Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of the kidney (HP:0000077)

Parent Node:
Abnormal renal morphology (HP:0012210)

..Starting node
..Nephrosclerosis (HP:0009741)

Term ID:

9741

Name:

Nephrosclerosis

Synonym:

Scarring of kidney arteries; Thickening of kidney artiries

Definition:

Nephrosclerosis refers to thickening or scarring ("sclerosis") resulting from damage to the renal arterioles, also referred to as arteriosclerosis of the kidney arteries.

Comments:

Reference:

HP:0009741

Genes and Diseases:

Child Nodes:

Sister Nodes:

Abnormal localization of kidney (HP:0100542)

Abnormal nephron morphology (HP:0012575)

Abnormal renal artery morphology (HP:0008776)

Abnormal renal calyx morphology (HP:0011130)

Abnormal renal collecting system morphology (HP:0004742)

Abnormal renal cortex morphology (HP:0011035)

Abnormal renal medulla morphology (HP:0100957)

Abnormal renal pelvis morphology (HP:0010944)

Decreased renal parenchymal thickness (HP:0025327)

Enlarged kidney (HP:0000105)

Hyperechogenic kidneys (HP:0004719)

Nephrocalcinosis (HP:0000121)

Nephrogenic rest (HP:0100880)

Nephrolithiasis (HP:0000787)

Perinephric fluid collection (HP:0031226)

Perirenal hematoma (HP:0030171)

Renal amyloidosis (HP:0001917)

Renal atrophy (HP:0012585)

Renal cyst (HP:0000107)

Renal duplication (HP:0000075)

Renal dysplasia (HP:0000110)

Renal fibrosis (HP:0030760)

Renal hypoplasia/aplasia (HP:0008678)

Renal malrotation (HP:0004712)

Renal steatosis (HP:0000799)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0009741	HP:0009741	Nephrosclerosis	0	FGF10 CL E G H	2255	3666	OMIM:149730	Lacrimoauriculodentodigital syndrome	.	17
HP:0009741	HP:0009741	Nephrosclerosis	0	FGFR2 CL E G H	2263	3689	OMIM:149730	Lacrimoauriculodentodigital syndrome	.	175
HP:0009741	HP:0009741	Nephrosclerosis	0	FGFR3 CL E G H	2261	3690	OMIM:149730	Lacrimoauriculodentodigital syndrome	.	145

Genes (3) :FGF10 FGFR2 FGFR3

Diseases (1) :OMIM:149730

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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