Human Phenotype Ontology 
Grandparent Node:
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Recurrent infections (HP:0002719)help
Grandparent Node:
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Respiratory tract infection (HP:0011947)help
Parent Node:
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Recurrent respiratory infections (HP:0002205)help
..Starting node
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Recurrent sinopulmonary infections (HP:0005425)help
Term ID: 5425
Name: Recurrent sinopulmonary infections
Synonym: Chronic sinopulmonary infection; Recurrent sinus and lung infections
Definition: An increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections.
Comments:
Reference: HP:0005425
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandRecurrent bronchopulmonary infections (HP:0006538) help
..expandRecurrent infections due to aspiration (HP:0004891) help
..expandRecurrent lower respiratory tract infections (HP:0002783) help
..expandRecurrent streptococcus pneumoniae infections (HP:0005366) help
..expandRecurrent upper respiratory tract infections (HP:0002788) help
..expandRespiratory infections in early life (HP:0004880) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0005425HP:0005425Recurrent sinopulmonary infections0ATP6V0A2 CL E G H2354518481ORPHA:2834Wrinkly skin syndromeHP:0040281 - Very frequent140
HP:0005425HP:0005425Recurrent sinopulmonary infections0BACH2 CL E G H6046814078OMIM:618394IMMUNODEFICIENCY 60 AND AUTOIMMUNITY; IMD60
HP:0005425HP:0005425Recurrent sinopulmonary infections0CASP8 CL E G H8411509OMIM:607271CASPASE 8 DEFICIENCY37
HP:0005425HP:0005425Recurrent sinopulmonary infections0CCDC103 CL E G H38838932700ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent36
HP:0005425HP:0005425Recurrent sinopulmonary infections0CCDC39 CL E G H33982925244ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent126
HP:0005425HP:0005425Recurrent sinopulmonary infections0CCDC40 CL E G H5503626090ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent182
HP:0005425HP:0005425Recurrent sinopulmonary infections0CCDC65 CL E G H8547829937ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent23
HP:0005425HP:0005425Recurrent sinopulmonary infections0CCNO CL E G H1030918576ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent23
HP:0005425HP:0005425Recurrent sinopulmonary infections0CFAP221 CL E G H20037333720ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0CFAP298 CL E G H566831301ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0CFAP300 CL E G H8501628188ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0CFTR CL E G H10801884ORPHA:498359Aquagenic palmoplantar keratodermaHP:0040283 - Occasional1371
HP:0005425HP:0005425Recurrent sinopulmonary infections0CLPB CL E G H8157030664ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040282 - Frequent38
HP:0005425HP:0005425Recurrent sinopulmonary infections0CTNNBL1 CL E G H5625915879OMIM:619846
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF1 CL E G H12387230539ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent116
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF11 CL E G H2363916725ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF2 CL E G H5517220188ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent78
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF3 CL E G H35290930492ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent63
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF4 CL E G H16158221493ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent27
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF5 CL E G H5491926013ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent62
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAAF6 CL E G H13921228570ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAH1 CL E G H259812940ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent21
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAH11 CL E G H87012942ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent542
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAH5 CL E G H17672950ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent527
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAH9 CL E G H17702953ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent18
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAI1 CL E G H270192954ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent73
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAI2 CL E G H6444618744ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent104
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAJB13 CL E G H37440730718ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent2
HP:0005425HP:0005425Recurrent sinopulmonary infections0DNAL1 CL E G H8354423247ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent167
HP:0005425HP:0005425Recurrent sinopulmonary infections0DOCK8 CL E G H8170419191OMIM:243700Hyper-Ige recurrent infection syndrome, autosomal recessive.217
HP:0005425HP:0005425Recurrent sinopulmonary infections0DRC1 CL E G H9274924245ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent44
HP:0005425HP:0005425Recurrent sinopulmonary infections0ELANE CL E G H19913309ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040282 - Frequent79
HP:0005425HP:0005425Recurrent sinopulmonary infections0FOXJ1 CL E G H23023816ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0GAS2L2 CL E G H24617624846ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent1
HP:0005425HP:0005425Recurrent sinopulmonary infections0GAS8 CL E G H26224166ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent9
HP:0005425HP:0005425Recurrent sinopulmonary infections0GFI1 CL E G H26724237ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040282 - Frequent56
HP:0005425HP:0005425Recurrent sinopulmonary infections0HYDIN CL E G H5476819368ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent21
HP:0005425HP:0005425Recurrent sinopulmonary infections0LRRC56 CL E G H11539925430ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0MCIDAS CL E G H34564340050ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent13
HP:0005425HP:0005425Recurrent sinopulmonary infections0NBN CL E G H46837652ORPHA:647Nijmegen breakage syndromeHP:0040281 - Very frequent706
HP:0005425HP:0005425Recurrent sinopulmonary infections0NEK10 CL E G H15211018592ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0NFKB1 CL E G H47907794OMIM:616576IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID127
HP:0005425HP:0005425Recurrent sinopulmonary infections0NME8 CL E G H5131416473ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent50
HP:0005425HP:0005425Recurrent sinopulmonary infections0ODAD1 CL E G H9323326560ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0ODAD2 CL E G H5513025583ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0ODAD3 CL E G H11594828303ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0ODAD4 CL E G H8353825280ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0OFD1 CL E G H84812567ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent201
HP:0005425HP:0005425Recurrent sinopulmonary infections0PIK3CD CL E G H52938977OMIM:615513IMMUNODEFICIENCY 14; IMD149
HP:0005425HP:0005425Recurrent sinopulmonary infections0PIK3CG CL E G H52948978OMIM:619802IMMUNODEFICIENCY 97 WITH AUTOINFLAMMATION; IMD972
HP:0005425HP:0005425Recurrent sinopulmonary infections0PLCG2 CL E G H53369066OMIM:614878Autoinflammation, antibody deficiency, and immune dysregulation, plcg2-associated21
HP:0005425HP:0005425Recurrent sinopulmonary infections0PLCG2 CL E G H53369066OMIM:614468FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 3; FCAS321
HP:0005425HP:0005425Recurrent sinopulmonary infections0RPGR CL E G H610310295ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent200
HP:0005425HP:0005425Recurrent sinopulmonary infections0RSPH1 CL E G H8976512371ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent31
HP:0005425HP:0005425Recurrent sinopulmonary infections0RSPH3 CL E G H8386121054ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent5
HP:0005425HP:0005425Recurrent sinopulmonary infections0RSPH4A CL E G H34589521558ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent58
HP:0005425HP:0005425Recurrent sinopulmonary infections0RSPH9 CL E G H22142121057ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent20
HP:0005425HP:0005425Recurrent sinopulmonary infections0SPAG1 CL E G H667411212ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent45
HP:0005425HP:0005425Recurrent sinopulmonary infections0SPEF2 CL E G H7992526293ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent15
HP:0005425HP:0005425Recurrent sinopulmonary infections0SRP54 CL E G H672911301ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0STAT3 CL E G H677411364OMIM:147060Hyper-IgE recurrent infection syndrome.110
HP:0005425HP:0005425Recurrent sinopulmonary infections0STK36 CL E G H2714817209ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent3
HP:0005425HP:0005425Recurrent sinopulmonary infections0TCIRG1 CL E G H1031211647ORPHA:486Autosomal dominant severe congenital neutropeniaHP:0040282 - Frequent82
HP:0005425HP:0005425Recurrent sinopulmonary infections0TFRC CL E G H703711763OMIM:616740Immunodeficiency 461
HP:0005425HP:0005425Recurrent sinopulmonary infections0TNFRSF13B CL E G H2349518153OMIM:609529Immunoglobulin A deficiency 2.32
HP:0005425HP:0005425Recurrent sinopulmonary infections0TTC12 CL E G H5497023700ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent
HP:0005425HP:0005425Recurrent sinopulmonary infections0ZMYND10 CL E G H5136419412ORPHA:244Primary ciliary dyskinesiaHP:0040282 - Frequent20


Genes (66) :ATP6V0A2 BACH2 CASP8 CCDC103 CCDC39 CCDC40 CCDC65 CCNO CFAP221 CFAP298 CFAP300 CFTR CLPB CTNNBL1 DNAAF1 DNAAF11 DNAAF2 DNAAF3 DNAAF4 DNAAF5 DNAAF6 DNAH1 DNAH11 DNAH5 DNAH9 DNAI1 DNAI2 DNAJB13 DNAL1 DOCK8 DRC1 ELANE FOXJ1 GAS2L2 GAS8 GFI1 HYDIN LRRC56 MCIDAS NBN NEK10 NFKB1 NME8 ODAD1 ODAD2 ODAD3 ODAD4 OFD1 PIK3CD PIK3CG PLCG2 RPGR RSPH1 RSPH3 RSPH4A RSPH9 SPAG1 SPEF2 SRP54 STAT3 STK36 TCIRG1 TFRC TNFRSF13B TTC12 ZMYND10

Diseases (17) :ORPHA:2834 OMIM:618394 OMIM:607271 ORPHA:244 ORPHA:498359 ORPHA:486 OMIM:619846 OMIM:243700 ORPHA:647 OMIM:616576 OMIM:615513 OMIM:619802 OMIM:614878 OMIM:614468 OMIM:147060 OMIM:616740 OMIM:609529
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.