Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal skin morphology of the palm (HP:0040211)

Grandparent Node:
Hyperhidrosis (HP:0000975)

Parent Node:
Abnormality of the plantar skin of foot (HP:0100872)

Parent Node:
Palmar hyperhidrosis (HP:0006089)

..Starting node
..Palmoplantar hyperhidrosis (HP:0007410)

Term ID:

7410

Name:

Palmoplantar hyperhidrosis

Synonym:

Excessive sweating of palms and soles; Hyperhidrosis of palms and soles

Definition:

An abnormally increased perspiration on palms and soles.

Comments:

Reference:

HP:0007410

Genes and Diseases:

Child Nodes:

Sister Nodes:

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	CDSN CL E G H	1041	1802	OMIM:270300	Peeling skin syndrome 1		7
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	CFTR CL E G H	1080	1884	ORPHA:498359	Aquagenic palmoplantar keratoderma	HP:0040282 - Frequent	1371
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	CTSB CL E G H	1508	2527	OMIM:148370	Keratolytic winter erythema	.	1
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	KRT16 CL E G H	3868	6423	ORPHA:2309	Pachyonychia congenita	HP:0040282 - Frequent	27
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	KRT17 CL E G H	3872	6427	ORPHA:2309	Pachyonychia congenita	HP:0040282 - Frequent	23
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	KRT17 CL E G H	3872	6427	OMIM:167210	Pachyonychia congenita 2	.	23
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	KRT6A CL E G H	3853	6443	ORPHA:2309	Pachyonychia congenita	HP:0040282 - Frequent	41
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	KRT6B CL E G H	3854	6444	ORPHA:2309	Pachyonychia congenita	HP:0040282 - Frequent	4
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	MBTPS2 CL E G H	51360	15455	ORPHA:659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	HP:0040281 - Very frequent	22
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	PERP CL E G H	64065	17637	ORPHA:659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	HP:0040281 - Very frequent
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	PLAA CL E G H	9373	9043	OMIM:617527	Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies		3
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	RSPO1 CL E G H	284654	21679	OMIM:610644	Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal	.	3
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	SERPINB7 CL E G H	8710	13902	OMIM:615598	Palmoplantar keratoderma, Nagashima type	.	4
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	TRPV3 CL E G H	162514	18084	ORPHA:659	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	HP:0040281 - Very frequent	151
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	WNT10A CL E G H	80326	13829	OMIM:257980	Odontoonychodermal dysplasia	.	71
HP:0007410	HP:0007410	Palmoplantar hyperhidrosis	0	WNT10A CL E G H	80326	13829	OMIM:150400	Tooth agenesis, selective, 4		71

Genes (14) :CDSN CFTR CTSB KRT16 KRT17 KRT6A KRT6B MBTPS2 PERP PLAA RSPO1 SERPINB7 TRPV3 WNT10A

Diseases (11) :OMIM:270300 ORPHA:498359 OMIM:148370 ORPHA:2309 OMIM:167210 ORPHA:659 OMIM:617527 OMIM:610644 OMIM:615598 OMIM:257980 OMIM:150400

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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