Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the dentition (HP:0000164)help
Parent Node:
expand
Tooth malposition (HP:0000692)help
..Starting node
..expand
Widely spaced teeth (HP:0000687)help
Term ID: 687
Name: Widely spaced teeth
Synonym: Generalised dental spacing; Generalised spacing of teeth; Generalized dental spacing; Generalized spacing of teeth; Multiple diastemata; Wide-spaced teeth; Widely spaced teeth; Widely-spaced teeth
Definition: Increased spaces (diastemata) between most of the teeth in the same dental arch.
Comments:
Reference: HP:0000687
Genes and Diseases:
 
       Child Nodes:
........expandWidely spaced primary teeth (HP:0006313) help

 Sister Nodes: 
..expandDental crowding (HP:0000678) help
..expandDental malocclusion (HP:0000689) help
..expandDiastema (HP:0000699) help
..expandIncreased overbite (HP:0011094) help
..expandIrregularly spaced teeth (HP:0006316) help
..expandMisalignment of incisors (HP:0011062) help
..expandOpen bite (HP:0010807) help
..expandOverjet (HP:0011095) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000687HP:0000687Widely spaced teeth0ACP4 CL E G H9365014376OMIM:617297AMELOGENESIS IMPERFECTA, TYPE IJ; AI1J7
HP:0000687HP:0000687Widely spaced teeth0ACVR1 CL E G H90171OMIM:135100Fibrodysplasia ossificans progressiva.49
HP:0000687HP:0000687Widely spaced teeth0ADNP CL E G H2339415766OMIM:615873Helsmoortel-van der Aa syndrome47
HP:0000687HP:0000687Widely spaced teeth0AFF3 CL E G H38996473OMIM:619297KINSSHIP SYNDROME; KINS1
HP:0000687HP:0000687Widely spaced teeth0AIMP2 CL E G H796520609OMIM:618006Leukodystrophy, hypomyelinating, 17.1
HP:0000687HP:0000687Widely spaced teeth0AIP CL E G H9049358ORPHA:963AcromegalyHP:0040282 - Frequent95
HP:0000687HP:0000687Widely spaced teeth0ALX4 CL E G H60529450OMIM:613451Frontonasal dysplasia 2132
HP:0000687HP:0000687Widely spaced teeth0ARSK CL E G H15364225239OMIM:619698MUCOPOLYSACCHARIDOSIS, TYPE X; MPS10
HP:0000687HP:0000687Widely spaced teeth0ATP6V1B2 CL E G H526854ORPHA:79500DOORS syndromeHP:0040283 - Occasional5
HP:0000687HP:0000687Widely spaced teeth0AXIN2 CL E G H8313904ORPHA:99798OligodontiaHP:0040282 - Frequent435
HP:0000687HP:0000687Widely spaced teeth0B3GLCT CL E G H14517320207ORPHA:709Peters plus syndromeHP:0040282 - Frequent36
HP:0000687HP:0000687Widely spaced teeth0B3GLCT CL E G H14517320207OMIM:261540Peters-Plus syndrome.36
HP:0000687HP:0000687Widely spaced teeth0BAP1 CL E G H8314950OMIM:619762KURY-ISIDOR SYNDROME; KURIS184
HP:0000687HP:0000687Widely spaced teeth0BCAS3 CL E G H5482814347OMIM:619641HENGEL-MAROOFIAN-SCHOLS SYNDROME; HEMARS2
HP:0000687HP:0000687Widely spaced teeth0BRD4 CL E G H2347613575ORPHA:199Cornelia de Lange syndromeHP:0040281 - Very frequent
HP:0000687HP:0000687Widely spaced teeth0CAMK2B CL E G H8161461OMIM:617799Mental retardation, autosomal dominant 54
HP:0000687HP:0000687Widely spaced teeth0CCDC47 CL E G H5700324856OMIM:618268Trichohepatoneurodevelopmental syndrome.
HP:0000687HP:0000687Widely spaced teeth0CDC42 CL E G H9981736ORPHA:487796Macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndromeHP:0040283 - Occasional6
HP:0000687HP:0000687Widely spaced teeth0CDC42 CL E G H9981736OMIM:616737Takenouchi-Kosaki syndrome.6
HP:0000687HP:0000687Widely spaced teeth0CDC42BPB CL E G H95781738OMIM:619841
HP:0000687HP:0000687Widely spaced teeth0CDH3 CL E G H10011762OMIM:225280Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome.87
HP:0000687HP:0000687Widely spaced teeth0CDH3 CL E G H10011762ORPHA:1897EEM syndromeHP:0040282 - Frequent87
HP:0000687HP:0000687Widely spaced teeth0CDK19 CL E G H2309719338OMIM:618916DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 87; DEE87
HP:0000687HP:0000687Widely spaced teeth0CDK5RAP2 CL E G H5575518672OMIM:604804Microcephaly 3, primary, autosomal recessive181
HP:0000687HP:0000687Widely spaced teeth0CERT1 CL E G H100872205OMIM:616351Mental retardation, autosomal dominant 34.
HP:0000687HP:0000687Widely spaced teeth0CHST3 CL E G H94691971OMIM:143095Spondyloepiphyseal dysplasia with congenital joint dislocations.165
HP:0000687HP:0000687Widely spaced teeth0DLX3 CL E G H17472916ORPHA:3352Tricho-dento-osseous syndromeHP:0040282 - Frequent48
HP:0000687HP:0000687Widely spaced teeth0DLX3 CL E G H17472916OMIM:190320Trichodentoosseous syndrome.48
HP:0000687HP:0000687Widely spaced teeth0DPH1 CL E G H18013003ORPHA:459061Craniofacial dysplasia-short stature-ectodermal anomalies-intellectual disability syndromeHP:0040283 - Occasional3
HP:0000687HP:0000687Widely spaced teeth0DYRK1A CL E G H18593091ORPHA:268261DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletionHP:0040284 - Very rare134
HP:0000687HP:0000687Widely spaced teeth0EDA CL E G H18963157ORPHA:99798OligodontiaHP:0040282 - Frequent115
HP:0000687HP:0000687Widely spaced teeth0EDARADD CL E G H12817814341ORPHA:99798OligodontiaHP:0040282 - Frequent56
HP:0000687HP:0000687Widely spaced teeth0EIF2S3 CL E G H19683267OMIM:300148Mehmo syndrome.8
HP:0000687HP:0000687Widely spaced teeth0ERCC1 CL E G H20673433ORPHA:90322Cockayne syndrome type 220
HP:0000687HP:0000687Widely spaced teeth0ERCC4 CL E G H20723436ORPHA:90321Cockayne syndrome type 1158
HP:0000687HP:0000687Widely spaced teeth0ERCC6 CL E G H20743438ORPHA:90321Cockayne syndrome type 1199
HP:0000687HP:0000687Widely spaced teeth0ERCC6 CL E G H20743438ORPHA:90322Cockayne syndrome type 2199
HP:0000687HP:0000687Widely spaced teeth0ERCC8 CL E G H11613439ORPHA:90321Cockayne syndrome type 155
HP:0000687HP:0000687Widely spaced teeth0ERCC8 CL E G H11613439ORPHA:90322Cockayne syndrome type 255
HP:0000687HP:0000687Widely spaced teeth0FGF3 CL E G H22483681ORPHA:90024Deafness with labyrinthine aplasia, microtia, and microdontiaHP:0040281 - Very frequent18
HP:0000687HP:0000687Widely spaced teeth0FGF3 CL E G H22483681OMIM:610706Deafness, congenital, with inner ear agenesis, microtia, and microdontia.18
HP:0000687HP:0000687Widely spaced teeth0FGFR1 CL E G H22603688ORPHA:99798OligodontiaHP:0040282 - Frequent172
HP:0000687HP:0000687Widely spaced teeth0GALNS CL E G H25884122OMIM:253000Morquio syndrome A.123
HP:0000687HP:0000687Widely spaced teeth0GJA5 CL E G H27024279OMIM:612474Chromosome 1q21.1 deletion syndrome, 1.35-mb39
HP:0000687HP:0000687Widely spaced teeth0GJA8 CL E G H27034281OMIM:612474Chromosome 1q21.1 deletion syndrome, 1.35-mb34
HP:0000687HP:0000687Widely spaced teeth0GLB1 CL E G H27204298OMIM:253010Mucopolysaccharidosis type IVB (Morquio).120
HP:0000687HP:0000687Widely spaced teeth0GPR101 CL E G H8355014963ORPHA:963AcromegalyHP:0040282 - Frequent5
HP:0000687HP:0000687Widely spaced teeth0GPR101 CL E G H8355014963OMIM:300942Chromosome Xq26.3 duplication syndrome5
HP:0000687HP:0000687Widely spaced teeth0GUSB CL E G H29904696OMIM:253220Mucopolysaccharidosis, type VII.54
HP:0000687HP:0000687Widely spaced teeth0H4C5 CL E G H83674790OMIM:619950
HP:0000687HP:0000687Widely spaced teeth0HDAC4 CL E G H975914063OMIM:619797NEURODEVELOPMENTAL DISORDER WITH CENTRAL HYPOTONIA AND DYSMORPHIC FACIES; NEDCHF33
HP:0000687HP:0000687Widely spaced teeth0HDAC8 CL E G H5586913315ORPHA:199Cornelia de Lange syndromeHP:0040281 - Very frequent37
HP:0000687HP:0000687Widely spaced teeth0HDAC8 CL E G H5586913315OMIM:300882Cornelia de Lange syndrome 5.37
HP:0000687HP:0000687Widely spaced teeth0HK1 CL E G H30984922OMIM:618547NEURODEVELOPMENTAL DISORDER WITH VISUAL DEFECTS AND BRAIN ANOMALIES; NEDVIBA11
HP:0000687HP:0000687Widely spaced teeth0IDS CL E G H34235389OMIM:309900Mucopolysaccharidosis, type II.86
HP:0000687HP:0000687Widely spaced teeth0IFT122 CL E G H5576413556OMIM:218330Cranioectodermal dysplasia.93
HP:0000687HP:0000687Widely spaced teeth0IFT140 CL E G H974229077OMIM:266920Short-rib thoracic dysplasia 9 with or without polydactyly.148
HP:0000687HP:0000687Widely spaced teeth0IFT43 CL E G H11275229669OMIM:614099Cranioectodermal dysplasia 3.11
HP:0000687HP:0000687Widely spaced teeth0IFT52 CL E G H5109815901OMIM:617102Short-Rib thoracic dysplasia 16 with or without polydactyly.4
HP:0000687HP:0000687Widely spaced teeth0IRF6 CL E G H36646121ORPHA:99798OligodontiaHP:0040282 - Frequent99
HP:0000687HP:0000687Widely spaced teeth0KANSL1 CL E G H28405824565OMIM:610443Koolen-De Vries syndrome283
HP:0000687HP:0000687Widely spaced teeth0KATNB1 CL E G H103006217OMIM:616212Lissencephaly 6, with microcephaly10
HP:0000687HP:0000687Widely spaced teeth0KDM1A CL E G H2302829079OMIM:616728Cleft palate, psychomotor retardation, and distinctive facial features3
HP:0000687HP:0000687Widely spaced teeth0KDM1A CL E G H2302829079ORPHA:477993Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndromeHP:0040282 - Frequent3
HP:0000687HP:0000687Widely spaced teeth0KDM6A CL E G H740312637ORPHA:2322Kabuki syndromeHP:0040282 - Frequent53
HP:0000687HP:0000687Widely spaced teeth0KIAA0753 CL E G H985129110OMIM:619479SHORT-RIB THORACIC DYSPLASIA 21 WITHOUT POLYDACTYLY; SRTD214
HP:0000687HP:0000687Widely spaced teeth0KMT2D CL E G H80857133ORPHA:2322Kabuki syndromeHP:0040282 - Frequent660
HP:0000687HP:0000687Widely spaced teeth0LARP7 CL E G H5157424912ORPHA:319671Alazami syndromeHP:0040281 - Very frequent16
HP:0000687HP:0000687Widely spaced teeth0LMBRD2 CL E G H9225525287OMIM:619694DEVELOPMENTAL DELAY WITH VARIABLE NEUROLOGIC AND BRAIN ABNORMALITIES; DENBA
HP:0000687HP:0000687Widely spaced teeth0LRP6 CL E G H40406698ORPHA:99798OligodontiaHP:0040282 - Frequent26
HP:0000687HP:0000687Widely spaced teeth0LTBP3 CL E G H40546716OMIM:601216Dental anomalies and short stature.12
HP:0000687HP:0000687Widely spaced teeth0MAN2B1 CL E G H41256826OMIM:248500Alpha-mannosidosis.136
HP:0000687HP:0000687Widely spaced teeth0MAN2B1 CL E G H41256826ORPHA:309282Alpha-mannosidosis, infantile formHP:0040283 - Occasional136
HP:0000687HP:0000687Widely spaced teeth0MAPK1 CL E G H55946871OMIM:619087NOONAN SYNDROME 13; NS132
HP:0000687HP:0000687Widely spaced teeth0MBD5 CL E G H5577720444OMIM:156200Mental retardation, autosomal dominant 1.252
HP:0000687HP:0000687Widely spaced teeth0MECP2 CL E G H42046990OMIM:300260Mental retardation, x-linked syndromic, Lubs type950
HP:0000687HP:0000687Widely spaced teeth0MED12 CL E G H996811957OMIM:300895Ohdo syndrome, X-linked228
HP:0000687HP:0000687Widely spaced teeth0MED13L CL E G H2338922962ORPHA:369891Developmental delay-facial dysmorphism syndrome due to MED13L deficiencyHP:0040283 - Occasional74
HP:0000687HP:0000687Widely spaced teeth0MED27 CL E G H94422377OMIM:619286NEURODEVELOPMENTAL DISORDER WITH SPASTICITY, CATARACTS, AND CEREBELLAR HYPOPLASIA; NEDSCAC
HP:0000687HP:0000687Widely spaced teeth0MSX1 CL E G H44877391ORPHA:99798OligodontiaHP:0040282 - Frequent12
HP:0000687HP:0000687Widely spaced teeth0NAA20 CL E G H5112615908OMIM:619717INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 73; MRT73
HP:0000687HP:0000687Widely spaced teeth0NARS1 CL E G H46777643OMIM:619092NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, IMPAIRED LANGUAGE, EPILEPSY, AND GAIT ABNORMALITIES; NEDMILEG
HP:0000687HP:0000687Widely spaced teeth0NDST1 CL E G H33407680OMIM:616116Mental retardation, autosomal recessive 4627
HP:0000687HP:0000687Widely spaced teeth0NECTIN4 CL E G H8160719688OMIM:613573Ectodermal dysplasia-syndactyly syndrome 1.7
HP:0000687HP:0000687Widely spaced teeth0NIPBL CL E G H2583628862ORPHA:199Cornelia de Lange syndromeHP:0040281 - Very frequent494
HP:0000687HP:0000687Widely spaced teeth0NIPBL CL E G H2583628862OMIM:122470Cornelia de Lange syndrome 1.494
HP:0000687HP:0000687Widely spaced teeth0NONO CL E G H48417871ORPHA:466791Macrocephaly-intellectual disability-left ventricular non compaction syndromeHP:0040283 - Occasional10
HP:0000687HP:0000687Widely spaced teeth0NONO CL E G H48417871OMIM:300967MENTAL RETARDATION, X-LINKED, SYNDROMIC 34; MRXS3410
HP:0000687HP:0000687Widely spaced teeth0OCA2 CL E G H49488101ORPHA:98794Angelman syndrome due to maternal 15q11q13 deletionHP:0040282 - Frequent121
HP:0000687HP:0000687Widely spaced teeth0PAX9 CL E G H50838623ORPHA:99798OligodontiaHP:0040282 - Frequent58
HP:0000687HP:0000687Widely spaced teeth0PCGF2 CL E G H770312929OMIM:618371Turnpenny-Fry syndrome.
HP:0000687HP:0000687Widely spaced teeth0PIGA CL E G H52778957OMIM:300868Multiple congenital anomalies-hypotonia-seizures syndrome 2.46
HP:0000687HP:0000687Widely spaced teeth0PIGA CL E G H52778957OMIM:301072NEURODEVELOPMENTAL DISORDER WITH EPILEPSY AND HEMOCHROMATOSIS; NEDEPH46
HP:0000687HP:0000687Widely spaced teeth0PIGL CL E G H94878966OMIM:280000Zunich neuroectodermal syndrome.36
HP:0000687HP:0000687Widely spaced teeth0PIGS CL E G H9400514937OMIM:618143GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 18; GPIBD18
HP:0000687HP:0000687Widely spaced teeth0PPP1CB CL E G H55009282OMIM:617506Noonan syndrome-like disorder with loose anagen hair 29
HP:0000687HP:0000687Widely spaced teeth0PRKD1 CL E G H55879407OMIM:617364Congenital heart defects and ectodermal dysplasia.7
HP:0000687HP:0000687Widely spaced teeth0PRR12 CL E G H5747929217OMIM:619539NEUROOCULAR SYNDROME; NOC1
HP:0000687HP:0000687Widely spaced teeth0PTPRF CL E G H57929670OMIM:616001Breasts and/or nipples, aplasia or hypoplasia of, 21
HP:0000687HP:0000687Widely spaced teeth0RAD21 CL E G H58859811ORPHA:199Cornelia de Lange syndromeHP:0040281 - Very frequent25
HP:0000687HP:0000687Widely spaced teeth0RDH11 CL E G H5110917964OMIM:616108Retinal dystrophy, juvenile cataracts, and short stature syndrome.2
HP:0000687HP:0000687Widely spaced teeth0RLIM CL E G H5113213429OMIM:300978Tonne-Kalscheuer syndrome7
HP:0000687HP:0000687Widely spaced teeth0RNF113A CL E G H773712974OMIM:300953Trichothiodystrophy 5, nonphotosensitive3
HP:0000687HP:0000687Widely spaced teeth0RPS6KA3 CL E G H619710432OMIM:303600Coffin-Lowry syndrome.65
HP:0000687HP:0000687Widely spaced teeth0RPS6KA3 CL E G H619710432ORPHA:192Coffin-Lowry syndromeHP:0040281 - Very frequent65
HP:0000687HP:0000687Widely spaced teeth0SATB1 CL E G H630410541OMIM:619229KOHLSCHUTTER-TONZ SYNDROME-LIKE; KTZSL
HP:0000687HP:0000687Widely spaced teeth0SETD1A CL E G H973929010OMIM:619056NEURODEVELOPMENTAL DISORDER WITH SPEECH IMPAIRMENT AND DYSMORPHIC FACIES; NEDSID6
HP:0000687HP:0000687Widely spaced teeth0SHANK3 CL E G H8535814294OMIM:606232Phelan-Mcdermid syndrome53
HP:0000687HP:0000687Widely spaced teeth0SMARCA2 CL E G H659511098OMIM:619293BLEPHAROPHIMOSIS-IMPAIRED INTELLECTUAL DEVELOPMENT SYNDROME; BIS146
HP:0000687HP:0000687Widely spaced teeth0SMARCA2 CL E G H659511098ORPHA:2728Blepharophimosis-intellectual disability syndrome, Ohdo typeHP:0040281 - Very frequent146
HP:0000687HP:0000687Widely spaced teeth0SMARCA2 CL E G H659511098OMIM:601358Nicolaides-Baraitser syndrome146
HP:0000687HP:0000687Widely spaced teeth0SMC1A CL E G H824311111ORPHA:199Cornelia de Lange syndromeHP:0040281 - Very frequent135
HP:0000687HP:0000687Widely spaced teeth0SMC1A CL E G H824311111OMIM:301044DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 85 WITH OR WITHOUT MIDLINE BRAIN DEFECTS; DEE85135
HP:0000687HP:0000687Widely spaced teeth0SMC3 CL E G H91262468ORPHA:199Cornelia de Lange syndromeHP:0040281 - Very frequent91
HP:0000687HP:0000687Widely spaced teeth0SNRPN CL E G H663811164OMIM:105830Angelman syndrome37
HP:0000687HP:0000687Widely spaced teeth0SSR4 CL E G H674811326OMIM:300934Congenital disorder of glycosylation, type Iy12
HP:0000687HP:0000687Widely spaced teeth0SSR4 CL E G H674811326ORPHA:370927SSR4-CDGHP:0040281 - Very frequent12
HP:0000687HP:0000687Widely spaced teeth0SUMO1 CL E G H734112502ORPHA:99798OligodontiaHP:0040282 - Frequent8
HP:0000687HP:0000687Widely spaced teeth0TANC2 CL E G H2611530212OMIM:618906INTELLECTUAL DEVELOPMENTAL DISORDER WITH AUTISTIC FEATURES AND LANGUAGE DELAY, WITH OR WITHOUT SEIZURES; IDDALDS
HP:0000687HP:0000687Widely spaced teeth0TBC1D24 CL E G H5746529203ORPHA:79500DOORS syndromeHP:0040283 - Occasional271
HP:0000687HP:0000687Widely spaced teeth0TBCD CL E G H690411581ORPHA:496641Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndromeHP:0040283 - Occasional16
HP:0000687HP:0000687Widely spaced teeth0TBCD CL E G H690411581OMIM:617193ENCEPHALOPATHY, PROGRESSIVE, EARLY-ONSET, WITH BRAIN ATROPHY AND THIN CORPUS CALLOSUM; PEBAT16
HP:0000687HP:0000687Widely spaced teeth0TBL1XR1 CL E G H7971829529OMIM:602342Pierpont syndrome22
HP:0000687HP:0000687Widely spaced teeth0TBL1XR1 CL E G H7971829529ORPHA:487825Pierpont syndromeHP:0040281 - Very frequent22
HP:0000687HP:0000687Widely spaced teeth0TBX4 CL E G H949611603ORPHA:26127917q23.1q23.2 microdeletion syndromeHP:0040283 - Occasional55
HP:0000687HP:0000687Widely spaced teeth0TCF4 CL E G H692511634OMIM:610954Pitt-Hopkins syndrome.241
HP:0000687HP:0000687Widely spaced teeth0TGFA CL E G H703911765ORPHA:99798OligodontiaHP:0040282 - Frequent
HP:0000687HP:0000687Widely spaced teeth0TP63 CL E G H862615979OMIM:106260Ankyloblepharon-Ectodermal defects-cleft lip/palate.140
HP:0000687HP:0000687Widely spaced teeth0TWIST2 CL E G H11758120670OMIM:209885Barber-Say syndrome7
HP:0000687HP:0000687Widely spaced teeth0UBE3A CL E G H733712496OMIM:105830Angelman syndrome278
HP:0000687HP:0000687Widely spaced teeth0UBE3A CL E G H733712496ORPHA:411511Angelman syndrome due to a point mutationHP:0040282 - Frequent278
HP:0000687HP:0000687Widely spaced teeth0UBE3A CL E G H733712496ORPHA:98794Angelman syndrome due to maternal 15q11q13 deletionHP:0040282 - Frequent278
HP:0000687HP:0000687Widely spaced teeth0UBE3A CL E G H733712496ORPHA:98795Angelman syndrome due to paternal uniparental disomy of chromosome 15HP:0040282 - Frequent278
HP:0000687HP:0000687Widely spaced teeth0WDR26 CL E G H8023221208ORPHA:513456Intellectual disability-seizures-abnormal gait-facial dysmorphism syndromeHP:0040281 - Very frequent8
HP:0000687HP:0000687Widely spaced teeth0WDR26 CL E G H8023221208OMIM:617616Skraban-Deardorff syndrome.8
HP:0000687HP:0000687Widely spaced teeth0WDR35 CL E G H5753929250OMIM:613610Cranioectodermal dysplasia 2.136
HP:0000687HP:0000687Widely spaced teeth0WNT10A CL E G H8032613829OMIM:257980Odontoonychodermal dysplasia71
HP:0000687HP:0000687Widely spaced teeth0WNT10A CL E G H8032613829ORPHA:99798OligodontiaHP:0040282 - Frequent71
HP:0000687HP:0000687Widely spaced teeth0WNT10B CL E G H748012775ORPHA:99798OligodontiaHP:0040282 - Frequent4
HP:0000687HP:0000687Widely spaced teeth0ZEB2 CL E G H983914881OMIM:235730Mowat-Wilson syndrome.362
HP:0000687HP:0000687Widely spaced teeth0ZNF526 CL E G H11611529415OMIM:61987724
HP:0000687HP:0000687Widely spaced teeth0ZSWIM6 CL E G H5768829316OMIM:617865Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features.5
HP:0000687HP:0006313Widely spaced primary teeth1ERCC1 CL E G H20673433ORPHA:90322Cockayne syndrome type 2HP:0040283 - Occasional20
HP:0000687HP:0006313Widely spaced primary teeth1ERCC4 CL E G H20723436ORPHA:90321Cockayne syndrome type 1HP:0040283 - Occasional158
HP:0000687HP:0006313Widely spaced primary teeth1ERCC6 CL E G H20743438ORPHA:90321Cockayne syndrome type 1HP:0040283 - Occasional199
HP:0000687HP:0006313Widely spaced primary teeth1ERCC6 CL E G H20743438ORPHA:90322Cockayne syndrome type 2HP:0040283 - Occasional199
HP:0000687HP:0006313Widely spaced primary teeth1ERCC8 CL E G H11613439ORPHA:90321Cockayne syndrome type 1HP:0040283 - Occasional55
HP:0000687HP:0006313Widely spaced primary teeth1ERCC8 CL E G H11613439ORPHA:90322Cockayne syndrome type 2HP:0040283 - Occasional55
HP:0000687HP:0006313Widely spaced primary teeth1RNF113A CL E G H773712974OMIM:300953Trichothiodystrophy 5, nonphotosensitive.3
HP:0000687HP:0006313Widely spaced primary teeth1WNT10A CL E G H8032613829OMIM:257980Odontoonychodermal dysplasia71


Genes (116) :ACP4 ACVR1 ADNP AFF3 AIMP2 AIP ALX4 ARSK ATP6V1B2 AXIN2 B3GLCT BAP1 BCAS3 BRD4 CAMK2B CCDC47 CDC42 CDC42BPB CDH3 CDK19 CDK5RAP2 CERT1 CHST3 DLX3 DPH1 DYRK1A EDA EDARADD EIF2S3 ERCC1 ERCC4 ERCC6 ERCC8 FGF3 FGFR1 GALNS GJA5 GJA8 GLB1 GPR101 GUSB H4C5 HDAC4 HDAC8 HK1 IDS IFT122 IFT140 IFT43 IFT52 IRF6 KANSL1 KATNB1 KDM1A KDM6A KIAA0753 KMT2D LARP7 LMBRD2 LRP6 LTBP3 MAN2B1 MAPK1 MBD5 MECP2 MED12 MED13L MED27 MSX1 NAA20 NARS1 NDST1 NECTIN4 NIPBL NONO OCA2 PAX9 PCGF2 PIGA PIGL PIGS PPP1CB PRKD1 PRR12 PTPRF RAD21 RDH11 RLIM RNF113A RPS6KA3 SATB1 SETD1A SHANK3 SMARCA2 SMC1A SMC3 SNRPN SSR4 SUMO1 TANC2 TBC1D24 TBCD TBL1XR1 TBX4 TCF4 TGFA TP63 TWIST2 UBE3A WDR26 WDR35 WNT10A WNT10B ZEB2 ZNF526 ZSWIM6

Diseases (116) :OMIM:617297 OMIM:135100 OMIM:615873 OMIM:619297 OMIM:618006 ORPHA:963 OMIM:613451 OMIM:619698 ORPHA:79500 ORPHA:99798 ORPHA:709 OMIM:261540 OMIM:619762 OMIM:619641 ORPHA:199 OMIM:617799 OMIM:618268 ORPHA:487796 OMIM:616737 OMIM:619841 OMIM:225280 ORPHA:1897 OMIM:618916 OMIM:604804 OMIM:616351 OMIM:143095 ORPHA:3352 OMIM:190320 ORPHA:459061 ORPHA:268261 OMIM:300148 ORPHA:90322 ORPHA:90321 ORPHA:90024 OMIM:610706 OMIM:253000 OMIM:612474 OMIM:253010 OMIM:300942 OMIM:253220 OMIM:619950 OMIM:619797 OMIM:300882 OMIM:618547 OMIM:309900 OMIM:218330 OMIM:266920 OMIM:614099 OMIM:617102 OMIM:610443 OMIM:616212 OMIM:616728 ORPHA:477993 ORPHA:2322 OMIM:619479 ORPHA:319671 OMIM:619694 OMIM:601216 OMIM:248500 ORPHA:309282 OMIM:619087 OMIM:156200 OMIM:300260 OMIM:300895 ORPHA:369891 OMIM:619286 OMIM:619717 OMIM:619092 OMIM:616116 OMIM:613573 OMIM:122470 ORPHA:466791 OMIM:300967 ORPHA:98794 OMIM:618371 OMIM:300868 OMIM:301072 OMIM:280000 OMIM:618143 OMIM:617506 OMIM:617364 OMIM:619539 OMIM:616001 OMIM:616108 OMIM:300978 OMIM:300953 OMIM:303600 ORPHA:192 OMIM:619229 OMIM:619056 OMIM:606232 OMIM:619293 ORPHA:2728 OMIM:601358 OMIM:301044 OMIM:105830 OMIM:300934 ORPHA:370927 OMIM:618906 ORPHA:496641 OMIM:617193 OMIM:602342 ORPHA:487825 ORPHA:261279 OMIM:610954 OMIM:106260 OMIM:209885 ORPHA:411511 ORPHA:98795 ORPHA:513456 OMIM:617616 OMIM:613610 OMIM:257980 OMIM:235730 OMIM:619877 OMIM:617865
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.