Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Adenocarcinoma of the intestines (HP:0040273)

Grandparent Node:
Neoplasm of the small intestine (HP:0100833)

Parent Node:
Adenocarcinoma of the small intestine (HP:0040274)

..Starting node
..Duodenal adenocarcinoma (HP:0006771)

Term ID:

6771

Name:

Duodenal adenocarcinoma

Synonym:

Duodenal cancer

Definition:

A malignant epithelial tumor with a glandular organization that originates in the duodenum.

Comments:

Reference:

HP:0006771

Genes and Diseases:

Child Nodes:

Sister Nodes:

Ileal adenocarcinoma (HP:0030412)

Jejunal adenocarcinoma (HP:0030411)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	APC CL E G H	324	583	OMIM:175100	Adenomatous polyposis coli		3179
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	APC CL E G H	324	583	ORPHA:247806	APC-related attenuated familial adenomatous polyposis	HP:0040284 - Very rare	3179
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	BMPR1A CL E G H	657	1076	ORPHA:157794	Hereditary mixed polyposis syndrome	HP:0040284 - Very rare	385
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	BMPR1A CL E G H	657	1076	OMIM:174900	Juvenile polyposis syndrome		385
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	GREM1 CL E G H	26585	2001	ORPHA:157794	Hereditary mixed polyposis syndrome	HP:0040284 - Very rare	9
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	MLH1 CL E G H	4292	7127	OMIM:158320	Muir-Torre syndrome	.	1819
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	MSH2 CL E G H	4436	7325	OMIM:158320	Muir-Torre syndrome	.	2162
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	NTHL1 CL E G H	4913	8028	OMIM:616415	Familial adenomatous polyposis 3		2
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	NTHL1 CL E G H	4913	8028	ORPHA:454840	NTHL1-related attenuated familial adenomatous polyposis	HP:0040283 - Occasional	2
HP:0006771	HP:0006771	Duodenal adenocarcinoma	0	SMAD4 CL E G H	4089	6770	OMIM:174900	Juvenile polyposis syndrome		504

Genes (7) :APC BMPR1A GREM1 MLH1 MSH2 NTHL1 SMAD4

Diseases (7) :OMIM:175100 ORPHA:247806 ORPHA:157794 OMIM:174900 OMIM:158320 OMIM:616415 ORPHA:454840

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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