Human Phenotype Ontology 
Grandparent Node:
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Tooth malposition (HP:0000692)help
Parent Node:
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Dental malocclusion (HP:0000689)help
..Starting node
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Anterior open-bite malocclusion (HP:0009102)help
Term ID: 9102
Name: Anterior open-bite malocclusion
Synonym: Absence of overlap of anterior upper and lower teeth; Anterior open bite; Anterior open bite between upper and lower teeth; Anterior openbite; AOB; Apertognathia malocclusion; Gap between upper and lower front teeth when biting
Definition: Anterior open bite is a malocclusion characterized by a gap between the anterior teeth (incisors), that is, by a deficiency in the normal vertical overlap between antagonist incisal edges when the posterior teeth are in occlusion.
Comments:
Reference: HP:0009102
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0009102HP:0009102Anterior open-bite malocclusion0AMELX CL E G H265461OMIM:301200Amelogenesis imperfecta, type IE.17
HP:0009102HP:0009102Anterior open-bite malocclusion0ATP6V1B2 CL E G H526854ORPHA:3473Zimmermann-Laband syndromeHP:0040282 - Frequent5
HP:0009102HP:0009102Anterior open-bite malocclusion0BMP2 CL E G H6501069OMIM:617877Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies.13
HP:0009102HP:0009102Anterior open-bite malocclusion0DSPP CL E G H18343054OMIM:125500Dentinogenesis imperfecta, shields type III38
HP:0009102HP:0009102Anterior open-bite malocclusion0ENAM CL E G H101173344OMIM:204650Amelogenesis imperfecta, type IC.50
HP:0009102HP:0009102Anterior open-bite malocclusion0FAM83H CL E G H28607724797OMIM:130900Amelogenesis imperfecta, type III.22
HP:0009102HP:0009102Anterior open-bite malocclusion0GNAI3 CL E G H27734387OMIM:602483Auriculocondylar syndrome 1.2
HP:0009102HP:0009102Anterior open-bite malocclusion0GPR68 CL E G H81114519OMIM:617217AMELOGENESIS IMPERFECTA, HYPOMATURATION TYPE, IIA6; AI2A63
HP:0009102HP:0009102Anterior open-bite malocclusion0ITGB6 CL E G H36946161OMIM:616221AMELOGENESIS IMPERFECTA, TYPE IH; AI1H8
HP:0009102HP:0009102Anterior open-bite malocclusion0KCNH1 CL E G H37566250ORPHA:3473Zimmermann-Laband syndromeHP:0040282 - Frequent13
HP:0009102HP:0009102Anterior open-bite malocclusion0KCNN3 CL E G H37826292ORPHA:3473Zimmermann-Laband syndromeHP:0040282 - Frequent7
HP:0009102HP:0009102Anterior open-bite malocclusion0KLK4 CL E G H96226365OMIM:204700Amelogenesis imperfecta, hypomaturation type, iia1HP:0040284 - Very rare6
HP:0009102HP:0009102Anterior open-bite malocclusion0MMP20 CL E G H93137167OMIM:612529Amelogenesis imperfecta, hypomaturation type, iia2HP:0040283 - Occasional37
HP:0009102HP:0009102Anterior open-bite malocclusion0RELT CL E G H8495713764OMIM:618386Amelogenesis imperfecta, type IIIC.


Genes (14) :AMELX ATP6V1B2 BMP2 DSPP ENAM FAM83H GNAI3 GPR68 ITGB6 KCNH1 KCNN3 KLK4 MMP20 RELT

Diseases (12) :OMIM:301200 ORPHA:3473 OMIM:617877 OMIM:125500 OMIM:204650 OMIM:130900 OMIM:602483 OMIM:617217 OMIM:616221 OMIM:204700 OMIM:612529 OMIM:618386
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.