Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the dentition (HP:0000164)help
Parent Node:
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Abnormality of dental eruption (HP:0006292)help
..Starting node
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Eruption failure (HP:0000706)help
Term ID: 706
Name: Eruption failure
Synonym: Failure of eruption of tooth; Pseudo-anodontia; Pseudoanodontia; Unerupted dentition; Unerupted tooth
Definition: A tooth which does not erupt within the teeth eruption timeline and after the loss of eruption potential.
Comments:
Reference: HP:0000706
Genes and Diseases:
 
       Child Nodes:
........expandMultiple unerupted teeth (HP:0006283) help
........expandFailure of eruption of permanent teeth (HP:0006352) help
........expandImpacted tooth (HP:0011079) help
................... HP:0001571 Multiple impacted teeth

 Sister Nodes: 
..expandAdvanced eruption of teeth (HP:0006288) help
..expandDelayed eruption of teeth (HP:0000684) help
..expandPersistence of primary teeth (HP:0006335) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000706HP:0000706Eruption failure0ANTXR1 CL E G H8416821014OMIM:230740Gapo syndrome.8
HP:0000706HP:0000706Eruption failure0APC CL E G H324583OMIM:175100Adenomatous polyposis coliHP:0040283 - Occasional3179
HP:0000706HP:0000706Eruption failure0APC CL E G H324583ORPHA:79665Gardner syndrome3179
HP:0000706HP:0000706Eruption failure0CDH11 CL E G H10091750OMIM:211380Elsahy-Waters syndrome2
HP:0000706HP:0000706Eruption failure0FGFR1 CL E G H22603688OMIM:166250Osteoglophonic dysplasia.172
HP:0000706HP:0000706Eruption failure0FGFR1 CL E G H22603688ORPHA:2645Osteoglosphonic dysplasia172
HP:0000706HP:0000706Eruption failure0FLNA CL E G H23163754OMIM:311300Otopalatodigital syndrome, type I493
HP:0000706HP:0000706Eruption failure0FLNB CL E G H23173755OMIM:272460Spondylocarpotarsal synostosis syndrome233
HP:0000706HP:0000706Eruption failure0HOXD13 CL E G H32395136OMIM:113300Brachydactyly, type E25
HP:0000706HP:0000706Eruption failure0IFIH1 CL E G H6413518873OMIM:182250Singleton-Merten syndrome 1.28
HP:0000706HP:0000706Eruption failure0LEMD2 CL E G H22149621244OMIM:619322MARBACH-RUSTAD PROGEROID SYNDROME; MARUPS1
HP:0000706HP:0000706Eruption failure0LMNA CL E G H40006636ORPHA:740Hutchinson-Gilford progeria syndrome645
HP:0000706HP:0000706Eruption failure0MAP3K7 CL E G H68856859ORPHA:3238Cardiospondylocarpofacial syndrome11
HP:0000706HP:0000706Eruption failure0PTH1R CL E G H57459608OMIM:125350Dental noneruption58
HP:0000706HP:0000706Eruption failure0PTH1R CL E G H57459608OMIM:600002Eiken syndrome58
HP:0000706HP:0000706Eruption failure0SH3BP2 CL E G H645210825OMIM:118400Cherubism177
HP:0000706HP:0000706Eruption failure0SMCHD1 CL E G H2334729090ORPHA:2250Hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndrome174
HP:0000706HP:0000706Eruption failure0TCF4 CL E G H692511634ORPHA:2896Pitt-Hopkins syndrome241
HP:0000706HP:0000706Eruption failure0TRIO CL E G H720412303ORPHA:476126Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndromeHP:0040283 - Occasional8
HP:0000706HP:0000706Eruption failure0ZMPSTE24 CL E G H1026912877ORPHA:740Hutchinson-Gilford progeria syndrome83
HP:0000706HP:0006283Multiple unerupted teeth1APC CL E G H324583ORPHA:79665Gardner syndromeHP:0040283 - Occasional3179
HP:0000706HP:0011079Impacted tooth1CDH11 CL E G H10091750OMIM:211380Elsahy-Waters syndrome2
HP:0000706HP:0006283Multiple unerupted teeth1FGFR1 CL E G H22603688ORPHA:2645Osteoglosphonic dysplasiaHP:0040281 - Very frequent172
HP:0000706HP:0011079Impacted tooth1FLNA CL E G H23163754OMIM:311300Otopalatodigital syndrome, type I493
HP:0000706HP:0006352Failure of eruption of permanent teeth1FLNB CL E G H23173755OMIM:272460Spondylocarpotarsal synostosis syndrome.233
HP:0000706HP:0011079Impacted tooth1HOXD13 CL E G H32395136OMIM:113300Brachydactyly, type E25
HP:0000706HP:0011079Impacted tooth1LMNA CL E G H40006636ORPHA:740Hutchinson-Gilford progeria syndromeHP:0040283 - Occasional645
HP:0000706HP:0006352Failure of eruption of permanent teeth1MAP3K7 CL E G H68856859ORPHA:3238Cardiospondylocarpofacial syndromeHP:0040282 - Frequent11
HP:0000706HP:0006352Failure of eruption of permanent teeth1PTH1R CL E G H57459608OMIM:125350Dental noneruption.58
HP:0000706HP:0006283Multiple unerupted teeth1PTH1R CL E G H57459608OMIM:600002Eiken syndrome58
HP:0000706HP:0011079Impacted tooth1PTH1R CL E G H57459608OMIM:600002Eiken syndrome58
HP:0000706HP:0011079Impacted tooth1SH3BP2 CL E G H645210825OMIM:118400Cherubism177
HP:0000706HP:0006352Failure of eruption of permanent teeth1SMCHD1 CL E G H2334729090ORPHA:2250Hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndromeHP:0040281 - Very frequent174
HP:0000706HP:0006352Failure of eruption of permanent teeth1TCF4 CL E G H692511634ORPHA:2896Pitt-Hopkins syndromeHP:0040281 - Very frequent241
HP:0000706HP:0011079Impacted tooth1ZMPSTE24 CL E G H1026912877ORPHA:740Hutchinson-Gilford progeria syndromeHP:0040283 - Occasional83
HP:0000706HP:0001571Multiple impacted teeth2CDH11 CL E G H10091750OMIM:211380Elsahy-Waters syndrome.2
HP:0000706HP:0001571Multiple impacted teeth2FLNA CL E G H23163754OMIM:311300Otopalatodigital syndrome, type I.493
HP:0000706HP:0001571Multiple impacted teeth2HOXD13 CL E G H32395136OMIM:113300Brachydactyly, type E.25
HP:0000706HP:0001571Multiple impacted teeth2PTH1R CL E G H57459608OMIM:600002Eiken syndrome58
HP:0000706HP:0001571Multiple impacted teeth2SH3BP2 CL E G H645210825OMIM:118400Cherubism177


Genes (17) :ANTXR1 APC CDH11 FGFR1 FLNA FLNB HOXD13 IFIH1 LEMD2 LMNA MAP3K7 PTH1R SH3BP2 SMCHD1 TCF4 TRIO ZMPSTE24

Diseases (19) :OMIM:230740 OMIM:175100 ORPHA:79665 OMIM:211380 OMIM:166250 ORPHA:2645 OMIM:311300 OMIM:272460 OMIM:113300 OMIM:182250 OMIM:619322 ORPHA:740 ORPHA:3238 OMIM:125350 OMIM:600002 OMIM:118400 ORPHA:2250 ORPHA:2896 ORPHA:476126
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.