Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the menstrual cycle (HP:0000140)help
Parent Node:
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Amenorrhea (HP:0000141)help
..Starting node
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Secondary amenorrhea (HP:0000869)help
Term ID: 869
Name: Secondary amenorrhea
Synonym: Previous menstrual periods stop
Definition:
Comments:
Reference: HP:0000869
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandPrimary amenorrhea (HP:0000786) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000869HP:0000869Secondary amenorrhea0ATRX CL E G H546886ORPHA:96253Cushing disease169
HP:0000869HP:0000869Secondary amenorrhea0BMP15 CL E G H92101068ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional16
HP:0000869HP:0000869Secondary amenorrhea0BMP15 CL E G H92101068OMIM:300510Ovarian dysgenesis 2.16
HP:0000869HP:0000869Secondary amenorrhea0BNC1 CL E G H6461081ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional
HP:0000869HP:0000869Secondary amenorrhea0BPTF CL E G H21863581ORPHA:52996217q24.2 microdeletion syndromeHP:0040283 - Occasional2
HP:0000869HP:0000869Secondary amenorrhea0BRAF CL E G H6731097ORPHA:96253Cushing disease276
HP:0000869HP:0000869Secondary amenorrhea0C14ORF39 CL E G H31776119849OMIM:619203PREMATURE OVARIAN FAILURE 18; POF18
HP:0000869HP:0000869Secondary amenorrhea0CDH23 CL E G H6407213733ORPHA:96253Cushing disease636
HP:0000869HP:0000869Secondary amenorrhea0CHD7 CL E G H5563620626ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent515
HP:0000869HP:0000869Secondary amenorrhea0DIAPH2 CL E G H17302877OMIM:300511Premature ovarian failure 2A.6
HP:0000869HP:0000869Secondary amenorrhea0DUSP6 CL E G H18483072ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent4
HP:0000869HP:0000869Secondary amenorrhea0EIF2B1 CL E G H19673257OMIM:603896Leukoencephalopathy with vanishing white matter.42
HP:0000869HP:0000869Secondary amenorrhea0EIF2B2 CL E G H88923258OMIM:603896Leukoencephalopathy with vanishing white matter.24
HP:0000869HP:0000869Secondary amenorrhea0EIF2B3 CL E G H88913259OMIM:603896Leukoencephalopathy with vanishing white matter.32
HP:0000869HP:0000869Secondary amenorrhea0EIF2B4 CL E G H88903260OMIM:603896Leukoencephalopathy with vanishing white matter.38
HP:0000869HP:0000869Secondary amenorrhea0EIF2B5 CL E G H88933261OMIM:603896Leukoencephalopathy with vanishing white matter.48
HP:0000869HP:0000869Secondary amenorrhea0ERAL1 CL E G H262843424OMIM:617565PERRAULT SYNDROME 6; PRLTS61
HP:0000869HP:0000869Secondary amenorrhea0ERCC6 CL E G H20743438OMIM:616946PREMATURE OVARIAN FAILURE 11; POF11199
HP:0000869HP:0000869Secondary amenorrhea0FGF17 CL E G H88223673ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent3
HP:0000869HP:0000869Secondary amenorrhea0FGF8 CL E G H22533686ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent17
HP:0000869HP:0000869Secondary amenorrhea0FGFR1 CL E G H22603688ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent172
HP:0000869HP:0000869Secondary amenorrhea0FIGLA CL E G H34401824669OMIM:612310PREMATURE OVARIAN FAILURE 6; POF617
HP:0000869HP:0000869Secondary amenorrhea0FOXL2 CL E G H6681092ORPHA:572333Blepharophimosis-ptosis-epicanthus inversus syndrome plusHP:0040283 - Occasional92
HP:0000869HP:0000869Secondary amenorrhea0FOXL2 CL E G H6681092OMIM:608996Premature ovarian failure 3.92
HP:0000869HP:0000869Secondary amenorrhea0FSHR CL E G H24923969ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional50
HP:0000869HP:0000869Secondary amenorrhea0GALT CL E G H25924135ORPHA:79239Classic galactosemiaHP:0040282 - Frequent351
HP:0000869HP:0000869Secondary amenorrhea0GNRH1 CL E G H27964419ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent15
HP:0000869HP:0000869Secondary amenorrhea0GNRHR CL E G H27984421ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent92
HP:0000869HP:0000869Secondary amenorrhea0HAMP CL E G H5781715598OMIM:613313Hemochromatosis, type 2B15
HP:0000869HP:0000869Secondary amenorrhea0HS6ST1 CL E G H93945201ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent8
HP:0000869HP:0000869Secondary amenorrhea0HSF2BP CL E G H110775226OMIM:619245PREMATURE OVARIAN FAILURE 19; POF191
HP:0000869HP:0000869Secondary amenorrhea0KISS1 CL E G H38146341ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent3
HP:0000869HP:0000869Secondary amenorrhea0KISS1R CL E G H846344510ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent14
HP:0000869HP:0000869Secondary amenorrhea0LARS2 CL E G H2339517095OMIM:615300Perrault syndrome 454
HP:0000869HP:0000869Secondary amenorrhea0LHB CL E G H39726584OMIM:228300Hypogonadotropic hypogonadism 23 without anosmia.9
HP:0000869HP:0000869Secondary amenorrhea0LMNA CL E G H40006636ORPHA:79474Atypical Werner syndromeHP:0040281 - Very frequent645
HP:0000869HP:0000869Secondary amenorrhea0LMNA CL E G H40006636ORPHA:280365Autosomal semi-dominant severe lipodystrophic laminopathyHP:0040282 - Frequent645
HP:0000869HP:0000869Secondary amenorrhea0LMNA CL E G H40006636ORPHA:2348Familial partial lipodystrophy, Dunnigan typeHP:0040282 - Frequent645
HP:0000869HP:0000869Secondary amenorrhea0MRPS22 CL E G H5694514508ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional25
HP:0000869HP:0000869Secondary amenorrhea0MSH4 CL E G H44387327OMIM:619938
HP:0000869HP:0000869Secondary amenorrhea0NOBOX CL E G H13593522448OMIM:611548Premature ovarian failure 5HP:0040281 - Very frequent40
HP:0000869HP:0000869Secondary amenorrhea0NR3C1 CL E G H29087978ORPHA:96253Cushing disease79
HP:0000869HP:0000869Secondary amenorrhea0NR5A1 CL E G H25167983ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional38
HP:0000869HP:0000869Secondary amenorrhea0NR5A1 CL E G H25167983OMIM:612964PREMATURE OVARIAN FAILURE 7; POF738
HP:0000869HP:0000869Secondary amenorrhea0NSMF CL E G H2601229843ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent6
HP:0000869HP:0000869Secondary amenorrhea0NUP107 CL E G H5712229914ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional5
HP:0000869HP:0000869Secondary amenorrhea0PAPSS2 CL E G H90608604OMIM:612847Brachyolmia 4 with mild epiphyseal and metaphyseal changes.20
HP:0000869HP:0000869Secondary amenorrhea0POLG CL E G H54289179OMIM:157640Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1.464
HP:0000869HP:0000869Secondary amenorrhea0POLG CL E G H54289179OMIM:258450Progressive external ophthalmoplegia with mitochondrial DNA deletions,autosomal recessive464
HP:0000869HP:0000869Secondary amenorrhea0POLR3H CL E G H17156830349ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional
HP:0000869HP:0000869Secondary amenorrhea0PPARG CL E G H54689236ORPHA:79083PPARG-related familial partial lipodystrophyHP:0040282 - Frequent42
HP:0000869HP:0000869Secondary amenorrhea0PRKAR1A CL E G H55739388OMIM:610489Pigmented nodular adrenocortical disease, primary, 1134
HP:0000869HP:0000869Secondary amenorrhea0PROK2 CL E G H6067518455ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent9
HP:0000869HP:0000869Secondary amenorrhea0PROKR2 CL E G H12867415836ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent34
HP:0000869HP:0000869Secondary amenorrhea0PSMC3IP CL E G H2989317928ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional2
HP:0000869HP:0000869Secondary amenorrhea0PSMD12 CL E G H57189557ORPHA:52996217q24.2 microdeletion syndromeHP:0040283 - Occasional4
HP:0000869HP:0000869Secondary amenorrhea0RCBTB1 CL E G H5521318243OMIM:617175RETINAL DYSTROPHY WITH OR WITHOUT EXTRAOCULAR ANOMALIES; RDEOA8
HP:0000869HP:0000869Secondary amenorrhea0SPIDR CL E G H2351428971ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional2
HP:0000869HP:0000869Secondary amenorrhea0SPRY4 CL E G H8184815533ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent5
HP:0000869HP:0000869Secondary amenorrhea0TAC3 CL E G H686611521ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent6
HP:0000869HP:0000869Secondary amenorrhea0TACR3 CL E G H687011528ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent34
HP:0000869HP:0000869Secondary amenorrhea0TBL1X CL E G H690711585OMIM:301033Hypothyroidism, congenital, nongoitrous, 8.1
HP:0000869HP:0000869Secondary amenorrhea0TKT CL E G H708611834ORPHA:488618Transketolase deficiencyHP:0040283 - Occasional4
HP:0000869HP:0000869Secondary amenorrhea0TP53 CL E G H715711998ORPHA:96253Cushing disease911
HP:0000869HP:0000869Secondary amenorrhea0USP48 CL E G H8419618533ORPHA:96253Cushing disease1
HP:0000869HP:0000869Secondary amenorrhea0USP8 CL E G H910112631ORPHA:96253Cushing disease7
HP:0000869HP:0000869Secondary amenorrhea0WDR11 CL E G H5571713831ORPHA:432Normosmic congenital hypogonadotropic hypogonadismHP:0040282 - Frequent10
HP:0000869HP:0000869Secondary amenorrhea0WRN CL E G H748612791ORPHA:902Werner syndromeHP:0040283 - Occasional310
HP:0000869HP:0000869Secondary amenorrhea0ZSWIM7 CL E G H12515026993ORPHA:24346,XX gonadal dysgenesisHP:0040283 - Occasional


Genes (63) :ATRX BMP15 BNC1 BPTF BRAF C14ORF39 CDH23 CHD7 DIAPH2 DUSP6 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 ERAL1 ERCC6 FGF17 FGF8 FGFR1 FIGLA FOXL2 FSHR GALT GNRH1 GNRHR HAMP HS6ST1 HSF2BP KISS1 KISS1R LARS2 LHB LMNA MRPS22 MSH4 NOBOX NR3C1 NR5A1 NSMF NUP107 PAPSS2 POLG POLR3H PPARG PRKAR1A PROK2 PROKR2 PSMC3IP PSMD12 RCBTB1 SPIDR SPRY4 TAC3 TACR3 TBL1X TKT TP53 USP48 USP8 WDR11 WRN ZSWIM7

Diseases (33) :ORPHA:96253 ORPHA:243 OMIM:300510 ORPHA:529962 OMIM:619203 ORPHA:432 OMIM:300511 OMIM:603896 OMIM:617565 OMIM:616946 OMIM:612310 ORPHA:572333 OMIM:608996 ORPHA:79239 OMIM:613313 OMIM:619245 OMIM:615300 OMIM:228300 ORPHA:79474 ORPHA:280365 ORPHA:2348 OMIM:619938 OMIM:611548 OMIM:612964 OMIM:612847 OMIM:157640 OMIM:258450 ORPHA:79083 OMIM:610489 OMIM:617175 OMIM:301033 ORPHA:488618 ORPHA:902
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.