Human Phenotype Ontology 
Grandparent Node:
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Abnormal oral cavity morphology (HP:0000163)help
Parent Node:
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Abnormality of the dentition (HP:0000164)help
..Starting node
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Periapical bone loss (HP:0000700)help
Term ID: 700
Name: Periapical bone loss
Synonym: Bone loss around tooth root; Dark spot around tooth root on x-ray; Periapical cyst; Periapical granuloma; Periapical lesion; Periapical radiolucencies; Periapical radiolucency
Definition: Radiolucency (reflecting a reduction in the bony substance) around the apex (the tip of the dental root).
Comments:
Reference: HP:0000700
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal number of teeth (HP:0006483) help
..expandAbnormal periodontium morphology (HP:0410026) help
..expandAbnormality of canine (HP:0011078) help
..expandAbnormality of dental eruption (HP:0006292) help
..expandAbnormality of dental morphology (HP:0006482) help
..expandAbnormality of dental structure (HP:0011061) help
..expandAbnormality of molar (HP:0011077) help
..expandAbnormality of premolar (HP:0011076) help
..expandAbnormality of primary teeth (HP:0006481) help
..expandAbnormality of the incisor (HP:0000676) help
..expandBuried teeth encased in mucopolysaccharide (HP:0006326) help
..expandFragile teeth (HP:0025124) help
..expandIrregular dentition (HP:0040079) help
..expandOdontogenic neoplasm (HP:0100612) help
..expandPeriodontitis (HP:0000704) help
..expandPremature loss of teeth (HP:0006480) help
..expandTooth malposition (HP:0000692) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000700HP:0000700Periapical bone loss0DSPP CL E G H18343054OMIM:125500Dentinogenesis imperfecta, shields type III38
HP:0000700HP:0000700Periapical bone loss0SMOC2 CL E G H6409420323OMIM:125400Dentin dysplasia, type I, with microdontia and misshapen teeth.4


Genes (2) :DSPP SMOC2

Diseases (2) :OMIM:125500 OMIM:125400
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.