Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the dentition (HP:0000164)help
Parent Node:
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Abnormality of dental eruption (HP:0006292)help
..Starting node
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Advanced eruption of teeth (HP:0006288)help
Term ID: 6288
Name: Advanced eruption of teeth
Synonym: Advanced dental eruption; Advanced tooth eruption; Early dental eruption; Early eruption of teeth; Eruption, advanced; Premature dental eruption; Premature eruption of teeth; Premature tooth eruption
Definition: Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age.
Comments:
Reference: HP:0006288
Genes and Diseases:
 
       Child Nodes:
........expandNatal tooth (HP:0000695) help
........expandPremature eruption of permanent teeth (HP:0006337) help

 Sister Nodes: 
..expandDelayed eruption of teeth (HP:0000684) help
..expandEruption failure (HP:0000706) help
..expandPersistence of primary teeth (HP:0006335) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0006288HP:0006288Advanced eruption of teeth0ADNP CL E G H2339415766ORPHA:404448ADNP syndromeHP:0040283 - Occasional47
HP:0006288HP:0006288Advanced eruption of teeth0ADNP CL E G H2339415766OMIM:615873Helsmoortel-van der Aa syndrome47
HP:0006288HP:0006288Advanced eruption of teeth0AMER1 CL E G H13928526837OMIM:300373Osteopathia striata with cranial sclerosis34
HP:0006288HP:0006288Advanced eruption of teeth0BCL11B CL E G H6491913222OMIM:617237Immunodeficiency 493
HP:0006288HP:0006288Advanced eruption of teeth0C2CD3 CL E G H2600524564OMIM:615948Orofaciodigital syndrome XIV27
HP:0006288HP:0006288Advanced eruption of teeth0CEP120 CL E G H15324126690OMIM:616300Short-Rib thoracic dysplasia 13 with or without polydactyly7
HP:0006288HP:0006288Advanced eruption of teeth0CILK1 CL E G H2285821219OMIM:612651ENDOCRINE-CEREBROOSTEODYSPLASIA
HP:0006288HP:0006288Advanced eruption of teeth0CREBBP CL E G H13872348ORPHA:353281Rubinstein-Taybi syndrome due to 16p13.3 microdeletion291
HP:0006288HP:0006288Advanced eruption of teeth0CREBBP CL E G H13872348ORPHA:353277Rubinstein-Taybi syndrome due to CREBBP mutations291
HP:0006288HP:0006288Advanced eruption of teeth0DHCR7 CL E G H17172860ORPHA:818Smith-Lemli-Opitz syndromeHP:0040283 - Occasional159
HP:0006288HP:0006288Advanced eruption of teeth0DSP CL E G H18323052OMIM:609638EPIDERMOLYSIS BULLOSA, LETHAL ACANTHOLYTIC; EBLA747
HP:0006288HP:0006288Advanced eruption of teeth0DSP CL E G H18323052ORPHA:158687Lethal acantholytic erosive disorder747
HP:0006288HP:0006288Advanced eruption of teeth0EHMT1 CL E G H7981324650OMIM:610253Kleefstra syndrome223
HP:0006288HP:0006288Advanced eruption of teeth0EHMT1 CL E G H7981324650ORPHA:261652Kleefstra syndrome due to a point mutation223
HP:0006288HP:0006288Advanced eruption of teeth0EP300 CL E G H20333373ORPHA:353284Rubinstein-Taybi syndrome due to EP300 haploinsufficiency250
HP:0006288HP:0006288Advanced eruption of teeth0EVC CL E G H21213497ORPHA:952Acrofacial dysostosis, Weyers typeHP:0040281 - Very frequent209
HP:0006288HP:0006288Advanced eruption of teeth0EVC CL E G H21213497OMIM:225500Ellis-Van creveld syndrome209
HP:0006288HP:0006288Advanced eruption of teeth0EVC2 CL E G H13288419747ORPHA:952Acrofacial dysostosis, Weyers typeHP:0040281 - Very frequent137
HP:0006288HP:0006288Advanced eruption of teeth0EVC2 CL E G H13288419747OMIM:225500Ellis-Van creveld syndrome137
HP:0006288HP:0006288Advanced eruption of teeth0FAM20C CL E G H5697522140OMIM:259775Raine syndrome35
HP:0006288HP:0006288Advanced eruption of teeth0FGFR2 CL E G H22633689ORPHA:313855FGFR2-related bent bone dysplasia175
HP:0006288HP:0006288Advanced eruption of teeth0FLNA CL E G H23163754ORPHA:99811Neuronal intestinal pseudoobstruction493
HP:0006288HP:0006288Advanced eruption of teeth0GLI3 CL E G H27374319OMIM:146510Pallister-Hall syndrome270
HP:0006288HP:0006288Advanced eruption of teeth0GLI3 CL E G H27374319ORPHA:672Pallister-Hall syndrome270
HP:0006288HP:0006288Advanced eruption of teeth0GTF2H5 CL E G H40467221157OMIM:616395Trichothiodystrophy 3, photosensitive3
HP:0006288HP:0006288Advanced eruption of teeth0INSR CL E G H36436091OMIM:262190Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities.229
HP:0006288HP:0006288Advanced eruption of teeth0INSR CL E G H36436091ORPHA:769Rabson-Mendenhall syndromeHP:0040283 - Occasional229
HP:0006288HP:0006288Advanced eruption of teeth0INTU CL E G H2715229239OMIM:617925Short-Rib thoracic dysplasia 20 with polydactyly
HP:0006288HP:0006288Advanced eruption of teeth0JUP CL E G H37286207ORPHA:158687Lethal acantholytic erosive disorder222
HP:0006288HP:0006288Advanced eruption of teeth0KDF1 CL E G H12669526624OMIM:617337Ectodermal dysplasia 12, Hypohidrotic/hair/tooth/nail type1
HP:0006288HP:0006288Advanced eruption of teeth0KDM6A CL E G H740312637OMIM:300867Kabuki syndrome 253
HP:0006288HP:0006288Advanced eruption of teeth0KMT2C CL E G H5850813726ORPHA:261652Kleefstra syndrome due to a point mutation99
HP:0006288HP:0006288Advanced eruption of teeth0KRT16 CL E G H38686423ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional27
HP:0006288HP:0006288Advanced eruption of teeth0KRT17 CL E G H38726427ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional23
HP:0006288HP:0006288Advanced eruption of teeth0KRT17 CL E G H38726427OMIM:167210Pachyonychia congenita 223
HP:0006288HP:0006288Advanced eruption of teeth0KRT6A CL E G H38536443ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional41
HP:0006288HP:0006288Advanced eruption of teeth0KRT6B CL E G H38546444ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional4
HP:0006288HP:0006288Advanced eruption of teeth0LMNA CL E G H40006636ORPHA:280365Autosomal semi-dominant severe lipodystrophic laminopathyHP:0040282 - Frequent645
HP:0006288HP:0006288Advanced eruption of teeth0LMNA CL E G H40006636ORPHA:2348Familial partial lipodystrophy, Dunnigan typeHP:0040282 - Frequent645
HP:0006288HP:0006288Advanced eruption of teeth0LMNA CL E G H40006636ORPHA:1662Restrictive dermopathy645
HP:0006288HP:0006288Advanced eruption of teeth0MID1 CL E G H42817095ORPHA:2745Opitz GBBB syndrome57
HP:0006288HP:0006288Advanced eruption of teeth0MKS1 CL E G H549037121OMIM:249000Meckel syndrome 1127
HP:0006288HP:0006288Advanced eruption of teeth0NEK1 CL E G H47507744ORPHA:2751Orofaciodigital syndrome type 2101
HP:0006288HP:0006288Advanced eruption of teeth0NFIX CL E G H47847788OMIM:614753Sotos syndrome 2.40
HP:0006288HP:0006288Advanced eruption of teeth0NSD1 CL E G H6432414234OMIM:117550Sotos syndrome 1544
HP:0006288HP:0006288Advanced eruption of teeth0POLR3A CL E G H1112830074ORPHA:3455Wiedemann-Rautenstrauch syndrome138
HP:0006288HP:0006288Advanced eruption of teeth0POLR3A CL E G H1112830074OMIM:264090Wiedemann-Rautenstrauch syndrome138
HP:0006288HP:0006288Advanced eruption of teeth0POLR3B CL E G H5570330348OMIM:614381Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism67
HP:0006288HP:0006288Advanced eruption of teeth0PTH1R CL E G H57459608ORPHA:50945Blomstrand lethal chondrodysplasia58
HP:0006288HP:0006288Advanced eruption of teeth0RPS6KA3 CL E G H619710432ORPHA:192Coffin-Lowry syndromeHP:0040283 - Occasional65
HP:0006288HP:0006288Advanced eruption of teeth0SPECC1L CL E G H2338429022OMIM:145420Hypertelorism, Teebi type6
HP:0006288HP:0006288Advanced eruption of teeth0SPECC1L CL E G H2338429022ORPHA:1519SPECC1L-related hypertelorism syndromeHP:0040283 - Occasional6
HP:0006288HP:0006288Advanced eruption of teeth0VARS1 CL E G H740712651OMIM:617802Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy
HP:0006288HP:0006288Advanced eruption of teeth0ZMPSTE24 CL E G H1026912877ORPHA:1662Restrictive dermopathy83
HP:0006288HP:0006288Advanced eruption of teeth0ZMPSTE24 CL E G H1026912877OMIM:275210Restrictive dermopathy, lethal83
HP:0006288HP:0006337Premature eruption of permanent teeth1 CL E G H
HP:0006288HP:0000695Natal tooth1AMER1 CL E G H13928526837OMIM:300373Osteopathia striata with cranial sclerosis.34
HP:0006288HP:0000695Natal tooth1BCL11B CL E G H6491913222OMIM:617237Immunodeficiency 49.3
HP:0006288HP:0000695Natal tooth1C2CD3 CL E G H2600524564OMIM:615948Orofaciodigital syndrome XIV.27
HP:0006288HP:0000695Natal tooth1CEP120 CL E G H15324126690OMIM:616300Short-Rib thoracic dysplasia 13 with or without polydactyly.7
HP:0006288HP:0000695Natal tooth1CILK1 CL E G H2285821219OMIM:612651ENDOCRINE-CEREBROOSTEODYSPLASIA.
HP:0006288HP:0000695Natal tooth1CREBBP CL E G H13872348ORPHA:353281Rubinstein-Taybi syndrome due to 16p13.3 microdeletionHP:0040284 - Very rare291
HP:0006288HP:0000695Natal tooth1CREBBP CL E G H13872348ORPHA:353277Rubinstein-Taybi syndrome due to CREBBP mutationsHP:0040284 - Very rare291
HP:0006288HP:0000695Natal tooth1DSP CL E G H18323052OMIM:609638EPIDERMOLYSIS BULLOSA, LETHAL ACANTHOLYTIC; EBLA747
HP:0006288HP:0000695Natal tooth1DSP CL E G H18323052ORPHA:158687Lethal acantholytic erosive disorderHP:0040282 - Frequent747
HP:0006288HP:0000695Natal tooth1EHMT1 CL E G H7981324650OMIM:610253Kleefstra syndrome223
HP:0006288HP:0000695Natal tooth1EHMT1 CL E G H7981324650ORPHA:261652Kleefstra syndrome due to a point mutationHP:0040284 - Very rare223
HP:0006288HP:0000695Natal tooth1EP300 CL E G H20333373ORPHA:353284Rubinstein-Taybi syndrome due to EP300 haploinsufficiencyHP:0040284 - Very rare250
HP:0006288HP:0000695Natal tooth1EVC CL E G H21213497OMIM:225500Ellis-Van creveld syndrome.209
HP:0006288HP:0000695Natal tooth1EVC2 CL E G H13288419747OMIM:225500Ellis-Van creveld syndrome.137
HP:0006288HP:0000695Natal tooth1FAM20C CL E G H5697522140OMIM:259775Raine syndromeHP:0040283 - Occasional35
HP:0006288HP:0000695Natal tooth1FGFR2 CL E G H22633689ORPHA:313855FGFR2-related bent bone dysplasiaHP:0040281 - Very frequent175
HP:0006288HP:0000695Natal tooth1FLNA CL E G H23163754ORPHA:99811Neuronal intestinal pseudoobstructionHP:0040281 - Very frequent493
HP:0006288HP:0000695Natal tooth1GLI3 CL E G H27374319ORPHA:672Pallister-Hall syndromeHP:0040282 - Frequent270
HP:0006288HP:0000695Natal tooth1GLI3 CL E G H27374319OMIM:146510Pallister-Hall syndromeHP:0040283 - Occasional270
HP:0006288HP:0000695Natal tooth1GTF2H5 CL E G H40467221157OMIM:616395Trichothiodystrophy 3, photosensitive3
HP:0006288HP:0000695Natal tooth1INTU CL E G H2715229239OMIM:617925Short-Rib thoracic dysplasia 20 with polydactyly
HP:0006288HP:0000695Natal tooth1JUP CL E G H37286207ORPHA:158687Lethal acantholytic erosive disorderHP:0040282 - Frequent222
HP:0006288HP:0000695Natal tooth1KDF1 CL E G H12669526624OMIM:617337Ectodermal dysplasia 12, Hypohidrotic/hair/tooth/nail typeHP:0040283 - Occasional1
HP:0006288HP:0000695Natal tooth1KDM6A CL E G H740312637OMIM:300867Kabuki syndrome 253
HP:0006288HP:0000695Natal tooth1KMT2C CL E G H5850813726ORPHA:261652Kleefstra syndrome due to a point mutationHP:0040284 - Very rare99
HP:0006288HP:0000695Natal tooth1KRT16 CL E G H38686423ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional27
HP:0006288HP:0000695Natal tooth1KRT17 CL E G H38726427ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional23
HP:0006288HP:0000695Natal tooth1KRT17 CL E G H38726427OMIM:167210Pachyonychia congenita 2.23
HP:0006288HP:0000695Natal tooth1KRT6A CL E G H38536443ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional41
HP:0006288HP:0000695Natal tooth1KRT6B CL E G H38546444ORPHA:2309Pachyonychia congenitaHP:0040283 - Occasional4
HP:0006288HP:0000695Natal tooth1LMNA CL E G H40006636ORPHA:1662Restrictive dermopathyHP:0040283 - Occasional645
HP:0006288HP:0000695Natal tooth1MID1 CL E G H42817095ORPHA:2745Opitz GBBB syndromeHP:0040284 - Very rare57
HP:0006288HP:0000695Natal tooth1MKS1 CL E G H549037121OMIM:249000Meckel syndrome 1.127
HP:0006288HP:0000695Natal tooth1NEK1 CL E G H47507744ORPHA:2751Orofaciodigital syndrome type 2HP:0040284 - Very rare101
HP:0006288HP:0000695Natal tooth1POLR3A CL E G H1112830074OMIM:264090Wiedemann-Rautenstrauch syndrome.138
HP:0006288HP:0000695Natal tooth1POLR3A CL E G H1112830074ORPHA:3455Wiedemann-Rautenstrauch syndromeHP:0040281 - Very frequent138
HP:0006288HP:0000695Natal tooth1POLR3B CL E G H5570330348OMIM:614381Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism67
HP:0006288HP:0000695Natal tooth1PTH1R CL E G H57459608ORPHA:50945Blomstrand lethal chondrodysplasiaHP:0040282 - Frequent58
HP:0006288HP:0000695Natal tooth1SPECC1L CL E G H2338429022OMIM:145420Hypertelorism, Teebi type.6
HP:0006288HP:0000695Natal tooth1VARS1 CL E G H740712651OMIM:617802Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy
HP:0006288HP:0000695Natal tooth1ZMPSTE24 CL E G H1026912877ORPHA:1662Restrictive dermopathyHP:0040283 - Occasional83
HP:0006288HP:0000695Natal tooth1ZMPSTE24 CL E G H1026912877OMIM:275210Restrictive dermopathy, lethal.83


Genes (41) :ADNP AMER1 BCL11B C2CD3 CEP120 CILK1 CREBBP DHCR7 DSP EHMT1 EP300 EVC EVC2 FAM20C FGFR2 FLNA GLI3 GTF2H5 INSR INTU JUP KDF1 KDM6A KMT2C KRT16 KRT17 KRT6A KRT6B LMNA MID1 MKS1 NEK1 NFIX NSD1 POLR3A POLR3B PTH1R RPS6KA3 SPECC1L VARS1 ZMPSTE24

Diseases (47) :ORPHA:404448 OMIM:615873 OMIM:300373 OMIM:617237 OMIM:615948 OMIM:616300 OMIM:612651 ORPHA:353281 ORPHA:353277 ORPHA:818 OMIM:609638 ORPHA:158687 OMIM:610253 ORPHA:261652 ORPHA:353284 ORPHA:952 OMIM:225500 OMIM:259775 ORPHA:313855 ORPHA:99811 OMIM:146510 ORPHA:672 OMIM:616395 OMIM:262190 ORPHA:769 OMIM:617925 OMIM:617337 OMIM:300867 ORPHA:2309 OMIM:167210 ORPHA:280365 ORPHA:2348 ORPHA:1662 ORPHA:2745 OMIM:249000 ORPHA:2751 OMIM:614753 OMIM:117550 ORPHA:3455 OMIM:264090 OMIM:614381 ORPHA:50945 ORPHA:192 OMIM:145420 ORPHA:1519 OMIM:617802 OMIM:275210
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.