Human Phenotype Ontology

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000962	HP:0000962	Hyperkeratosis	0	AAAS CL E G H	8086	13666	OMIM:231550	Achalasia-Addisonianism-Alacrima syndrome		57
HP:0000962	HP:0000962	Hyperkeratosis	0	AAAS CL E G H	8086	13666	ORPHA:869	Triple A syndrome		57
HP:0000962	HP:0000962	Hyperkeratosis	0	AAGAB CL E G H	79719	25662	OMIM:148600	Palmoplantar keratoderma, punctate type IA		7
HP:0000962	HP:0000962	Hyperkeratosis	0	AAGAB CL E G H	79719	25662	ORPHA:79501	Punctate palmoplantar keratoderma type 1		7
HP:0000962	HP:0000962	Hyperkeratosis	0	ABCA12 CL E G H	26154	14637	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		130
HP:0000962	HP:0000962	Hyperkeratosis	0	ABCA12 CL E G H	26154	14637	ORPHA:457	Harlequin ichthyosis	HP:0040281 - Very frequent	130
HP:0000962	HP:0000962	Hyperkeratosis	0	ABCA12 CL E G H	26154	14637	OMIM:601277	Ichthyosis, congenital, autosomal recessive 4A		130
HP:0000962	HP:0000962	Hyperkeratosis	0	ABCA12 CL E G H	26154	14637	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	130
HP:0000962	HP:0000962	Hyperkeratosis	0	ABCC9 CL E G H	10060	60	ORPHA:154	Familial isolated dilated cardiomyopathy		254
HP:0000962	HP:0000962	Hyperkeratosis	0	ACTC1 CL E G H	70	143	ORPHA:154	Familial isolated dilated cardiomyopathy		208
HP:0000962	HP:0000962	Hyperkeratosis	0	ACTN2 CL E G H	88	164	ORPHA:154	Familial isolated dilated cardiomyopathy		307
HP:0000962	HP:0000962	Hyperkeratosis	0	ADAM10 CL E G H	102	188	OMIM:615537	Reticulate acropigmentation of kitamura	.	7
HP:0000962	HP:0000962	Hyperkeratosis	0	ADAMTS2 CL E G H	9509	218	OMIM:225410	Ehlers-Danlos syndrome, type VII, autosomal recessive		165
HP:0000962	HP:0000962	Hyperkeratosis	0	AKT1 CL E G H	207	391	ORPHA:201	Cowden syndrome		54
HP:0000962	HP:0000962	Hyperkeratosis	0	AKT1 CL E G H	207	391	OMIM:615109	Cowden syndrome 6		54
HP:0000962	HP:0000962	Hyperkeratosis	0	AKT1 CL E G H	207	391	ORPHA:744	Proteus syndrome		54
HP:0000962	HP:0000962	Hyperkeratosis	0	AKT1 CL E G H	207	391	OMIM:176920	Proteus syndrome, somatic	.	54
HP:0000962	HP:0000962	Hyperkeratosis	0	ALDH3A2 CL E G H	224	403	ORPHA:816	Sjögren-Larsson syndrome	HP:0040281 - Very frequent	87
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOX12B CL E G H	242	430	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		75
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOX12B CL E G H	242	430	OMIM:242100	Ichthyosis, congenital, autosomal recessive 2	.	75
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOX12B CL E G H	242	430	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	75
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOXE3 CL E G H	59344	13743	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		63
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOXE3 CL E G H	59344	13743	OMIM:242100	Ichthyosis, congenital, autosomal recessive 2	.	63
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOXE3 CL E G H	59344	13743	OMIM:606545	Ichthyosis, congenital, autosomal recessive 3	.	63
HP:0000962	HP:0000962	Hyperkeratosis	0	ALOXE3 CL E G H	59344	13743	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	63
HP:0000962	HP:0000962	Hyperkeratosis	0	ANAPC1 CL E G H	64682	19988	ORPHA:221008	Rothmund-Thomson syndrome type 1		2
HP:0000962	HP:0000962	Hyperkeratosis	0	ANAPC1 CL E G H	64682	19988	OMIM:618625	ROTHMUND-THOMSON SYNDROME, TYPE 1; RTS1		2
HP:0000962	HP:0000962	Hyperkeratosis	0	ANKRD1 CL E G H	27063	15819	ORPHA:154	Familial isolated dilated cardiomyopathy		95
HP:0000962	HP:0000962	Hyperkeratosis	0	AP1B1 CL E G H	162	554	OMIM:242150	Ichthyosiform erythroderma, corneal involvement, and deafness
HP:0000962	HP:0000962	Hyperkeratosis	0	AP1B1 CL E G H	162	554	ORPHA:171851	MEDNIK syndrome	HP:0040281 - Very frequent
HP:0000962	HP:0000962	Hyperkeratosis	0	AP1S1 CL E G H	1174	559	ORPHA:171851	MEDNIK syndrome	HP:0040281 - Very frequent	1
HP:0000962	HP:0000962	Hyperkeratosis	0	AQP5 CL E G H	362	638	ORPHA:2337	Non-epidermolytic palmoplantar keratoderma		5
HP:0000962	HP:0000962	Hyperkeratosis	0	AQP5 CL E G H	362	638	OMIM:600231	PALMOPLANTAR KERATODERMA, BOTHNIAN TYPE; PPKB		5
HP:0000962	HP:0000962	Hyperkeratosis	0	ASPRV1 CL E G H	151516	26321	OMIM:146750	Ichthyosis, lamellar, autosomal dominant	.	1
HP:0000962	HP:0000962	Hyperkeratosis	0	ASPRV1 CL E G H	151516	26321	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	1
HP:0000962	HP:0000962	Hyperkeratosis	0	ATL1 CL E G H	51062	11231	ORPHA:36386	Hereditary sensory and autonomic neuropathy type 1	HP:0040282 - Frequent	71
HP:0000962	HP:0000962	Hyperkeratosis	0	ATL3 CL E G H	25923	24526	ORPHA:36386	Hereditary sensory and autonomic neuropathy type 1	HP:0040282 - Frequent	5
HP:0000962	HP:0000962	Hyperkeratosis	0	ATL3 CL E G H	25923	24526	OMIM:615632	Neuropathy, hereditary sensory, type IF	.	5
HP:0000962	HP:0000962	Hyperkeratosis	0	ATP2A2 CL E G H	488	812	OMIM:101900	Acrokeratosis verruciformis	.	86
HP:0000962	HP:0000962	Hyperkeratosis	0	ATP2A2 CL E G H	488	812	ORPHA:79151	Acrokeratosis verruciformis of Hopf	HP:0040281 - Very frequent	86
HP:0000962	HP:0000962	Hyperkeratosis	0	ATP2A2 CL E G H	488	812	ORPHA:218	Darier disease		86
HP:0000962	HP:0000962	Hyperkeratosis	0	ATP2A2 CL E G H	488	812	OMIM:124200	Darier-White disease		86
HP:0000962	HP:0000962	Hyperkeratosis	0	ATP2C1 CL E G H	27032	13211	ORPHA:2841	Familial benign chronic pemphigus	HP:0040281 - Very frequent	56
HP:0000962	HP:0000962	Hyperkeratosis	0	BAG3 CL E G H	9531	939	ORPHA:154	Familial isolated dilated cardiomyopathy		204
HP:0000962	HP:0000962	Hyperkeratosis	0	BAG5 CL E G H	9529	941	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0000962	Hyperkeratosis	0	BRAF CL E G H	673	1097	ORPHA:1340	Cardiofaciocutaneous syndrome	HP:0040282 - Frequent	276
HP:0000962	HP:0000962	Hyperkeratosis	0	BRAF CL E G H	673	1097	OMIM:115150	Cardiofaciocutaneous syndrome 1		276
HP:0000962	HP:0000962	Hyperkeratosis	0	BRAF CL E G H	673	1097	OMIM:613707	Leopard syndrome 3		276
HP:0000962	HP:0000962	Hyperkeratosis	0	CAP2 CL E G H	10486	20039	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0000962	Hyperkeratosis	0	CARD14 CL E G H	79092	16446	ORPHA:2897	Pityriasis rubra pilaris		33
HP:0000962	HP:0000962	Hyperkeratosis	0	CARD14 CL E G H	79092	16446	OMIM:173200	Pityriasis rubra pilaris		33
HP:0000962	HP:0000962	Hyperkeratosis	0	CARD14 CL E G H	79092	16446	OMIM:602723	PSORIASIS 2; PSORS2		33
HP:0000962	HP:0000962	Hyperkeratosis	0	CAST CL E G H	831	1515	OMIM:616295	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	CD28 CL E G H	940	1653	ORPHA:2584	Classic mycosis fungoides	HP:0040283 - Occasional
HP:0000962	HP:0000962	Hyperkeratosis	0	CD28 CL E G H	940	1653	ORPHA:3162	Sézary syndrome
HP:0000962	HP:0000962	Hyperkeratosis	0	CDH3 CL E G H	1001	1762	ORPHA:1573	Hypotrichosis with juvenile macular degeneration	HP:0040283 - Occasional	87
HP:0000962	HP:0000962	Hyperkeratosis	0	CDSN CL E G H	1041	1802	ORPHA:90368	Hypotrichosis simplex of the scalp		7
HP:0000962	HP:0000962	Hyperkeratosis	0	CERS3 CL E G H	204219	23752	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		5
HP:0000962	HP:0000962	Hyperkeratosis	0	CERS3 CL E G H	204219	23752	OMIM:615023	Ichthyosis, congenital, autosomal recessive 9		5
HP:0000962	HP:0000962	Hyperkeratosis	0	CFTR CL E G H	1080	1884	ORPHA:498359	Aquagenic palmoplantar keratoderma		1371
HP:0000962	HP:0000962	Hyperkeratosis	0	CLEC7A CL E G H	64581	14558	ORPHA:1334	Chronic mucocutaneous candidiasis	HP:0040281 - Very frequent	3
HP:0000962	HP:0000962	Hyperkeratosis	0	COG6 CL E G H	57511	18621	OMIM:614576	CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIl; CDG2L		71
HP:0000962	HP:0000962	Hyperkeratosis	0	COG6 CL E G H	57511	18621	ORPHA:363523	Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome		71
HP:0000962	HP:0000962	Hyperkeratosis	0	COG6 CL E G H	57511	18621	OMIM:615328	Shaheen syndrome		71
HP:0000962	HP:0000962	Hyperkeratosis	0	COL12A1 CL E G H	1303	2188	ORPHA:610	Bethlem myopathy	HP:0040283 - Occasional	65
HP:0000962	HP:0000962	Hyperkeratosis	0	COL14A1 CL E G H	7373	2191	ORPHA:79501	Punctate palmoplantar keratoderma type 1		2
HP:0000962	HP:0000962	Hyperkeratosis	0	COL17A1 CL E G H	1308	2194	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		129
HP:0000962	HP:0000962	Hyperkeratosis	0	COL6A1 CL E G H	1291	2211	ORPHA:610	Bethlem myopathy	HP:0040283 - Occasional	442
HP:0000962	HP:0000962	Hyperkeratosis	0	COL6A1 CL E G H	1291	2211	OMIM:254090	Ullrich congenital muscular dystrophy 1		442
HP:0000962	HP:0000962	Hyperkeratosis	0	COL6A2 CL E G H	1292	2212	ORPHA:610	Bethlem myopathy	HP:0040283 - Occasional	478
HP:0000962	HP:0000962	Hyperkeratosis	0	COL6A2 CL E G H	1292	2212	OMIM:254090	Ullrich congenital muscular dystrophy 1		478
HP:0000962	HP:0000962	Hyperkeratosis	0	COL6A3 CL E G H	1293	2213	ORPHA:610	Bethlem myopathy	HP:0040283 - Occasional	702
HP:0000962	HP:0000962	Hyperkeratosis	0	COL6A3 CL E G H	1293	2213	OMIM:254090	Ullrich congenital muscular dystrophy 1		702
HP:0000962	HP:0000962	Hyperkeratosis	0	COL7A1 CL E G H	1294	2214	ORPHA:89843	Dystrophic epidermolysis bullosa pruriginosa	HP:0040283 - Occasional	263
HP:0000962	HP:0000962	Hyperkeratosis	0	COL7A1 CL E G H	1294	2214	OMIM:131850	Epidermolysis bullosa dystrophica, pretibial	.	263
HP:0000962	HP:0000962	Hyperkeratosis	0	COL7A1 CL E G H	1294	2214	ORPHA:158673	Localized dystrophic epidermolysis bullosa, acral form		263
HP:0000962	HP:0000962	Hyperkeratosis	0	COL7A1 CL E G H	1294	2214	ORPHA:79410	Localized dystrophic epidermolysis bullosa, pretibial form		263
HP:0000962	HP:0000962	Hyperkeratosis	0	CRYAB CL E G H	1410	2389	ORPHA:154	Familial isolated dilated cardiomyopathy		46
HP:0000962	HP:0000962	Hyperkeratosis	0	CSRP3 CL E G H	8048	2472	ORPHA:154	Familial isolated dilated cardiomyopathy		104
HP:0000962	HP:0000962	Hyperkeratosis	0	CSTA CL E G H	1475	2481	OMIM:607936	Peeling skin syndrome 4	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	CTC1 CL E G H	80169	26169	ORPHA:1775	Dyskeratosis congenita		160
HP:0000962	HP:0000962	Hyperkeratosis	0	CTLA4 CL E G H	1493	2505	ORPHA:2584	Classic mycosis fungoides	HP:0040283 - Occasional	10
HP:0000962	HP:0000962	Hyperkeratosis	0	CTLA4 CL E G H	1493	2505	ORPHA:3162	Sézary syndrome		10
HP:0000962	HP:0000962	Hyperkeratosis	0	CTSC CL E G H	1075	2528	OMIM:245010	Haim-Munk syndrome		50
HP:0000962	HP:0000962	Hyperkeratosis	0	CTSC CL E G H	1075	2528	ORPHA:678	Papillon-Lefèvre syndrome		50
HP:0000962	HP:0000962	Hyperkeratosis	0	CTSC CL E G H	1075	2528	OMIM:245000	Papillon-Lefevre syndrome		50
HP:0000962	HP:0000962	Hyperkeratosis	0	CYP4F22 CL E G H	126410	26820	OMIM:604777	Ichthyosis, congenital, autosomal recessive 5		54
HP:0000962	HP:0000962	Hyperkeratosis	0	CYP4F22 CL E G H	126410	26820	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	54
HP:0000962	HP:0000962	Hyperkeratosis	0	DDB2 CL E G H	1643	2718	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	30
HP:0000962	HP:0000962	Hyperkeratosis	0	DDR2 CL E G H	4921	2731	OMIM:618175	WARBURG-CINOTTI SYNDROME; WRCN		45
HP:0000962	HP:0000962	Hyperkeratosis	0	DES CL E G H	1674	2770	ORPHA:154	Familial isolated dilated cardiomyopathy		263
HP:0000962	HP:0000962	Hyperkeratosis	0	DIP2B CL E G H	57609	29284	OMIM:136630	Mental retardation, Fra12a type	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	DKC1 CL E G H	1736	2890	ORPHA:1775	Dyskeratosis congenita		65
HP:0000962	HP:0000962	Hyperkeratosis	0	DMD CL E G H	1756	2928	ORPHA:154	Familial isolated dilated cardiomyopathy		1496
HP:0000962	HP:0000962	Hyperkeratosis	0	DNAJC21 CL E G H	134218	27030	OMIM:617052	Bone marrow failure syndrome 3	.	5
HP:0000962	HP:0000962	Hyperkeratosis	0	DOLK CL E G H	22845	23406	OMIM:610768	Congenital disorder of glycosylation, type Im		55
HP:0000962	HP:0000962	Hyperkeratosis	0	DOLK CL E G H	22845	23406	ORPHA:154	Familial isolated dilated cardiomyopathy		55
HP:0000962	HP:0000962	Hyperkeratosis	0	DSC2 CL E G H	1824	3036	OMIM:610476	Arrhythmogenic right ventricular dysplasia, familial, 11		268
HP:0000962	HP:0000962	Hyperkeratosis	0	DSC3 CL E G H	1825	3037	OMIM:613102	HYPOTRICHOSIS AND RECURRENT SKIN VESICLES		2
HP:0000962	HP:0000962	Hyperkeratosis	0	DSG1 CL E G H	1828	3048	OMIM:615508	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige		16
HP:0000962	HP:0000962	Hyperkeratosis	0	DSG1 CL E G H	1828	3048	OMIM:148700	Keratosis palmoplantaris striata I		16
HP:0000962	HP:0000962	Hyperkeratosis	0	DSG1 CL E G H	1828	3048	ORPHA:50942	Striate palmoplantar keratoderma		16
HP:0000962	HP:0000962	Hyperkeratosis	0	DSG2 CL E G H	1829	3049	ORPHA:154	Familial isolated dilated cardiomyopathy		358
HP:0000962	HP:0000962	Hyperkeratosis	0	DSG4 CL E G H	147409	21307	OMIM:607903	Hypotrichosis 6		63
HP:0000962	HP:0000962	Hyperkeratosis	0	DSG4 CL E G H	147409	21307	ORPHA:573	Monilethrix		63
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	OMIM:605676	Cardiomyopathy, dilated, with woolly hair and keratoderma		747
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	OMIM:615821	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	.	747
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	ORPHA:65282	Carvajal syndrome		747
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	ORPHA:154	Familial isolated dilated cardiomyopathy		747
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	OMIM:612908	Keratosis palmoplantaris striata II		747
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	OMIM:607655	Skin fragility-woolly hair syndrome		747
HP:0000962	HP:0000962	Hyperkeratosis	0	DSP CL E G H	1832	3052	ORPHA:50942	Striate palmoplantar keratoderma		747
HP:0000962	HP:0000962	Hyperkeratosis	0	ECM1 CL E G H	1893	3153	ORPHA:530	Lipoid proteinosis	HP:0040282 - Frequent	14
HP:0000962	HP:0000962	Hyperkeratosis	0	ECM1 CL E G H	1893	3153	OMIM:247100	Urbach-Wiethe disease		14
HP:0000962	HP:0000962	Hyperkeratosis	0	ELMO2 CL E G H	63916	17233	ORPHA:3019	Ramon syndrome	HP:0040283 - Occasional	3
HP:0000962	HP:0000962	Hyperkeratosis	0	ELOVL1 CL E G H	64834	14418	OMIM:618527	Ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facial features
HP:0000962	HP:0000962	Hyperkeratosis	0	ELOVL4 CL E G H	6785	14415	OMIM:614457	Ichthyosis, spastic quadriplegia, and mental retardation	.	62
HP:0000962	HP:0000962	Hyperkeratosis	0	ELOVL4 CL E G H	6785	14415	OMIM:133190	Spinocerebellar ataxia 34	.	62
HP:0000962	HP:0000962	Hyperkeratosis	0	ENPP1 CL E G H	5167	3356	OMIM:615522	Cole disease	.	151
HP:0000962	HP:0000962	Hyperkeratosis	0	EPHB4 CL E G H	2050	3395	ORPHA:90186	Meige disease		3
HP:0000962	HP:0000962	Hyperkeratosis	0	ERCC2 CL E G H	2068	3434	OMIM:601675	Trichothiodystrophy 1, photosensitive	.	106
HP:0000962	HP:0000962	Hyperkeratosis	0	ERCC2 CL E G H	2068	3434	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	106
HP:0000962	HP:0000962	Hyperkeratosis	0	ERCC3 CL E G H	2071	3435	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	54
HP:0000962	HP:0000962	Hyperkeratosis	0	ERCC4 CL E G H	2072	3436	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	158
HP:0000962	HP:0000962	Hyperkeratosis	0	ERCC5 CL E G H	2073	3437	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	83
HP:0000962	HP:0000962	Hyperkeratosis	0	ERMARD CL E G H	55780	21056	ORPHA:75857	6q terminal deletion syndrome	HP:0040283 - Occasional	36
HP:0000962	HP:0000962	Hyperkeratosis	0	EXPH5 CL E G H	23086	30578	OMIM:615028	Epidermolysis bullosa, nonspecific, autosomal recessive	.	2
HP:0000962	HP:0000962	Hyperkeratosis	0	FERMT1 CL E G H	55612	15889	ORPHA:2908	Kindler epidermolysis bullosa	HP:0040283 - Occasional	136
HP:0000962	HP:0000962	Hyperkeratosis	0	FERMT1 CL E G H	55612	15889	OMIM:173650	Kindler syndrome		136
HP:0000962	HP:0000962	Hyperkeratosis	0	FGFR2 CL E G H	2263	3689	ORPHA:1555	Cutis gyrata-acanthosis nigricans-craniosynostosis syndrome		175
HP:0000962	HP:0000962	Hyperkeratosis	0	FHL2 CL E G H	2274	3703	ORPHA:154	Familial isolated dilated cardiomyopathy		36
HP:0000962	HP:0000962	Hyperkeratosis	0	FIG4 CL E G H	9896	16873	OMIM:216340	Yunis-Varon syndrome		111
HP:0000962	HP:0000962	Hyperkeratosis	0	FKBP14 CL E G H	55033	18625	OMIM:614557	Ehlers-Danlos syndrome, kyphoscoliotic type, 2		13
HP:0000962	HP:0000962	Hyperkeratosis	0	FKBP14 CL E G H	55033	18625	ORPHA:300179	Kyphoscoliotic Ehlers-Danlos syndrome due to FKBP22 deficiency		13
HP:0000962	HP:0000962	Hyperkeratosis	0	FKTN CL E G H	2218	3622	ORPHA:154	Familial isolated dilated cardiomyopathy		184
HP:0000962	HP:0000962	Hyperkeratosis	0	FLG CL E G H	2312	3748	ORPHA:461	Recessive X-linked ichthyosis	HP:0040281 - Very frequent	63
HP:0000962	HP:0000962	Hyperkeratosis	0	FLT4 CL E G H	2324	3767	OMIM:153100	Lymphatic malformation 1		90
HP:0000962	HP:0000962	Hyperkeratosis	0	FLT4 CL E G H	2324	3767	ORPHA:79452	Milroy disease	HP:0040282 - Frequent	90
HP:0000962	HP:0000962	Hyperkeratosis	0	FUCA1 CL E G H	2517	4006	ORPHA:349	Fucosidosis		43
HP:0000962	HP:0000962	Hyperkeratosis	0	GATAD1 CL E G H	57798	29941	ORPHA:154	Familial isolated dilated cardiomyopathy		35
HP:0000962	HP:0000962	Hyperkeratosis	0	GBA1 CL E G H	2629	4177	OMIM:608013	Gaucher disease, perinatal lethal	.
HP:0000962	HP:0000962	Hyperkeratosis	0	GJA1 CL E G H	2697	4274	ORPHA:1010	Autosomal dominant palmoplantar keratoderma and congenital alopecia		68
HP:0000962	HP:0000962	Hyperkeratosis	0	GJA1 CL E G H	2697	4274	ORPHA:317	Erythrokeratodermia variabilis	HP:0040281 - Very frequent	68
HP:0000962	HP:0000962	Hyperkeratosis	0	GJA1 CL E G H	2697	4274	OMIM:617525	Erythrokeratodermia variabilis et progressiva 3	.	68
HP:0000962	HP:0000962	Hyperkeratosis	0	GJA1 CL E G H	2697	4274	ORPHA:2710	Oculodentodigital dysplasia		68
HP:0000962	HP:0000962	Hyperkeratosis	0	GJA1 CL E G H	2697	4274	OMIM:104100	Palmoplantar keratoderma with congenital alopecia		68
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	OMIM:602540	Ichthyosis, hystrix-like, with deafness	.	199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	OMIM:148210	Keratitis-Ichthyosis-Deafness syndrome, autosomal dominant	.	199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	ORPHA:494	Keratoderma hereditarium mutilans	HP:0040281 - Very frequent	199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	OMIM:148350	Keratoderma, palmoplantar, with deafness		199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	ORPHA:477	KID syndrome		199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	OMIM:149200	Knuckle pads, leukonychia, and sensorineural deafness		199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	ORPHA:2698	Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome	HP:0040281 - Very frequent	199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	ORPHA:2202	Palmoplantar keratoderma-deafness syndrome	HP:0040281 - Very frequent	199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB2 CL E G H	2706	4284	OMIM:124500	VOHWINKEL SYNDROME; VOWNKL		199
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB3 CL E G H	2707	4285	ORPHA:317	Erythrokeratodermia variabilis	HP:0040281 - Very frequent	74
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB3 CL E G H	2707	4285	OMIM:133200	Erythrokeratodermia variabilis et progressiva 1		74
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB4 CL E G H	127534	4286	ORPHA:317	Erythrokeratodermia variabilis	HP:0040281 - Very frequent	12
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB4 CL E G H	127534	4286	OMIM:617524	Erythrokeratodermia variabilis et progressiva 2		12
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB6 CL E G H	10804	4288	OMIM:129500	Clouston syndrome		56
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB6 CL E G H	10804	4288	ORPHA:189	Hidrotic ectodermal dysplasia		56
HP:0000962	HP:0000962	Hyperkeratosis	0	GJB6 CL E G H	10804	4288	ORPHA:477	KID syndrome		56
HP:0000962	HP:0000962	Hyperkeratosis	0	GJC2 CL E G H	57165	17494	ORPHA:79452	Milroy disease	HP:0040282 - Frequent	37
HP:0000962	HP:0000962	Hyperkeratosis	0	GLA CL E G H	2717	4296	ORPHA:324	Fabry disease	HP:0040281 - Very frequent	291
HP:0000962	HP:0000962	Hyperkeratosis	0	GLS CL E G H	2744	4331	OMIM:618339	Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development	.
HP:0000962	HP:0000962	Hyperkeratosis	0	GMPPA CL E G H	29926	22923	OMIM:615510	Alacrima, achalasia, and mental retardation syndrome	HP:0040283 - Occasional	24
HP:0000962	HP:0000962	Hyperkeratosis	0	GMPPA CL E G H	29926	22923	ORPHA:869	Triple A syndrome		24
HP:0000962	HP:0000962	Hyperkeratosis	0	GRHL2 CL E G H	79977	2799	OMIM:616029	Ectodermal dysplasia/short stature syndrome	.	33
HP:0000962	HP:0000962	Hyperkeratosis	0	HAND2 CL E G H	9464	4808	ORPHA:154	Familial isolated dilated cardiomyopathy		2
HP:0000962	HP:0000962	Hyperkeratosis	0	HDAC6 CL E G H	10013	14064	ORPHA:163966	X-linked dominant chondrodysplasia, Chassaing-Lacombe type	HP:0040283 - Occasional	2
HP:0000962	HP:0000962	Hyperkeratosis	0	HLA-B CL E G H	3106	4932	ORPHA:29207	Reactive arthritis	HP:0040281 - Very frequent	4
HP:0000962	HP:0000962	Hyperkeratosis	0	HLA-DRA CL E G H	3122	4947	ORPHA:505	Graham Little-Piccardi-Lassueur syndrome
HP:0000962	HP:0000962	Hyperkeratosis	0	HPGD CL E G H	3248	5154	OMIM:259100	Hypertrophic osteoarthropathy, primary, autosomal recessive 1		55
HP:0000962	HP:0000962	Hyperkeratosis	0	HPGD CL E G H	3248	5154	ORPHA:2796	Pachydermoperiostosis		55
HP:0000962	HP:0000962	Hyperkeratosis	0	HRAS CL E G H	3265	5173	ORPHA:3071	Costello syndrome	HP:0040281 - Very frequent	113
HP:0000962	HP:0000962	Hyperkeratosis	0	IKBKG CL E G H	8517	5961	OMIM:308300	Incontinentia pigmenti	.	52
HP:0000962	HP:0000962	Hyperkeratosis	0	IKBKG CL E G H	8517	5961	ORPHA:464	Incontinentia pigmenti	HP:0040282 - Frequent	52
HP:0000962	HP:0000962	Hyperkeratosis	0	IL17F CL E G H	112744	16404	ORPHA:1334	Chronic mucocutaneous candidiasis	HP:0040281 - Very frequent	14
HP:0000962	HP:0000962	Hyperkeratosis	0	IL17RA CL E G H	23765	5985	ORPHA:1334	Chronic mucocutaneous candidiasis	HP:0040281 - Very frequent	196
HP:0000962	HP:0000962	Hyperkeratosis	0	IL17RC CL E G H	84818	18358	ORPHA:1334	Chronic mucocutaneous candidiasis	HP:0040281 - Very frequent	4
HP:0000962	HP:0000962	Hyperkeratosis	0	IL1RN CL E G H	3557	6000	OMIM:612852	Interleukin 1 receptor antagonist deficiency		40
HP:0000962	HP:0000962	Hyperkeratosis	0	INSR CL E G H	3643	6091	OMIM:246200	Donohue syndrome	.	229
HP:0000962	HP:0000962	Hyperkeratosis	0	INSR CL E G H	3643	6091	ORPHA:2297	Insulin-resistance syndrome type A	HP:0040281 - Very frequent	229
HP:0000962	HP:0000962	Hyperkeratosis	0	INSR CL E G H	3643	6091	ORPHA:508	Leprechaunism	HP:0040281 - Very frequent	229
HP:0000962	HP:0000962	Hyperkeratosis	0	ITGB4 CL E G H	3691	6158	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		124
HP:0000962	HP:0000962	Hyperkeratosis	0	JUP CL E G H	3728	6207	OMIM:601214	Naxos disease		222
HP:0000962	HP:0000962	Hyperkeratosis	0	JUP CL E G H	3728	6207	ORPHA:34217	Naxos disease		222
HP:0000962	HP:0000962	Hyperkeratosis	0	KANK2 CL E G H	25959	29300	OMIM:616099	Palmoplantar keratoderma and woolly hair		1
HP:0000962	HP:0000962	Hyperkeratosis	0	KANSL1 CL E G H	284058	24565	ORPHA:363958	17q21.31 microdeletion syndrome	HP:0040283 - Occasional	283
HP:0000962	HP:0000962	Hyperkeratosis	0	KANSL1 CL E G H	284058	24565	ORPHA:363965	Koolen-De Vries syndrome due to a point mutation	HP:0040283 - Occasional	283
HP:0000962	HP:0000962	Hyperkeratosis	0	KDF1 CL E G H	126695	26624	OMIM:617337	Ectodermal dysplasia 12, Hypohidrotic/hair/tooth/nail type	.	1
HP:0000962	HP:0000962	Hyperkeratosis	0	KDSR CL E G H	2531	4021	ORPHA:317	Erythrokeratodermia variabilis	HP:0040281 - Very frequent	4
HP:0000962	HP:0000962	Hyperkeratosis	0	KDSR CL E G H	2531	4021	OMIM:617526	Erythrokeratodermia variabilis et progressiva 4	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	KDSR CL E G H	2531	4021	ORPHA:316	Progressive symmetric erythrokeratodermia		4
HP:0000962	HP:0000962	Hyperkeratosis	0	KITLG CL E G H	4254	6343	OMIM:145250	Hyperpigmentation, familial progressive	.	9
HP:0000962	HP:0000962	Hyperkeratosis	0	KLHL24 CL E G H	54800	25947	OMIM:617294	Epidermolysis bullosa simplex, generalized, with scarring and hair loss		5
HP:0000962	HP:0000962	Hyperkeratosis	0	KLLN CL E G H	100144748	37212	ORPHA:201	Cowden syndrome		1
HP:0000962	HP:0000962	Hyperkeratosis	0	KRAS CL E G H	3845	6407	ORPHA:1340	Cardiofaciocutaneous syndrome	HP:0040282 - Frequent	196
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	ORPHA:312	Autosomal dominant epidermolytic ichthyosis	HP:0040281 - Very frequent	100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	OMIM:113800	Epidermolytic hyperkeratosis		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	ORPHA:2199	Epidermolytic palmoplantar keratoderma		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	ORPHA:79503	Ichthyosis hystrix of Curth-Macklin	HP:0040281 - Very frequent	100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	OMIM:607654	KERATOSIS PALMOPLANTARIS STRIATA III; PPKS3		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	ORPHA:530838	KRT1-related diffuse nonepidermolytic keratoderma		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	OMIM:144200	Palmoplantar keratoderma, epidermolytic		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	OMIM:600962	PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC; NEPPK		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT1 CL E G H	3848	6412	ORPHA:50942	Striate palmoplantar keratoderma		100
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT10 CL E G H	3858	6413	ORPHA:312	Autosomal dominant epidermolytic ichthyosis	HP:0040281 - Very frequent	45
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT10 CL E G H	3858	6413	OMIM:113800	Epidermolytic hyperkeratosis		45
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT10 CL E G H	3858	6413	OMIM:609165	Erythroderma, ichthyosiform, congenital reticular	.	45
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT10 CL E G H	3858	6413	OMIM:607602	Ichthyosis, cyclic, with epidermolytic hyperkeratosis		45
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT13 CL E G H	3860	6415	OMIM:615785	White sponge nevus 2		46
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	ORPHA:79399	Autosomal dominant generalized epidermolysis bullosa simplex, intermediate form	HP:0040281 - Very frequent	110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	ORPHA:79396	Autosomal dominant generalized epidermolysis bullosa simplex, severe form		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	ORPHA:89838	Autosomal recessive generalized epidermolysis bullosa simplex	HP:0040282 - Frequent	110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	OMIM:125595	Dermatopathia pigmentosa reticularis		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	ORPHA:79397	Epidermolysis bullosa simplex with mottled pigmentation		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	OMIM:131760	Epidermolysis bullosa simplex, Dowling-Meara type		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	OMIM:131900	Epidermolysis bullosa simplex, Koebner type		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	ORPHA:79400	Localized epidermolysis bullosa simplex		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	OMIM:161000	Naegeli syndrome		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT14 CL E G H	3861	6416	ORPHA:69087	Naegeli-Franceschetti-Jadassohn syndrome		110
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT16 CL E G H	3868	6423	ORPHA:2199	Epidermolytic palmoplantar keratoderma		27
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT16 CL E G H	3868	6423	ORPHA:2309	Pachyonychia congenita		27
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT16 CL E G H	3868	6423	OMIM:167200	Pachyonychia congenita, type 1		27
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT16 CL E G H	3868	6423	OMIM:613000	Palmoplantar keratoderma, nonepidermolytic, focal 1		27
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT17 CL E G H	3872	6427	ORPHA:2309	Pachyonychia congenita		23
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT17 CL E G H	3872	6427	OMIM:167210	Pachyonychia congenita 2		23
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT2 CL E G H	3849	6439	ORPHA:455	Superficial epidermolytic ichthyosis		67
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	ORPHA:79399	Autosomal dominant generalized epidermolysis bullosa simplex, intermediate form	HP:0040281 - Very frequent	173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	ORPHA:79396	Autosomal dominant generalized epidermolysis bullosa simplex, severe form		173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	ORPHA:79145	Dowling-Degos disease	HP:0040282 - Frequent	173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	OMIM:619555	EPIDERMOLYSIS BULLOSA SIMPLEX 2A, GENERALIZED SEVERE; EBS2A		173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	OMIM:131960	Epidermolysis bullosa simplex with mottled pigmentation		173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	ORPHA:79397	Epidermolysis bullosa simplex with mottled pigmentation		173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	OMIM:131760	Epidermolysis bullosa simplex, Dowling-Meara type		173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT5 CL E G H	3852	6442	ORPHA:79400	Localized epidermolysis bullosa simplex		173
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT6A CL E G H	3853	6443	ORPHA:2309	Pachyonychia congenita		41
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT6A CL E G H	3853	6443	OMIM:615726	Pachyonychia congenita 3	.	41
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT6B CL E G H	3854	6444	ORPHA:2309	Pachyonychia congenita		4
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT6B CL E G H	3854	6444	OMIM:615728	Pachyonychia congenita 4	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT6C CL E G H	286887	20406	OMIM:615735	Palmoplantar keratoderma, nonepidermolytic, focal or diffuse		4
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT74 CL E G H	121391	28929	ORPHA:90368	Hypotrichosis simplex of the scalp		5
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT81 CL E G H	3887	6458	ORPHA:573	Monilethrix		3
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT81 CL E G H	3887	6458	OMIM:158000	MONILETHRIX		3
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT83 CL E G H	3889	6460	OMIM:617756	Erythrokeratodermia variabilis et progressiva 5	.	65
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT83 CL E G H	3889	6460	ORPHA:573	Monilethrix		65
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT83 CL E G H	3889	6460	OMIM:158000	MONILETHRIX		65
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT83 CL E G H	3889	6460	ORPHA:316	Progressive symmetric erythrokeratodermia		65
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT86 CL E G H	3892	6463	ORPHA:573	Monilethrix		10
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT86 CL E G H	3892	6463	OMIM:158000	MONILETHRIX		10
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT9 CL E G H	3857	6447	ORPHA:2199	Epidermolytic palmoplantar keratoderma		66
HP:0000962	HP:0000962	Hyperkeratosis	0	KRT9 CL E G H	3857	6447	OMIM:144200	Palmoplantar keratoderma, epidermolytic		66
HP:0000962	HP:0000962	Hyperkeratosis	0	LAMA3 CL E G H	3909	6483	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		116
HP:0000962	HP:0000962	Hyperkeratosis	0	LAMA4 CL E G H	3910	6484	ORPHA:154	Familial isolated dilated cardiomyopathy		279
HP:0000962	HP:0000962	Hyperkeratosis	0	LAMB3 CL E G H	3914	6490	OMIM:226650	Epidermolysis bullosa, junctional, Non-Herlitz type		167
HP:0000962	HP:0000962	Hyperkeratosis	0	LAMB3 CL E G H	3914	6490	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		167
HP:0000962	HP:0000962	Hyperkeratosis	0	LAMC2 CL E G H	3918	6493	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		135
HP:0000962	HP:0000962	Hyperkeratosis	0	LDB3 CL E G H	11155	15710	ORPHA:154	Familial isolated dilated cardiomyopathy		286
HP:0000962	HP:0000962	Hyperkeratosis	0	LEMD3 CL E G H	23592	28887	ORPHA:1306	Buschke-Ollendorff syndrome		68
HP:0000962	HP:0000962	Hyperkeratosis	0	LIPN CL E G H	643418	23452	OMIM:613943	Ichthyosis, congenital, autosomal recessive 8	.	1
HP:0000962	HP:0000962	Hyperkeratosis	0	LIPN CL E G H	643418	23452	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	1
HP:0000962	HP:0000962	Hyperkeratosis	0	LMNA CL E G H	4000	6636	ORPHA:79474	Atypical Werner syndrome	HP:0040281 - Very frequent	645
HP:0000962	HP:0000962	Hyperkeratosis	0	LMNA CL E G H	4000	6636	ORPHA:154	Familial isolated dilated cardiomyopathy		645
HP:0000962	HP:0000962	Hyperkeratosis	0	LMNA CL E G H	4000	6636	ORPHA:1662	Restrictive dermopathy		645
HP:0000962	HP:0000962	Hyperkeratosis	0	LORICRIN CL E G H	4014	6663	ORPHA:79395	Keratoderma hereditarium mutilans with ichthyosis
HP:0000962	HP:0000962	Hyperkeratosis	0	LORICRIN CL E G H	4014	6663	ORPHA:316	Progressive symmetric erythrokeratodermia
HP:0000962	HP:0000962	Hyperkeratosis	0	LORICRIN CL E G H	4014	6663	OMIM:604117	Vohwinkel syndrome, variant form	.
HP:0000962	HP:0000962	Hyperkeratosis	0	LRP1 CL E G H	4035	6692	ORPHA:79100	Atrophoderma vermiculata		4
HP:0000962	HP:0000962	Hyperkeratosis	0	LZTR1 CL E G H	8216	6742	OMIM:616564	Noonan syndrome 10		43
HP:0000962	HP:0000962	Hyperkeratosis	0	LZTR1 CL E G H	8216	6742	OMIM:605275	Noonan syndrome 2		43
HP:0000962	HP:0000962	Hyperkeratosis	0	MAP2K1 CL E G H	5604	6840	ORPHA:1340	Cardiofaciocutaneous syndrome	HP:0040282 - Frequent	134
HP:0000962	HP:0000962	Hyperkeratosis	0	MAP2K1 CL E G H	5604	6840	OMIM:615279	Cardiofaciocutaneous syndrome 3		134
HP:0000962	HP:0000962	Hyperkeratosis	0	MAP2K2 CL E G H	5605	6842	ORPHA:1340	Cardiofaciocutaneous syndrome	HP:0040282 - Frequent	178
HP:0000962	HP:0000962	Hyperkeratosis	0	MAP2K2 CL E G H	5605	6842	OMIM:615280	Cardiofaciocutaneous syndrome 4		178
HP:0000962	HP:0000962	Hyperkeratosis	0	MBTPS2 CL E G H	51360	15455	ORPHA:2273	Ichthyosis follicularis-alopecia-photophobia syndrome	HP:0040282 - Frequent	22
HP:0000962	HP:0000962	Hyperkeratosis	0	MBTPS2 CL E G H	51360	15455	OMIM:308205	Ifap syndrome with or without bresheck syndrome		22
HP:0000962	HP:0000962	Hyperkeratosis	0	MBTPS2 CL E G H	51360	15455	OMIM:308800	Keratosis follicularis spinulosa decalvans, X-linked		22
HP:0000962	HP:0000962	Hyperkeratosis	0	MBTPS2 CL E G H	51360	15455	ORPHA:659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques		22
HP:0000962	HP:0000962	Hyperkeratosis	0	MBTPS2 CL E G H	51360	15455	OMIM:300918	Palmoplantar keratoderma, mutilating, with periorificial keratotic plaques, X-linked	.	22
HP:0000962	HP:0000962	Hyperkeratosis	0	MCOLN1 CL E G H	57192	13356	ORPHA:578	Mucolipidosis type IV		78
HP:0000962	HP:0000962	Hyperkeratosis	0	MDFIC CL E G H	29969	28870	OMIM:620014
HP:0000962	HP:0000962	Hyperkeratosis	0	MPDU1 CL E G H	9526	7207	OMIM:609180	Congenital disorder of glycosylation, type IF	.	32
HP:0000962	HP:0000962	Hyperkeratosis	0	MTX2 CL E G H	10651	7506	OMIM:619127	MANDIBULOACRAL DYSPLASIA PROGEROID SYNDROME; MDPS
HP:0000962	HP:0000962	Hyperkeratosis	0	MVK CL E G H	4598	7530	ORPHA:735	Porokeratosis of Mibelli	HP:0040281 - Very frequent	150
HP:0000962	HP:0000962	Hyperkeratosis	0	MYBPC3 CL E G H	4607	7551	ORPHA:154	Familial isolated dilated cardiomyopathy		1143
HP:0000962	HP:0000962	Hyperkeratosis	0	MYH6 CL E G H	4624	7576	ORPHA:154	Familial isolated dilated cardiomyopathy		452
HP:0000962	HP:0000962	Hyperkeratosis	0	MYH7 CL E G H	4625	7577	ORPHA:154	Familial isolated dilated cardiomyopathy		1269
HP:0000962	HP:0000962	Hyperkeratosis	0	MYPN CL E G H	84665	23246	ORPHA:154	Familial isolated dilated cardiomyopathy		217
HP:0000962	HP:0000962	Hyperkeratosis	0	NAGA CL E G H	4668	7631	ORPHA:79279	Alpha-N-acetylgalactosaminidase deficiency type 1	HP:0040282 - Frequent	47
HP:0000962	HP:0000962	Hyperkeratosis	0	NAGA CL E G H	4668	7631	ORPHA:79280	Alpha-N-acetylgalactosaminidase deficiency type 2	HP:0040281 - Very frequent	47
HP:0000962	HP:0000962	Hyperkeratosis	0	NAGA CL E G H	4668	7631	OMIM:609242	Kanzaki disease	.	47
HP:0000962	HP:0000962	Hyperkeratosis	0	NECTIN1 CL E G H	5818	9706	OMIM:225060	Cleft lip/palate-ectodermal dysplasia syndrome		4
HP:0000962	HP:0000962	Hyperkeratosis	0	NECTIN1 CL E G H	5818	9706	ORPHA:3253	Cleft lip/palate-ectodermal dysplasia syndrome		4
HP:0000962	HP:0000962	Hyperkeratosis	0	NECTIN4 CL E G H	81607	19688	OMIM:613573	Ectodermal dysplasia-syndactyly syndrome 1		7
HP:0000962	HP:0000962	Hyperkeratosis	0	NEU1 CL E G H	4758	7758	ORPHA:812	Sialidosis type 1	HP:0040281 - Very frequent	43
HP:0000962	HP:0000962	Hyperkeratosis	0	NEXN CL E G H	91624	29557	ORPHA:154	Familial isolated dilated cardiomyopathy		167
HP:0000962	HP:0000962	Hyperkeratosis	0	NHP2 CL E G H	55651	14377	ORPHA:1775	Dyskeratosis congenita		27
HP:0000962	HP:0000962	Hyperkeratosis	0	NHP2 CL E G H	55651	14377	OMIM:224230	Dyskeratosis congenita, autosomal recessive 1		27
HP:0000962	HP:0000962	Hyperkeratosis	0	NIPAL4 CL E G H	348938	28018	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		60
HP:0000962	HP:0000962	Hyperkeratosis	0	NIPAL4 CL E G H	348938	28018	OMIM:612281	Ichthyosis, congenital, autosomal recessive 6	.	60
HP:0000962	HP:0000962	Hyperkeratosis	0	NIPAL4 CL E G H	348938	28018	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	60
HP:0000962	HP:0000962	Hyperkeratosis	0	NLRP1 CL E G H	22861	14374	OMIM:617388	AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSIS; AIADK		37
HP:0000962	HP:0000962	Hyperkeratosis	0	NLRP1 CL E G H	22861	14374	OMIM:615225	Palmoplantar carcinoma, multiple self-healing		37
HP:0000962	HP:0000962	Hyperkeratosis	0	NOP10 CL E G H	55505	14378	ORPHA:1775	Dyskeratosis congenita		17
HP:0000962	HP:0000962	Hyperkeratosis	0	NOP10 CL E G H	55505	14378	OMIM:224230	Dyskeratosis congenita, autosomal recessive 1		17
HP:0000962	HP:0000962	Hyperkeratosis	0	NPM1 CL E G H	4869	7910	ORPHA:1775	Dyskeratosis congenita		12
HP:0000962	HP:0000962	Hyperkeratosis	0	NSDHL CL E G H	50814	13398	OMIM:308050	Congenital hemidysplasia with ichthyosiform erythroderma and limb defects		34
HP:0000962	HP:0000962	Hyperkeratosis	0	PARN CL E G H	5073	8609	ORPHA:1775	Dyskeratosis congenita		26
HP:0000962	HP:0000962	Hyperkeratosis	0	PDGFRB CL E G H	5159	8804	OMIM:601812	Premature aging syndrome, Penttinen type	.	28
HP:0000962	HP:0000962	Hyperkeratosis	0	PEPD CL E G H	5184	8840	ORPHA:742	Prolidase deficiency	HP:0040281 - Very frequent	66
HP:0000962	HP:0000962	Hyperkeratosis	0	PERP CL E G H	64065	17637	OMIM:619209	ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA 7; EKVP7
HP:0000962	HP:0000962	Hyperkeratosis	0	PERP CL E G H	64065	17637	ORPHA:659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques
HP:0000962	HP:0000962	Hyperkeratosis	0	PERP CL E G H	64065	17637	OMIM:619208	OLMSTED SYNDROME 2; OLMS2
HP:0000962	HP:0000962	Hyperkeratosis	0	PIGL CL E G H	9487	8966	ORPHA:3474	CHIME syndrome	HP:0040283 - Occasional	36
HP:0000962	HP:0000962	Hyperkeratosis	0	PIGL CL E G H	9487	8966	OMIM:280000	Zunich neuroectodermal syndrome		36
HP:0000962	HP:0000962	Hyperkeratosis	0	PIK3CA CL E G H	5290	8975	ORPHA:201	Cowden syndrome		162
HP:0000962	HP:0000962	Hyperkeratosis	0	PIK3CA CL E G H	5290	8975	OMIM:615108	Cowden syndrome 5		162
HP:0000962	HP:0000962	Hyperkeratosis	0	PIK3CA CL E G H	5290	8975	ORPHA:276280	Hemihyperplasia-multiple lipomatosis syndrome		162
HP:0000962	HP:0000962	Hyperkeratosis	0	PKP1 CL E G H	5317	9023	ORPHA:158668	Ectodermal dysplasia-skin fragility syndrome		107
HP:0000962	HP:0000962	Hyperkeratosis	0	PKP1 CL E G H	5317	9023	OMIM:604536	ECTODERMAL DYSPLASIA/SKIN FRAGILITY SYNDROME		107
HP:0000962	HP:0000962	Hyperkeratosis	0	PLEC CL E G H	5339	9069	OMIM:226670	Epidermolysis bullosa simplex with muscular dystrophy		759
HP:0000962	HP:0000962	Hyperkeratosis	0	PLEC CL E G H	5339	9069	OMIM:616487	Epidermolysis bullosa simplex with nail dystrophy		759
HP:0000962	HP:0000962	Hyperkeratosis	0	PLEC CL E G H	5339	9069	ORPHA:79401	PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement		759
HP:0000962	HP:0000962	Hyperkeratosis	0	PLN CL E G H	5350	9080	ORPHA:154	Familial isolated dilated cardiomyopathy		57
HP:0000962	HP:0000962	Hyperkeratosis	0	PLOD1 CL E G H	5351	9081	OMIM:225400	Ehlers-Danlos syndrome, kyphoscoliotic type, 1		105
HP:0000962	HP:0000962	Hyperkeratosis	0	PMVK CL E G H	10654	9141	ORPHA:735	Porokeratosis of Mibelli	HP:0040281 - Very frequent	3
HP:0000962	HP:0000962	Hyperkeratosis	0	PNPLA1 CL E G H	285848	21246	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		47
HP:0000962	HP:0000962	Hyperkeratosis	0	PNPLA1 CL E G H	285848	21246	OMIM:615024	Ichthyosis, congenital, autosomal recessive 10		47
HP:0000962	HP:0000962	Hyperkeratosis	0	POFUT1 CL E G H	23509	14988	ORPHA:79145	Dowling-Degos disease	HP:0040282 - Frequent	2
HP:0000962	HP:0000962	Hyperkeratosis	0	POFUT1 CL E G H	23509	14988	OMIM:615327	Dowling-Degos disease 2		2
HP:0000962	HP:0000962	Hyperkeratosis	0	POGLUT1 CL E G H	56983	22954	ORPHA:79145	Dowling-Degos disease	HP:0040282 - Frequent	6
HP:0000962	HP:0000962	Hyperkeratosis	0	POLA1 CL E G H	5422	9173	OMIM:301220	PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS, X-LINKED; PDR		2
HP:0000962	HP:0000962	Hyperkeratosis	0	POMP CL E G H	51371	20330	OMIM:601952	Keratosis linearis with ichthyosis congenita and sclerosing keratoderma		2
HP:0000962	HP:0000962	Hyperkeratosis	0	POMP CL E G H	51371	20330	ORPHA:281201	Keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome		2
HP:0000962	HP:0000962	Hyperkeratosis	0	PPCS CL E G H	79717	25686	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0000962	Hyperkeratosis	0	PRDM16 CL E G H	63976	14000	ORPHA:154	Familial isolated dilated cardiomyopathy		148
HP:0000962	HP:0000962	Hyperkeratosis	0	PSEN1 CL E G H	5663	9508	ORPHA:154	Familial isolated dilated cardiomyopathy		241
HP:0000962	HP:0000962	Hyperkeratosis	0	PSEN2 CL E G H	5664	9509	ORPHA:154	Familial isolated dilated cardiomyopathy		59
HP:0000962	HP:0000962	Hyperkeratosis	0	PSENEN CL E G H	55851	30100	OMIM:613736	Acne inversa, familial, 2, with or without dowling-degos disease		2
HP:0000962	HP:0000962	Hyperkeratosis	0	PSENEN CL E G H	55851	30100	ORPHA:79145	Dowling-Degos disease	HP:0040282 - Frequent	2
HP:0000962	HP:0000962	Hyperkeratosis	0	PTEN CL E G H	5728	9588	ORPHA:201	Cowden syndrome		948
HP:0000962	HP:0000962	Hyperkeratosis	0	PTEN CL E G H	5728	9588	OMIM:158350	Cowden syndrome 1		948
HP:0000962	HP:0000962	Hyperkeratosis	0	PTEN CL E G H	5728	9588	ORPHA:744	Proteus syndrome		948
HP:0000962	HP:0000962	Hyperkeratosis	0	RAF1 CL E G H	5894	9829	ORPHA:154	Familial isolated dilated cardiomyopathy		212
HP:0000962	HP:0000962	Hyperkeratosis	0	RBM20 CL E G H	282996	27424	ORPHA:154	Familial isolated dilated cardiomyopathy		363
HP:0000962	HP:0000962	Hyperkeratosis	0	RECQL4 CL E G H	9401	9949	ORPHA:221016	Rothmund-Thomson syndrome type 2		445
HP:0000962	HP:0000962	Hyperkeratosis	0	RHBDF2 CL E G H	79651	20788	ORPHA:2198	Palmoplantar keratoderma-esophageal carcinoma syndrome		80
HP:0000962	HP:0000962	Hyperkeratosis	0	RHBDF2 CL E G H	79651	20788	OMIM:148500	Tylosis with esophageal cancer		80
HP:0000962	HP:0000962	Hyperkeratosis	0	RIGI CL E G H	23586	19102	OMIM:616298	Singleton-Merten syndrome 2	.
HP:0000962	HP:0000962	Hyperkeratosis	0	RIT1 CL E G H	6016	10023	OMIM:615355	NOONAN SYNDROME 8; NS8		39
HP:0000962	HP:0000962	Hyperkeratosis	0	RNU4ATAC CL E G H	100151683	34016	OMIM:210710	Microcephalic osteodysplastic primordial dwarfism, type I	.	15
HP:0000962	HP:0000962	Hyperkeratosis	0	RSPO1 CL E G H	284654	21679	OMIM:610644	Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal		3
HP:0000962	HP:0000962	Hyperkeratosis	0	RSPO1 CL E G H	284654	21679	ORPHA:85112	Palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome		3
HP:0000962	HP:0000962	Hyperkeratosis	0	RTEL1 CL E G H	51750	15888	ORPHA:1775	Dyskeratosis congenita		77
HP:0000962	HP:0000962	Hyperkeratosis	0	SASH1 CL E G H	23328	19182	OMIM:618373	Cancer, alopecia, pigment dyscrasia, onychodystrophy, and keratoderma		1
HP:0000962	HP:0000962	Hyperkeratosis	0	SCN5A CL E G H	6331	10593	ORPHA:154	Familial isolated dilated cardiomyopathy		1134
HP:0000962	HP:0000962	Hyperkeratosis	0	SDHA CL E G H	6389	10680	ORPHA:154	Familial isolated dilated cardiomyopathy		304
HP:0000962	HP:0000962	Hyperkeratosis	0	SDHB CL E G H	6390	10681	ORPHA:201	Cowden syndrome		237
HP:0000962	HP:0000962	Hyperkeratosis	0	SDHC CL E G H	6391	10682	ORPHA:201	Cowden syndrome		147
HP:0000962	HP:0000962	Hyperkeratosis	0	SDHD CL E G H	6392	10683	ORPHA:201	Cowden syndrome		129
HP:0000962	HP:0000962	Hyperkeratosis	0	SDR9C7 CL E G H	121214	29958	OMIM:617574	Ichthyosis, congenital, autosomal recessive 13	.	2
HP:0000962	HP:0000962	Hyperkeratosis	0	SDR9C7 CL E G H	121214	29958	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	2
HP:0000962	HP:0000962	Hyperkeratosis	0	SEC23B CL E G H	10483	10702	ORPHA:201	Cowden syndrome		60
HP:0000962	HP:0000962	Hyperkeratosis	0	SERPINA12 CL E G H	145264	18359	ORPHA:86923	Hereditary palmoplantar keratoderma, Gamborg-Nielsen type
HP:0000962	HP:0000962	Hyperkeratosis	0	SERPINB7 CL E G H	8710	13902	OMIM:615598	Palmoplantar keratoderma, Nagashima type		4
HP:0000962	HP:0000962	Hyperkeratosis	0	SERPINB7 CL E G H	8710	13902	ORPHA:140966	Palmoplantar keratoderma, Nagashima type		4
HP:0000962	HP:0000962	Hyperkeratosis	0	SERPINB8 CL E G H	5271	8952	OMIM:617115	Peeling skin syndrome 5	.	3
HP:0000962	HP:0000962	Hyperkeratosis	0	SGCD CL E G H	6444	10807	ORPHA:154	Familial isolated dilated cardiomyopathy		223
HP:0000962	HP:0000962	Hyperkeratosis	0	SHOC2 CL E G H	8036	15454	OMIM:607721	Noonan syndrome-like with loose anagen hair 1		74
HP:0000962	HP:0000962	Hyperkeratosis	0	SLC27A4 CL E G H	10999	10998	OMIM:608649	ICHTHYOSIS PREMATURITY SYNDROME; IPS		26
HP:0000962	HP:0000962	Hyperkeratosis	0	SLCO2A1 CL E G H	6578	10955	ORPHA:2796	Pachydermoperiostosis		13
HP:0000962	HP:0000962	Hyperkeratosis	0	SLURP1 CL E G H	57152	18746	ORPHA:86923	Hereditary palmoplantar keratoderma, Gamborg-Nielsen type		15
HP:0000962	HP:0000962	Hyperkeratosis	0	SLURP1 CL E G H	57152	18746	ORPHA:87503	Mal de Meleda		15
HP:0000962	HP:0000962	Hyperkeratosis	0	SLURP1 CL E G H	57152	18746	OMIM:248300	Meleda disease		15
HP:0000962	HP:0000962	Hyperkeratosis	0	SMARCAD1 CL E G H	56916	18398	OMIM:129200	Basan syndrome		6
HP:0000962	HP:0000962	Hyperkeratosis	0	SMARCAD1 CL E G H	56916	18398	OMIM:136000	Fingerprints, absence of		6
HP:0000962	HP:0000962	Hyperkeratosis	0	SMARCAD1 CL E G H	56916	18398	ORPHA:384	Huriez syndrome		6
HP:0000962	HP:0000962	Hyperkeratosis	0	SMARCAD1 CL E G H	56916	18398	OMIM:181600	Huriez syndrome		6
HP:0000962	HP:0000962	Hyperkeratosis	0	SNAP29 CL E G H	9342	11133	ORPHA:66631	CEDNIK syndrome		94
HP:0000962	HP:0000962	Hyperkeratosis	0	SNAP29 CL E G H	9342	11133	OMIM:609528	Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome		94
HP:0000962	HP:0000962	Hyperkeratosis	0	SOX18 CL E G H	54345	11194	OMIM:137940	Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome		7
HP:0000962	HP:0000962	Hyperkeratosis	0	SPTLC1 CL E G H	10558	11277	ORPHA:36386	Hereditary sensory and autonomic neuropathy type 1	HP:0040282 - Frequent	54
HP:0000962	HP:0000962	Hyperkeratosis	0	SPTLC2 CL E G H	9517	11278	ORPHA:36386	Hereditary sensory and autonomic neuropathy type 1	HP:0040282 - Frequent	149
HP:0000962	HP:0000962	Hyperkeratosis	0	SRD5A3 CL E G H	79644	25812	OMIM:612379	Congenital disorder of glycosylation, type IQ	.	80
HP:0000962	HP:0000962	Hyperkeratosis	0	SRD5A3 CL E G H	79644	25812	ORPHA:324737	SRD5A3-CDG		80
HP:0000962	HP:0000962	Hyperkeratosis	0	SREBF1 CL E G H	6720	11289	OMIM:158310	Mucoepithelial dysplasia, hereditary		1
HP:0000962	HP:0000962	Hyperkeratosis	0	ST14 CL E G H	6768	11344	OMIM:602400	Ichthyosis, congenital, autosomal recessive 11	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	STS CL E G H	412	11425	OMIM:308100	Ichthyosis, X-linked		19
HP:0000962	HP:0000962	Hyperkeratosis	0	STS CL E G H	412	11425	ORPHA:461	Recessive X-linked ichthyosis	HP:0040281 - Very frequent	19
HP:0000962	HP:0000962	Hyperkeratosis	0	STS CL E G H	412	11425	ORPHA:281090	Syndromic recessive X-linked ichthyosis	HP:0040281 - Very frequent	19
HP:0000962	HP:0000962	Hyperkeratosis	0	SULT2B1 CL E G H	6820	11459	OMIM:617571	Ichthyosis, congenital, autosomal recessive 14	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	SULT2B1 CL E G H	6820	11459	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	4
HP:0000962	HP:0000962	Hyperkeratosis	0	TAF1A CL E G H	9015	11532	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0000962	Hyperkeratosis	0	TAFAZZIN CL E G H	6901	11577	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0000962	Hyperkeratosis	0	TARS1 CL E G H	6897	11572	OMIM:618546	Trichothiodystrophy 7, nonphotosensitive
HP:0000962	HP:0000962	Hyperkeratosis	0	TAT CL E G H	6898	11573	ORPHA:28378	Tyrosinemia type 2	HP:0040281 - Very frequent	43
HP:0000962	HP:0000962	Hyperkeratosis	0	TCAP CL E G H	8557	11610	ORPHA:154	Familial isolated dilated cardiomyopathy		78
HP:0000962	HP:0000962	Hyperkeratosis	0	TERC CL E G H	7012	11727	ORPHA:1775	Dyskeratosis congenita		48
HP:0000962	HP:0000962	Hyperkeratosis	0	TERT CL E G H	7015	11730	ORPHA:1775	Dyskeratosis congenita		238
HP:0000962	HP:0000962	Hyperkeratosis	0	TERT CL E G H	7015	11730	OMIM:613989	Dyskeratosis congenita, autosomal dominant 2		238
HP:0000962	HP:0000962	Hyperkeratosis	0	TGM1 CL E G H	7051	11777	ORPHA:100976	Bathing suit ichthyosis		98
HP:0000962	HP:0000962	Hyperkeratosis	0	TGM1 CL E G H	7051	11777	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		98
HP:0000962	HP:0000962	Hyperkeratosis	0	TGM1 CL E G H	7051	11777	OMIM:242300	Ichthyosis, congenital, autosomal recessive 1		98
HP:0000962	HP:0000962	Hyperkeratosis	0	TGM1 CL E G H	7051	11777	ORPHA:313	Lamellar ichthyosis	HP:0040281 - Very frequent	98
HP:0000962	HP:0000962	Hyperkeratosis	0	TINF2 CL E G H	26277	11824	ORPHA:1775	Dyskeratosis congenita		60
HP:0000962	HP:0000962	Hyperkeratosis	0	TMPO CL E G H	7112	11875	ORPHA:154	Familial isolated dilated cardiomyopathy		136
HP:0000962	HP:0000962	Hyperkeratosis	0	TMPRSS6 CL E G H	164656	16517	ORPHA:209981	IRIDA syndrome	HP:0040281 - Very frequent	65
HP:0000962	HP:0000962	Hyperkeratosis	0	TNFRSF1B CL E G H	7133	11917	ORPHA:2584	Classic mycosis fungoides	HP:0040283 - Occasional
HP:0000962	HP:0000962	Hyperkeratosis	0	TNFRSF1B CL E G H	7133	11917	ORPHA:3162	Sézary syndrome
HP:0000962	HP:0000962	Hyperkeratosis	0	TNNC1 CL E G H	7134	11943	ORPHA:154	Familial isolated dilated cardiomyopathy		73
HP:0000962	HP:0000962	Hyperkeratosis	0	TNNI3 CL E G H	7137	11947	ORPHA:154	Familial isolated dilated cardiomyopathy		180
HP:0000962	HP:0000962	Hyperkeratosis	0	TNNT2 CL E G H	7139	11949	ORPHA:154	Familial isolated dilated cardiomyopathy		248
HP:0000962	HP:0000962	Hyperkeratosis	0	TP63 CL E G H	8626	15979	OMIM:106260	Ankyloblepharon-Ectodermal defects-cleft lip/palate		140
HP:0000962	HP:0000962	Hyperkeratosis	0	TP63 CL E G H	8626	15979	OMIM:604292	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	.	140
HP:0000962	HP:0000962	Hyperkeratosis	0	TP63 CL E G H	8626	15979	ORPHA:1896	EEC syndrome	HP:0040281 - Very frequent	140
HP:0000962	HP:0000962	Hyperkeratosis	0	TP63 CL E G H	8626	15979	OMIM:129400	Rapp-Hodgkin syndrome		140
HP:0000962	HP:0000962	Hyperkeratosis	0	TPM1 CL E G H	7168	12010	ORPHA:154	Familial isolated dilated cardiomyopathy		230
HP:0000962	HP:0000962	Hyperkeratosis	0	TRAF3IP2 CL E G H	10758	1343	ORPHA:1334	Chronic mucocutaneous candidiasis	HP:0040281 - Very frequent	4
HP:0000962	HP:0000962	Hyperkeratosis	0	TRAPPC11 CL E G H	60684	25751	ORPHA:869	Triple A syndrome		27
HP:0000962	HP:0000962	Hyperkeratosis	0	TRIP4 CL E G H	9325	12310	ORPHA:486815	Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome		4
HP:0000962	HP:0000962	Hyperkeratosis	0	TRIP4 CL E G H	9325	12310	OMIM:617066	Muscular dystrophy, congenital, Davignon-Chauveau type		4
HP:0000962	HP:0000962	Hyperkeratosis	0	TRNS1 CL E G H	4574	7497	ORPHA:2202	Palmoplantar keratoderma-deafness syndrome	HP:0040281 - Very frequent
HP:0000962	HP:0000962	Hyperkeratosis	0	TRPM4 CL E G H	54795	17993	ORPHA:316	Progressive symmetric erythrokeratodermia		124
HP:0000962	HP:0000962	Hyperkeratosis	0	TRPV3 CL E G H	162514	18084	ORPHA:659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques		151
HP:0000962	HP:0000962	Hyperkeratosis	0	TRPV3 CL E G H	162514	18084	OMIM:614594	Palmoplantar keratoderma, mutilating, with periorificial keratoticplaques		151
HP:0000962	HP:0000962	Hyperkeratosis	0	TRPV3 CL E G H	162514	18084	OMIM:616400	Palmoplantar keratoderma, nonepidermolytic, focal 2	.	151
HP:0000962	HP:0000962	Hyperkeratosis	0	TTN CL E G H	7273	12403	ORPHA:154	Familial isolated dilated cardiomyopathy		7128
HP:0000962	HP:0000962	Hyperkeratosis	0	TXNRD2 CL E G H	10587	18155	ORPHA:154	Familial isolated dilated cardiomyopathy		85
HP:0000962	HP:0000962	Hyperkeratosis	0	TYMS CL E G H	7298	12441	ORPHA:1775	Dyskeratosis congenita		1
HP:0000962	HP:0000962	Hyperkeratosis	0	TYR CL E G H	7299	12442	ORPHA:79431	Oculocutaneous albinism type 1A	HP:0040283 - Occasional	146
HP:0000962	HP:0000962	Hyperkeratosis	0	USB1 CL E G H	79650	25792	ORPHA:1775	Dyskeratosis congenita		8
HP:0000962	HP:0000962	Hyperkeratosis	0	USB1 CL E G H	79650	25792	OMIM:604173	Poikiloderma with neutropenia		8
HP:0000962	HP:0000962	Hyperkeratosis	0	USF3 CL E G H	205717	30494	ORPHA:201	Cowden syndrome		1
HP:0000962	HP:0000962	Hyperkeratosis	0	VCL CL E G H	7414	12665	ORPHA:154	Familial isolated dilated cardiomyopathy		248
HP:0000962	HP:0000962	Hyperkeratosis	0	VEGFC CL E G H	7424	12682	OMIM:615907	Lymphedema, hereditary, ID	.	4
HP:0000962	HP:0000962	Hyperkeratosis	0	VPS33B CL E G H	26276	12712	OMIM:620009			63
HP:0000962	HP:0000962	Hyperkeratosis	0	WNT10A CL E G H	80326	13829	OMIM:257980	Odontoonychodermal dysplasia		71
HP:0000962	HP:0000962	Hyperkeratosis	0	WNT10A CL E G H	80326	13829	ORPHA:50944	Schöpf-Schulz-Passarge syndrome		71
HP:0000962	HP:0000962	Hyperkeratosis	0	WNT10A CL E G H	80326	13829	OMIM:224750	Schopf-Schulz-Passarge syndrome		71
HP:0000962	HP:0000962	Hyperkeratosis	0	WNT10A CL E G H	80326	13829	OMIM:150400	Tooth agenesis, selective, 4		71
HP:0000962	HP:0000962	Hyperkeratosis	0	WRAP53 CL E G H	55135	25522	ORPHA:1775	Dyskeratosis congenita		40
HP:0000962	HP:0000962	Hyperkeratosis	0	WRN CL E G H	7486	12791	ORPHA:902	Werner syndrome	HP:0040282 - Frequent	310
HP:0000962	HP:0000962	Hyperkeratosis	0	XPA CL E G H	7507	12814	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	34
HP:0000962	HP:0000962	Hyperkeratosis	0	XPC CL E G H	7508	12816	ORPHA:910	Xeroderma pigmentosum	HP:0040282 - Frequent	86
HP:0000962	HP:0000962	Hyperkeratosis	0	ZC4H2 CL E G H	55906	24931	OMIM:314580	Wieacker-Wolff syndrome		19
HP:0000962	HP:0000962	Hyperkeratosis	0	ZMPSTE24 CL E G H	10269	12877	ORPHA:1662	Restrictive dermopathy		83
HP:0000962	HP:0000962	Hyperkeratosis	0	ZMPSTE24 CL E G H	10269	12877	OMIM:275210	Restrictive dermopathy, lethal		83
HP:0000962	HP:0000962	Hyperkeratosis	0	ZNF750 CL E G H	79755	25843	OMIM:610227	Seborrhea-Like dermatitis with psoriasiform elements	.	2
HP:0000962	HP:0008399	Circumungual hyperkeratosis	1	CL E G H
HP:0000962	HP:0007570	Hyperkeratosis lenticularis perstans	1	CL E G H
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AAAS CL E G H	8086	13666	OMIM:231550	Achalasia-Addisonianism-Alacrima syndrome		57
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AAAS CL E G H	8086	13666	OMIM:231550	Achalasia-Addisonianism-Alacrima syndrome		57
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AAAS CL E G H	8086	13666	ORPHA:869	Triple A syndrome		57
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AAAS CL E G H	8086	13666	ORPHA:869	Triple A syndrome	HP:0040283 - Occasional	57
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AAGAB CL E G H	79719	25662	OMIM:148600	Palmoplantar keratoderma, punctate type IA		7
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AAGAB CL E G H	79719	25662	OMIM:148600	Palmoplantar keratoderma, punctate type IA		7
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AAGAB CL E G H	79719	25662	ORPHA:79501	Punctate palmoplantar keratoderma type 1		7
HP:0000962	HP:0045059	Hyperkeratotic papule	1	AAGAB CL E G H	79719	25662	ORPHA:79501	Punctate palmoplantar keratoderma type 1	HP:0040281 - Very frequent	7
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AAGAB CL E G H	79719	25662	ORPHA:79501	Punctate palmoplantar keratoderma type 1		7
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ABCA12 CL E G H	26154	14637	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		130
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ABCA12 CL E G H	26154	14637	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		130
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ABCA12 CL E G H	26154	14637	OMIM:601277	Ichthyosis, congenital, autosomal recessive 4A		130
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ABCA12 CL E G H	26154	14637	OMIM:601277	Ichthyosis, congenital, autosomal recessive 4A		130
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ABCC9 CL E G H	10060	60	ORPHA:154	Familial isolated dilated cardiomyopathy		254
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ABCC9 CL E G H	10060	60	ORPHA:154	Familial isolated dilated cardiomyopathy		254
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ACTC1 CL E G H	70	143	ORPHA:154	Familial isolated dilated cardiomyopathy		208
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ACTC1 CL E G H	70	143	ORPHA:154	Familial isolated dilated cardiomyopathy		208
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ACTN2 CL E G H	88	164	ORPHA:154	Familial isolated dilated cardiomyopathy		307
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ACTN2 CL E G H	88	164	ORPHA:154	Familial isolated dilated cardiomyopathy		307
HP:0000962	HP:0000222	Gingival hyperkeratosis	1	ADAMTS2 CL E G H	9509	218	OMIM:225410	Ehlers-Danlos syndrome, type VII, autosomal recessive	.	165
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AKT1 CL E G H	207	391	ORPHA:201	Cowden syndrome		54
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AKT1 CL E G H	207	391	ORPHA:201	Cowden syndrome		54
HP:0000962	HP:0005595	Generalized hyperkeratosis	1	AKT1 CL E G H	207	391	ORPHA:201	Cowden syndrome	HP:0040281 - Very frequent	54
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AKT1 CL E G H	207	391	OMIM:615109	Cowden syndrome 6		54
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AKT1 CL E G H	207	391	OMIM:615109	Cowden syndrome 6		54
HP:0000962	HP:0005595	Generalized hyperkeratosis	1	AKT1 CL E G H	207	391	ORPHA:744	Proteus syndrome	HP:0040282 - Frequent	54
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ALOX12B CL E G H	242	430	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		75
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ALOX12B CL E G H	242	430	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		75
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ALOX12B CL E G H	242	430	OMIM:242100	Ichthyosis, congenital, autosomal recessive 2		75
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ALOX12B CL E G H	242	430	OMIM:242100	Ichthyosis, congenital, autosomal recessive 2		75
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ALOXE3 CL E G H	59344	13743	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		63
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ALOXE3 CL E G H	59344	13743	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		63
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ALOXE3 CL E G H	59344	13743	OMIM:242100	Ichthyosis, congenital, autosomal recessive 2		63
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ALOXE3 CL E G H	59344	13743	OMIM:242100	Ichthyosis, congenital, autosomal recessive 2		63
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ALOXE3 CL E G H	59344	13743	OMIM:606545	Ichthyosis, congenital, autosomal recessive 3		63
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ALOXE3 CL E G H	59344	13743	OMIM:606545	Ichthyosis, congenital, autosomal recessive 3		63
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ANAPC1 CL E G H	64682	19988	ORPHA:221008	Rothmund-Thomson syndrome type 1	HP:0040283 - Occasional	2
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ANKRD1 CL E G H	27063	15819	ORPHA:154	Familial isolated dilated cardiomyopathy		95
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ANKRD1 CL E G H	27063	15819	ORPHA:154	Familial isolated dilated cardiomyopathy		95
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AP1B1 CL E G H	162	554	OMIM:242150	Ichthyosiform erythroderma, corneal involvement, and deafness
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AP1B1 CL E G H	162	554	OMIM:242150	Ichthyosiform erythroderma, corneal involvement, and deafness
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AQP5 CL E G H	362	638	ORPHA:2337	Non-epidermolytic palmoplantar keratoderma		5
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AQP5 CL E G H	362	638	ORPHA:2337	Non-epidermolytic palmoplantar keratoderma		5
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	AQP5 CL E G H	362	638	OMIM:600231	PALMOPLANTAR KERATODERMA, BOTHNIAN TYPE; PPKB		5
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	AQP5 CL E G H	362	638	OMIM:600231	PALMOPLANTAR KERATODERMA, BOTHNIAN TYPE; PPKB		5
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ATP2A2 CL E G H	488	812	OMIM:101900	Acrokeratosis verruciformis		86
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ATP2A2 CL E G H	488	812	OMIM:101900	Acrokeratosis verruciformis		86
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ATP2A2 CL E G H	488	812	ORPHA:79151	Acrokeratosis verruciformis of Hopf		86
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ATP2A2 CL E G H	488	812	ORPHA:79151	Acrokeratosis verruciformis of Hopf		86
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ATP2A2 CL E G H	488	812	ORPHA:218	Darier disease		86
HP:0000962	HP:0008410	Subungual hyperkeratotic fragments	1	ATP2A2 CL E G H	488	812	ORPHA:218	Darier disease	HP:0040281 - Very frequent	86
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ATP2A2 CL E G H	488	812	ORPHA:218	Darier disease		86
HP:0000962	HP:0008410	Subungual hyperkeratotic fragments	1	ATP2A2 CL E G H	488	812	OMIM:124200	Darier-White disease	.	86
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	BAG3 CL E G H	9531	939	ORPHA:154	Familial isolated dilated cardiomyopathy		204
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	BAG3 CL E G H	9531	939	ORPHA:154	Familial isolated dilated cardiomyopathy		204
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	BAG5 CL E G H	9529	941	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	BAG5 CL E G H	9529	941	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	BRAF CL E G H	673	1097	ORPHA:1340	Cardiofaciocutaneous syndrome		276
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	BRAF CL E G H	673	1097	ORPHA:1340	Cardiofaciocutaneous syndrome		276
HP:0000962	HP:0007543	Epidermal hyperkeratosis	1	BRAF CL E G H	673	1097	OMIM:613707	Leopard syndrome 3		276
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CAP2 CL E G H	10486	20039	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CAP2 CL E G H	10486	20039	ORPHA:154	Familial isolated dilated cardiomyopathy
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CARD14 CL E G H	79092	16446	OMIM:173200	Pityriasis rubra pilaris		33
HP:0000962	HP:0008392	Subungual hyperkeratosis	1	CARD14 CL E G H	79092	16446	ORPHA:2897	Pityriasis rubra pilaris	HP:0040282 - Frequent	33
HP:0000962	HP:0008392	Subungual hyperkeratosis	1	CARD14 CL E G H	79092	16446	OMIM:173200	Pityriasis rubra pilaris	.	33
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CARD14 CL E G H	79092	16446	OMIM:173200	Pityriasis rubra pilaris		33
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CARD14 CL E G H	79092	16446	ORPHA:2897	Pityriasis rubra pilaris		33
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CARD14 CL E G H	79092	16446	ORPHA:2897	Pityriasis rubra pilaris		33
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CAST CL E G H	831	1515	OMIM:616295	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CAST CL E G H	831	1515	OMIM:616295	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CD28 CL E G H	940	1653	ORPHA:3162	Sézary syndrome
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CD28 CL E G H	940	1653	ORPHA:3162	Sézary syndrome
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CERS3 CL E G H	204219	23752	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		5
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CERS3 CL E G H	204219	23752	ORPHA:79394	Congenital non-bullous ichthyosiform erythroderma		5
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CFTR CL E G H	1080	1884	ORPHA:498359	Aquagenic palmoplantar keratoderma		1371
HP:0000962	HP:0025080	Orthokeratotic hyperkeratosis	1	CFTR CL E G H	1080	1884	ORPHA:498359	Aquagenic palmoplantar keratoderma	HP:0040282 - Frequent	1371
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CFTR CL E G H	1080	1884	ORPHA:498359	Aquagenic palmoplantar keratoderma		1371
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	COG6 CL E G H	57511	18621	ORPHA:363523	Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome		71
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	COG6 CL E G H	57511	18621	ORPHA:363523	Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome		71
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	COG6 CL E G H	57511	18621	OMIM:615328	Shaheen syndrome		71
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	COG6 CL E G H	57511	18621	OMIM:615328	Shaheen syndrome		71
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	COL14A1 CL E G H	7373	2191	ORPHA:79501	Punctate palmoplantar keratoderma type 1		2
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	COL14A1 CL E G H	7373	2191	ORPHA:79501	Punctate palmoplantar keratoderma type 1		2
HP:0000962	HP:0045059	Hyperkeratotic papule	1	COL14A1 CL E G H	7373	2191	ORPHA:79501	Punctate palmoplantar keratoderma type 1	HP:0040281 - Very frequent	2
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	COL17A1 CL E G H	1308	2194	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		129
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	COL17A1 CL E G H	1308	2194	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		129
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	COL6A1 CL E G H	1291	2211	OMIM:254090	Ullrich congenital muscular dystrophy 1	.	442
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	COL6A2 CL E G H	1292	2212	OMIM:254090	Ullrich congenital muscular dystrophy 1	.	478
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	COL6A3 CL E G H	1293	2213	OMIM:254090	Ullrich congenital muscular dystrophy 1	.	702
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	COL7A1 CL E G H	1294	2214	ORPHA:158673	Localized dystrophic epidermolysis bullosa, acral form		263
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	COL7A1 CL E G H	1294	2214	ORPHA:158673	Localized dystrophic epidermolysis bullosa, acral form		263
HP:0000962	HP:0045059	Hyperkeratotic papule	1	COL7A1 CL E G H	1294	2214	ORPHA:79410	Localized dystrophic epidermolysis bullosa, pretibial form	HP:0040283 - Occasional	263
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CRYAB CL E G H	1410	2389	ORPHA:154	Familial isolated dilated cardiomyopathy		46
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CRYAB CL E G H	1410	2389	ORPHA:154	Familial isolated dilated cardiomyopathy		46
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CSRP3 CL E G H	8048	2472	ORPHA:154	Familial isolated dilated cardiomyopathy		104
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CSRP3 CL E G H	8048	2472	ORPHA:154	Familial isolated dilated cardiomyopathy		104
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CSTA CL E G H	1475	2481	OMIM:607936	Peeling skin syndrome 4		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CSTA CL E G H	1475	2481	OMIM:607936	Peeling skin syndrome 4		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CTC1 CL E G H	80169	26169	ORPHA:1775	Dyskeratosis congenita		160
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CTC1 CL E G H	80169	26169	ORPHA:1775	Dyskeratosis congenita		160
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CTLA4 CL E G H	1493	2505	ORPHA:3162	Sézary syndrome		10
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CTLA4 CL E G H	1493	2505	ORPHA:3162	Sézary syndrome		10
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CTSC CL E G H	1075	2528	OMIM:245010	Haim-Munk syndrome		50
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CTSC CL E G H	1075	2528	OMIM:245010	Haim-Munk syndrome		50
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CTSC CL E G H	1075	2528	ORPHA:678	Papillon-Lefèvre syndrome		50
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CTSC CL E G H	1075	2528	ORPHA:678	Papillon-Lefèvre syndrome		50
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CTSC CL E G H	1075	2528	OMIM:245000	Papillon-Lefevre syndrome		50
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CTSC CL E G H	1075	2528	OMIM:245000	Papillon-Lefevre syndrome		50
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	CYP4F22 CL E G H	126410	26820	OMIM:604777	Ichthyosis, congenital, autosomal recessive 5		54
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	CYP4F22 CL E G H	126410	26820	OMIM:604777	Ichthyosis, congenital, autosomal recessive 5		54
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	DDR2 CL E G H	4921	2731	OMIM:618175	WARBURG-CINOTTI SYNDROME; WRCN		45
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DES CL E G H	1674	2770	ORPHA:154	Familial isolated dilated cardiomyopathy		263
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DES CL E G H	1674	2770	ORPHA:154	Familial isolated dilated cardiomyopathy		263
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DKC1 CL E G H	1736	2890	ORPHA:1775	Dyskeratosis congenita		65
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DKC1 CL E G H	1736	2890	ORPHA:1775	Dyskeratosis congenita		65
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DMD CL E G H	1756	2928	ORPHA:154	Familial isolated dilated cardiomyopathy		1496
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DMD CL E G H	1756	2928	ORPHA:154	Familial isolated dilated cardiomyopathy		1496
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DOLK CL E G H	22845	23406	ORPHA:154	Familial isolated dilated cardiomyopathy		55
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DOLK CL E G H	22845	23406	ORPHA:154	Familial isolated dilated cardiomyopathy		55
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSC2 CL E G H	1824	3036	OMIM:610476	Arrhythmogenic right ventricular dysplasia, familial, 11		268
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSC2 CL E G H	1824	3036	OMIM:610476	Arrhythmogenic right ventricular dysplasia, familial, 11		268
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	DSC3 CL E G H	1825	3037	OMIM:613102	HYPOTRICHOSIS AND RECURRENT SKIN VESICLES		2
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSG1 CL E G H	1828	3048	OMIM:615508	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige		16
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSG1 CL E G H	1828	3048	OMIM:615508	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige		16
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSG1 CL E G H	1828	3048	OMIM:148700	Keratosis palmoplantaris striata I		16
HP:0000962	HP:0007501	Streaks of hyperkeratosis along each finger onto the palm	1	DSG1 CL E G H	1828	3048	OMIM:148700	Keratosis palmoplantaris striata I		16
HP:0000962	HP:0025080	Orthokeratotic hyperkeratosis	1	DSG1 CL E G H	1828	3048	OMIM:148700	Keratosis palmoplantaris striata I		16
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSG1 CL E G H	1828	3048	OMIM:148700	Keratosis palmoplantaris striata I		16
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSG1 CL E G H	1828	3048	ORPHA:50942	Striate palmoplantar keratoderma		16
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSG1 CL E G H	1828	3048	ORPHA:50942	Striate palmoplantar keratoderma		16
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSG2 CL E G H	1829	3049	ORPHA:154	Familial isolated dilated cardiomyopathy		358
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSG2 CL E G H	1829	3049	ORPHA:154	Familial isolated dilated cardiomyopathy		358
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	DSG4 CL E G H	147409	21307	OMIM:607903	Hypotrichosis 6	.	63
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	DSG4 CL E G H	147409	21307	ORPHA:573	Monilethrix	HP:0040281 - Very frequent	63
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:605676	Cardiomyopathy, dilated, with woolly hair and keratoderma		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:605676	Cardiomyopathy, dilated, with woolly hair and keratoderma		747
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:615821	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:615821	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	ORPHA:65282	Carvajal syndrome		747
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	ORPHA:65282	Carvajal syndrome		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	ORPHA:154	Familial isolated dilated cardiomyopathy		747
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	ORPHA:154	Familial isolated dilated cardiomyopathy		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:612908	Keratosis palmoplantaris striata II		747
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:612908	Keratosis palmoplantaris striata II		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:607655	Skin fragility-woolly hair syndrome		747
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	OMIM:607655	Skin fragility-woolly hair syndrome		747
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	DSP CL E G H	1832	3052	ORPHA:50942	Striate palmoplantar keratoderma		747
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	DSP CL E G H	1832	3052	ORPHA:50942	Striate palmoplantar keratoderma		747
HP:0000962	HP:0007543	Epidermal hyperkeratosis	1	ELOVL4 CL E G H	6785	14415	OMIM:133190	Spinocerebellar ataxia 34		62
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ENPP1 CL E G H	5167	3356	OMIM:615522	Cole disease		151
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ENPP1 CL E G H	5167	3356	OMIM:615522	Cole disease		151
HP:0000962	HP:0031288	Cobblestone-like hyperkeratosis	1	EPHB4 CL E G H	2050	3395	ORPHA:90186	Meige disease	HP:0040282 - Frequent	3
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	FERMT1 CL E G H	55612	15889	ORPHA:2908	Kindler epidermolysis bullosa		136
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	FERMT1 CL E G H	55612	15889	ORPHA:2908	Kindler epidermolysis bullosa		136
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	FERMT1 CL E G H	55612	15889	OMIM:173650	Kindler syndrome		136
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	FERMT1 CL E G H	55612	15889	OMIM:173650	Kindler syndrome		136
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	FGFR2 CL E G H	2263	3689	ORPHA:1555	Cutis gyrata-acanthosis nigricans-craniosynostosis syndrome		175
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	FGFR2 CL E G H	2263	3689	ORPHA:1555	Cutis gyrata-acanthosis nigricans-craniosynostosis syndrome		175
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	FHL2 CL E G H	2274	3703	ORPHA:154	Familial isolated dilated cardiomyopathy		36
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	FHL2 CL E G H	2274	3703	ORPHA:154	Familial isolated dilated cardiomyopathy		36
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	FIG4 CL E G H	9896	16873	OMIM:216340	Yunis-Varon syndrome		111
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	FIG4 CL E G H	9896	16873	OMIM:216340	Yunis-Varon syndrome		111
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	FKBP14 CL E G H	55033	18625	OMIM:614557	Ehlers-Danlos syndrome, kyphoscoliotic type, 2	.	13
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	FKBP14 CL E G H	55033	18625	ORPHA:300179	Kyphoscoliotic Ehlers-Danlos syndrome due to FKBP22 deficiency	HP:0040281 - Very frequent	13
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	FKTN CL E G H	2218	3622	ORPHA:154	Familial isolated dilated cardiomyopathy		184
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	FKTN CL E G H	2218	3622	ORPHA:154	Familial isolated dilated cardiomyopathy		184
HP:0000962	HP:0007448	Hyperkeratosis over edematous areas	1	FLT4 CL E G H	2324	3767	OMIM:153100	Lymphatic malformation 1	.	90
HP:0000962	HP:0005595	Generalized hyperkeratosis	1	FUCA1 CL E G H	2517	4006	ORPHA:349	Fucosidosis	HP:0040281 - Very frequent	43
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GATAD1 CL E G H	57798	29941	ORPHA:154	Familial isolated dilated cardiomyopathy		35
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GATAD1 CL E G H	57798	29941	ORPHA:154	Familial isolated dilated cardiomyopathy		35
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJA1 CL E G H	2697	4274	ORPHA:1010	Autosomal dominant palmoplantar keratoderma and congenital alopecia		68
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJA1 CL E G H	2697	4274	ORPHA:1010	Autosomal dominant palmoplantar keratoderma and congenital alopecia		68
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJA1 CL E G H	2697	4274	ORPHA:317	Erythrokeratodermia variabilis		68
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJA1 CL E G H	2697	4274	ORPHA:317	Erythrokeratodermia variabilis		68
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJA1 CL E G H	2697	4274	OMIM:617525	Erythrokeratodermia variabilis et progressiva 3		68
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJA1 CL E G H	2697	4274	OMIM:617525	Erythrokeratodermia variabilis et progressiva 3		68
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJA1 CL E G H	2697	4274	ORPHA:2710	Oculodentodigital dysplasia		68
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJA1 CL E G H	2697	4274	ORPHA:2710	Oculodentodigital dysplasia		68
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJA1 CL E G H	2697	4274	OMIM:104100	Palmoplantar keratoderma with congenital alopecia		68
HP:0000962	HP:0007543	Epidermal hyperkeratosis	1	GJA1 CL E G H	2697	4274	OMIM:104100	Palmoplantar keratoderma with congenital alopecia		68
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJA1 CL E G H	2697	4274	OMIM:104100	Palmoplantar keratoderma with congenital alopecia		68
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:602540	Ichthyosis, hystrix-like, with deafness		199
HP:0000962	HP:0031288	Cobblestone-like hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:602540	Ichthyosis, hystrix-like, with deafness		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:602540	Ichthyosis, hystrix-like, with deafness		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:494	Keratoderma hereditarium mutilans		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:494	Keratoderma hereditarium mutilans		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:148350	Keratoderma, palmoplantar, with deafness		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:148350	Keratoderma, palmoplantar, with deafness		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:477	KID syndrome		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:477	KID syndrome		199
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:477	KID syndrome		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:149200	Knuckle pads, leukonychia, and sensorineural deafness		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:149200	Knuckle pads, leukonychia, and sensorineural deafness		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:2698	Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome		199
HP:0000962	HP:0045059	Hyperkeratotic papule	1	GJB2 CL E G H	2706	4284	ORPHA:2698	Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:2698	Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:2202	Palmoplantar keratoderma-deafness syndrome		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	ORPHA:2202	Palmoplantar keratoderma-deafness syndrome		199
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:124500	VOHWINKEL SYNDROME; VOWNKL		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB2 CL E G H	2706	4284	OMIM:124500	VOHWINKEL SYNDROME; VOWNKL		199
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB3 CL E G H	2707	4285	ORPHA:317	Erythrokeratodermia variabilis		74
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB3 CL E G H	2707	4285	ORPHA:317	Erythrokeratodermia variabilis		74
HP:0000962	HP:0005595	Generalized hyperkeratosis	1	GJB3 CL E G H	2707	4285	OMIM:133200	Erythrokeratodermia variabilis et progressiva 1		74
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB3 CL E G H	2707	4285	OMIM:133200	Erythrokeratodermia variabilis et progressiva 1		74
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB3 CL E G H	2707	4285	OMIM:133200	Erythrokeratodermia variabilis et progressiva 1		74
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB4 CL E G H	127534	4286	ORPHA:317	Erythrokeratodermia variabilis		12
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB4 CL E G H	127534	4286	ORPHA:317	Erythrokeratodermia variabilis		12
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB4 CL E G H	127534	4286	OMIM:617524	Erythrokeratodermia variabilis et progressiva 2		12
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB4 CL E G H	127534	4286	OMIM:617524	Erythrokeratodermia variabilis et progressiva 2		12
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB6 CL E G H	10804	4288	OMIM:129500	Clouston syndrome		56
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB6 CL E G H	10804	4288	OMIM:129500	Clouston syndrome		56
HP:0000962	HP:0031288	Cobblestone-like hyperkeratosis	1	GJB6 CL E G H	10804	4288	ORPHA:189	Hidrotic ectodermal dysplasia		56
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB6 CL E G H	10804	4288	ORPHA:189	Hidrotic ectodermal dysplasia		56
HP:0000962	HP:0045059	Hyperkeratotic papule	1	GJB6 CL E G H	10804	4288	ORPHA:189	Hidrotic ectodermal dysplasia		56
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB6 CL E G H	10804	4288	ORPHA:189	Hidrotic ectodermal dysplasia		56
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GJB6 CL E G H	10804	4288	ORPHA:477	KID syndrome		56
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GJB6 CL E G H	10804	4288	ORPHA:477	KID syndrome		56
HP:0000962	HP:0007502	Follicular hyperkeratosis	1	GJB6 CL E G H	10804	4288	ORPHA:477	KID syndrome		56
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	GMPPA CL E G H	29926	22923	ORPHA:869	Triple A syndrome	HP:0040283 - Occasional	24
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	GMPPA CL E G H	29926	22923	ORPHA:869	Triple A syndrome		24
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	HAND2 CL E G H	9464	4808	ORPHA:154	Familial isolated dilated cardiomyopathy		2
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	HAND2 CL E G H	9464	4808	ORPHA:154	Familial isolated dilated cardiomyopathy		2
HP:0000962	HP:0007468	Perifollicular hyperkeratosis	1	HLA-DRA CL E G H	3122	4947	ORPHA:505	Graham Little-Piccardi-Lassueur syndrome	HP:0040281 - Very frequent
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	HPGD CL E G H	3248	5154	OMIM:259100	Hypertrophic osteoarthropathy, primary, autosomal recessive 1		55
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	HPGD CL E G H	3248	5154	OMIM:259100	Hypertrophic osteoarthropathy, primary, autosomal recessive 1		55
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	HPGD CL E G H	3248	5154	ORPHA:2796	Pachydermoperiostosis		55
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	HPGD CL E G H	3248	5154	ORPHA:2796	Pachydermoperiostosis		55
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	ITGB4 CL E G H	3691	6158	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		124
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	ITGB4 CL E G H	3691	6158	ORPHA:79402	Intermediate generalized junctional epidermolysis bullosa		124
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	JUP CL E G H	3728	6207	ORPHA:34217	Naxos disease		222
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	JUP CL E G H	3728	6207	OMIM:601214	Naxos disease		222
HP:0000962	HP:0008392	Subungual hyperkeratosis	1	JUP CL E G H	3728	6207	OMIM:601214	Naxos disease		222
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	JUP CL E G H	3728	6207	ORPHA:34217	Naxos disease		222
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	JUP CL E G H	3728	6207	OMIM:601214	Naxos disease		222
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KANK2 CL E G H	25959	29300	OMIM:616099	Palmoplantar keratoderma and woolly hair		1
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KANK2 CL E G H	25959	29300	OMIM:616099	Palmoplantar keratoderma and woolly hair		1
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KDSR CL E G H	2531	4021	ORPHA:317	Erythrokeratodermia variabilis		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KDSR CL E G H	2531	4021	ORPHA:317	Erythrokeratodermia variabilis		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KDSR CL E G H	2531	4021	OMIM:617526	Erythrokeratodermia variabilis et progressiva 4		4
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KDSR CL E G H	2531	4021	OMIM:617526	Erythrokeratodermia variabilis et progressiva 4		4
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KDSR CL E G H	2531	4021	ORPHA:316	Progressive symmetric erythrokeratodermia		4
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KDSR CL E G H	2531	4021	ORPHA:316	Progressive symmetric erythrokeratodermia		4
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KLHL24 CL E G H	54800	25947	OMIM:617294	Epidermolysis bullosa simplex, generalized, with scarring and hair loss		5
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KLHL24 CL E G H	54800	25947	OMIM:617294	Epidermolysis bullosa simplex, generalized, with scarring and hair loss		5
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KLLN CL E G H	100144748	37212	ORPHA:201	Cowden syndrome		1
HP:0000962	HP:0005595	Generalized hyperkeratosis	1	KLLN CL E G H	100144748	37212	ORPHA:201	Cowden syndrome	HP:0040281 - Very frequent	1
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KLLN CL E G H	100144748	37212	ORPHA:201	Cowden syndrome		1
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRAS CL E G H	3845	6407	ORPHA:1340	Cardiofaciocutaneous syndrome		196
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRAS CL E G H	3845	6407	ORPHA:1340	Cardiofaciocutaneous syndrome		196
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:312	Autosomal dominant epidermolytic ichthyosis		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:312	Autosomal dominant epidermolytic ichthyosis		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:113800	Epidermolytic hyperkeratosis		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:113800	Epidermolytic hyperkeratosis		100
HP:0000962	HP:0007543	Epidermal hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:2199	Epidermolytic palmoplantar keratoderma		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:2199	Epidermolytic palmoplantar keratoderma		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:2199	Epidermolytic palmoplantar keratoderma		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:79503	Ichthyosis hystrix of Curth-Macklin		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:79503	Ichthyosis hystrix of Curth-Macklin		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:607654	KERATOSIS PALMOPLANTARIS STRIATA III; PPKS3		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:607654	KERATOSIS PALMOPLANTARIS STRIATA III; PPKS3		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:530838	KRT1-related diffuse nonepidermolytic keratoderma		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:530838	KRT1-related diffuse nonepidermolytic keratoderma		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:144200	Palmoplantar keratoderma, epidermolytic	.	100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:144200	Palmoplantar keratoderma, epidermolytic	.	100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:600962	PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC; NEPPK		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	OMIM:600962	PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC; NEPPK		100
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:50942	Striate palmoplantar keratoderma		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT1 CL E G H	3848	6412	ORPHA:50942	Striate palmoplantar keratoderma		100
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT10 CL E G H	3858	6413	ORPHA:312	Autosomal dominant epidermolytic ichthyosis		45
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT10 CL E G H	3858	6413	ORPHA:312	Autosomal dominant epidermolytic ichthyosis		45
HP:0000962	HP:0010765	Palmar hyperkeratosis	1	KRT10 CL E G H	3858	6413	OMIM:113800	Epidermolytic hyperkeratosis		45
HP:0000962	HP:0007556	Plantar hyperkeratosis	1	KRT10 CL E G H	3858	6413	OMIM:113800	Epidermolytic hyperkeratosis		45