Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal nervous system physiology (HP:0012638)

Parent Node:
Behavioral abnormality (HP:0000708)

..Starting node
..Low frustration tolerance (HP:0000744)

Term ID:

744

Name:

Low frustration tolerance

Synonym:

Intolerance to frustration

Definition:

The feeling of frustration can be defined as an emotional reaction that occurs if a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration characterized by crying or temper tantrums (in children) or aggressive or other undesirable behaviors.

Comments:

Reference:

HP:0000744

Genes and Diseases:

Child Nodes:

Sister Nodes:

Abnormal consumption behavior (HP:0040202)

Abnormal emotion/affect behavior (HP:0100851)

Abnormal social behavior (HP:0012433)

Abnormal temper tantrums (HP:0025160)

Addictive behavior (HP:0030858)

Autistic behavior (HP:0000729)

Delusions (HP:0000746)

Drooling (HP:0002307)

Echolalia (HP:0010529)

Hallucinations (HP:0000738)

Hyperorality (HP:0000710)

Impairment in personality functioning (HP:0031466)

Inflexible adherence to routines or rituals (HP:0000732)

Lack of insight (HP:0000757)

Lack of spontaneous play (HP:0000721)

Mania (HP:0100754)

Mutism (HP:0002300)

Obsessive-compulsive behavior (HP:0000722)

obsolete Psychomotor retardation (HP:0025356)

Oppositional defiant disorder (HP:0010865)

Perseveration (HP:0030223)

Personality changes (HP:0000751)

Photophobia (HP:0000613)

Pseudobulbar behavioral symptoms (HP:0002193)

Psychosis (HP:0000709)

Restlessness (HP:0000711)

Schizophrenia (HP:0100753)

Self-neglect (HP:0025479)

Short attention span (HP:0000736)

Sleep disturbance (HP:0002360)

Sound sensitivity (HP:0025112)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000744	HP:0000744	Low frustration tolerance	0	CNTNAP2 CL E G H	26047	13830	ORPHA:163681	CNTNAP2-related developmental and epileptic encephalopathy		518
HP:0000744	HP:0000744	Low frustration tolerance	0	DNAJC13 CL E G H	23317	30343	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional	2
HP:0000744	HP:0000744	Low frustration tolerance	0	EIF4G1 CL E G H	1981	3296	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional	2
HP:0000744	HP:0000744	Low frustration tolerance	0	GATAD2B CL E G H	57459	30778	ORPHA:363686	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	HP:0040283 - Occasional	33
HP:0000744	HP:0000744	Low frustration tolerance	0	GBA1 CL E G H	2629	4177	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional
HP:0000744	HP:0000744	Low frustration tolerance	0	GIGYF2 CL E G H	26058	11960	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional	8
HP:0000744	HP:0000744	Low frustration tolerance	0	GNB2 CL E G H	2783	4398	OMIM:619503	NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND DYSMORPHIC FACIES; NEDHYDF
HP:0000744	HP:0000744	Low frustration tolerance	0	KDM5C CL E G H	8242	11114	OMIM:300534	Mental retardation, X-linked, syndromic, Claes-Jensen type	.	81
HP:0000744	HP:0000744	Low frustration tolerance	0	KMT2A CL E G H	4297	7132	ORPHA:319182	Wiedemann-Steiner syndrome	HP:0040282 - Frequent	91
HP:0000744	HP:0000744	Low frustration tolerance	0	LRRK2 CL E G H	120892	18618	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional	221
HP:0000744	HP:0000744	Low frustration tolerance	0	MAOA CL E G H	4128	6833	OMIM:300615	Brunner syndrome		22
HP:0000744	HP:0000744	Low frustration tolerance	0	MED12 CL E G H	9968	11957	OMIM:309520	Lujan-Fryns syndrome	.	228
HP:0000744	HP:0000744	Low frustration tolerance	0	OPHN1 CL E G H	4983	8148	OMIM:300486	Mental retardation, X-linked, with cerebellar hypoplasia and distinctive facial appearance		55
HP:0000744	HP:0000744	Low frustration tolerance	0	PPP2R5D CL E G H	5528	9312	ORPHA:457279	Intellectual disability-macrocephaly-hypotonia-behavioral abnormalities syndrome	HP:0040282 - Frequent	10
HP:0000744	HP:0000744	Low frustration tolerance	0	PUF60 CL E G H	22827	17042	ORPHA:508488	8q24.3 microdeletion syndrome	HP:0040283 - Occasional	19
HP:0000744	HP:0000744	Low frustration tolerance	0	SMARCA2 CL E G H	6595	11098	OMIM:619293	BLEPHAROPHIMOSIS-IMPAIRED INTELLECTUAL DEVELOPMENT SYNDROME; BIS		146
HP:0000744	HP:0000744	Low frustration tolerance	0	SNCA CL E G H	6622	11138	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional	65
HP:0000744	HP:0000744	Low frustration tolerance	0	VPS35 CL E G H	55737	13487	ORPHA:411602	Hereditary late-onset Parkinson disease	HP:0040283 - Occasional	37

Genes (18) :CNTNAP2 DNAJC13 EIF4G1 GATAD2B GBA1 GIGYF2 GNB2 KDM5C KMT2A LRRK2 MAOA MED12 OPHN1 PPP2R5D PUF60 SMARCA2 SNCA VPS35

Diseases (12) :ORPHA:163681 ORPHA:411602 ORPHA:363686 OMIM:619503 OMIM:300534 ORPHA:319182 OMIM:300615 OMIM:309520 OMIM:300486 ORPHA:457279 ORPHA:508488 OMIM:619293

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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