Human Phenotype Ontology 
Grandparent Node:
expand
Abnormal nervous system physiology (HP:0012638)help
Parent Node:
expand
Behavioral abnormality (HP:0000708)help
..Starting node
..expand
Personality changes (HP:0000751)help
Term ID: 751
Name: Personality changes
Synonym: Personality change; Personality changes
Definition: An abnormal shift in patterns of thinking, acting, or feeling.
Comments:
Reference: HP:0000751
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal consumption behavior (HP:0040202) help
..expandAbnormal emotion/affect behavior (HP:0100851) help
..expandAbnormal social behavior (HP:0012433) help
..expandAbnormal temper tantrums (HP:0025160) help
..expandAddictive behavior (HP:0030858) help
..expandAutistic behavior (HP:0000729) help
..expandDelusions (HP:0000746) help
..expandDrooling (HP:0002307) help
..expandEcholalia (HP:0010529) help
..expandHallucinations (HP:0000738) help
..expandHyperorality (HP:0000710) help
..expandImpairment in personality functioning (HP:0031466) help
..expandInflexible adherence to routines or rituals (HP:0000732) help
..expandLack of insight (HP:0000757) help
..expandLack of spontaneous play (HP:0000721) help
..expandLow frustration tolerance (HP:0000744) help
..expandMania (HP:0100754) help
..expandMutism (HP:0002300) help
..expandObsessive-compulsive behavior (HP:0000722) help
..expandOppositional defiant disorder (HP:0010865) help
..expandPerseveration (HP:0030223) help
..expandPhotophobia (HP:0000613) help
..expandPseudobulbar behavioral symptoms (HP:0002193) help
..expandPsychomotor retardation (HP:0025356) help
..expandPsychosis (HP:0000709) help
..expandRestlessness (HP:0000711) help
..expandSchizophrenia (HP:0100753) help
..expandSelf-neglect (HP:0025479) help
..expandShort attention span (HP:0000736) help
..expandSleep disturbance (HP:0002360) help
..expandSound sensitivity (HP:0025112) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0000751HP:0000751Personality changes0ATP7B CL E G H540277900Wilson disease277900C0019202OMIM11806870606882
HP:0000751HP:0000751Personality changes0C9orf72 CL E G H203228275864ORPHA117328337614260
HP:0000751HP:0000751Personality changes0CHMP2B CL E G H25978275864ORPHA114124537609512
HP:0000751HP:0000751Personality changes0CHMP2B CL E G H25978600795Frontotemporal Dementia, Chromosome 3-Linked600795C1833296OMIM114124537609512
HP:0000751HP:0000751Personality changes0EIF2B1 CL E G H1967603896Leukoencephalopathy with vanishing white matter603896C1858991OMIM11423257606686
HP:0000751HP:0000751Personality changes0EIF2B2 CL E G H8892603896Leukoencephalopathy with vanishing white matter603896C1858991OMIM11383258606454
HP:0000751HP:0000751Personality changes0EIF2B3 CL E G H8891603896Leukoencephalopathy with vanishing white matter603896C1858991OMIM11403259606273
HP:0000751HP:0000751Personality changes0EIF2B4 CL E G H8890603896Leukoencephalopathy with vanishing white matter603896C1858991OMIM11703260606687
HP:0000751HP:0000751Personality changes0EIF2B5 CL E G H8893603896Leukoencephalopathy with vanishing white matter603896C1858991OMIM14223261603945
HP:0000751HP:0000751Personality changes0GRN CL E G H2896275864ORPHA14174601138945
HP:0000751HP:0000751Personality changes0GRN CL E G H2896607485Frontotemporal dementia, ubiquitin-positive607485C1843792OMIM14174601138945
HP:0000751HP:0000751Personality changes0HTT CL E G H3064143100Huntington's chorea143100C0020179OMIM17354851613004
HP:0000751HP:0000751Personality changes0JPH3 CL E G H5733898934ORPHA112514203605268
HP:0000751HP:0000751Personality changes0LMNB1 CL E G H4001169500Leukodystrophy, adult-onset, autosomal dominant169500C1868512OMIM11696637150340
HP:0000751HP:0000751Personality changes0MAPT CL E G H4137275864ORPHA15146893157140
HP:0000751HP:0000751Personality changes0MAPT CL E G H4137600274Frontotemporal dementia600274C0338451OMIM15146893157140
HP:0000751HP:0000751Personality changes0MAPT CL E G H4137172700Pick's disease172700C0236642OMIM15146893157140
HP:0000751HP:0000751Personality changes0NR4A2 CL E G H4929168600Parkinson disease, late-onset168600C3160718OMIM11127981601828
HP:0000751HP:0000751Personality changes0PLA2G6 CL E G H8398612953Parkinson disease 14612953C2751842OMIM15989039603604
HP:0000751HP:0000751Personality changes0PRNP CL E G H5621282166ORPHA11649449176640
HP:0000751HP:0000751Personality changes0PRNP CL E G H5621137440Gerstmann-Straussler-Scheinker syndrome137440C0017495OMIM11649449176640
HP:0000751HP:0000751Personality changes0PRNP CL E G H5621603218Huntington disease-like 1603218C1864112OMIM11649449176640
HP:0000751HP:0000751Personality changes0PRNP CL E G H5621123400Jakob-Creutzfeldt disease123400C0022336OMIM11649449176640
HP:0000751HP:0000751Personality changes0PRNP CL E G H5621606688Spongiform encephalopathy with neuropsychiatric features606688C1847650OMIM11649449176640
HP:0000751HP:0000751Personality changes0PSEN1 CL E G H5663275864ORPHA14529508104311
HP:0000751HP:0000751Personality changes0PSEN1 CL E G H5663607822Alzheimer disease, type 3607822C1843013OMIM14529508104311
HP:0000751HP:0000751Personality changes0PSEN1 CL E G H5663600274Frontotemporal dementia600274C0338451OMIM14529508104311
HP:0000751HP:0000751Personality changes0PSEN1 CL E G H5663172700Pick's disease172700C0236642OMIM14529508104311
HP:0000751HP:0000751Personality changes0SNCAIP CL E G H9627168600Parkinson disease, late-onset168600C3160718OMIM111811139603779
HP:0000751HP:0000751Personality changes0SQSTM1 CL E G H8878275864ORPHA154211280601530
HP:0000751HP:0000751Personality changes0SQSTM1 CL E G H8878616437Frontotemporal dementia and/or amyotrophic lateral sclerosis 3616437C4225326OMIM154211280601530
HP:0000751HP:0000751Personality changes0TBK1 CL E G H29110616439Frontotemporal dementia and/or amyotrophic lateral sclerosis 4616439C4225325OMIM129411584604834
HP:0000751HP:0000751Personality changes0TMEM106B CL E G H54664275864ORPHA18722407613413
HP:0000751HP:0000751Personality changes0TREM2 CL E G H542092770ORPHA111017761605086
HP:0000751HP:0000751Personality changes0TREM2 CL E G H54209275864ORPHA111017761605086
HP:0000751HP:0000751Personality changes0TYROBP CL E G H73052770ORPHA18512449604142
HP:0000751HP:0000751Personality changes0TYROBP CL E G H7305221770Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy221770C1857316OMIM18512449604142
HP:0000751HP:0000751Personality changes0VCP CL E G H7415275864ORPHA147312666601023
HP:0000751HP:0000751Personality changes0VPS13A CL E G H23230200150Choreoacanthocytosis200150C0393576OMIM117351908605978
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000751HP:0000751Personality changes0C9orf72 CL E G H203228100070ORPHA017328337614260
HP:0000751HP:0000751Personality changes0CHMP2B CL E G H25978100070ORPHA014124537609512
HP:0000751HP:0000751Personality changes0DCTN1 CL E G H1639178509ORPHA08582711601143
HP:0000751HP:0000751Personality changes0GRN CL E G H2896100070ORPHA04174601138945
HP:0000751HP:0000751Personality changes0MAPT CL E G H4137100070ORPHA05146893157140
HP:0000751HP:0000751Personality changes0PLA2G6 CL E G H8398199351ORPHA05989039603604
HP:0000751HP:0000751Personality changes0PNPLA6 CL E G H109081173CDG syndrome type 3ORPHA094316268603197
HP:0000751HP:0000751Personality changes0PSEN1 CL E G H5663100070ORPHA04529508104311
HP:0000751HP:0000751Personality changes0RNF216 CL E G H544761173CDG syndrome type 3ORPHA021121698609948
HP:0000751HP:0000751Personality changes0TMEM106B CL E G H54664100070ORPHA08722407613413
HP:0000751HP:0000751Personality changes0TREM2 CL E G H54209100070ORPHA011017761605086
HP:0000751HP:0000751Personality changes0VCP CL E G H7415100070ORPHA047312666601023


Genes (29) :ATP7B C9ORF72 C9orf72 CHMP2B DCTN1 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 GRN HTT JPH3 LMNB1 MAPT NR4A2 PLA2G6 PNPLA6 PRNP PSEN1 RNF216 SNCAIP SQSTM1 TBK1 TMEM106B TREM2 TYROBP VCP VPS13A

Diseases (27) :277900 275864 100070 600795 178509 603896 607485 143100 98934 169500 600274 172700 168600 199351 612953 1173 282166 137440 603218 123400 606688 607822 616437 616439 2770 221770 200150
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.