Human Phenotype Ontology 
Grandparent Node:
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Abnormal jaw morphology (HP:0030791)help
Parent Node:
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Abnormal mandible morphology (HP:0000277)help
..Starting node
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Trismus (HP:0000211)help
Term ID: 211
Name: Trismus
Synonym: Decrease in jaw mobility; Decrease in jaw movement; Decrease in jaw opening; Decrease in mandibular mobility; Decrease in mandibular movement; Decrease in mandibular opening; Limited jaw mobility; Limited jaw movement; Limited jaw opening; Limited mandibular mobility; Limited mandibular opening; Limited mouth opening; Lockjaw; Pain of muscles of mastication
Definition: Limitation in the ability to open the mouth.
Comments:
Reference: HP:0000211
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal mandible condylar process morphology (HP:3000077) help
..expandAbnormal mandible coronoid process morphology (HP:3000078) help
..expandAbnormal mandibular ramus morphology (HP:3000003) help
..expandAbnormality of the temporomandibular joint (HP:0010754) help
..expandAplasia/Hypoplasia of the mandible (HP:0009118) help
..expandAsymmetry of the mandible (HP:0009940) help
..expandBroad jaw (HP:0012802) help
..expandFibrous syngnathia (HP:0009754) help
..expandGiant cell granuloma of mandible (HP:0100955) help
..expandIncreased size of the mandible (HP:0040309) help
..expandJaw ankylosis (HP:0040263) help
..expandMandibular osteomyelitis (HP:0007626) help
..expandMandibular pain (HP:0200025) help
..expandMandibular prognathia (HP:0000303) help
..expandMidline defect of mandible (HP:0010753) help
..expandNarrow jaw (HP:0012801) help
..expandObtuse angle of mandible (HP:0005446) help
..expandRecurrent mandibular subluxations (HP:0005332) help
..expandRetrognathia (HP:0000278) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000211HP:0000211Trismus0CLPB CL E G H8157030664OMIM:6162713-Methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia38
HP:0000211HP:0000211Trismus0COL2A1 CL E G H12802200OMIM:616583Spondyloepiphyseal dysplasia, Stanescu typeHP:0040283 - Occasional284
HP:0000211HP:0000211Trismus0CRLF1 CL E G H92442364OMIM:272430Crisponi/cold-induced sweating syndrome 1.24
HP:0000211HP:0000211Trismus0EDNRA CL E G H19093179OMIM:616367Mandibulofacial dysostosis with alopecia.3
HP:0000211HP:0000211Trismus0GBA1 CL E G H26294177OMIM:230900Gaucher disease, type II.
HP:0000211HP:0000211Trismus0HSPG2 CL E G H33395273ORPHA:800Schwartz-Jampel syndromeHP:0040281 - Very frequent345
HP:0000211HP:0000211Trismus0KCNC2 CL E G H37476234OMIM:619913
HP:0000211HP:0000211Trismus0LIFR CL E G H39776597ORPHA:3206Stüve-Wiedemann syndromeHP:0040282 - Frequent144
HP:0000211HP:0000211Trismus0MYH8 CL E G H46267578OMIM:158300Arthrogryposis, distal, type 7.93
HP:0000211HP:0000211Trismus0MYH8 CL E G H46267578OMIM:608837CARNEY COMPLEX VARIANT93
HP:0000211HP:0000211Trismus0MYMK CL E G H38982733778OMIM:254940Carey-Fineman-Ziter syndrome.5
HP:0000211HP:0000211Trismus0PNKD CL E G H259539153ORPHA:98810Paroxysmal non-kinesigenic dyskinesiaHP:0040283 - Occasional66
HP:0000211HP:0000211Trismus0PRRT2 CL E G H11247630500ORPHA:98810Paroxysmal non-kinesigenic dyskinesiaHP:0040283 - Occasional94
HP:0000211HP:0000211Trismus0SF3B4 CL E G H1026210771OMIM:154400Acrofacial dysostosis 1, Nager type.49
HP:0000211HP:0000211Trismus0TPM2 CL E G H716912011OMIM:108120Arthrogryposis, distal, type 1A.54


Genes (14) :CLPB COL2A1 CRLF1 EDNRA GBA1 HSPG2 KCNC2 LIFR MYH8 MYMK PNKD PRRT2 SF3B4 TPM2

Diseases (14) :OMIM:616271 OMIM:616583 OMIM:272430 OMIM:616367 OMIM:230900 ORPHA:800 OMIM:619913 ORPHA:3206 OMIM:158300 OMIM:608837 OMIM:254940 ORPHA:98810 OMIM:154400 OMIM:108120
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.