Human Phenotype Ontology 
Grandparent Node:
expandHyperkeratosis (HP:0000962)help
Parent Node:
expandPalmoplantar keratoderma (HP:0000982)help
..Starting node
..expandNonepidermolytic palmoplantar hyperkeratosis (HP:0007404)help
Term ID: 7404
Name: Nonepidermolytic palmoplantar hyperkeratosis
Synonym: Nonepidermolytic palmoplantar keratoderma
Definition: Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis.
Comments:
Reference: HP:0007404
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandHoneycomb palmoplantar hyperkeratosis (HP:0007465) help
..expandobsolete Congenital palmoplantar keratodermia (HP:0007597) help
..expandobsolete Diffuse palmoplantar keratoderma (HP:0007435) help
..expandPatchy palmoplantar hyperkeratosis (HP:0005588) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0007404HP:0007404Nonepidermolytic palmoplantar hyperkeratosis0KRT1 CL E G H38486412ORPHA:530838KRT1-related diffuse nonepidermolytic keratodermaHP:0040280 - Obligate100
HP:0007404HP:0007404Nonepidermolytic palmoplantar hyperkeratosis0KRT1 CL E G H38486412OMIM:600962PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC; NEPPK100
HP:0007404HP:0007404Nonepidermolytic palmoplantar hyperkeratosis0SLURP1 CL E G H5715218746ORPHA:87503Mal de Meleda15


Genes (2) :KRT1 SLURP1

Diseases (3) :ORPHA:530838 OMIM:600962 ORPHA:87503
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.