Human Phenotype Ontology 
Grandparent Node:
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Somatic sensory dysfunction (HP:0003474)help
Parent Node:
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Impaired vibratory sensation (HP:0002495)help
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Impaired distal vibration sensation (HP:0006886)help
Term ID: 6886
Name: Impaired distal vibration sensation
Synonym: Decreased distal vibration sense
Definition: A decrease in the ability to perceive vibration in the distal portions of the limbs.
Comments:
Reference: HP:0006886
Genes and Diseases:
 
       Child Nodes:
........expandImpaired vibration sensation at ankles (HP:0006938) help

 Sister Nodes: 
..expandAbolished vibration sense (HP:0006944) help
..expandImpaired vibration sensation in the lower limbs (HP:0002166) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006886HP:0006886Impaired distal vibration sensation0ABCD1 CL E G H21561OMIM:300100Adrenoleukodystrophy135
HP:0006886HP:0006886Impaired distal vibration sensation0ALDH18A1 CL E G H58329722ORPHA:447760Autosomal recessive spastic paraplegia type 9B89
HP:0006886HP:0006886Impaired distal vibration sensation0ALDH18A1 CL E G H58329722OMIM:616586Spastic paraplegia 9B, autosomal recessive89
HP:0006886HP:0006886Impaired distal vibration sensation0AMPD2 CL E G H271469OMIM:615686Spastic paraplegia 63, autosomal recessive21
HP:0006886HP:0006886Impaired distal vibration sensation0APTX CL E G H5484015984OMIM:208920Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia61
HP:0006886HP:0006886Impaired distal vibration sensation0ATP1A1 CL E G H476799OMIM:618036Charcot-Marie-Tooth disease, axonal, type 2DD4
HP:0006886HP:0006886Impaired distal vibration sensation0B4GALNT1 CL E G H25834117ORPHA:101006Autosomal recessive spastic paraplegia type 2625
HP:0006886HP:0006886Impaired distal vibration sensation0CACNA1G CL E G H89131394OMIM:616795Spinocerebellar ataxia 4232
HP:0006886HP:0006886Impaired distal vibration sensation0CACNA1G CL E G H89131394ORPHA:458803Spinocerebellar ataxia type 4232
HP:0006886HP:0006886Impaired distal vibration sensation0CADM3 CL E G H5786317601OMIM:619519CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2FF; CMT2FF1
HP:0006886HP:0006886Impaired distal vibration sensation0CHCHD10 CL E G H40091615559ORPHA:276435Lower motor neuron syndrome with late-adult onsetHP:0040283 - Occasional11
HP:0006886HP:0006886Impaired distal vibration sensation0CHP1 CL E G H1126117433OMIM:618438Spastic ataxia 9, autosomal recessive
HP:0006886HP:0006886Impaired distal vibration sensation0CPT1C CL E G H12612918540OMIM:616282Spastic paraplegia 73, autosomal dominant1
HP:0006886HP:0006886Impaired distal vibration sensation0DCAF8 CL E G H5071724891OMIM:610100Giant axonal neuropathy, autosomal dominant.2
HP:0006886HP:0006886Impaired distal vibration sensation0DHH CL E G H508462865OMIM:60708046,XY GONADAL DYSGENESIS, PARTIAL, WITH MINIFASCICULAR NEUROPATHY21
HP:0006886HP:0006886Impaired distal vibration sensation0DHTKD1 CL E G H5552623537OMIM:615025Charcot-Marie-Tooth disease, axonal, type 2Q12
HP:0006886HP:0006886Impaired distal vibration sensation0EGR2 CL E G H19593239OMIM:145900Hypertrophic neuropathy of dejerine-sottas58
HP:0006886HP:0006886Impaired distal vibration sensation0FMR1 CL E G H23323775OMIM:300623Fragile X tremor/ataxia syndrome30
HP:0006886HP:0006886Impaired distal vibration sensation0GBA2 CL E G H5770418986ORPHA:320391Autosomal recessive spastic paraplegia type 4630
HP:0006886HP:0006886Impaired distal vibration sensation0GCH1 CL E G H26434193OMIM:128230Dystonia, DOPA-responsive, with or without hyperphenylalaninemia86
HP:0006886HP:0006886Impaired distal vibration sensation0GDAP1 CL E G H5433215968ORPHA:99948Charcot-Marie-Tooth disease type 4A108
HP:0006886HP:0006886Impaired distal vibration sensation0GDAP1 CL E G H5433215968OMIM:607706Charcot-Marie-Tooth disease, axonal, with vocal cord paresis, autosomalrecessive108
HP:0006886HP:0006886Impaired distal vibration sensation0JAG1 CL E G H1826188OMIM:619574CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2HH; CMT2HH257
HP:0006886HP:0006886Impaired distal vibration sensation0KCNC3 CL E G H37486235OMIM:605259Spinocerebellar ataxia 1317
HP:0006886HP:0006886Impaired distal vibration sensation0KCNC3 CL E G H37486235ORPHA:98768Spinocerebellar ataxia type 13HP:0040282 - Frequent17
HP:0006886HP:0006886Impaired distal vibration sensation0KCND3 CL E G H37526239ORPHA:98772Spinocerebellar ataxia type 19/2235
HP:0006886HP:0006886Impaired distal vibration sensation0KIF1A CL E G H547888OMIM:614213Neuropathy, hereditary sensory, type IIC276
HP:0006886HP:0006886Impaired distal vibration sensation0KIF5A CL E G H37986323ORPHA:100991Autosomal dominant spastic paraplegia type 10HP:0040282 - Frequent93
HP:0006886HP:0006886Impaired distal vibration sensation0LMNB1 CL E G H40016637ORPHA:99027Adult-onset autosomal dominant leukodystrophyHP:0040283 - Occasional44
HP:0006886HP:0006886Impaired distal vibration sensation0LRSAM1 CL E G H9067825135OMIM:614436Charcot-Marie-Tooth disease, axonal, type 2P.102
HP:0006886HP:0006886Impaired distal vibration sensation0MAG CL E G H40996783OMIM:616680Spastic paraplegia 75, autosomal recessive4
HP:0006886HP:0006886Impaired distal vibration sensation0MORC2 CL E G H2288023573OMIM:616688Charcot-Marie-Tooth disease, axonal, type 2Z8
HP:0006886HP:0006886Impaired distal vibration sensation0MPZ CL E G H43597225OMIM:145900Hypertrophic neuropathy of dejerine-sottas134
HP:0006886HP:0006886Impaired distal vibration sensation0MTRFR CL E G H9157426784OMIM:615035Spastic paraplegia 55, autosomal recessive
HP:0006886HP:0006886Impaired distal vibration sensation0NEFL CL E G H47477739OMIM:607684Charcot-Marie-Tooth disease, axonal, type 2E118
HP:0006886HP:0006886Impaired distal vibration sensation0PDYN CL E G H51738820ORPHA:101108Spinocerebellar ataxia type 23HP:0040282 - Frequent52
HP:0006886HP:0006886Impaired distal vibration sensation0PEX10 CL E G H51928851OMIM:614871Peroxisome biogenesis disorder 6B75
HP:0006886HP:0006886Impaired distal vibration sensation0PMP2 CL E G H53759117OMIM:618279Charcot-Marie-Tooth disease, demyelinating, type 1G1
HP:0006886HP:0006886Impaired distal vibration sensation0PMP22 CL E G H53769118OMIM:145900Hypertrophic neuropathy of dejerine-sottas79
HP:0006886HP:0006886Impaired distal vibration sensation0POLG CL E G H54289179OMIM:157640Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1.464
HP:0006886HP:0006886Impaired distal vibration sensation0POLG CL E G H54289179OMIM:258450Progressive external ophthalmoplegia with mitochondrial DNA deletions,autosomal recessive.464
HP:0006886HP:0006886Impaired distal vibration sensation0POLG CL E G H54289179OMIM:607459Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis.464
HP:0006886HP:0006886Impaired distal vibration sensation0POLR3B CL E G H5570330348OMIM:619742CHARCOT-MARIE-TOOTH DISEASE, DEMYELINATING, TYPE 1I; CMT1I67
HP:0006886HP:0006886Impaired distal vibration sensation0PRKCG CL E G H55829402OMIM:605361Spinocerebellar ataxia 1483
HP:0006886HP:0006886Impaired distal vibration sensation0PRX CL E G H5771613797OMIM:145900Hypertrophic neuropathy of dejerine-sottas170
HP:0006886HP:0006886Impaired distal vibration sensation0REEP2 CL E G H5130817975ORPHA:401849Autosomal spastic paraplegia type 723
HP:0006886HP:0006886Impaired distal vibration sensation0SETX CL E G H23064445OMIM:606002Spinocerebellar ataxia, autosomal recessive 1162
HP:0006886HP:0006886Impaired distal vibration sensation0SH3TC2 CL E G H7962829427ORPHA:99949Charcot-Marie-Tooth disease type 4CHP:0040282 - Frequent493
HP:0006886HP:0006886Impaired distal vibration sensation0SPAST CL E G H668311233ORPHA:100985Autosomal dominant spastic paraplegia type 4208
HP:0006886HP:0006886Impaired distal vibration sensation0TWNK CL E G H566521160OMIM:607459Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis.113
HP:0006886HP:0006886Impaired distal vibration sensation0UCHL1 CL E G H734512513OMIM:615491Spastic paraplegia 79, autosomal recessive21
HP:0006886HP:0006886Impaired distal vibration sensation0VCP CL E G H741512666ORPHA:435387Autosomal dominant Charcot-Marie-Tooth disease type 2YHP:0040283 - Occasional63
HP:0006886HP:0006886Impaired distal vibration sensation0XK CL E G H750412811OMIM:300842Mcleod syndrome8
HP:0006886HP:0006886Impaired distal vibration sensation0XRCC1 CL E G H751512828OMIM:617633Spinocerebellar ataxia, autosomal recessive 264
HP:0006886HP:0006938Impaired vibration sensation at ankles1ABCD1 CL E G H21561OMIM:300100Adrenoleukodystrophy135
HP:0006886HP:0006938Impaired vibration sensation at ankles1ALDH18A1 CL E G H58329722ORPHA:447760Autosomal recessive spastic paraplegia type 9BHP:0040283 - Occasional89
HP:0006886HP:0006938Impaired vibration sensation at ankles1AMPD2 CL E G H271469OMIM:615686Spastic paraplegia 63, autosomal recessive21
HP:0006886HP:0006938Impaired vibration sensation at ankles1B4GALNT1 CL E G H25834117ORPHA:101006Autosomal recessive spastic paraplegia type 26HP:0040283 - Occasional25
HP:0006886HP:0006938Impaired vibration sensation at ankles1CACNA1G CL E G H89131394OMIM:616795Spinocerebellar ataxia 4232
HP:0006886HP:0006938Impaired vibration sensation at ankles1CACNA1G CL E G H89131394ORPHA:458803Spinocerebellar ataxia type 42HP:0040282 - Frequent32
HP:0006886HP:0006938Impaired vibration sensation at ankles1GBA2 CL E G H5770418986ORPHA:320391Autosomal recessive spastic paraplegia type 46HP:0040283 - Occasional30
HP:0006886HP:0006938Impaired vibration sensation at ankles1KCND3 CL E G H37526239ORPHA:98772Spinocerebellar ataxia type 19/22HP:0040282 - Frequent35
HP:0006886HP:0006938Impaired vibration sensation at ankles1PRKCG CL E G H55829402OMIM:605361Spinocerebellar ataxia 14.83
HP:0006886HP:0006938Impaired vibration sensation at ankles1REEP2 CL E G H5130817975ORPHA:401849Autosomal spastic paraplegia type 72HP:0040283 - Occasional3
HP:0006886HP:0006938Impaired vibration sensation at ankles1SPAST CL E G H668311233ORPHA:100985Autosomal dominant spastic paraplegia type 4HP:0040282 - Frequent208
HP:0006886HP:0006938Impaired vibration sensation at ankles1UCHL1 CL E G H734512513OMIM:615491Spastic paraplegia 79, autosomal recessive21
HP:0006886HP:0006938Impaired vibration sensation at ankles1XK CL E G H750412811OMIM:300842Mcleod syndrome8


Genes (48) :ABCD1 ALDH18A1 AMPD2 APTX ATP1A1 B4GALNT1 CACNA1G CADM3 CHCHD10 CHP1 CPT1C DCAF8 DHH DHTKD1 EGR2 FMR1 GBA2 GCH1 GDAP1 JAG1 KCNC3 KCND3 KIF1A KIF5A LMNB1 LRSAM1 MAG MORC2 MPZ MTRFR NEFL PDYN PEX10 PMP2 PMP22 POLG POLR3B PRKCG PRX REEP2 SETX SH3TC2 SPAST TWNK UCHL1 VCP XK XRCC1

Diseases (50) :OMIM:300100 ORPHA:447760 OMIM:616586 OMIM:615686 OMIM:208920 OMIM:618036 ORPHA:101006 OMIM:616795 ORPHA:458803 OMIM:619519 ORPHA:276435 OMIM:618438 OMIM:616282 OMIM:610100 OMIM:607080 OMIM:615025 OMIM:145900 OMIM:300623 ORPHA:320391 OMIM:128230 ORPHA:99948 OMIM:607706 OMIM:619574 OMIM:605259 ORPHA:98768 ORPHA:98772 OMIM:614213 ORPHA:100991 ORPHA:99027 OMIM:614436 OMIM:616680 OMIM:616688 OMIM:615035 OMIM:607684 ORPHA:101108 OMIM:614871 OMIM:618279 OMIM:157640 OMIM:258450 OMIM:607459 OMIM:619742 OMIM:605361 ORPHA:401849 OMIM:606002 ORPHA:99949 ORPHA:100985 OMIM:615491 ORPHA:435387 OMIM:300842 OMIM:617633
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.