Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal emotion/affect behavior (HP:0100851)

Parent Node:
Abnormal aggressive, impulsive or violent behavior (HP:0006919)

..Starting node
..Aggressive behavior (HP:0000718)

Term ID:

718

Name:

Aggressive behavior

Synonym:

Aggression; Aggressive behavior; Aggressive behaviour; Aggressiveness; physical aggression

Definition:

Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself.

Comments:

Reference:

HP:0000718

Genes and Diseases:

Child Nodes:

Sister Nodes:

Self-injurious behavior (HP:0100716)

Violent behavior (HP:0008760)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	DiseaseId	DiseaseName	DiseaseMIM	ConceptID	Source	Typical association	ClinVar variants	HGNC ID	GeneMIM
HPO disease - gene - phenotype typical associations:
HP:0000718	HP:0000718	Aggressive behavior	0	ADSL CL E G H	158	103050	Adenylosuccinate lyase deficiency	103050	C0268126	OMIM	1	639	291	608222
HP:0000718	HP:0000718	Aggressive behavior	0	AFF2 CL E G H	2334	309548	FRAXE	309548	C0751157	OMIM	1	366	3776	300806
HP:0000718	HP:0000718	Aggressive behavior	0	ALDH5A1 CL E G H	7915	271980	Succinate-semialdehyde dehydrogenase deficiency	271980	C0268631	OMIM	1	597	408	610045
HP:0000718	HP:0000718	Aggressive behavior	0	AMT CL E G H	275	605899	Non-ketotic hyperglycinemia	605899	C0751748	OMIM	1	457	473	238310
HP:0000718	HP:0000718	Aggressive behavior	0	ANK3 CL E G H	288	615493	Mental retardation, autosomal recessive 37	615493	C3809672	OMIM	1	615	494	600465
HP:0000718	HP:0000718	Aggressive behavior	0	AP1S2 CL E G H	8905	85335				ORPHA	1	218	560	300629
HP:0000718	HP:0000718	Aggressive behavior	0	AP1S2 CL E G H	8905	85329				ORPHA	1	218	560	300629
HP:0000718	HP:0000718	Aggressive behavior	0	ARID1B CL E G H	57492	135900	Coffin-Siris syndrome 1	135900	C3281201	OMIM	1	1206	18040	614556
HP:0000718	HP:0000718	Aggressive behavior	0	ATP13A2 CL E G H	23400	606693	Parkinson disease 9	606693	C1847640	OMIM	1	738	30213	610513
HP:0000718	HP:0000718	Aggressive behavior	0	ATP13A2 CL E G H	23400	617225	Spastic paraplegia 78, autosomal recessive	617225	C4310662	OMIM	1	738	30213	610513
HP:0000718	HP:0000718	Aggressive behavior	0	ATP7B CL E G H	540	905				ORPHA	1	1806	870	606882
HP:0000718	HP:0000718	Aggressive behavior	0	BCOR CL E G H	54880	309800	Lenz microphthalmia syndrome	309800	C0796016	OMIM	1	570	20893	300485
HP:0000718	HP:0000718	Aggressive behavior	0	C9orf72 CL E G H	203228	275864				ORPHA	1	173	28337	614260
HP:0000718	HP:0000718	Aggressive behavior	0	CAMTA1 CL E G H	23261	314647				ORPHA	1	334	18806	611501
HP:0000718	HP:0000718	Aggressive behavior	0	CAMTA1 CL E G H	23261	614756	Cerebellar ataxia, nonprogressive, with mental retardation	614756	C3553661	OMIM	1	334	18806	611501
HP:0000718	HP:0000718	Aggressive behavior	0	CEP152 CL E G H	22995	614852	Primary autosomal recessive microcephaly 9	614852	C3553886	OMIM	1	450	29298	613529
HP:0000718	HP:0000718	Aggressive behavior	0	CHD2 CL E G H	1106	2382				ORPHA	1	1526	1917	602119
HP:0000718	HP:0000718	Aggressive behavior	0	CHMP2B CL E G H	25978	275864				ORPHA	1	141	24537	609512
HP:0000718	HP:0000718	Aggressive behavior	0	CHMP2B CL E G H	25978	600795	Frontotemporal Dementia, Chromosome 3-Linked	600795	C1833296	OMIM	1	141	24537	609512
HP:0000718	HP:0000718	Aggressive behavior	0	CLCN4 CL E G H	1183	300114	Mental retardation 49, X-linked	300114	C3887959	OMIM	1	591	2022	302910
HP:0000718	HP:0000718	Aggressive behavior	0	CNTNAP2 CL E G H	26047	610042	Pitt-Hopkins-like syndrome 1	610042	C2750246	OMIM	1	1634	13830	604569
HP:0000718	HP:0000718	Aggressive behavior	0	CPLX1 CL E G H	10815	352582				ORPHA	1	167	2309	605032
HP:0000718	HP:0000718	Aggressive behavior	0	CUL4B CL E G H	8450	85293				ORPHA	1	347	2555	300304
HP:0000718	HP:0000718	Aggressive behavior	0	CUX2 CL E G H	23316	2382				ORPHA	1	101	19347	610648
HP:0000718	HP:0000718	Aggressive behavior	0	DDX3X CL E G H	1654	457260				ORPHA	1	602	2745	300160
HP:0000718	HP:0000718	Aggressive behavior	0	DEAF1 CL E G H	10522	617171	Dyskinesia, seizures, and intellectual developmental disorder	617171	C4310683	OMIM	1	452	14677	602635
HP:0000718	HP:0000718	Aggressive behavior	0	DEAF1 CL E G H	10522	615828	Mental retardation, autosomal dominant 24	615828	C4014414	OMIM	1	452	14677	602635
HP:0000718	HP:0000718	Aggressive behavior	0	DGCR2 CL E G H	9993	192430	Shprintzen syndrome	192430	C0220704	OMIM	1	409	2845	600594
HP:0000718	HP:0000718	Aggressive behavior	0	DGCR6 CL E G H	8214	192430	Shprintzen syndrome	192430	C0220704	OMIM	1	336	2846	601279
HP:0000718	HP:0000718	Aggressive behavior	0	DGCR8 CL E G H	54487	192430	Shprintzen syndrome	192430	C0220704	OMIM	1	398	2847	609030
HP:0000718	HP:0000718	Aggressive behavior	0	DHCR7 CL E G H	1717	270400	Smith-Lemli-Opitz syndrome	270400	C0175694	OMIM	1	648	2860	602858
HP:0000718	HP:0000718	Aggressive behavior	0	DNM1 CL E G H	1759	2382				ORPHA	1	622	2972	602377
HP:0000718	HP:0000718	Aggressive behavior	0	ECM1 CL E G H	1893	247100	Lipid proteinosis	247100	C0023795	OMIM	1	81	3153	602201
HP:0000718	HP:0000718	Aggressive behavior	0	EEF1A2 CL E G H	1917	616409	Epileptic encephalopathy, early infantile, 33	616409	C4225337	OMIM	1	493	3192	602959
HP:0000718	HP:0000718	Aggressive behavior	0	EEF1A2 CL E G H	1917	616393	Mental retardation, autosomal dominant 38	616393	C4225343	OMIM	1	493	3192	602959
HP:0000718	HP:0000718	Aggressive behavior	0	EHMT1 CL E G H	79813	610253	Chromosome 9q deletion syndrome	610253	C0795833	OMIM	1	1570	24650	607001
HP:0000718	HP:0000718	Aggressive behavior	0	EIF2S3 CL E G H	1968	300148	MEHMO syndrome	300148	C1846278	OMIM	1	190	3267	300161
HP:0000718	HP:0000718	Aggressive behavior	0	ELP2 CL E G H	55250	617270	Mental retardation, autosomal recessive 58	617270	C4310641	OMIM	1	110	18248	616054
HP:0000718	HP:0000718	Aggressive behavior	0	ENTPD1 CL E G H	953	401810				ORPHA	1	136	3363	601752
HP:0000718	HP:0000718	Aggressive behavior	0	ENTPD1 CL E G H	953	615683	Spastic paraplegia 64, autosomal recessive	615683	C3810289	OMIM	1	136	3363	601752
HP:0000718	HP:0000718	Aggressive behavior	0	ESS2 CL E G H	8220	192430	Shprintzen syndrome	192430	C0220704	OMIM	1	398	16817	601755
HP:0000718	HP:0000718	Aggressive behavior	0	FGF14 CL E G H	2259	98764				ORPHA	1	208	3671	601515
HP:0000718	HP:0000718	Aggressive behavior	0	FIG4 CL E G H	9896	612691	Polymicrogyria, bilateral temporooccipital	612691	C2675191	OMIM	1	749	16873	609390
HP:0000718	HP:0000718	Aggressive behavior	0	FOXP1 CL E G H	27086	613670	Mental retardation with language impairment and with or without autistic features	613670	C3150923	OMIM	1	449	3823	605515
HP:0000718	HP:0000718	Aggressive behavior	0	FRMPD4 CL E G H	9758	300983	Mental retardation, X-linked 104	300983	C4310817	OMIM	1	352	29007	300838
HP:0000718	HP:0000718	Aggressive behavior	0	GABRB3 CL E G H	2562	2382				ORPHA	1	732	4083	137192
HP:0000718	HP:0000718	Aggressive behavior	0	GCSH CL E G H	2653	605899	Non-ketotic hyperglycinemia	605899	C0751748	OMIM	1	162	4208	238330
HP:0000718	HP:0000718	Aggressive behavior	0	GLDC CL E G H	2731	605899	Non-ketotic hyperglycinemia	605899	C0751748	OMIM	1	1816	4313	238300
HP:0000718	HP:0000718	Aggressive behavior	0	GRIA3 CL E G H	2892	300699	Mental retardation, X-linked, syndromic, wu type	300699	C2678051	OMIM	1	455	4573	305915
HP:0000718	HP:0000718	Aggressive behavior	0	GRN CL E G H	2896	275864				ORPHA	1	417	4601	138945
HP:0000718	HP:0000718	Aggressive behavior	0	HERC2 CL E G H	8924	615516	Mental retardation, autosomal recessive 38	615516	C3809753	OMIM	1	641	4868	605837
HP:0000718	HP:0000718	Aggressive behavior	0	HNRNPH2 CL E G H	3188	300986	Mental retardation, X-linked, syndromic, Bain type	300986	C4310814	OMIM	1	186	5042	300610
HP:0000718	HP:0000718	Aggressive behavior	0	HSD17B10 CL E G H	3028	300438	2-methyl-3-hydroxybutyric aciduria	300438	C3266731	OMIM	1	222	4800	300256
HP:0000718	HP:0000718	Aggressive behavior	0	IMPA1 CL E G H	3612	617323	Mental retardation, autosomal recessive 59	617323	C4310619	OMIM	1	50	6050	602064
HP:0000718	HP:0000718	Aggressive behavior	0	INPP5E CL E G H	56623	213300	Joubert syndrome 1	213300	CN119531	OMIM	1	620	21474	613037
HP:0000718	HP:0000718	Aggressive behavior	0	KDM5C CL E G H	8242	85279				ORPHA	1	596	11114	314690
HP:0000718	HP:0000718	Aggressive behavior	0	KMT2A CL E G H	4297	319182				ORPHA	1	1317	7132	159555
HP:0000718	HP:0000718	Aggressive behavior	0	KMT2A CL E G H	4297	605130	Wiedemann-Steiner syndrome	605130	C1854630	OMIM	1	1317	7132	159555
HP:0000718	HP:0000718	Aggressive behavior	0	KNL1 CL E G H	57082	604321	Primary autosomal recessive microcephaly 4	604321	C1858516	OMIM	1	319	24054	609173
HP:0000718	HP:0000718	Aggressive behavior	0	LEPR CL E G H	3953	614963	Leptin receptor deficiency	614963	C3554225	OMIM	1	222	6554	601007
HP:0000718	HP:0000718	Aggressive behavior	0	MAN1B1 CL E G H	11253	614202	Mental retardation, autosomal recessive 15	614202	C3280127	OMIM	1	398	6823	604346
HP:0000718	HP:0000718	Aggressive behavior	0	MANBA CL E G H	4126	248510	Beta-D-mannosidosis	248510	C4048196	OMIM	1	349	6831	609489
HP:0000718	HP:0000718	Aggressive behavior	0	MAOA CL E G H	4128	300615	Monoamine oxidase A deficiency	300615	C0796275	OMIM	1	259	6833	309850
HP:0000718	HP:0000718	Aggressive behavior	0	MAPK10 CL E G H	5602	2382				ORPHA	1	66	6872	602897
HP:0000718	HP:0000718	Aggressive behavior	0	MAPT CL E G H	4137	275864				ORPHA	1	514	6893	157140
HP:0000718	HP:0000718	Aggressive behavior	0	MBD5 CL E G H	55777	156200	Mental retardation, autosomal dominant 1	156200	C1969562	OMIM	1	1149	20444	611472
HP:0000718	HP:0000718	Aggressive behavior	0	MED12 CL E G H	9968	309520	X-linked mental retardation with marfanoid habitus syndrome	309520	C0796022	OMIM	1	1236	11957	300188
HP:0000718	HP:0000718	Aggressive behavior	0	MGAT2 CL E G H	4247	212066	Carbohydrate-deficient glycoprotein syndrome type II	212066	C2931008	OMIM	1	123	7045	602616
HP:0000718	HP:0000718	Aggressive behavior	0	MYT1L CL E G H	23040	616521	Mental retardation, autosomal dominant 39	616521	C4225296	OMIM	1	383	7623	613084
HP:0000718	HP:0000718	Aggressive behavior	0	NAA10 CL E G H	8260	309800	Lenz microphthalmia syndrome	309800	C0796016	OMIM	1	361	18704	300013
HP:0000718	HP:0000718	Aggressive behavior	0	NAGLU CL E G H	4669	252920	Mucopolysaccharidosis, MPS-III-B	252920	C0086648	OMIM	1	775	7632	609701
HP:0000718	HP:0000718	Aggressive behavior	0	NAGS CL E G H	162417	237310	Hyperammonemia, type III	237310	C0268543	OMIM	1	345	17996	608300
HP:0000718	HP:0000718	Aggressive behavior	0	NDP CL E G H	4693	310600	Atrophia bulborum hereditaria	310600	C0266526	OMIM	1	272	7678	300658
HP:0000718	HP:0000718	Aggressive behavior	0	NDST1 CL E G H	3340	616116	Mental retardation, autosomal recessive 46	616116	C4015283	OMIM	1	125	7680	600853
HP:0000718	HP:0000718	Aggressive behavior	0	NONO CL E G H	4841	300967	Mental retardation, X-linked, syndromic 34	300967	C4225417	OMIM	1	204	7871	300084
HP:0000718	HP:0000718	Aggressive behavior	0	NSDHL CL E G H	50814	300831	NSDHL-Related Disorders	300831	C3151781	OMIM	1	312	13398	300275
HP:0000718	HP:0000718	Aggressive behavior	0	OCRL CL E G H	4952	309000	Lowe syndrome	309000	C0028860	OMIM	1	508	8108	300535
HP:0000718	HP:0000718	Aggressive behavior	0	PACS1 CL E G H	55690	615009	Schuurs-hoeijmakers syndrome	615009	C3554343	OMIM	1	329	30032	607492
HP:0000718	HP:0000718	Aggressive behavior	0	PAH CL E G H	5053	261600	Phenylketonuria	261600	C0031485	OMIM	1	1316	8582	612349
HP:0000718	HP:0000718	Aggressive behavior	0	PAK3 CL E G H	5063	300558	Mental retardation 30, X-linked	300558	C0796237	OMIM	1	292	8592	300142
HP:0000718	HP:0000718	Aggressive behavior	0	PCDH19 CL E G H	57526	300088	Early infantile epileptic encephalopathy 9	300088	C1848137	OMIM	1	1120	14270	300460
HP:0000718	HP:0000718	Aggressive behavior	0	PHIP CL E G H	55023	617991	DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES	617991	CN248510	OMIM	1	249	15673	612870
HP:0000718	HP:0000718	Aggressive behavior	0	PIGH CL E G H	5283	618010	GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 17	618010	CN248527	OMIM	1	18	8964	600154
HP:0000718	HP:0000718	Aggressive behavior	0	PIGY CL E G H	84992	616809	Hyperphosphatasia with mental retardation syndrome 6	616809	C4225201	OMIM	1	36	28213	610662
HP:0000718	HP:0000718	Aggressive behavior	0	PLA2G6 CL E G H	8398	612953	Parkinson disease 14	612953	C2751842	OMIM	1	598	9039	603604
HP:0000718	HP:0000718	Aggressive behavior	0	PRNP CL E G H	5621	137440	Gerstmann-Straussler-Scheinker syndrome	137440	C0017495	OMIM	1	164	9449	176640
HP:0000718	HP:0000718	Aggressive behavior	0	PRNP CL E G H	5621	603218	Huntington disease-like 1	603218	C1864112	OMIM	1	164	9449	176640
HP:0000718	HP:0000718	Aggressive behavior	0	PRODH CL E G H	5625	239500	Proline dehydrogenase deficiency	239500	C0268529	OMIM	1	639	9453	606810
HP:0000718	HP:0000718	Aggressive behavior	0	PSEN1 CL E G H	5663	275864				ORPHA	1	452	9508	104311
HP:0000718	HP:0000718	Aggressive behavior	0	RBBP8 CL E G H	5932	251255	Microcephaly with mental retardation and digital anomalies	251255	C0796063	OMIM	1	237	9891	604124
HP:0000718	HP:0000718	Aggressive behavior	0	RLIM CL E G H	51132	300978	Mental retardation, X-linked 61	300978	C4283894	OMIM	1	187	13429	300379
HP:0000718	HP:0000718	Aggressive behavior	0	RUSC2 CL E G H	9853	617773	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 61	617773	C4540424	OMIM	1	584	23625	611053
HP:0000718	HP:0000718	Aggressive behavior	0	SASS6 CL E G H	163786	616402	Primary autosomal recessive microcephaly 14	616402	C4225338	OMIM	1	80	25403	609321
HP:0000718	HP:0000718	Aggressive behavior	0	SATB2 CL E G H	23314	612313	Chromosome 2q32-q33 deletion syndrome	612313	C2676739	OMIM	1	566	21637	608148
HP:0000718	HP:0000718	Aggressive behavior	0	SCN1A CL E G H	6323	2382				ORPHA	1	3464	10585	182389
HP:0000718	HP:0000718	Aggressive behavior	0	SETD2 CL E G H	29072	616831	Luscan-lumish syndrome	616831	C4085873	OMIM	1	830	18420	612778
HP:0000718	HP:0000718	Aggressive behavior	0	SH2B1 CL E G H	25970	329249				ORPHA	1	204	30417	608937
HP:0000718	HP:0000718	Aggressive behavior	0	SIN3A CL E G H	25942	613406	Witteveen-kolk syndrome	613406	C3150674	OMIM	1	218	19353	607776
HP:0000718	HP:0000718	Aggressive behavior	0	SLC6A17 CL E G H	388662	616269	Mental retardation, autosomal recessive 48	616269	C4225395	OMIM	1	61	31399	610299
HP:0000718	HP:0000718	Aggressive behavior	0	SLC6A8 CL E G H	6535	300352	Creatine deficiency, X-linked	300352	C1845862	OMIM	1	903	11055	300036
HP:0000718	HP:0000718	Aggressive behavior	0	SLITRK1 CL E G H	114798	137580	Tourette Syndrome	137580	C0040517	OMIM	1	181	20297	609678
HP:0000718	HP:0000718	Aggressive behavior	0	SMARCA2 CL E G H	6595	601358	Nicolaides-Baraitser syndrome	601358	C1303073	OMIM	1	886	11098	600014
HP:0000718	HP:0000718	Aggressive behavior	0	SMC1A CL E G H	8243	319182				ORPHA	1	798	11111	300040
HP:0000718	HP:0000718	Aggressive behavior	0	SPAST CL E G H	6683	182601	Spastic paraplegia 4, autosomal dominant	182601	C1866855	OMIM	1	1014	11233	604277
HP:0000718	HP:0000718	Aggressive behavior	0	SPR CL E G H	6697	612716	Sepiapterin reductase deficiency	612716	C0268468	OMIM	1	160	11257	182125
HP:0000718	HP:0000718	Aggressive behavior	0	SQSTM1 CL E G H	8878	275864				ORPHA	1	542	11280	601530
HP:0000718	HP:0000718	Aggressive behavior	0	SYN1 CL E G H	6853	85294				ORPHA	1	463	11494	313440
HP:0000718	HP:0000718	Aggressive behavior	0	SYN1 CL E G H	6853	300491	Epilepsy, X-linked, with variable learning disabilities and behavior disorders	300491	C1845343	OMIM	1	463	11494	313440
HP:0000718	HP:0000718	Aggressive behavior	0	TBC1D24 CL E G H	57465	352582				ORPHA	1	795	29203	613577
HP:0000718	HP:0000718	Aggressive behavior	0	TBP CL E G H	6908	607136	Spinocerebellar ataxia 17	607136	C1846707	OMIM	1	116	11588	600075
HP:0000718	HP:0000718	Aggressive behavior	0	TBX1 CL E G H	6899	192430	Shprintzen syndrome	192430	C0220704	OMIM	1	972	11592	602054
HP:0000718	HP:0000718	Aggressive behavior	0	TCF4 CL E G H	6925	610954	Pitt-Hopkins syndrome	610954	C1970431	OMIM	1	913	11634	602272
HP:0000718	HP:0000718	Aggressive behavior	0	TMEM106B CL E G H	54664	275864				ORPHA	1	87	22407	613413
HP:0000718	HP:0000718	Aggressive behavior	0	TMEM231 CL E G H	79583	614970	Joubert syndrome 20	614970	C3554235	OMIM	1	341	37234	614949
HP:0000718	HP:0000718	Aggressive behavior	0	TMEM240 CL E G H	339453	607454	Spinocerebellar ataxia 21	607454	C1843891	OMIM	1	192	25186	616101
HP:0000718	HP:0000718	Aggressive behavior	0	TREM2 CL E G H	54209	275864				ORPHA	1	110	17761	605086
HP:0000718	HP:0000718	Aggressive behavior	0	TRIO CL E G H	7204	617061	Mental retardation, autosomal dominant 44	617061	C4310740	OMIM	1	930	12303	601893
HP:0000718	HP:0000718	Aggressive behavior	0	TRIP12 CL E G H	9320	617752	MENTAL RETARDATION, AUTOSOMAL DOMINANT 49	617752	C4540324	OMIM	1	247	12306	604506
HP:0000718	HP:0000718	Aggressive behavior	0	TTC19 CL E G H	54902	615157	Mitochondrial complex III deficiency, nuclear type 2	615157	C3554605	OMIM	1	263	26006	613814
HP:0000718	HP:0000718	Aggressive behavior	0	TTI2 CL E G H	80185	615541	Mental retardation, autosomal recessive 39	615541	C3809853	OMIM	1	110	26262	614426
HP:0000718	HP:0000718	Aggressive behavior	0	TYROBP CL E G H	7305	221770	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	221770	C1857316	OMIM	1	85	12449	604142
HP:0000718	HP:0000718	Aggressive behavior	0	UBE2A CL E G H	7319	300860	Syndromic mental retardation, Nascimento type, X-linked	300860	C3275464	OMIM	1	207	12472	312180
HP:0000718	HP:0000718	Aggressive behavior	0	UQCC2 CL E G H	84300	615824	Mitochondrial complex III deficiency, nuclear type 7	615824	C4014408	OMIM	1	49	21237	614461
HP:0000718	HP:0000718	Aggressive behavior	0	UROC1 CL E G H	131669	276880	Urocanate hydratase deficiency	276880	C0268514	OMIM	1	80	26444	613012
HP:0000718	HP:0000718	Aggressive behavior	0	VCP CL E G H	7415	275864				ORPHA	1	473	12666	601023
HP:0000718	HP:0000718	Aggressive behavior	0	VPS13A CL E G H	23230	200150	Choreoacanthocytosis	200150	C0393576	OMIM	1	1735	1908	605978
HP:0000718	HP:0000718	Aggressive behavior	0	WAC CL E G H	51322	616708	Desanto-shinawi syndrome	616708	C4225239	OMIM	1	213	17327	615049
HP:0000718	HP:0000718	Aggressive behavior	0	WDR62 CL E G H	284403	604317	Primary autosomal recessive microcephaly 2	604317	C1858535	OMIM	1	687	24502	613583
HP:0000718	HP:0000718	Aggressive behavior	0	ZMYND11 CL E G H	10771	616083	Mental retardation, autosomal dominant 30	616083	C4015167	OMIM	1	179	16966	608668
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000718	HP:0000718	Aggressive behavior	0	ADAT3 CL E G H	113179	615286	Mental retardation, autosomal recessive 36	615286	C3809039	OMIM	0	93	25151	615302
HP:0000718	HP:0000718	Aggressive behavior	0	ATXN10 CL E G H	25814	98761				ORPHA	0	108	10549	611150
HP:0000718	HP:0000718	Aggressive behavior	0	BCAP31 CL E G H	10134	369939				ORPHA	0	308	16695	300398
HP:0000718	HP:0000718	Aggressive behavior	0	BPTF CL E G H	2186	529962				ORPHA	0	191	3581	601819
HP:0000718	HP:0000718	Aggressive behavior	0	C12orf4 CL E G H	57102	618221	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 66	618221		OMIM	0	79	1184	616082
HP:0000718	HP:0000718	Aggressive behavior	0	CACNB4 CL E G H	785	307				ORPHA	0	312	1404	601949
HP:0000718	HP:0000718	Aggressive behavior	0	CHD2 CL E G H	1106	1942				ORPHA	0	1526	1917	602119
HP:0000718	HP:0000718	Aggressive behavior	0	CLCN2 CL E G H	1181	307				ORPHA	0	227	2020	600570
HP:0000718	HP:0000718	Aggressive behavior	0	CUL4B CL E G H	8450	300354	Syndromic X-linked mental retardation, Cabezas type	300354	C1845861	OMIM	0	347	2555	300304
HP:0000718	HP:0000718	Aggressive behavior	0	DDX3X CL E G H	1654	300958	Mental retardation, X-linked 102	300958	C4085582	OMIM	0	602	2745	300160
HP:0000718	HP:0000718	Aggressive behavior	0	DPAGT1 CL E G H	1798	608093	Congenital disorder of glycosylation type 1J	608093	C2931004	OMIM	0	258	2995	191350
HP:0000718	HP:0000718	Aggressive behavior	0	DPYD CL E G H	1806	293948				ORPHA	0	379	3012	612779
HP:0000718	HP:0000718	Aggressive behavior	0	EFHC1 CL E G H	114327	307				ORPHA	0	436	16406	608815
HP:0000718	HP:0000718	Aggressive behavior	0	GABRA1 CL E G H	2554	307				ORPHA	0	519	4075	137160
HP:0000718	HP:0000718	Aggressive behavior	0	GABRD CL E G H	2563	307				ORPHA	0	397	4084	137163
HP:0000718	HP:0000718	Aggressive behavior	0	ICK CL E G H	22858	307				ORPHA	0		21219	612325
HP:0000718	HP:0000718	Aggressive behavior	0	JRK CL E G H	8629	307				ORPHA	0	71	6199	603210
HP:0000718	HP:0000718	Aggressive behavior	0	KCNQ3 CL E G H	3786	307				ORPHA	0	1082	6297	602232
HP:0000718	HP:0000718	Aggressive behavior	0	KCNT1 CL E G H	57582	615005	Epilepsy, nocturnal frontal lobe, 5	615005	C3554306	OMIM	0	1678	18865	608167
HP:0000718	HP:0000718	Aggressive behavior	0	KDM5C CL E G H	8242	300534	Mental retardation, syndromic, Claes-Jensen type, X-linked	300534	C1845243	OMIM	0	596	11114	314690
HP:0000718	HP:0000718	Aggressive behavior	0	KIF11 CL E G H	3832	152950	Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation	152950	C1835265	OMIM	0	605	6388	148760
HP:0000718	HP:0000718	Aggressive behavior	0	LINS1 CL E G H	55180	614340	Mental retardation, autosomal recessive 27	614340	C3280538	OMIM	0	255	30922	610350
HP:0000718	HP:0000718	Aggressive behavior	0	NFIB CL E G H	4781	618286	618286	618286		OMIM	0	175	7785	600728
HP:0000718	HP:0000718	Aggressive behavior	0	PRRT2 CL E G H	112476	98811				ORPHA	0	702	30500	614386
HP:0000718	HP:0000718	Aggressive behavior	0	PSMD12 CL E G H	5718	529962				ORPHA	0	53	9557	604450
HP:0000718	HP:0000718	Aggressive behavior	0	SATB2 CL E G H	23314	251019				ORPHA	0	566	21637	608148
HP:0000718	HP:0000718	Aggressive behavior	0	SHANK3 CL E G H	85358	606232	22q13.3 deletion syndrome	606232	C1853490	OMIM	0	776	14294	606230
HP:0000718	HP:0000718	Aggressive behavior	0	SLC2A1 CL E G H	6513	98811				ORPHA	0	827	11005	138140
HP:0000718	HP:0000718	Aggressive behavior	0	SLC52A2 CL E G H	79581	97229				ORPHA	0	458	30224	607882
HP:0000718	HP:0000718	Aggressive behavior	0	SLC52A2 CL E G H	79581	614707	Brown-Vialetto-Van Laere syndrome 2	614707	C3553538	OMIM	0	458	30224	607882
HP:0000718	HP:0000718	Aggressive behavior	0	SLC52A3 CL E G H	113278	97229				ORPHA	0	399	16187	613350
HP:0000718	HP:0000718	Aggressive behavior	0	SLC6A1 CL E G H	6529	1942				ORPHA	0	674	11042	137165
HP:0000718	HP:0000718	Aggressive behavior	0	SOX5 CL E G H	6660	313892				ORPHA	0	205	11201	604975
HP:0000718	HP:0000718	Aggressive behavior	0	TCF4 CL E G H	6925	2896	Hypogonadism retinitis pigmentosa			ORPHA	0	913	11634	602272
HP:0000718	HP:0000718	Aggressive behavior	0	USP9X CL E G H	8239	300919	Mental retardation, X-linked 99	300919	C3806746	OMIM	0	568	12632	300072
HP:0000718	HP:0000718	Aggressive behavior	0	WDR45 CL E G H	11152	329284				ORPHA	0	504	28912	300526
HP:0000718	HP:0000718	Aggressive behavior	0	WDR45 CL E G H	11152	300894	Neurodegeneration with brain iron accumulation 5	300894	C3550973	OMIM	0	504	28912	300526
HP:0000718	HP:0000718	Aggressive behavior	0	ZBTB20 CL E G H	26137	259050	Primrose syndrome	259050	C0796121	OMIM	0	168	13503	606025

Genes (150) :ADAT3 ADSL AFF2 ALDH5A1 AMT ANK3 AP1S2 ARID1B ATP13A2 ATP7B ATXN10 BCAP31 BCOR BPTF C12ORF4 C9ORF72 C9orf72 CACNB4 CAMTA1 CEP152 CHD2 CHMP2B CLCN2 CLCN4 CNTNAP2 CPLX1 CUL4B CUX2 DDX3X DEAF1 DGCR2 DGCR6 DGCR8 DHCR7 DNM1 DPAGT1 DPYD ECM1 EEF1A2 EFHC1 EHMT1 EIF2S3 ELP2 ENTPD1 ESS2 FGF14 FIG4 FOXP1 FRMPD4 GABRA1 GABRB3 GABRD GCSH GLDC GRIA3 GRN HERC2 HNRNPH2 HSD17B10 ICK IMPA1 INPP5E JRK KCNQ3 KCNT1 KDM5C KIF11 KMT2A KNL1 LEPR LINS1 MAN1B1 MANBA MAOA MAPK10 MAPT MBD5 MED12 MGAT2 MYT1L NAA10 NAGLU NAGS NDP NDST1 NFIB NONO NSDHL OCRL PACS1 PAH PAK3 PCDH19 PHIP PIGH PIGY PLA2G6 PRNP PRODH PRRT2 PSEN1 PSMD12 RBBP8 RLIM RUSC2 SASS6 SATB2 SCN1A SETD2 SH2B1 SHANK3 SIN3A SLC2A1 SLC52A2 SLC52A3 SLC6A1 SLC6A17 SLC6A8 SLITRK1 SMARCA2 SMC1A SOX5 SPAST SPR SQSTM1 SYN1 TBC1D24 TBP TBX1 TCF4 TMEM106B TMEM231 TMEM240 TREM2 TRIO TRIP12 TTC19 TTI2 TYROBP UBE2A UQCC2 UROC1 USP9X VCP VPS13A WAC WDR45 WDR62 ZBTB20 ZMYND11

Diseases (134) :615286 103050 309548 271980 605899 615493 85335 85329 135900 606693 617225 905 98761 369939 309800 529962 618221 275864 307 314647 614756 614852 2382 1942 600795 300114 610042 352582 85293 300354 457260 300958 617171 615828 192430 270400 608093 293948 247100 616409 616393 610253 300148 617270 401810 615683 98764 612691 613670 300983 300699 615516 300986 300438 617323 213300 615005 85279 300534 152950 319182 605130 604321 614963 614340 614202 248510 300615 156200 309520 212066 616521 252920 237310 310600 616116 618286 300967 300831 309000 615009 261600 300558 300088 617991 618010 616809 612953 137440 603218 239500 98811 251255 300978 617773 616402 251019 612313 616831 329249 606232 613406 97229 614707 616269 300352 137580 601358 313892 182601 612716 85294 300491 607136 2896 610954 614970 607454 617061 617752 615157 615541 221770 300860 615824 276880 300919 200150 616708 329284 300894 604317 259050 616083

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.

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