Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Recurrent infections (HP:0002719)

Parent Node:
Recurrent bacterial infections (HP:0002718)

..Starting node
..Recurrent staphylococcal infections (HP:0007499)

Term ID:

7499

Name:

Recurrent staphylococcal infections

Synonym:

Recurrent staphylococcal infections

Definition:

Increased susceptibility to staphylococcal infections, as manifested by recurrent episodes of staphylococcal infections.

Comments:

Reference:

HP:0007499

Genes and Diseases:

Child Nodes:

........

Recurrent Staphylococcus aureus infections (HP:0002726)

Sister Nodes:

Recurrent bacterial skin infections (HP:0005406)

Recurrent gram-negative bacterial infections (HP:0005420)

Recurrent mycobacterial infections (HP:0011274)

Recurrent systemic pyogenic infections (HP:0005429)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CEACAM3 CL E G H	1084	1815	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CEACAM6 CL E G H	4680	1818	ORPHA:586	Cystic fibrosis		1
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CFTR CL E G H	1080	1884	ORPHA:586	Cystic fibrosis		1371
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CIITA CL E G H	4261	7067	ORPHA:572	Immunodeficiency by defective expression of MHC class II		118
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CLCA4 CL E G H	22802	2018	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CYBA CL E G H	1535	2577	OMIM:233690	GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE		27
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	CYBB CL E G H	1536	2578	OMIM:306400	Chronic granulomatous disease, X-linked		111
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	DCTN4 CL E G H	51164	15518	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	EDNRA CL E G H	1909	3179	ORPHA:586	Cystic fibrosis		3
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	FCN3 CL E G H	8547	3625	OMIM:613860	FICOLIN 3 DEFICIENCY		1
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	GCLC CL E G H	2729	4311	ORPHA:586	Cystic fibrosis		2
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	GSTM3 CL E G H	2947	4635	ORPHA:586	Cystic fibrosis		1
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	HFE CL E G H	3077	4886	ORPHA:586	Cystic fibrosis		38
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	HMOX1 CL E G H	3162	5013	ORPHA:586	Cystic fibrosis		3
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	IL17RA CL E G H	23765	5985	OMIM:613953	Immunodeficiency 51		196
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	IRAK4 CL E G H	51135	17967	OMIM:607676	Immunodeficiency 67		58
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	IRAK4 CL E G H	51135	17967	ORPHA:70592	Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency	HP:0040281 - Very frequent	58
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	ITGB2 CL E G H	3689	6155	OMIM:116920	Leukocyte adhesion deficiency, type I	.	114
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	KCNN4 CL E G H	3783	6293	ORPHA:586	Cystic fibrosis		3
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	LYST CL E G H	1130	1968	ORPHA:167	Chédiak-Higashi syndrome	HP:0040282 - Frequent	239
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	MIF CL E G H	4282	7097	ORPHA:586	Cystic fibrosis		1
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	NCF1 CL E G H	653361	7660	OMIM:233700	Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I		13
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	NCF2 CL E G H	4688	7661	OMIM:233710	Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II		67
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	NTRK1 CL E G H	4914	8031	ORPHA:642	Hereditary sensory and autonomic neuropathy type 4		97
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	PGM3 CL E G H	5238	8907	OMIM:615816	Immunodeficiency 23		15
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	RFX5 CL E G H	5993	9986	ORPHA:572	Immunodeficiency by defective expression of MHC class II		38
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	RFXANK CL E G H	8625	9987	ORPHA:572	Immunodeficiency by defective expression of MHC class II		26
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	RFXAP CL E G H	5994	9988	ORPHA:572	Immunodeficiency by defective expression of MHC class II		34
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	SERPINA1 CL E G H	5265	8941	ORPHA:586	Cystic fibrosis		131
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	SLC11A1 CL E G H	6556	10907	ORPHA:586	Cystic fibrosis		2
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	SLC26A9 CL E G H	115019	14469	ORPHA:586	Cystic fibrosis		5
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	SLC6A14 CL E G H	11254	11047	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	SLC9A3 CL E G H	6550	11073	ORPHA:586	Cystic fibrosis		7
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	STAT3 CL E G H	6774	11364	OMIM:147060	Hyper-IgE recurrent infection syndrome		110
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	STX1A CL E G H	6804	11433	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0007499	Recurrent staphylococcal infections	0	TGFB1 CL E G H	7040	11766	ORPHA:586	Cystic fibrosis		13
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CEACAM3 CL E G H	1084	1815	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CEACAM6 CL E G H	4680	1818	ORPHA:586	Cystic fibrosis		1
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CFTR CL E G H	1080	1884	ORPHA:586	Cystic fibrosis		1371
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CIITA CL E G H	4261	7067	ORPHA:572	Immunodeficiency by defective expression of MHC class II	HP:0040282 - Frequent	118
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CLCA4 CL E G H	22802	2018	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CYBA CL E G H	1535	2577	OMIM:233690	GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE	.	27
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	CYBB CL E G H	1536	2578	OMIM:306400	Chronic granulomatous disease, X-linked	.	111
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	DCTN4 CL E G H	51164	15518	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	EDNRA CL E G H	1909	3179	ORPHA:586	Cystic fibrosis		3
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	FCN3 CL E G H	8547	3625	OMIM:613860	FICOLIN 3 DEFICIENCY		1
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	GCLC CL E G H	2729	4311	ORPHA:586	Cystic fibrosis		2
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	GSTM3 CL E G H	2947	4635	ORPHA:586	Cystic fibrosis		1
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	HFE CL E G H	3077	4886	ORPHA:586	Cystic fibrosis		38
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	HMOX1 CL E G H	3162	5013	ORPHA:586	Cystic fibrosis		3
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	IL17RA CL E G H	23765	5985	OMIM:613953	Immunodeficiency 51		196
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	KCNN4 CL E G H	3783	6293	ORPHA:586	Cystic fibrosis		3
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	MIF CL E G H	4282	7097	ORPHA:586	Cystic fibrosis		1
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	NCF1 CL E G H	653361	7660	OMIM:233700	Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I	.	13
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	NCF2 CL E G H	4688	7661	OMIM:233710	Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II	.	67
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	NTRK1 CL E G H	4914	8031	ORPHA:642	Hereditary sensory and autonomic neuropathy type 4	HP:0040281 - Very frequent	97
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	PGM3 CL E G H	5238	8907	OMIM:615816	Immunodeficiency 23		15
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	RFX5 CL E G H	5993	9986	ORPHA:572	Immunodeficiency by defective expression of MHC class II	HP:0040282 - Frequent	38
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	RFXANK CL E G H	8625	9987	ORPHA:572	Immunodeficiency by defective expression of MHC class II	HP:0040282 - Frequent	26
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	RFXAP CL E G H	5994	9988	ORPHA:572	Immunodeficiency by defective expression of MHC class II	HP:0040282 - Frequent	34
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	SERPINA1 CL E G H	5265	8941	ORPHA:586	Cystic fibrosis		131
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	SLC11A1 CL E G H	6556	10907	ORPHA:586	Cystic fibrosis		2
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	SLC26A9 CL E G H	115019	14469	ORPHA:586	Cystic fibrosis		5
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	SLC6A14 CL E G H	11254	11047	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	SLC9A3 CL E G H	6550	11073	ORPHA:586	Cystic fibrosis		7
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	STAT3 CL E G H	6774	11364	OMIM:147060	Hyper-IgE recurrent infection syndrome		110
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	STX1A CL E G H	6804	11433	ORPHA:586	Cystic fibrosis
HP:0007499	HP:0002726	Recurrent Staphylococcus aureus infections	1	TGFB1 CL E G H	7040	11766	ORPHA:586	Cystic fibrosis		13

Genes (35) :CEACAM3 CEACAM6 CFTR CIITA CLCA4 CYBA CYBB DCTN4 EDNRA FCN3 GCLC GSTM3 HFE HMOX1 IL17RA IRAK4 ITGB2 KCNN4 LYST MIF NCF1 NCF2 NTRK1 PGM3 RFX5 RFXANK RFXAP SERPINA1 SLC11A1 SLC26A9 SLC6A14 SLC9A3 STAT3 STX1A TGFB1

Diseases (15) :ORPHA:586 ORPHA:572 OMIM:233690 OMIM:306400 OMIM:613860 OMIM:613953 OMIM:607676 ORPHA:70592 OMIM:116920 ORPHA:167 OMIM:233700 OMIM:233710 ORPHA:642 OMIM:615816 OMIM:147060

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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