Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the pancreas (HP:0001732)help
Grandparent Node:
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Neoplasm by anatomical site (HP:0011793)help
Parent Node:
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Neoplasm of the pancreas (HP:0002894)help
..Starting node
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Pancreatic adenocarcinoma (HP:0006725)help
Term ID: 6725
Name: Pancreatic adenocarcinoma
Synonym:
Definition: The presence of an adenocarcinoma of the pancreas.
Comments:
Reference: HP:0006725
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandPancreatic islet cell adenoma (HP:0008261) help
..expandPancreatic squamous cell carcinoma (HP:0012142) help
..expandPancreatoblastoma (HP:0100757) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006725HP:0006725Pancreatic adenocarcinoma0AAGAB CL E G H7971925662ORPHA:79501Punctate palmoplantar keratoderma type 1HP:0040284 - Very rare7
HP:0006725HP:0006725Pancreatic adenocarcinoma0BMPR1A CL E G H6571076ORPHA:440437Familial colorectal cancer Type XHP:0040283 - Occasional385
HP:0006725HP:0006725Pancreatic adenocarcinoma0BRCA1 CL E G H6721100ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate5769
HP:0006725HP:0006725Pancreatic adenocarcinoma0BRCA2 CL E G H6751101ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate7642
HP:0006725HP:0006725Pancreatic adenocarcinoma0CDC73 CL E G H7957716783OMIM:145001Hyperparathyroidism 2.169
HP:0006725HP:0006725Pancreatic adenocarcinoma0CDC73 CL E G H7957716783ORPHA:99880Hyperparathyroidism-jaw tumor syndromeHP:0040284 - Very rare169
HP:0006725HP:0006725Pancreatic adenocarcinoma0CDC73 CL E G H7957716783ORPHA:143Parathyroid carcinomaHP:0040284 - Very rare169
HP:0006725HP:0006725Pancreatic adenocarcinoma0CDKN2A CL E G H10291787ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate289
HP:0006725HP:0006725Pancreatic adenocarcinoma0CDKN2A CL E G H10291787OMIM:606719Melanoma-Pancreatic cancer syndrome.289
HP:0006725HP:0006725Pancreatic adenocarcinoma0COL14A1 CL E G H73732191ORPHA:79501Punctate palmoplantar keratoderma type 1HP:0040284 - Very rare2
HP:0006725HP:0006725Pancreatic adenocarcinoma0CTRC CL E G H113302523ORPHA:103918Tropical pancreatitis39
HP:0006725HP:0006725Pancreatic adenocarcinoma0EPCAM CL E G H407211529ORPHA:144Lynch syndromeHP:0040283 - Occasional170
HP:0006725HP:0006725Pancreatic adenocarcinoma0FAN1 CL E G H2290929170ORPHA:144Lynch syndromeHP:0040283 - Occasional15
HP:0006725HP:0006725Pancreatic adenocarcinoma0KRAS CL E G H38456407ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate196
HP:0006725HP:0006725Pancreatic adenocarcinoma0KRAS CL E G H38456407ORPHA:144Lynch syndromeHP:0040283 - Occasional196
HP:0006725HP:0006725Pancreatic adenocarcinoma0MLH1 CL E G H42927127ORPHA:144Lynch syndromeHP:0040283 - Occasional1819
HP:0006725HP:0006725Pancreatic adenocarcinoma0MLH3 CL E G H270307128ORPHA:144Lynch syndromeHP:0040283 - Occasional131
HP:0006725HP:0006725Pancreatic adenocarcinoma0MSH2 CL E G H44367325ORPHA:144Lynch syndromeHP:0040283 - Occasional2162
HP:0006725HP:0006725Pancreatic adenocarcinoma0MSH6 CL E G H29567329ORPHA:144Lynch syndromeHP:0040283 - Occasional2232
HP:0006725HP:0006725Pancreatic adenocarcinoma0NTHL1 CL E G H49138028OMIM:616415Familial adenomatous polyposis 32
HP:0006725HP:0006725Pancreatic adenocarcinoma0NTHL1 CL E G H49138028ORPHA:454840NTHL1-related attenuated familial adenomatous polyposisHP:0040283 - Occasional2
HP:0006725HP:0006725Pancreatic adenocarcinoma0PALB2 CL E G H7972826144ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate1349
HP:0006725HP:0006725Pancreatic adenocarcinoma0PALLD CL E G H2302217068ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate192
HP:0006725HP:0006725Pancreatic adenocarcinoma0PALLD CL E G H2302217068OMIM:606856PANCREATIC CANCER, SUSCEPTIBILITY TO, 1192
HP:0006725HP:0006725Pancreatic adenocarcinoma0PIK3CA CL E G H52908975ORPHA:144Lynch syndromeHP:0040283 - Occasional162
HP:0006725HP:0006725Pancreatic adenocarcinoma0PMS1 CL E G H53789121ORPHA:144Lynch syndromeHP:0040283 - Occasional56
HP:0006725HP:0006725Pancreatic adenocarcinoma0PMS2 CL E G H53959122ORPHA:144Lynch syndromeHP:0040283 - Occasional1121
HP:0006725HP:0006725Pancreatic adenocarcinoma0RABL3 CL E G H28528218072ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate
HP:0006725HP:0006725Pancreatic adenocarcinoma0RABL3 CL E G H28528218072OMIM:618680PANCREATIC CANCER, SUSCEPTIBILITY TO, 5; PNCA5
HP:0006725HP:0006725Pancreatic adenocarcinoma0RNF43 CL E G H5489418505ORPHA:157798Serrated polyposis syndromeHP:0040284 - Very rare5
HP:0006725HP:0006725Pancreatic adenocarcinoma0RPS20 CL E G H622410405ORPHA:440437Familial colorectal cancer Type XHP:0040283 - Occasional1
HP:0006725HP:0006725Pancreatic adenocarcinoma0SEMA4A CL E G H6421810729ORPHA:440437Familial colorectal cancer Type XHP:0040283 - Occasional48
HP:0006725HP:0006725Pancreatic adenocarcinoma0SMAD4 CL E G H40896770ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate504
HP:0006725HP:0006725Pancreatic adenocarcinoma0SPINK1 CL E G H669011244ORPHA:103918Tropical pancreatitis34
HP:0006725HP:0006725Pancreatic adenocarcinoma0STK11 CL E G H679411389ORPHA:2869Peutz-Jeghers syndromeHP:0040283 - Occasional740
HP:0006725HP:0006725Pancreatic adenocarcinoma0TGFBR2 CL E G H704811773ORPHA:144Lynch syndromeHP:0040283 - Occasional253
HP:0006725HP:0006725Pancreatic adenocarcinoma0TP53 CL E G H715711998ORPHA:1333Familial pancreatic carcinomaHP:0040280 - Obligate911


Genes (30) :AAGAB BMPR1A BRCA1 BRCA2 CDC73 CDKN2A COL14A1 CTRC EPCAM FAN1 KRAS MLH1 MLH3 MSH2 MSH6 NTHL1 PALB2 PALLD PIK3CA PMS1 PMS2 RABL3 RNF43 RPS20 SEMA4A SMAD4 SPINK1 STK11 TGFBR2 TP53

Diseases (15) :ORPHA:79501 ORPHA:440437 ORPHA:1333 OMIM:145001 ORPHA:99880 ORPHA:143 OMIM:606719 ORPHA:103918 ORPHA:144 OMIM:616415 ORPHA:454840 OMIM:606856 OMIM:618680 ORPHA:157798 ORPHA:2869
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.