Human Phenotype Ontology 
Grandparent Node:
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Abnormality of vision (HP:0000504)help
Parent Node:
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Abnormality of binocular vision (HP:0011514)help
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Diplopia (HP:0000651)help
Term ID: 651
Name: Diplopia
Synonym: Double vision
Definition: Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.
Comments:
Reference: HP:0000651
Genes and Diseases:
 
       Child Nodes:

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..expandAbnormal stereopsis (HP:0011515) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000651HP:0000651Diplopia0ADPRS CL E G H5493621304OMIM:618170Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures
HP:0000651HP:0000651Diplopia0AGRN CL E G H375790329ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional127
HP:0000651HP:0000651Diplopia0AGRN CL E G H375790329ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare127
HP:0000651HP:0000651Diplopia0AIP CL E G H9049358ORPHA:2965ProlactinomaHP:0040283 - Occasional95
HP:0000651HP:0000651Diplopia0AK9 CL E G H22126433814ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional1
HP:0000651HP:0000651Diplopia0ANO10 CL E G H5512925519ORPHA:284289Adult-onset autosomal recessive cerebellar ataxiaHP:0040283 - Occasional64
HP:0000651HP:0000651Diplopia0ATP1A2 CL E G H477800ORPHA:569Familial or sporadic hemiplegic migraineHP:0040282 - Frequent239
HP:0000651HP:0000651Diplopia0ATP1A2 CL E G H477800OMIM:602481Migraine, familial hemiplegic, 2.239
HP:0000651HP:0000651Diplopia0ATXN3 CL E G H42877106OMIM:109150Machado-Joseph disease.14
HP:0000651HP:0000651Diplopia0ATXN3 CL E G H42877106ORPHA:276238Machado-Joseph disease type 1HP:0040282 - Frequent14
HP:0000651HP:0000651Diplopia0ATXN3 CL E G H42877106ORPHA:276241Machado-Joseph disease type 2HP:0040282 - Frequent14
HP:0000651HP:0000651Diplopia0ATXN3 CL E G H42877106ORPHA:276244Machado-Joseph disease type 3HP:0040282 - Frequent14
HP:0000651HP:0000651Diplopia0CACNA1A CL E G H7731388OMIM:108500Episodic ataxia, type 2.449
HP:0000651HP:0000651Diplopia0CACNA1A CL E G H7731388ORPHA:569Familial or sporadic hemiplegic migraineHP:0040282 - Frequent449
HP:0000651HP:0000651Diplopia0CACNA1A CL E G H7731388ORPHA:97Familial paroxysmal ataxiaHP:0040282 - Frequent449
HP:0000651HP:0000651Diplopia0CACNA1A CL E G H7731388ORPHA:98758Spinocerebellar ataxia type 6HP:0040282 - Frequent449
HP:0000651HP:0000651Diplopia0CACNA1G CL E G H89131394OMIM:616795Spinocerebellar ataxia 4232
HP:0000651HP:0000651Diplopia0CACNA1G CL E G H89131394ORPHA:458803Spinocerebellar ataxia type 42HP:0040283 - Occasional32
HP:0000651HP:0000651Diplopia0CDH23 CL E G H6407213733ORPHA:2965ProlactinomaHP:0040283 - Occasional636
HP:0000651HP:0000651Diplopia0CDH23 CL E G H6407213733ORPHA:91347TSH-secreting pituitary adenomaHP:0040283 - Occasional636
HP:0000651HP:0000651Diplopia0CHAT CL E G H11031912ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare65
HP:0000651HP:0000651Diplopia0CHRNA1 CL E G H11341955ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional74
HP:0000651HP:0000651Diplopia0CHRNB1 CL E G H11401961ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional53
HP:0000651HP:0000651Diplopia0CHRND CL E G H11441965ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional88
HP:0000651HP:0000651Diplopia0CHRNE CL E G H11451966ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional139
HP:0000651HP:0000651Diplopia0COL13A1 CL E G H13052190ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional6
HP:0000651HP:0000651Diplopia0COL13A1 CL E G H13052190ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare6
HP:0000651HP:0000651Diplopia0DARS2 CL E G H5515725538ORPHA:137898Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndromeHP:0040284 - Very rare60
HP:0000651HP:0000651Diplopia0DKK1 CL E G H229432891ORPHA:268882Arnold-Chiari malformation type IHP:0040283 - Occasional
HP:0000651HP:0000651Diplopia0DNAJC13 CL E G H2331730343ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent2
HP:0000651HP:0000651Diplopia0DNAJC6 CL E G H982915469ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare6
HP:0000651HP:0000651Diplopia0DOK7 CL E G H28548926594ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional91
HP:0000651HP:0000651Diplopia0EIF4G1 CL E G H19813296ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent2
HP:0000651HP:0000651Diplopia0ERCC2 CL E G H20683434ORPHA:220295Xeroderma pigmentosum-Cockayne syndrome complexHP:0040282 - Frequent106
HP:0000651HP:0000651Diplopia0ERCC3 CL E G H20713435ORPHA:220295Xeroderma pigmentosum-Cockayne syndrome complexHP:0040282 - Frequent54
HP:0000651HP:0000651Diplopia0ERCC4 CL E G H20723436ORPHA:220295Xeroderma pigmentosum-Cockayne syndrome complexHP:0040282 - Frequent158
HP:0000651HP:0000651Diplopia0ERCC5 CL E G H20733437ORPHA:220295Xeroderma pigmentosum-Cockayne syndrome complexHP:0040282 - Frequent83
HP:0000651HP:0000651Diplopia0GBA1 CL E G H26294177ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent
HP:0000651HP:0000651Diplopia0GIGYF2 CL E G H2605811960ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent8
HP:0000651HP:0000651Diplopia0GRK1 CL E G H601110013ORPHA:75382Oguchi diseaseHP:0040284 - Very rare4
HP:0000651HP:0000651Diplopia0HLA-B CL E G H31064932ORPHA:397Giant cell arteritisHP:0040283 - Occasional4
HP:0000651HP:0000651Diplopia0HLA-DQB1 CL E G H31194944OMIM:126200Multiple sclerosis, susceptibility to.
HP:0000651HP:0000651Diplopia0HLA-DRB1 CL E G H31234948ORPHA:397Giant cell arteritisHP:0040283 - Occasional2
HP:0000651HP:0000651Diplopia0HLA-DRB1 CL E G H31234948OMIM:126200Multiple sclerosis, susceptibility to.2
HP:0000651HP:0000651Diplopia0HTRA2 CL E G H2742914348ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare39
HP:0000651HP:0000651Diplopia0KCNA1 CL E G H37366218ORPHA:37612Episodic ataxia type 1HP:0040282 - Frequent145
HP:0000651HP:0000651Diplopia0KCND3 CL E G H37526239ORPHA:98772Spinocerebellar ataxia type 19/22HP:0040283 - Occasional35
HP:0000651HP:0000651Diplopia0LRP4 CL E G H40386696ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional124
HP:0000651HP:0000651Diplopia0LRRK2 CL E G H12089218618ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent221
HP:0000651HP:0000651Diplopia0LRRK2 CL E G H12089218618ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare221
HP:0000651HP:0000651Diplopia0MAPT CL E G H41376893OMIM:601104Supranuclear palsy, progressive, 1.140
HP:0000651HP:0000651Diplopia0MEN1 CL E G H42217010ORPHA:2965ProlactinomaHP:0040283 - Occasional462
HP:0000651HP:0000651Diplopia0MUSK CL E G H45937525ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional72
HP:0000651HP:0000651Diplopia0MYO5A CL E G H46447602ORPHA:79476Griscelli syndrome type 1HP:0040281 - Very frequent35
HP:0000651HP:0000651Diplopia0MYO9A CL E G H46497608ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare
HP:0000651HP:0000651Diplopia0NAB2 CL E G H46657627ORPHA:2126Solitary fibrous tumor/hemangiopericytomaHP:0040284 - Very rare
HP:0000651HP:0000651Diplopia0NF2 CL E G H47717773ORPHA:637Neurofibromatosis type 2HP:0040283 - Occasional220
HP:0000651HP:0000651Diplopia0NFKB2 CL E G H47917795ORPHA:293978Deficiency in anterior pituitary function-variable immunodeficiency syndromeHP:0040283 - Occasional11
HP:0000651HP:0000651Diplopia0NOP56 CL E G H1052815911ORPHA:276198Spinocerebellar ataxia type 36HP:0040284 - Very rare9
HP:0000651HP:0000651Diplopia0P4HA2 CL E G H89748547ORPHA:397Giant cell arteritisHP:0040283 - Occasional3
HP:0000651HP:0000651Diplopia0PARK7 CL E G H1131516369ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare23
HP:0000651HP:0000651Diplopia0PDCD1 CL E G H51338760OMIM:126200Multiple sclerosis, susceptibility to.1
HP:0000651HP:0000651Diplopia0PINK1 CL E G H6501814581ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare55
HP:0000651HP:0000651Diplopia0PODXL CL E G H54209171ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare6
HP:0000651HP:0000651Diplopia0POLG CL E G H54289179OMIM:603041Mitochondrial DNA depletion syndrome 1 (mngie type)464
HP:0000651HP:0000651Diplopia0POLG CL E G H54289179OMIM:157640Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1464
HP:0000651HP:0000651Diplopia0POLG CL E G H54289179OMIM:258450Progressive external ophthalmoplegia with mitochondrial DNA deletions,autosomal recessive464
HP:0000651HP:0000651Diplopia0PRKN CL E G H50718607ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare138
HP:0000651HP:0000651Diplopia0PRNP CL E G H56219449OMIM:600072Fatal familial insomnia.69
HP:0000651HP:0000651Diplopia0PRRT2 CL E G H11247630500ORPHA:569Familial or sporadic hemiplegic migraineHP:0040282 - Frequent94
HP:0000651HP:0000651Diplopia0PTPN22 CL E G H261919652ORPHA:397Giant cell arteritisHP:0040283 - Occasional3
HP:0000651HP:0000651Diplopia0PUM1 CL E G H969814957OMIM:617931Spinocerebellar ataxia 47HP:0040284 - Very rare1
HP:0000651HP:0000651Diplopia0RAPSN CL E G H59139863ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional73
HP:0000651HP:0000651Diplopia0RILPL1 CL E G H35311626814OMIM:619790OCULOPHARYNGODISTAL MYOPATHY 4; OPDM4
HP:0000651HP:0000651Diplopia0SAG CL E G H629510521ORPHA:75382Oguchi diseaseHP:0040284 - Very rare32
HP:0000651HP:0000651Diplopia0SAMD9L CL E G H2192851349OMIM:619806SPINOCEREBELLAR ATAXIA 49; SCA494
HP:0000651HP:0000651Diplopia0SCN1A CL E G H632310585ORPHA:569Familial or sporadic hemiplegic migraineHP:0040282 - Frequent1053
HP:0000651HP:0000651Diplopia0SCN4A CL E G H632910591ORPHA:99734Myotonia fluctuansHP:0040283 - Occasional263
HP:0000651HP:0000651Diplopia0SCN4A CL E G H632910591ORPHA:98913Postsynaptic congenital myasthenic syndromesHP:0040283 - Occasional263
HP:0000651HP:0000651Diplopia0SDHA CL E G H638910680OMIM:619259NEURODEGENERATION WITH ATAXIA AND LATE-ONSET OPTIC ATROPHY; NDAXOA304
HP:0000651HP:0000651Diplopia0SERPINI1 CL E G H52748943OMIM:604218Encephalopathy, familial, with neuroserpin inclusion bodies.28
HP:0000651HP:0000651Diplopia0SLC18A3 CL E G H657210936ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare2
HP:0000651HP:0000651Diplopia0SLC1A3 CL E G H650710941ORPHA:209967Episodic ataxia type 6HP:0040283 - Occasional63
HP:0000651HP:0000651Diplopia0SLC1A3 CL E G H650710941OMIM:612656Episodic ataxia, type 6.63
HP:0000651HP:0000651Diplopia0SLC25A1 CL E G H657610979ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare28
HP:0000651HP:0000651Diplopia0SLC2A1 CL E G H651311005OMIM:601042Dystonia 9.255
HP:0000651HP:0000651Diplopia0SLC2A1 CL E G H651311005ORPHA:53583Paroxysmal dystonic choreathetosis with episodic ataxia and spasticityHP:0040282 - Frequent255
HP:0000651HP:0000651Diplopia0SLC5A7 CL E G H6048214025ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare9
HP:0000651HP:0000651Diplopia0SNAP25 CL E G H661611132ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare2
HP:0000651HP:0000651Diplopia0SNCA CL E G H662211138ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent65
HP:0000651HP:0000651Diplopia0SNCA CL E G H662211138ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare65
HP:0000651HP:0000651Diplopia0SPTBN2 CL E G H671211276ORPHA:352403Spectrin-associated autosomal recessive cerebellar ataxiaHP:0040283 - Occasional126
HP:0000651HP:0000651Diplopia0STAT6 CL E G H677811368ORPHA:2126Solitary fibrous tumor/hemangiopericytomaHP:0040284 - Very rare1
HP:0000651HP:0000651Diplopia0SYNJ1 CL E G H886711503ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare9
HP:0000651HP:0000651Diplopia0SYT2 CL E G H12783311510ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare4
HP:0000651HP:0000651Diplopia0TGFB1 CL E G H704011766OMIM:131300Camurati-Engelmann disease13
HP:0000651HP:0000651Diplopia0TMEM240 CL E G H33945325186ORPHA:98773Spinocerebellar ataxia type 21HP:0040283 - Occasional9
HP:0000651HP:0000651Diplopia0TOP3A CL E G H715611992OMIM:618098Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5.
HP:0000651HP:0000651Diplopia0TPP1 CL E G H12002073ORPHA:284324Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxiaHP:0040282 - Frequent203
HP:0000651HP:0000651Diplopia0TPP1 CL E G H12002073OMIM:609270Spinocerebellar ataxia, autosomal recessive 7.203
HP:0000651HP:0000651Diplopia0TYMP CL E G H18903148OMIM:603041Mitochondrial DNA depletion syndrome 1 (mngie type)138
HP:0000651HP:0000651Diplopia0UCHL1 CL E G H734512513ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare21
HP:0000651HP:0000651Diplopia0VAMP1 CL E G H684312642ORPHA:98914Presynaptic congenital myasthenic syndromesHP:0040284 - Very rare2
HP:0000651HP:0000651Diplopia0VPS13C CL E G H5483223594ORPHA:2828Young-onset Parkinson diseaseHP:0040284 - Very rare8
HP:0000651HP:0000651Diplopia0VPS35 CL E G H5573713487ORPHA:411602Hereditary late-onset Parkinson diseaseHP:0040282 - Frequent37


Genes (85) :ADPRS AGRN AIP AK9 ANO10 ATP1A2 ATXN3 CACNA1A CACNA1G CDH23 CHAT CHRNA1 CHRNB1 CHRND CHRNE COL13A1 DARS2 DKK1 DNAJC13 DNAJC6 DOK7 EIF4G1 ERCC2 ERCC3 ERCC4 ERCC5 GBA1 GIGYF2 GRK1 HLA-B HLA-DQB1 HLA-DRB1 HTRA2 KCNA1 KCND3 LRP4 LRRK2 MAPT MEN1 MUSK MYO5A MYO9A NAB2 NF2 NFKB2 NOP56 P4HA2 PARK7 PDCD1 PINK1 PODXL POLG PRKN PRNP PRRT2 PTPN22 PUM1 RAPSN RILPL1 SAG SAMD9L SCN1A SCN4A SDHA SERPINI1 SLC18A3 SLC1A3 SLC25A1 SLC2A1 SLC5A7 SNAP25 SNCA SPTBN2 STAT6 SYNJ1 SYT2 TGFB1 TMEM240 TOP3A TPP1 TYMP UCHL1 VAMP1 VPS13C VPS35

Diseases (53) :OMIM:618170 ORPHA:98913 ORPHA:98914 ORPHA:2965 ORPHA:284289 ORPHA:569 OMIM:602481 OMIM:109150 ORPHA:276238 ORPHA:276241 ORPHA:276244 OMIM:108500 ORPHA:97 ORPHA:98758 OMIM:616795 ORPHA:458803 ORPHA:91347 ORPHA:137898 ORPHA:268882 ORPHA:411602 ORPHA:2828 ORPHA:220295 ORPHA:75382 ORPHA:397 OMIM:126200 ORPHA:37612 ORPHA:98772 OMIM:601104 ORPHA:79476 ORPHA:2126 ORPHA:637 ORPHA:293978 ORPHA:276198 OMIM:603041 OMIM:157640 OMIM:258450 OMIM:600072 OMIM:617931 OMIM:619790 OMIM:619806 ORPHA:99734 OMIM:619259 OMIM:604218 ORPHA:209967 OMIM:612656 OMIM:601042 ORPHA:53583 ORPHA:352403 OMIM:131300 ORPHA:98773 OMIM:618098 ORPHA:284324 OMIM:609270
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.