Human Phenotype Ontology 
Grandparent Node:
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Abnormality of eye movement (HP:0000496)help
Parent Node:
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Abnormal saccadic eye movements (HP:0000570)help
..Starting node
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Dysmetric saccades (HP:0000641)help
Term ID: 641
Name: Dysmetric saccades
Synonym: Dysmetric eye movements; Dysmetric eye saccades; Uncoordinated eye movement
Definition: The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results.
Comments:
Reference: HP:0000641
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandHypermetric saccades (HP:0007338) help
..expandHypometric saccades (HP:0000571) help
..expandSlow saccadic eye movements (HP:0000514) help
..expandSquare-wave jerks (HP:0025402) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0000641HP:0000641Dysmetric saccades0AFG3L2 CL E G H10939610246Spinocerebellar ataxia 28610246C1853249OMIM1385315604581
HP:0000641HP:0000641Dysmetric saccades0ANO10 CL E G H55129284289ORPHA124025519613726
HP:0000641HP:0000641Dysmetric saccades0ATXN1 CL E G H6310164400Spinocerebellar ataxia 1164400C0752120OMIM18610548601556
HP:0000641HP:0000641Dysmetric saccades0ATXN2 CL E G H6311183090Spinocerebellar ataxia 2183090C0752121OMIM15310555601517
HP:0000641HP:0000641Dysmetric saccades0ATXN3 CL E G H4287109150Azorean disease109150C0024408OMIM1467106607047
HP:0000641HP:0000641Dysmetric saccades0ATXN8 CL E G H724066608768Spinocerebellar ataxia 8608768C1837454OMIM1232925613289
HP:0000641HP:0000641Dysmetric saccades0ATXN8OS CL E G H6315608768Spinocerebellar ataxia 8608768C1837454OMIM17910561603680
HP:0000641HP:0000641Dysmetric saccades0EEF2 CL E G H1938101112ORPHA12043214130610
HP:0000641HP:0000641Dysmetric saccades0EEF2 CL E G H1938609306Spinocerebellar ataxia 26609306C1836395OMIM12043214130610
HP:0000641HP:0000641Dysmetric saccades0FGF14 CL E G H2259609307Spinocerebellar ataxia 27609307C1836383OMIM12083671601515
HP:0000641HP:0000641Dysmetric saccades0ITPR1 CL E G H3708606658Spinocerebellar ataxia 15606658C1847725OMIM111346180147265
HP:0000641HP:0000641Dysmetric saccades0MFN2 CL E G H9927601152Hereditary motor and sensory neuropathy with optic atrophy601152C0393807OMIM1106316877608507
HP:0000641HP:0000641Dysmetric saccades0PEX10 CL E G H5192614871Peroxisome biogenesis disorder 6B614871C3553948OMIM16548851602859
HP:0000641HP:0000641Dysmetric saccades0SCYL1 CL E G H57410466794ORPHA17314372607982
HP:0000641HP:0000641Dysmetric saccades0TPP1 CL E G H1200284324ORPHA18492073607998
HP:0000641HP:0032015Dysmetric horizontal saccades1AFG3L2 CL E G H10939610246Spinocerebellar ataxia 28610246C1853249OMIM1385315604581
HP:0000641HP:0032014Dysmetric vertical saccades1AFG3L2 CL E G H10939610246Spinocerebellar ataxia 28610246C1853249OMIM1385315604581
HP:0000641HP:0032014Dysmetric vertical saccades1ANO10 CL E G H55129284289ORPHA124025519613726
HP:0000641HP:0032015Dysmetric horizontal saccades1ANO10 CL E G H55129284289ORPHA124025519613726
HP:0000641HP:0032015Dysmetric horizontal saccades1ATXN1 CL E G H6310164400Spinocerebellar ataxia 1164400C0752120OMIM18610548601556
HP:0000641HP:0032014Dysmetric vertical saccades1ATXN1 CL E G H6310164400Spinocerebellar ataxia 1164400C0752120OMIM18610548601556
HP:0000641HP:0032014Dysmetric vertical saccades1ATXN2 CL E G H6311183090Spinocerebellar ataxia 2183090C0752121OMIM15310555601517
HP:0000641HP:0032015Dysmetric horizontal saccades1ATXN2 CL E G H6311183090Spinocerebellar ataxia 2183090C0752121OMIM15310555601517
HP:0000641HP:0032014Dysmetric vertical saccades1ATXN3 CL E G H4287109150Azorean disease109150C0024408OMIM1467106607047
HP:0000641HP:0032015Dysmetric horizontal saccades1ATXN3 CL E G H4287109150Azorean disease109150C0024408OMIM1467106607047
HP:0000641HP:0032015Dysmetric horizontal saccades1ATXN8 CL E G H724066608768Spinocerebellar ataxia 8608768C1837454OMIM1232925613289
HP:0000641HP:0032014Dysmetric vertical saccades1ATXN8 CL E G H724066608768Spinocerebellar ataxia 8608768C1837454OMIM1232925613289
HP:0000641HP:0032014Dysmetric vertical saccades1ATXN8OS CL E G H6315608768Spinocerebellar ataxia 8608768C1837454OMIM17910561603680
HP:0000641HP:0032015Dysmetric horizontal saccades1ATXN8OS CL E G H6315608768Spinocerebellar ataxia 8608768C1837454OMIM17910561603680
HP:0000641HP:0032014Dysmetric vertical saccades1EEF2 CL E G H1938101112ORPHA12043214130610
HP:0000641HP:0032015Dysmetric horizontal saccades1EEF2 CL E G H1938101112ORPHA12043214130610
HP:0000641HP:0032014Dysmetric vertical saccades1EEF2 CL E G H1938609306Spinocerebellar ataxia 26609306C1836395OMIM12043214130610
HP:0000641HP:0032015Dysmetric horizontal saccades1EEF2 CL E G H1938609306Spinocerebellar ataxia 26609306C1836395OMIM12043214130610
HP:0000641HP:0032014Dysmetric vertical saccades1FGF14 CL E G H2259609307Spinocerebellar ataxia 27609307C1836383OMIM12083671601515
HP:0000641HP:0032015Dysmetric horizontal saccades1FGF14 CL E G H2259609307Spinocerebellar ataxia 27609307C1836383OMIM12083671601515
HP:0000641HP:0032014Dysmetric vertical saccades1ITPR1 CL E G H3708606658Spinocerebellar ataxia 15606658C1847725OMIM111346180147265
HP:0000641HP:0032015Dysmetric horizontal saccades1ITPR1 CL E G H3708606658Spinocerebellar ataxia 15606658C1847725OMIM111346180147265
HP:0000641HP:0032014Dysmetric vertical saccades1MFN2 CL E G H9927601152Hereditary motor and sensory neuropathy with optic atrophy601152C0393807OMIM1106316877608507
HP:0000641HP:0032015Dysmetric horizontal saccades1MFN2 CL E G H9927601152Hereditary motor and sensory neuropathy with optic atrophy601152C0393807OMIM1106316877608507
HP:0000641HP:0032014Dysmetric vertical saccades1PEX10 CL E G H5192614871Peroxisome biogenesis disorder 6B614871C3553948OMIM16548851602859
HP:0000641HP:0032015Dysmetric horizontal saccades1PEX10 CL E G H5192614871Peroxisome biogenesis disorder 6B614871C3553948OMIM16548851602859
HP:0000641HP:0032015Dysmetric horizontal saccades1SCYL1 CL E G H57410466794ORPHA17314372607982
HP:0000641HP:0032014Dysmetric vertical saccades1SCYL1 CL E G H57410466794ORPHA17314372607982
HP:0000641HP:0032014Dysmetric vertical saccades1TPP1 CL E G H1200284324ORPHA18492073607998
HP:0000641HP:0032015Dysmetric horizontal saccades1TPP1 CL E G H1200284324ORPHA18492073607998
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000641HP:0000641Dysmetric saccades0MRE11 CL E G H4361251347ORPHA017297230600814
HP:0000641HP:0000641Dysmetric saccades0SPTBN2 CL E G H6712352403ORPHA071611276604985
HP:0000641HP:0000641Dysmetric saccades0TGM6 CL E G H343641276193ORPHA028916255613900
HP:0000641HP:0032014Dysmetric vertical saccades1MRE11 CL E G H4361251347ORPHA017297230600814
HP:0000641HP:0032015Dysmetric horizontal saccades1MRE11 CL E G H4361251347ORPHA017297230600814
HP:0000641HP:0032014Dysmetric vertical saccades1SPTBN2 CL E G H6712352403ORPHA071611276604985
HP:0000641HP:0032015Dysmetric horizontal saccades1SPTBN2 CL E G H6712352403ORPHA071611276604985
HP:0000641HP:0032015Dysmetric horizontal saccades1TGM6 CL E G H343641276193ORPHA028916255613900
HP:0000641HP:0032014Dysmetric vertical saccades1TGM6 CL E G H343641276193ORPHA028916255613900


Genes (17) :AFG3L2 ANO10 ATXN1 ATXN2 ATXN3 ATXN8 ATXN8OS EEF2 FGF14 ITPR1 MFN2 MRE11 PEX10 SCYL1 SPTBN2 TGM6 TPP1

Diseases (17) :610246 284289 164400 183090 109150 608768 101112 609306 609307 606658 601152 251347 614871 466794 352403 276193 284324
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.