CL E G H92441545Corsello Opitz syndromeORPHA1712364604237
HP:0000966HP:0000966Hypohidrosis0CTNS CL E G H1497219800Nephropathic cystinosis219800C0010690OMIM15502518606272
HP:0000966HP:0000966Hypohidrosis0CTNS CL E G H1497219800Nephropathic cystinosis219800C0010690OMIM15912518606272
HP:0000966HP:0000966Hypohidrosis0EDA CL E G H1896181ORPHA14953157300451
HP:0000966HP:0000966Hypohidrosis0EDA CL E G H1896181ORPHA14603157300451
HP:0000966HP:0000966Hypohidrosis0EDA CL E G H1896305100Hypohidrotic X-linked ectodermal dysplasia305100C0162359OMIM14953157300451
HP:0000966HP:0000966Hypohidrosis0EDA CL E G H1896305100Hypohidrotic X-linked ectodermal dysplasia305100C0162359OMIM14603157300451
HP:0000966HP:0000966Hypohidrosis0EDA2R CL E G H60401181ORPHA116817756300276
HP:0000966HP:0000966Hypohidrosis0EDA2R CL E G H60401181ORPHA116417756300276
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H10913129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM12912895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H10913129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM12782895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H10913224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM12912895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H10913224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM12782895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H109131810Der Kaloustian Mcintosh Silver syndromeORPHA12912895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H109131810Der Kaloustian Mcintosh Silver syndromeORPHA12782895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H10913248Schaap Taylor Baraitser syndromeORPHA12912895604095
HP:0000966HP:0000966Hypohidrosis0EDAR CL E G H10913248Schaap Taylor Baraitser syndromeORPHA12782895604095
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H128178129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM118814341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H128178129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM119414341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H128178224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM118814341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H128178224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM119414341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H1281781810Der Kaloustian Mcintosh Silver syndromeORPHA119414341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H1281781810Der Kaloustian Mcintosh Silver syndromeORPHA118814341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H128178248Schaap Taylor Baraitser syndromeORPHA119414341606603
HP:0000966HP:0000966Hypohidrosis0EDARADD CL E G H128178248Schaap Taylor Baraitser syndromeORPHA118814341606603
HP:0000966HP:0000966Hypohidrosis0ELOVL4 CL E G H67851955ORPHA117814415605512
HP:0000966HP:0000966Hypohidrosis0ELOVL4 CL E G H67851955ORPHA121314415605512
HP:0000966HP:0000966Hypohidrosis0ELP1 CL E G H85181764ORPHA111815959603722
HP:0000966HP:0000966Hypohidrosis0ELP1 CL E G H85181764ORPHA110545959603722
HP:0000966HP:0000966Hypohidrosis0FAM111B CL E G H374393615704Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis615704C3810325OMIM12724200615584
HP:0000966HP:0000966Hypohidrosis0GJB2 CL E G H2706477ORPHA14824284121011
HP:0000966HP:0000966Hypohidrosis0GJB2 CL E G H2706477ORPHA14604284121011
HP:0000966HP:0000966Hypohidrosis0GJB2 CL E G H2706148210Keratitis-ichthyosis-deafness syndrome, autosomal dominant148210C1835678OMIM14604284121011
HP:0000966HP:0000966Hypohidrosis0GJB2 CL E G H2706148210Keratitis-ichthyosis-deafness syndrome, autosomal dominant148210C1835678OMIM14824284121011
HP:0000966HP:0000966Hypohidrosis0GJB6 CL E G H10804477ORPHA12234288604418
HP:0000966HP:0000966Hypohidrosis0GJB6 CL E G H10804477ORPHA12144288604418
HP:0000966HP:0000966Hypohidrosis0GLA CL E G H2717301500Fabry disease301500C0002986OMIM18994296300644
HP:0000966HP:0000966Hypohidrosis0GLA CL E G H2717301500Fabry disease301500C0002986OMIM19484296300644
HP:0000966HP:0000966Hypohidrosis0GLA CL E G H2717324Slti Salem syndromeORPHA19484296300644
HP:0000966HP:0000966Hypohidrosis0GLA CL E G H2717324Slti Salem syndromeORPHA18994296300644
HP:0000966HP:0000966Hypohidrosis0HEXB CL E G H3074268800Sandhoff disease268800C0036161OMIM13974879606873
HP:0000966HP:0000966Hypohidrosis0HEXB CL E G H3074268800Sandhoff disease268800C0036161OMIM13614879606873
HP:0000966HP:0000966Hypohidrosis0KDF1 CL E G H1266951810Der Kaloustian Mcintosh Silver syndromeORPHA11926624616758
HP:0000966HP:0000966Hypohidrosis0KDF1 CL E G H1266951810Der Kaloustian Mcintosh Silver syndromeORPHA11726624616758
HP:0000966HP:0000966Hypohidrosis0KDF1 CL E G H126695617337Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type617337C4310616OMIM11926624616758
HP:0000966HP:0000966Hypohidrosis0KDF1 CL E G H126695617337Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type617337C4310616OMIM11726624616758
HP:0000966HP:0000966Hypohidrosis0KRT14 CL E G H3861125595Dermatopathia pigmentosa reticularis125595C0406778OMIM11556416148066
HP:0000966HP:0000966Hypohidrosis0KRT14 CL E G H3861125595Dermatopathia pigmentosa reticularis125595C0406778OMIM11486416148066
HP:0000966HP:0000966Hypohidrosis0KRT14 CL E G H3861161000Naegeli-Franceschetti-Jadassohn syndrome161000C0343111OMIM11556416148066
HP:0000966HP:0000966Hypohidrosis0KRT14 CL E G H3861161000Naegeli-Franceschetti-Jadassohn syndrome161000C0343111OMIM11486416148066
HP:0000966HP:0000966Hypohidrosis0LIFR CL E G H39773206ORPHA15546597151443
HP:0000966HP:0000966Hypohidrosis0LIFR CL E G H39773206ORPHA16106597151443
HP:0000966HP:0000966Hypohidrosis0LMNA CL E G H4000740Aortic arch interruptionORPHA114866636150330
HP:0000966HP:0000966Hypohidrosis0LMNA CL E G H4000740Aortic arch interruptionORPHA113476636150330
HP:0000966HP:0000966Hypohidrosis0MBTPS2 CL E G H513602273Fara Chlupackova syndromeORPHA123115455300294
HP:0000966HP:0000966Hypohidrosis0MBTPS2 CL E G H513602273Fara Chlupackova syndromeORPHA124215455300294
HP:0000966HP:0000966Hypohidrosis0MBTPS2 CL E G H51360308205IFAP syndrome with or without BRESHECK syndrome308205C1839988OMIM123115455300294
HP:0000966HP:0000966Hypohidrosis0MBTPS2 CL E G H51360308205IFAP syndrome with or without BRESHECK syndrome308205C1839988OMIM124215455300294
HP:0000966HP:0000966Hypohidrosis0NFKBIA CL E G H4792612132Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant612132C2677481OMIM11527797164008
HP:0000966HP:0000966Hypohidrosis0NFKBIA CL E G H4792612132Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant612132C2677481OMIM11767797164008
HP:0000966HP:0000966Hypohidrosis0NIPAL4 CL E G H34893879394ORPHA114728018609383
HP:0000966HP:0000966Hypohidrosis0NIPAL4 CL E G H34893879394ORPHA115128018609383
HP:0000966HP:0000966Hypohidrosis0PNPLA1 CL E G H28584879394ORPHA114121246612121
HP:0000966HP:0000966Hypohidrosis0PNPLA1 CL E G H28584879394ORPHA113821246612121
HP:0000966HP:0000966Hypohidrosis0POLA1 CL E G H5422301220Pigmentary disorder, reticulate, with systemic manifestations, X-linked301220C1845050OMIM13219173312040
HP:0000966HP:0000966Hypohidrosis0POLA1 CL E G H5422301220Pigmentary disorder, reticulate, with systemic manifestations, X-linked301220C1845050OMIM12169173312040
HP:0000966HP:0000966Hypohidrosis0PRDM12 CL E G H59335616488Neuropathy, hereditary sensory and autonomic, type VIII616488C4225308OMIM118313997616458
HP:0000966HP:0000966Hypohidrosis0PRDM12 CL E G H59335616488Neuropathy, hereditary sensory and autonomic, type VIII616488C4225308OMIM113713997616458
HP:0000966HP:0000966Hypohidrosis0RIPK4 CL E G H541011401ORPHA1272496605706
HP:0000966HP:0000966Hypohidrosis0RIPK4 CL E G H541011401ORPHA1268496605706
HP:0000966HP:0000966Hypohidrosis0ROGDI CL E G H796411946ORPHA133729478614574
HP:0000966HP:0000966Hypohidrosis0ROGDI CL E G H796411946ORPHA139929478614574
HP:0000966HP:0000966Hypohidrosis0SCN9A CL E G H6335243000Indifference to pain, congenital, autosomal recessive243000C1855739OMIM1170810597603415
HP:0000966HP:0000966Hypohidrosis0SCN9A CL E G H6335243000Indifference to pain, congenital, autosomal recessive243000C1855739OMIM1143810597603415
HP:0000966HP:0000966Hypohidrosis0SHANK3 CL E G H8535848652ORPHA161714294606230
HP:0000966HP:0000966Hypohidrosis0SHANK3 CL E G H8535848652ORPHA163814294606230
HP:0000966HP:0000966Hypohidrosis0SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM163814294606230
HP:0000966HP:0000966Hypohidrosis0SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM161714294606230
HP:0000966HP:0000966Hypohidrosis0SLC13A5 CL E G H2841111946ORPHA149123089608305
HP:0000966HP:0000966Hypohidrosis0SLC13A5 CL E G H2841111946ORPHA143523089608305
HP:0000966HP:0000966Hypohidrosis0SMARCAD1 CL E G H569161658Cytoplasmic body myopathyORPHA15818398612761
HP:0000966HP:0000966Hypohidrosis0SMARCAD1 CL E G H569161658Cytoplasmic body myopathyORPHA15618398612761
HP:0000966HP:0000966Hypohidrosis0STIM1 CL E G H6786612783Immune dysfunction with T-cell inactivation due to calcium entry defect 2612783C2748557OMIM137911386605921
HP:0000966HP:0000966Hypohidrosis0STIM1 CL E G H6786612783Immune dysfunction with T-cell inactivation due to calcium entry defect 2612783C2748557OMIM145211386605921
HP:0000966HP:0000966Hypohidrosis0STS CL E G H412281090ORPHA144711425300747
HP:0000966HP:0000966Hypohidrosis0STS CL E G H412281090ORPHA144011425300747
HP:0000966HP:0000966Hypohidrosis0STS CL E G H412461ORPHA144711425300747
HP:0000966HP:0000966Hypohidrosis0STS CL E G H412461ORPHA144011425300747
HP:0000966HP:0000966Hypohidrosis0TGM1 CL E G H705179394ORPHA147611777190195
HP:0000966HP:0000966Hypohidrosis0TGM1 CL E G H705179394ORPHA151411777190195
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H86261071ORPHA144415979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H86261071ORPHA137615979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H8626603543Limb-mammary syndrome603543C1863753OMIM137615979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H8626603543Limb-mammary syndrome603543C1863753OMIM144415979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0000966HP:0000966Hypohidrosis0TRAF6 CL E G H71891810Der Kaloustian Mcintosh Silver syndromeORPHA12512036602355
HP:0000966HP:0000966Hypohidrosis0WNT10A CL E G H80326248Schaap Taylor Baraitser syndromeORPHA130913829606268
HP:0000966HP:0000966Hypohidrosis0WNT10A CL E G H80326248Schaap Taylor Baraitser syndromeORPHA129113829606268
HP:0000966HP:0000966Hypohidrosis0ZFHX2 CL E G H85446147430Indifference to pain, congenital, autosomal dominant147430C1840219OMIM13720152617828
HP:0000966HP:0000966Hypohidrosis0ZFHX2 CL E G H85446147430Indifference to pain, congenital, autosomal dominant147430C1840219OMIM13620152617828
HP:0000966HP:0000966Hypohidrosis0ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA116712877606480
HP:0000966HP:0000966Hypohidrosis0ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA114912877606480
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ABCA12 CL E G H2615479394ORPHA133614637607800
HP:0000966HP:0034012Palmoplantar hypohidrosis1ABCA12 CL E G H2615479394ORPHA136114637607800
HP:0000966HP:0034012Palmoplantar hypohidrosis1ABCA12 CL E G H2615479394ORPHA133614637607800
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ABCA12 CL E G H2615479394ORPHA136114637607800
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOX12B CL E G H24279394ORPHA1285430603741
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOX12B CL E G H24279394ORPHA1291430603741
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOX12B CL E G H24279394ORPHA1285430603741
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOX12B CL E G H24279394ORPHA1291430603741
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOX12B CL E G H242242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM1285430603741
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOX12B CL E G H242242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM1291430603741
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOX12B CL E G H242242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM1285430603741
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOX12B CL E G H242242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM1291430603741
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOXE3 CL E G H5934479394ORPHA120213743607206
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOXE3 CL E G H5934479394ORPHA120913743607206
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOXE3 CL E G H5934479394ORPHA120213743607206
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOXE3 CL E G H5934479394ORPHA120913743607206
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOXE3 CL E G H59344242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM120213743607206
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOXE3 CL E G H59344242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM120913743607206
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOXE3 CL E G H59344242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM120213743607206
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOXE3 CL E G H59344242100Autosomal recessive congenital ichthyosis 2242100C1855792OMIM120913743607206
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOXE3 CL E G H59344606545Autosomal recessive congenital ichthyosis 3606545C1847849OMIM120213743607206
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOXE3 CL E G H59344606545Autosomal recessive congenital ichthyosis 3606545C1847849OMIM120913743607206
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALOXE3 CL E G H59344606545Autosomal recessive congenital ichthyosis 3606545C1847849OMIM120213743607206
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALOXE3 CL E G H59344606545Autosomal recessive congenital ichthyosis 3606545C1847849OMIM120913743607206
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ARX CL E G H170302452ORPHA162418060300382
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ARX CL E G H170302452ORPHA156518060300382
HP:0000966HP:0034012Palmoplantar hypohidrosis1ARX CL E G H170302452ORPHA162418060300382
HP:0000966HP:0034012Palmoplantar hypohidrosis1ARX CL E G H170302452ORPHA156518060300382
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CASK CL E G H8573300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia300749C2677903OMIM15831497300172
HP:0000966HP:0034012Palmoplantar hypohidrosis1CASK CL E G H8573300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia300749C2677903OMIM16331497300172
HP:0000966HP:0034012Palmoplantar hypohidrosis1CASK CL E G H8573300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia300749C2677903OMIM15831497300172
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CASK CL E G H8573300749Mental retardation and microcephaly with pontine and cerebellar hypoplasia300749C2677903OMIM16331497300172
HP:0000966HP:0034012Palmoplantar hypohidrosis1CERS3 CL E G H20421979394ORPHA116023752615276
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CERS3 CL E G H20421979394ORPHA116623752615276
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CERS3 CL E G H20421979394ORPHA116023752615276
HP:0000966HP:0034012Palmoplantar hypohidrosis1CERS3 CL E G H20421979394ORPHA116623752615276
HP:0000966HP:0034012Palmoplantar hypohidrosis1CLCF1 CL E G H235291545Corsello Opitz syndromeORPHA12817412607672
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CLCF1 CL E G H235291545Corsello Opitz syndromeORPHA12817412607672
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CLDN10 CL E G H9071617671HELIX SYNDROME617671C4522164OMIM1892033617579
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CLDN10 CL E G H9071617671HELIX SYNDROME617671C4522164OMIM1862033617579
HP:0000966HP:0034012Palmoplantar hypohidrosis1CLDN10 CL E G H9071617671HELIX SYNDROME617671C4522164OMIM1892033617579
HP:0000966HP:0034012Palmoplantar hypohidrosis1CLDN10 CL E G H9071617671HELIX SYNDROME617671C4522164OMIM1862033617579
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1COG6 CL E G H57511614576Congenital disorder of glycosylation type 2L614576C3553230OMIM128118621606977
HP:0000966HP:0034012Palmoplantar hypohidrosis1COG6 CL E G H57511614576Congenital disorder of glycosylation type 2L614576C3553230OMIM129718621606977
HP:0000966HP:0034012Palmoplantar hypohidrosis1COG6 CL E G H57511614576Congenital disorder of glycosylation type 2L614576C3553230OMIM128118621606977
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1COG6 CL E G H57511614576Congenital disorder of glycosylation type 2L614576C3553230OMIM129718621606977
HP:0000966HP:0034012Palmoplantar hypohidrosis1COG6 CL E G H57511615328Shaheen syndrome615328C3809160OMIM128118621606977
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1COG6 CL E G H57511615328Shaheen syndrome615328C3809160OMIM129718621606977
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1COG6 CL E G H57511615328Shaheen syndrome615328C3809160OMIM128118621606977
HP:0000966HP:0034012Palmoplantar hypohidrosis1COG6 CL E G H57511615328Shaheen syndrome615328C3809160OMIM129718621606977
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1COL11A1 CL E G H1301560ORPHA113392186120280
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1COL11A1 CL E G H1301560ORPHA110282186120280
HP:0000966HP:0034012Palmoplantar hypohidrosis1COL11A1 CL E G H1301560ORPHA113392186120280
HP:0000966HP:0034012Palmoplantar hypohidrosis1COL11A1 CL E G H1301560ORPHA110282186120280
HP:0000966HP:0034012Palmoplantar hypohidrosis1CRLF1 CL E G H92441545Corsello Opitz syndromeORPHA1712364604237
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CRLF1 CL E G H92441545Corsello Opitz syndromeORPHA1712364604237
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CTNS CL E G H1497219800Nephropathic cystinosis219800C0010690OMIM15502518606272
HP:0000966HP:0034012Palmoplantar hypohidrosis1CTNS CL E G H1497219800Nephropathic cystinosis219800C0010690OMIM15912518606272
HP:0000966HP:0034012Palmoplantar hypohidrosis1CTNS CL E G H1497219800Nephropathic cystinosis219800C0010690OMIM15502518606272
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1CTNS CL E G H1497219800Nephropathic cystinosis219800C0010690OMIM15912518606272
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDA CL E G H1896181ORPHA14953157300451
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDA CL E G H1896181ORPHA14603157300451
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDA CL E G H1896181ORPHA14953157300451
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDA CL E G H1896181ORPHA14603157300451
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDA CL E G H1896305100Hypohidrotic X-linked ectodermal dysplasia305100C0162359OMIM14603157300451
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDA CL E G H1896305100Hypohidrotic X-linked ectodermal dysplasia305100C0162359OMIM14953157300451
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDA CL E G H1896305100Hypohidrotic X-linked ectodermal dysplasia305100C0162359OMIM14603157300451
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDA CL E G H1896305100Hypohidrotic X-linked ectodermal dysplasia305100C0162359OMIM14953157300451
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDA2R CL E G H60401181ORPHA116817756300276
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDA2R CL E G H60401181ORPHA116417756300276
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDA2R CL E G H60401181ORPHA116817756300276
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDA2R CL E G H60401181ORPHA116417756300276
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H10913129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM12782895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H10913129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM12912895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H10913129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM12782895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H10913129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM12912895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H10913224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM12782895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H10913224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM12912895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H10913224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM12782895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H10913224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM12912895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H109131810Der Kaloustian Mcintosh Silver syndromeORPHA12912895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H109131810Der Kaloustian Mcintosh Silver syndromeORPHA12782895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H109131810Der Kaloustian Mcintosh Silver syndromeORPHA12912895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H109131810Der Kaloustian Mcintosh Silver syndromeORPHA12782895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H10913248Schaap Taylor Baraitser syndromeORPHA12912895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDAR CL E G H10913248Schaap Taylor Baraitser syndromeORPHA12782895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H10913248Schaap Taylor Baraitser syndromeORPHA12912895604095
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDAR CL E G H10913248Schaap Taylor Baraitser syndromeORPHA12782895604095
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H128178129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM118814341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H128178129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM119414341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H128178129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM118814341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H128178129490Autosomal dominant hypohidrotic ectodermal dysplasia129490C1720965OMIM119414341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H128178224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM118814341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H128178224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM119414341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H128178224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM118814341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H128178224900Autosomal recessive hypohidrotic ectodermal dysplasia syndrome224900C0406702OMIM119414341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H1281781810Der Kaloustian Mcintosh Silver syndromeORPHA119414341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H1281781810Der Kaloustian Mcintosh Silver syndromeORPHA118814341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H1281781810Der Kaloustian Mcintosh Silver syndromeORPHA119414341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H1281781810Der Kaloustian Mcintosh Silver syndromeORPHA118814341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H128178248Schaap Taylor Baraitser syndromeORPHA119414341606603
HP:0000966HP:0034012Palmoplantar hypohidrosis1EDARADD CL E G H128178248Schaap Taylor Baraitser syndromeORPHA118814341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H128178248Schaap Taylor Baraitser syndromeORPHA119414341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1EDARADD CL E G H128178248Schaap Taylor Baraitser syndromeORPHA118814341606603
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ELOVL4 CL E G H67851955ORPHA117814415605512
HP:0000966HP:0034012Palmoplantar hypohidrosis1ELOVL4 CL E G H67851955ORPHA121314415605512
HP:0000966HP:0034012Palmoplantar hypohidrosis1ELOVL4 CL E G H67851955ORPHA117814415605512
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ELOVL4 CL E G H67851955ORPHA121314415605512
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ELP1 CL E G H85181764ORPHA111815959603722
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ELP1 CL E G H85181764ORPHA110545959603722
HP:0000966HP:0034012Palmoplantar hypohidrosis1ELP1 CL E G H85181764ORPHA111815959603722
HP:0000966HP:0034012Palmoplantar hypohidrosis1ELP1 CL E G H85181764ORPHA110545959603722
HP:0000966HP:0034012Palmoplantar hypohidrosis1FAM111B CL E G H374393615704Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis615704C3810325OMIM12724200615584
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1FAM111B CL E G H374393615704Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis615704C3810325OMIM12724200615584
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GJB2 CL E G H2706477ORPHA14824284121011
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GJB2 CL E G H2706477ORPHA14604284121011
HP:0000966HP:0034012Palmoplantar hypohidrosis1GJB2 CL E G H2706477ORPHA14824284121011
HP:0000966HP:0034012Palmoplantar hypohidrosis1GJB2 CL E G H2706477ORPHA14604284121011
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GJB2 CL E G H2706148210Keratitis-ichthyosis-deafness syndrome, autosomal dominant148210C1835678OMIM14604284121011
HP:0000966HP:0034012Palmoplantar hypohidrosis1GJB2 CL E G H2706148210Keratitis-ichthyosis-deafness syndrome, autosomal dominant148210C1835678OMIM14824284121011
HP:0000966HP:0034012Palmoplantar hypohidrosis1GJB2 CL E G H2706148210Keratitis-ichthyosis-deafness syndrome, autosomal dominant148210C1835678OMIM14604284121011
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GJB2 CL E G H2706148210Keratitis-ichthyosis-deafness syndrome, autosomal dominant148210C1835678OMIM14824284121011
HP:0000966HP:0034012Palmoplantar hypohidrosis1GJB6 CL E G H10804477ORPHA12234288604418
HP:0000966HP:0034012Palmoplantar hypohidrosis1GJB6 CL E G H10804477ORPHA12144288604418
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GJB6 CL E G H10804477ORPHA12234288604418
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GJB6 CL E G H10804477ORPHA12144288604418
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GLA CL E G H2717301500Fabry disease301500C0002986OMIM18994296300644
HP:0000966HP:0034012Palmoplantar hypohidrosis1GLA CL E G H2717301500Fabry disease301500C0002986OMIM19484296300644
HP:0000966HP:0034012Palmoplantar hypohidrosis1GLA CL E G H2717301500Fabry disease301500C0002986OMIM18994296300644
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GLA CL E G H2717301500Fabry disease301500C0002986OMIM19484296300644
HP:0000966HP:0034012Palmoplantar hypohidrosis1GLA CL E G H2717324Slti Salem syndromeORPHA19484296300644
HP:0000966HP:0034012Palmoplantar hypohidrosis1GLA CL E G H2717324Slti Salem syndromeORPHA18994296300644
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GLA CL E G H2717324Slti Salem syndromeORPHA19484296300644
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GLA CL E G H2717324Slti Salem syndromeORPHA18994296300644
HP:0000966HP:0034012Palmoplantar hypohidrosis1HEXB CL E G H3074268800Sandhoff disease268800C0036161OMIM13614879606873
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1HEXB CL E G H3074268800Sandhoff disease268800C0036161OMIM13974879606873
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1HEXB CL E G H3074268800Sandhoff disease268800C0036161OMIM13614879606873
HP:0000966HP:0034012Palmoplantar hypohidrosis1HEXB CL E G H3074268800Sandhoff disease268800C0036161OMIM13974879606873
HP:0000966HP:0034012Palmoplantar hypohidrosis1KDF1 CL E G H1266951810Der Kaloustian Mcintosh Silver syndromeORPHA11926624616758
HP:0000966HP:0034012Palmoplantar hypohidrosis1KDF1 CL E G H1266951810Der Kaloustian Mcintosh Silver syndromeORPHA11726624616758
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KDF1 CL E G H1266951810Der Kaloustian Mcintosh Silver syndromeORPHA11926624616758
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KDF1 CL E G H1266951810Der Kaloustian Mcintosh Silver syndromeORPHA11726624616758
HP:0000966HP:0034012Palmoplantar hypohidrosis1KDF1 CL E G H126695617337Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type617337C4310616OMIM11926624616758
HP:0000966HP:0034012Palmoplantar hypohidrosis1KDF1 CL E G H126695617337Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type617337C4310616OMIM11726624616758
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KDF1 CL E G H126695617337Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type617337C4310616OMIM11926624616758
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KDF1 CL E G H126695617337Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type617337C4310616OMIM11726624616758
HP:0000966HP:0034012Palmoplantar hypohidrosis1KRT14 CL E G H3861125595Dermatopathia pigmentosa reticularis125595C0406778OMIM11486416148066
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KRT14 CL E G H3861125595Dermatopathia pigmentosa reticularis125595C0406778OMIM11556416148066
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KRT14 CL E G H3861125595Dermatopathia pigmentosa reticularis125595C0406778OMIM11486416148066
HP:0000966HP:0034012Palmoplantar hypohidrosis1KRT14 CL E G H3861125595Dermatopathia pigmentosa reticularis125595C0406778OMIM11556416148066
HP:0000966HP:0034012Palmoplantar hypohidrosis1KRT14 CL E G H3861161000Naegeli-Franceschetti-Jadassohn syndrome161000C0343111OMIM11486416148066
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KRT14 CL E G H3861161000Naegeli-Franceschetti-Jadassohn syndrome161000C0343111OMIM11556416148066
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KRT14 CL E G H3861161000Naegeli-Franceschetti-Jadassohn syndrome161000C0343111OMIM11486416148066
HP:0000966HP:0034012Palmoplantar hypohidrosis1KRT14 CL E G H3861161000Naegeli-Franceschetti-Jadassohn syndrome161000C0343111OMIM11556416148066
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1LIFR CL E G H39773206ORPHA15546597151443
HP:0000966HP:0034012Palmoplantar hypohidrosis1LIFR CL E G H39773206ORPHA16106597151443
HP:0000966HP:0034012Palmoplantar hypohidrosis1LIFR CL E G H39773206ORPHA15546597151443
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1LIFR CL E G H39773206ORPHA16106597151443
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1LMNA CL E G H4000740Aortic arch interruptionORPHA114866636150330
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1LMNA CL E G H4000740Aortic arch interruptionORPHA113476636150330
HP:0000966HP:0034012Palmoplantar hypohidrosis1LMNA CL E G H4000740Aortic arch interruptionORPHA114866636150330
HP:0000966HP:0034012Palmoplantar hypohidrosis1LMNA CL E G H4000740Aortic arch interruptionORPHA113476636150330
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1MBTPS2 CL E G H513602273Fara Chlupackova syndromeORPHA123115455300294
HP:0000966HP:0034012Palmoplantar hypohidrosis1MBTPS2 CL E G H513602273Fara Chlupackova syndromeORPHA124215455300294
HP:0000966HP:0034012Palmoplantar hypohidrosis1MBTPS2 CL E G H513602273Fara Chlupackova syndromeORPHA123115455300294
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1MBTPS2 CL E G H513602273Fara Chlupackova syndromeORPHA124215455300294
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1MBTPS2 CL E G H51360308205IFAP syndrome with or without BRESHECK syndrome308205C1839988OMIM123115455300294
HP:0000966HP:0034012Palmoplantar hypohidrosis1MBTPS2 CL E G H51360308205IFAP syndrome with or without BRESHECK syndrome308205C1839988OMIM124215455300294
HP:0000966HP:0034012Palmoplantar hypohidrosis1MBTPS2 CL E G H51360308205IFAP syndrome with or without BRESHECK syndrome308205C1839988OMIM123115455300294
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1MBTPS2 CL E G H51360308205IFAP syndrome with or without BRESHECK syndrome308205C1839988OMIM124215455300294
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NFKBIA CL E G H4792612132Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant612132C2677481OMIM11527797164008
HP:0000966HP:0034012Palmoplantar hypohidrosis1NFKBIA CL E G H4792612132Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant612132C2677481OMIM11767797164008
HP:0000966HP:0034012Palmoplantar hypohidrosis1NFKBIA CL E G H4792612132Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant612132C2677481OMIM11527797164008
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NFKBIA CL E G H4792612132Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, autosomal dominant612132C2677481OMIM11767797164008
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NIPAL4 CL E G H34893879394ORPHA114728018609383
HP:0000966HP:0034012Palmoplantar hypohidrosis1NIPAL4 CL E G H34893879394ORPHA115128018609383
HP:0000966HP:0034012Palmoplantar hypohidrosis1NIPAL4 CL E G H34893879394ORPHA114728018609383
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NIPAL4 CL E G H34893879394ORPHA115128018609383
HP:0000966HP:0034012Palmoplantar hypohidrosis1PNPLA1 CL E G H28584879394ORPHA113821246612121
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1PNPLA1 CL E G H28584879394ORPHA114121246612121
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1PNPLA1 CL E G H28584879394ORPHA113821246612121
HP:0000966HP:0034012Palmoplantar hypohidrosis1PNPLA1 CL E G H28584879394ORPHA114121246612121
HP:0000966HP:0034012Palmoplantar hypohidrosis1POLA1 CL E G H5422301220Pigmentary disorder, reticulate, with systemic manifestations, X-linked301220C1845050OMIM12169173312040
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1POLA1 CL E G H5422301220Pigmentary disorder, reticulate, with systemic manifestations, X-linked301220C1845050OMIM13219173312040
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1POLA1 CL E G H5422301220Pigmentary disorder, reticulate, with systemic manifestations, X-linked301220C1845050OMIM12169173312040
HP:0000966HP:0034012Palmoplantar hypohidrosis1POLA1 CL E G H5422301220Pigmentary disorder, reticulate, with systemic manifestations, X-linked301220C1845050OMIM13219173312040
HP:0000966HP:0034012Palmoplantar hypohidrosis1PRDM12 CL E G H59335616488Neuropathy, hereditary sensory and autonomic, type VIII616488C4225308OMIM118313997616458
HP:0000966HP:0034012Palmoplantar hypohidrosis1PRDM12 CL E G H59335616488Neuropathy, hereditary sensory and autonomic, type VIII616488C4225308OMIM113713997616458
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1PRDM12 CL E G H59335616488Neuropathy, hereditary sensory and autonomic, type VIII616488C4225308OMIM118313997616458
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1PRDM12 CL E G H59335616488Neuropathy, hereditary sensory and autonomic, type VIII616488C4225308OMIM113713997616458
HP:0000966HP:0034012Palmoplantar hypohidrosis1RIPK4 CL E G H541011401ORPHA1272496605706
HP:0000966HP:0034012Palmoplantar hypohidrosis1RIPK4 CL E G H541011401ORPHA1268496605706
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1RIPK4 CL E G H541011401ORPHA1272496605706
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1RIPK4 CL E G H541011401ORPHA1268496605706
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ROGDI CL E G H796411946ORPHA133729478614574
HP:0000966HP:0034012Palmoplantar hypohidrosis1ROGDI CL E G H796411946ORPHA139929478614574
HP:0000966HP:0034012Palmoplantar hypohidrosis1ROGDI CL E G H796411946ORPHA133729478614574
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ROGDI CL E G H796411946ORPHA139929478614574
HP:0000966HP:0034012Palmoplantar hypohidrosis1SCN9A CL E G H6335243000Indifference to pain, congenital, autosomal recessive243000C1855739OMIM1143810597603415
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SCN9A CL E G H6335243000Indifference to pain, congenital, autosomal recessive243000C1855739OMIM1170810597603415
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SCN9A CL E G H6335243000Indifference to pain, congenital, autosomal recessive243000C1855739OMIM1143810597603415
HP:0000966HP:0034012Palmoplantar hypohidrosis1SCN9A CL E G H6335243000Indifference to pain, congenital, autosomal recessive243000C1855739OMIM1170810597603415
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SHANK3 CL E G H8535848652ORPHA161714294606230
HP:0000966HP:0034012Palmoplantar hypohidrosis1SHANK3 CL E G H8535848652ORPHA163814294606230
HP:0000966HP:0034012Palmoplantar hypohidrosis1SHANK3 CL E G H8535848652ORPHA161714294606230
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SHANK3 CL E G H8535848652ORPHA163814294606230
HP:0000966HP:0034012Palmoplantar hypohidrosis1SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM161714294606230
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM163814294606230
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM161714294606230
HP:0000966HP:0034012Palmoplantar hypohidrosis1SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM163814294606230
HP:0000966HP:0034012Palmoplantar hypohidrosis1SLC13A5 CL E G H2841111946ORPHA143523089608305
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SLC13A5 CL E G H2841111946ORPHA149123089608305
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SLC13A5 CL E G H2841111946ORPHA143523089608305
HP:0000966HP:0034012Palmoplantar hypohidrosis1SLC13A5 CL E G H2841111946ORPHA149123089608305
HP:0000966HP:0034012Palmoplantar hypohidrosis1SMARCAD1 CL E G H569161658Cytoplasmic body myopathyORPHA15818398612761
HP:0000966HP:0034012Palmoplantar hypohidrosis1SMARCAD1 CL E G H569161658Cytoplasmic body myopathyORPHA15618398612761
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SMARCAD1 CL E G H569161658Cytoplasmic body myopathyORPHA15818398612761
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SMARCAD1 CL E G H569161658Cytoplasmic body myopathyORPHA15618398612761
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1STIM1 CL E G H6786612783Immune dysfunction with T-cell inactivation due to calcium entry defect 2612783C2748557OMIM137911386605921
HP:0000966HP:0034012Palmoplantar hypohidrosis1STIM1 CL E G H6786612783Immune dysfunction with T-cell inactivation due to calcium entry defect 2612783C2748557OMIM145211386605921
HP:0000966HP:0034012Palmoplantar hypohidrosis1STIM1 CL E G H6786612783Immune dysfunction with T-cell inactivation due to calcium entry defect 2612783C2748557OMIM137911386605921
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1STIM1 CL E G H6786612783Immune dysfunction with T-cell inactivation due to calcium entry defect 2612783C2748557OMIM145211386605921
HP:0000966HP:0034012Palmoplantar hypohidrosis1STS CL E G H412281090ORPHA144011425300747
HP:0000966HP:0034012Palmoplantar hypohidrosis1STS CL E G H412461ORPHA144711425300747
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1STS CL E G H412281090ORPHA144711425300747
HP:0000966HP:0034012Palmoplantar hypohidrosis1STS CL E G H412461ORPHA144011425300747
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1STS CL E G H412281090ORPHA144011425300747
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1STS CL E G H412461ORPHA144711425300747
HP:0000966HP:0034012Palmoplantar hypohidrosis1STS CL E G H412281090ORPHA144711425300747
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1STS CL E G H412461ORPHA144011425300747
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TGM1 CL E G H705179394ORPHA147611777190195
HP:0000966HP:0034012Palmoplantar hypohidrosis1TGM1 CL E G H705179394ORPHA151411777190195
HP:0000966HP:0034012Palmoplantar hypohidrosis1TGM1 CL E G H705179394ORPHA147611777190195
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TGM1 CL E G H705179394ORPHA151411777190195
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H86261071ORPHA144415979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H86261071ORPHA137615979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H86261071ORPHA144415979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H86261071ORPHA137615979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H8626603543Limb-mammary syndrome603543C1863753OMIM137615979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H8626603543Limb-mammary syndrome603543C1863753OMIM144415979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H8626603543Limb-mammary syndrome603543C1863753OMIM137615979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H8626603543Limb-mammary syndrome603543C1863753OMIM144415979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TRAF6 CL E G H71891810Der Kaloustian Mcintosh Silver syndromeORPHA12512036602355
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TRAF6 CL E G H71891810Der Kaloustian Mcintosh Silver syndromeORPHA12512036602355
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1WNT10A CL E G H80326248Schaap Taylor Baraitser syndromeORPHA130913829606268
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1WNT10A CL E G H80326248Schaap Taylor Baraitser syndromeORPHA129113829606268
HP:0000966HP:0034012Palmoplantar hypohidrosis1WNT10A CL E G H80326248Schaap Taylor Baraitser syndromeORPHA130913829606268
HP:0000966HP:0034012Palmoplantar hypohidrosis1WNT10A CL E G H80326248Schaap Taylor Baraitser syndromeORPHA129113829606268
HP:0000966HP:0034012Palmoplantar hypohidrosis1ZFHX2 CL E G H85446147430Indifference to pain, congenital, autosomal dominant147430C1840219OMIM13620152617828
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ZFHX2 CL E G H85446147430Indifference to pain, congenital, autosomal dominant147430C1840219OMIM13720152617828
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ZFHX2 CL E G H85446147430Indifference to pain, congenital, autosomal dominant147430C1840219OMIM13620152617828
HP:0000966HP:0034012Palmoplantar hypohidrosis1ZFHX2 CL E G H85446147430Indifference to pain, congenital, autosomal dominant147430C1840219OMIM13720152617828
HP:0000966HP:0034012Palmoplantar hypohidrosis1ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA116712877606480
HP:0000966HP:0034012Palmoplantar hypohidrosis1ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA114912877606480
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA116712877606480
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA114912877606480
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000966HP:0000966Hypohidrosis0ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM0246450605420
HP:0000966HP:0000966Hypohidrosis0ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM0245450605420
HP:0000966HP:0000966Hypohidrosis0ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA08416876606036
HP:0000966HP:0000966Hypohidrosis0ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA06216876606036
HP:0000966HP:0000966Hypohidrosis0FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA05303688136350
HP:0000966HP:0000966Hypohidrosis0FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA05973688136350
HP:0000966HP:0000966Hypohidrosis0GHR CL E G H2690633ORPHA02374263600946
HP:0000966HP:0000966Hypohidrosis0GHR CL E G H2690633ORPHA02064263600946
HP:0000966HP:0000966Hypohidrosis0GMPPA CL E G H29926615510Alacrima, achalasia, and mental retardation syndrome615510C3809738OMIM09822923615495
HP:0000966HP:0000966Hypohidrosis0GMPPA CL E G H29926615510Alacrima, achalasia, and mental retardation syndrome615510C3809738OMIM010722923615495
HP:0000966HP:0000966Hypohidrosis0HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA0744877601802
HP:0000966HP:0000966Hypohidrosis0HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA0634877601802
HP:0000966HP:0000966Hypohidrosis0KCTD1 CL E G H2842522036ORPHA06818249613420
HP:0000966HP:0000966Hypohidrosis0KCTD1 CL E G H2842522036ORPHA06418249613420
HP:0000966HP:0000966Hypohidrosis0LMNB1 CL E G H400199027ORPHA01516637150340
HP:0000966HP:0000966Hypohidrosis0LMNB1 CL E G H400199027ORPHA01296637150340
HP:0000966HP:0000966Hypohidrosis0NECTIN1 CL E G H58183253Limb dystoniaORPHA02079706600644
HP:0000966HP:0000966Hypohidrosis0NECTIN1 CL E G H58183253Limb dystoniaORPHA01999706600644
HP:0000966HP:0000966Hypohidrosis0NIPAL4 CL E G H348938612281Autosomal recessive congenital ichthyosis 6612281C2677065OMIM015128018609383
HP:0000966HP:0000966Hypohidrosis0NIPAL4 CL E G H348938612281Autosomal recessive congenital ichthyosis 6612281C2677065OMIM014728018609383
HP:0000966HP:0000966Hypohidrosis0OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA01388522600037
HP:0000966HP:0000966Hypohidrosis0OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA01628522600037
HP:0000966HP:0000966Hypohidrosis0PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA012715836607123
HP:0000966HP:0000966Hypohidrosis0PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA012015836607123
HP:0000966HP:0000966Hypohidrosis0SOX10 CL E G H6663163746ORPHA024711190602229
HP:0000966HP:0000966Hypohidrosis0SOX10 CL E G H6663163746ORPHA027311190602229
HP:0000966HP:0000966Hypohidrosis0SOX10 CL E G H6663609136Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease609136C1836727OMIM027311190602229
HP:0000966HP:0000966Hypohidrosis0SOX10 CL E G H6663609136Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease609136C1836727OMIM024711190602229
HP:0000966HP:0000966Hypohidrosis0SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA015511195184429
HP:0000966HP:0000966Hypohidrosis0SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA016011195184429
HP:0000966HP:0000966Hypohidrosis0SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA023011199313430
HP:0000966HP:0000966Hypohidrosis0SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA022511199313430
HP:0000966HP:0000966Hypohidrosis0ST14 CL E G H6768602400Ichthyosis, congenital, autosomal recessive 11602400C1865595OMIM016211344606797
HP:0000966HP:0000966Hypohidrosis0ST14 CL E G H6768602400Ichthyosis, congenital, autosomal recessive 11602400C1865595OMIM016011344606797
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H862669085ORPHA044415979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H862669085ORPHA037615979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H86261896Dominant cleft palateORPHA044415979603273
HP:0000966HP:0000966Hypohidrosis0TP63 CL E G H86261896Dominant cleft palateORPHA037615979603273
HP:0000966HP:0000966Hypohidrosis0TRIP4 CL E G H9325616866Spinal muscular atrophy with congenital bone fractures 1616866C4225177OMIM013112310604501
HP:0000966HP:0000966Hypohidrosis0TRIP4 CL E G H9325616866Spinal muscular atrophy with congenital bone fractures 1616866C4225177OMIM012112310604501
HP:0000966HP:0000966Hypohidrosis0TSPEAR CL E G H54084618180ECTODERMAL DYSPLASIA 14, HAIR/TOOTH TYPE WITH OR WITHOUT HYPOHIDROSIS618180OMIM03591268612920
HP:0000966HP:0000966Hypohidrosis0TSPEAR CL E G H54084618180ECTODERMAL DYSPLASIA 14, HAIR/TOOTH TYPE WITH OR WITHOUT HYPOHIDROSIS618180OMIM03221268612920
HP:0000966HP:0000966Hypohidrosis0WNT10A CL E G H80326257980Odontoonychodermal dysplasia257980C0796093OMIM029113829606268
HP:0000966HP:0000966Hypohidrosis0WNT10A CL E G H80326257980Odontoonychodermal dysplasia257980C0796093OMIM030913829606268
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM0245450605420
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM0246450605420
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM0245450605420
HP:0000966HP:0034012Palmoplantar hypohidrosis1ALX4 CL E G H60529613451Frontonasal dysplasia 2613451C3150703OMIM0246450605420
HP:0000966HP:0034012Palmoplantar hypohidrosis1ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA06216876606036
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA08416876606036
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA06216876606036
HP:0000966HP:0034012Palmoplantar hypohidrosis1ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA08416876606036
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA05303688136350
HP:0000966HP:0034012Palmoplantar hypohidrosis1FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA05973688136350
HP:0000966HP:0034012Palmoplantar hypohidrosis1FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA05303688136350
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA05973688136350
HP:0000966HP:0034012Palmoplantar hypohidrosis1GHR CL E G H2690633ORPHA02374263600946
HP:0000966HP:0034012Palmoplantar hypohidrosis1GHR CL E G H2690633ORPHA02064263600946
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GHR CL E G H2690633ORPHA02374263600946
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GHR CL E G H2690633ORPHA02064263600946
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GMPPA CL E G H29926615510Alacrima, achalasia, and mental retardation syndrome615510C3809738OMIM09822923615495
HP:0000966HP:0034012Palmoplantar hypohidrosis1GMPPA CL E G H29926615510Alacrima, achalasia, and mental retardation syndrome615510C3809738OMIM010722923615495
HP:0000966HP:0034012Palmoplantar hypohidrosis1GMPPA CL E G H29926615510Alacrima, achalasia, and mental retardation syndrome615510C3809738OMIM09822923615495
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1GMPPA CL E G H29926615510Alacrima, achalasia, and mental retardation syndrome615510C3809738OMIM010722923615495
HP:0000966HP:0034012Palmoplantar hypohidrosis1HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA0634877601802
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA0744877601802
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA0634877601802
HP:0000966HP:0034012Palmoplantar hypohidrosis1HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA0744877601802
HP:0000966HP:0034012Palmoplantar hypohidrosis1KCTD1 CL E G H2842522036ORPHA06418249613420
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KCTD1 CL E G H2842522036ORPHA06818249613420
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1KCTD1 CL E G H2842522036ORPHA06418249613420
HP:0000966HP:0034012Palmoplantar hypohidrosis1KCTD1 CL E G H2842522036ORPHA06818249613420
HP:0000966HP:0034012Palmoplantar hypohidrosis1LMNB1 CL E G H400199027ORPHA01296637150340
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1LMNB1 CL E G H400199027ORPHA01516637150340
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1LMNB1 CL E G H400199027ORPHA01296637150340
HP:0000966HP:0034012Palmoplantar hypohidrosis1LMNB1 CL E G H400199027ORPHA01516637150340
HP:0000966HP:0034012Palmoplantar hypohidrosis1NECTIN1 CL E G H58183253Limb dystoniaORPHA01999706600644
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NECTIN1 CL E G H58183253Limb dystoniaORPHA02079706600644
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NECTIN1 CL E G H58183253Limb dystoniaORPHA01999706600644
HP:0000966HP:0034012Palmoplantar hypohidrosis1NECTIN1 CL E G H58183253Limb dystoniaORPHA02079706600644
HP:0000966HP:0034012Palmoplantar hypohidrosis1NIPAL4 CL E G H348938612281Autosomal recessive congenital ichthyosis 6612281C2677065OMIM014728018609383
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NIPAL4 CL E G H348938612281Autosomal recessive congenital ichthyosis 6612281C2677065OMIM015128018609383
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1NIPAL4 CL E G H348938612281Autosomal recessive congenital ichthyosis 6612281C2677065OMIM014728018609383
HP:0000966HP:0034012Palmoplantar hypohidrosis1NIPAL4 CL E G H348938612281Autosomal recessive congenital ichthyosis 6612281C2677065OMIM015128018609383
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA01388522600037
HP:0000966HP:0034012Palmoplantar hypohidrosis1OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA01628522600037
HP:0000966HP:0034012Palmoplantar hypohidrosis1OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA01388522600037
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA01628522600037
HP:0000966HP:0034012Palmoplantar hypohidrosis1PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA012015836607123
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA012715836607123
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA012015836607123
HP:0000966HP:0034012Palmoplantar hypohidrosis1PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA012715836607123
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX10 CL E G H6663163746ORPHA024711190602229
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX10 CL E G H6663163746ORPHA027311190602229
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX10 CL E G H6663163746ORPHA024711190602229
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX10 CL E G H6663163746ORPHA027311190602229
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX10 CL E G H6663609136Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease609136C1836727OMIM024711190602229
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX10 CL E G H6663609136Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease609136C1836727OMIM027311190602229
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX10 CL E G H6663609136Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease609136C1836727OMIM024711190602229
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX10 CL E G H6663609136Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease609136C1836727OMIM027311190602229
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA015511195184429
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA016011195184429
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA015511195184429
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA016011195184429
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA022511199313430
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA023011199313430
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA022511199313430
HP:0000966HP:0034012Palmoplantar hypohidrosis1SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA023011199313430
HP:0000966HP:0034012Palmoplantar hypohidrosis1ST14 CL E G H6768602400Ichthyosis, congenital, autosomal recessive 11602400C1865595OMIM016011344606797
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ST14 CL E G H6768602400Ichthyosis, congenital, autosomal recessive 11602400C1865595OMIM016211344606797
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1ST14 CL E G H6768602400Ichthyosis, congenital, autosomal recessive 11602400C1865595OMIM016011344606797
HP:0000966HP:0034012Palmoplantar hypohidrosis1ST14 CL E G H6768602400Ichthyosis, congenital, autosomal recessive 11602400C1865595OMIM016211344606797
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H862669085ORPHA037615979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H862669085ORPHA044415979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H862669085ORPHA037615979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H862669085ORPHA044415979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H86261896Dominant cleft palateORPHA037615979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H86261896Dominant cleft palateORPHA044415979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TP63 CL E G H86261896Dominant cleft palateORPHA037615979603273
HP:0000966HP:0034012Palmoplantar hypohidrosis1TP63 CL E G H86261896Dominant cleft palateORPHA044415979603273
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TRIP4 CL E G H9325616866Spinal muscular atrophy with congenital bone fractures 1616866C4225177OMIM013112310604501
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TRIP4 CL E G H9325616866Spinal muscular atrophy with congenital bone fractures 1616866C4225177OMIM012112310604501
HP:0000966HP:0034012Palmoplantar hypohidrosis1TRIP4 CL E G H9325616866Spinal muscular atrophy with congenital bone fractures 1616866C4225177OMIM013112310604501
HP:0000966HP:0034012Palmoplantar hypohidrosis1TRIP4 CL E G H9325616866Spinal muscular atrophy with congenital bone fractures 1616866C4225177OMIM012112310604501
HP:0000966HP:0034012Palmoplantar hypohidrosis1TSPEAR CL E G H54084618180ECTODERMAL DYSPLASIA 14, HAIR/TOOTH TYPE WITH OR WITHOUT HYPOHIDROSIS618180OMIM03591268612920
HP:0000966HP:0034012Palmoplantar hypohidrosis1TSPEAR CL E G H54084618180ECTODERMAL DYSPLASIA 14, HAIR/TOOTH TYPE WITH OR WITHOUT HYPOHIDROSIS618180OMIM03221268612920
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TSPEAR CL E G H54084618180ECTODERMAL DYSPLASIA 14, HAIR/TOOTH TYPE WITH OR WITHOUT HYPOHIDROSIS618180OMIM03591268612920
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1TSPEAR CL E G H54084618180ECTODERMAL DYSPLASIA 14, HAIR/TOOTH TYPE WITH OR WITHOUT HYPOHIDROSIS618180OMIM03221268612920
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1WNT10A CL E G H80326257980Odontoonychodermal dysplasia257980C0796093OMIM029113829606268
HP:0000966HP:0034012Palmoplantar hypohidrosis1WNT10A CL E G H80326257980Odontoonychodermal dysplasia257980C0796093OMIM030913829606268
HP:0000966HP:0034012Palmoplantar hypohidrosis1WNT10A CL E G H80326257980Odontoonychodermal dysplasia257980C0796093OMIM029113829606268
HP:0000966HP:0007480Decreased sweating due to autonomic dysfunction1WNT10A CL E G H80326257980Odontoonychodermal dysplasia257980C0796093OMIM030913829606268


Genes (64) :ABCA12 ALOX12B ALOXE3 ALX4 ARNT2 ARX CASK CERS3 CLCF1 CLDN10 COG6 COL11A1 CRLF1 CTNS EDA EDA2R EDAR EDARADD ELOVL4 ELP1 FAM111B FGFR1 GHR GJB2 GJB6 GLA GMPPA HESX1 HEXB KCTD1 KDF1 KRT14 LIFR LMNA LMNB1 MBTPS2 NECTIN1 NFKBIA NIPAL4 OTX2 PNPLA1 POLA1 PRDM12 PROKR2 RIPK4 ROGDI SCN9A SHANK3 SLC13A5 SMARCAD1 SOX10 SOX2 SOX3 ST14 STIM1 STS TGM1 TP63 TRAF6 TRIP4 TSPEAR WNT10A ZFHX2 ZMPSTE24

Diseases (65) :79394 242100 606545 613451 3157 452 300749 1545 617671 614576 615328 560 219800 181 305100 129490 224900 1810 248 1955 1764 615704 633 477 148210 301500 324 615510 268800 2036 617337 125595 161000 3206 740 99027 2273 308205 3253 612132 612281 301220 616488 1401 1946 243000 48652 606232 1658 163746 609136 602400 612783 461 281090 1071 69085 1896 603543 129400 616866 618180 257980 147430 169500
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.