Human Phenotype Ontology 
Grandparent Node:
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Abnormality of eye movement (HP:0000496)help
Parent Node:
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Abnormal saccadic eye movements (HP:0000570)help
..Starting node
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Dysmetric saccades (HP:0000641)help
Term ID: 641
Name: Dysmetric saccades
Synonym: Dysmetric eye movements; Dysmetric eye saccades; Uncoordinated eye movement
Definition: The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results.
Comments:
Reference: HP:0000641
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandHypermetric saccades (HP:0007338) help
..expandHypometric saccades (HP:0000571) help
..expandSlow saccadic eye movements (HP:0000514) help
..expandSquare-wave jerks (HP:0025402) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000641HP:0000641Dysmetric saccades0AFG3L2 CL E G H10939315OMIM:610246Spinocerebellar ataxia 28.86
HP:0000641HP:0000641Dysmetric saccades0ANO10 CL E G H5512925519ORPHA:284289Adult-onset autosomal recessive cerebellar ataxiaHP:0040282 - Frequent64
HP:0000641HP:0000641Dysmetric saccades0ATXN1 CL E G H631010548OMIM:164400Spinocerebellar ataxia 1.19
HP:0000641HP:0000641Dysmetric saccades0ATXN2 CL E G H631110555OMIM:183090Spinocerebellar ataxia 2.11
HP:0000641HP:0000641Dysmetric saccades0ATXN3 CL E G H42877106OMIM:109150Machado-Joseph disease.14
HP:0000641HP:0000641Dysmetric saccades0ATXN8 CL E G H72406632925OMIM:608768Spinocerebellar ataxia 8.1
HP:0000641HP:0000641Dysmetric saccades0ATXN8OS CL E G H631510561OMIM:608768Spinocerebellar ataxia 8.1
HP:0000641HP:0000641Dysmetric saccades0EEF2 CL E G H19383214OMIM:609306Spinocerebellar ataxia 26.4
HP:0000641HP:0000641Dysmetric saccades0EEF2 CL E G H19383214ORPHA:101112Spinocerebellar ataxia type 26HP:0040282 - Frequent4
HP:0000641HP:0000641Dysmetric saccades0ITPR1 CL E G H37086180OMIM:606658Spinocerebellar ataxia 15.177
HP:0000641HP:0000641Dysmetric saccades0MFN2 CL E G H992716877OMIM:601152Hereditary motor and sensory neuropathy VI.203
HP:0000641HP:0000641Dysmetric saccades0MRE11 CL E G H43617230ORPHA:251347Ataxia-telangiectasia-like disorderHP:0040283 - Occasional532
HP:0000641HP:0000641Dysmetric saccades0PEX10 CL E G H51928851OMIM:614871Peroxisome biogenesis disorder 6B.75
HP:0000641HP:0000641Dysmetric saccades0SCYL1 CL E G H5741014372ORPHA:466794Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndromeHP:0040282 - Frequent5
HP:0000641HP:0000641Dysmetric saccades0SPTBN2 CL E G H671211276ORPHA:352403Spectrin-associated autosomal recessive cerebellar ataxiaHP:0040283 - Occasional126
HP:0000641HP:0000641Dysmetric saccades0TGM6 CL E G H34364116255ORPHA:276193Spinocerebellar ataxia type 35HP:0040283 - Occasional58
HP:0000641HP:0000641Dysmetric saccades0TPP1 CL E G H12002073ORPHA:284324Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxiaHP:0040282 - Frequent203
HP:0000641HP:0000641Dysmetric saccades0UBAP1 CL E G H5127112461OMIM:618418Spastic paraplegia 80, autosomal dominantHP:0040284 - Very rare
HP:0000641HP:0032015Dysmetric horizontal saccades1 CL E G H
HP:0000641HP:0032014Dysmetric vertical saccades1 CL E G H


Genes (17) :AFG3L2 ANO10 ATXN1 ATXN2 ATXN3 ATXN8 ATXN8OS EEF2 ITPR1 MFN2 MRE11 PEX10 SCYL1 SPTBN2 TGM6 TPP1 UBAP1

Diseases (17) :OMIM:610246 ORPHA:284289 OMIM:164400 OMIM:183090 OMIM:109150 OMIM:608768 OMIM:609306 ORPHA:101112 OMIM:606658 OMIM:601152 ORPHA:251347 OMIM:614871 ORPHA:466794 ORPHA:352403 ORPHA:276193 ORPHA:284324 OMIM:618418
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.