Human Phenotype Ontology 
Grandparent Node:
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Recurrent infections (HP:0002719)help
Parent Node:
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Recurrent bacterial infections (HP:0002718)help
..Starting node
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Recurrent gram-negative bacterial infections (HP:0005420)help
Term ID: 5420
Name: Recurrent gram-negative bacterial infections
Synonym:
Definition: Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents.
Comments:
Reference: HP:0005420
Genes and Diseases:
 
       Child Nodes:
........expandRecurrent E. coli infections (HP:0002740) help
........expandRecurrent Serratia marcescens infections (HP:0002741) help
........expandRecurrent Klebsiella infections (HP:0002742) help
........expandRecurrent Burkholderia cepacia infections (HP:0002842) help
........expandRecurrent Haemophilus influenzae infections (HP:0005376) help
........expandRecurrent Neisserial infections (HP:0005430) help
................... HP:0005381 Recurrent meningococcal disease

 Sister Nodes: 
..expandRecurrent bacterial skin infections (HP:0005406) help
..expandRecurrent mycobacterial infections (HP:0011274) help
..expandRecurrent staphylococcal infections (HP:0007499) help
..expandRecurrent systemic pyogenic infections (HP:0005429) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0C5 CL E G H7271331OMIM:609536C5 deficiency16
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0C6 CL E G H7291339OMIM:612446COMPLEMENT COMPONENT 6 DEFICIENCY; C6D12
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0C7 CL E G H7301346OMIM:610102COMPLEMENT COMPONENT 7 DEFICIENCY; C7D14
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0C8B CL E G H7321353OMIM:613789Complement component 8 deficiency, type II7
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CEACAM3 CL E G H10841815ORPHA:586Cystic fibrosis
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CEACAM6 CL E G H46801818ORPHA:586Cystic fibrosis1
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CFB CL E G H6291037OMIM:615561COMPLEMENT FACTOR B DEFICIENCY; CFBD30
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CFI CL E G H34265394OMIM:610984Complement factor I deficiency57
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CFTR CL E G H10801884ORPHA:586Cystic fibrosis1371
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CFTR CL E G H10801884ORPHA:60033Idiopathic bronchiectasis1371
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CLCA4 CL E G H228022018ORPHA:586Cystic fibrosis
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CYBA CL E G H15352577OMIM:233690GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE27
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0CYBB CL E G H15362578OMIM:306400Chronic granulomatous disease, X-linked111
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0DCTN4 CL E G H5116415518ORPHA:586Cystic fibrosis
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0EDNRA CL E G H19093179ORPHA:586Cystic fibrosis3
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0GCLC CL E G H27294311ORPHA:586Cystic fibrosis2
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0GSTM3 CL E G H29474635ORPHA:586Cystic fibrosis1
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0HFE CL E G H30774886ORPHA:586Cystic fibrosis38
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0HMOX1 CL E G H31625013ORPHA:586Cystic fibrosis3
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0IL12RB1 CL E G H35945971ORPHA:319552Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency46
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0IL2RG CL E G H35616010ORPHA:276T-B+ severe combined immunodeficiency due to gamma chain deficiency48
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0ITGB2 CL E G H36896155OMIM:116920Leukocyte adhesion deficiency, type I.114
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0KCNN4 CL E G H37836293ORPHA:586Cystic fibrosis3
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0MBL2 CL E G H41536922OMIM:614372Mannose-Binding lectin deficiency54
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0MIF CL E G H42827097ORPHA:586Cystic fibrosis1
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0NCF1 CL E G H6533617660OMIM:233700Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I13
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0NCF2 CL E G H46887661OMIM:233710Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II67
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0RPGR CL E G H610310295OMIM:300455RETINITIS PIGMENTOSA, X-LINKED, AND SINORESPIRATORY INFECTIONS, WITH OR WITHOUT DEAFNESS200
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SCNN1A CL E G H633710599ORPHA:60033Idiopathic bronchiectasis67
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SCNN1B CL E G H633810600ORPHA:60033Idiopathic bronchiectasis61
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SCNN1G CL E G H634010602ORPHA:60033Idiopathic bronchiectasis57
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SERPINA1 CL E G H52658941ORPHA:586Cystic fibrosis131
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SLC11A1 CL E G H655610907ORPHA:586Cystic fibrosis2
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SLC26A9 CL E G H11501914469ORPHA:586Cystic fibrosis5
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SLC6A14 CL E G H1125411047ORPHA:586Cystic fibrosis
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0SLC9A3 CL E G H655011073ORPHA:586Cystic fibrosis7
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0STX1A CL E G H680411433ORPHA:586Cystic fibrosis
HP:0005420HP:0005420Recurrent gram-negative bacterial infections0TGFB1 CL E G H704011766ORPHA:586Cystic fibrosis13
HP:0005420HP:0005430Recurrent Neisserial infections1C5 CL E G H7271331OMIM:609536C5 deficiency16
HP:0005420HP:0005430Recurrent Neisserial infections1C6 CL E G H7291339OMIM:612446COMPLEMENT COMPONENT 6 DEFICIENCY; C6D12
HP:0005420HP:0005430Recurrent Neisserial infections1C7 CL E G H7301346OMIM:610102COMPLEMENT COMPONENT 7 DEFICIENCY; C7D14
HP:0005420HP:0005430Recurrent Neisserial infections1C8B CL E G H7321353OMIM:613789Complement component 8 deficiency, type II.7
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1CEACAM3 CL E G H10841815ORPHA:586Cystic fibrosis
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1CEACAM3 CL E G H10841815ORPHA:586Cystic fibrosis
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1CEACAM6 CL E G H46801818ORPHA:586Cystic fibrosis1
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1CEACAM6 CL E G H46801818ORPHA:586Cystic fibrosis1
HP:0005420HP:0005430Recurrent Neisserial infections1CFB CL E G H6291037OMIM:615561COMPLEMENT FACTOR B DEFICIENCY; CFBD30
HP:0005420HP:0005430Recurrent Neisserial infections1CFI CL E G H34265394OMIM:610984Complement factor I deficiency57
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1CFI CL E G H34265394OMIM:610984Complement factor I deficiency.57
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1CFTR CL E G H10801884ORPHA:586Cystic fibrosis1371
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1CFTR CL E G H10801884ORPHA:586Cystic fibrosis1371
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1CFTR CL E G H10801884ORPHA:60033Idiopathic bronchiectasisHP:0040282 - Frequent1371
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1CLCA4 CL E G H228022018ORPHA:586Cystic fibrosis
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1CLCA4 CL E G H228022018ORPHA:586Cystic fibrosis
HP:0005420HP:0002740Recurrent E. coli infections1CYBA CL E G H15352577OMIM:233690GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE.27
HP:0005420HP:0002741Recurrent Serratia marcescens infections1CYBA CL E G H15352577OMIM:233690GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE.27
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1CYBA CL E G H15352577OMIM:233690GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE.27
HP:0005420HP:0002742Recurrent Klebsiella infections1CYBA CL E G H15352577OMIM:233690GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE.27
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1CYBB CL E G H15362578OMIM:306400Chronic granulomatous disease, X-linked.111
HP:0005420HP:0002741Recurrent Serratia marcescens infections1CYBB CL E G H15362578OMIM:306400Chronic granulomatous disease, X-linked.111
HP:0005420HP:0002742Recurrent Klebsiella infections1CYBB CL E G H15362578OMIM:306400Chronic granulomatous disease, X-linked.111
HP:0005420HP:0002740Recurrent E. coli infections1CYBB CL E G H15362578OMIM:306400Chronic granulomatous disease, X-linked.111
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1DCTN4 CL E G H5116415518ORPHA:586Cystic fibrosis
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1DCTN4 CL E G H5116415518ORPHA:586Cystic fibrosis
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1EDNRA CL E G H19093179ORPHA:586Cystic fibrosis3
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1EDNRA CL E G H19093179ORPHA:586Cystic fibrosis3
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1GCLC CL E G H27294311ORPHA:586Cystic fibrosis2
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1GCLC CL E G H27294311ORPHA:586Cystic fibrosis2
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1GSTM3 CL E G H29474635ORPHA:586Cystic fibrosis1
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1GSTM3 CL E G H29474635ORPHA:586Cystic fibrosis1
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1HFE CL E G H30774886ORPHA:586Cystic fibrosis38
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1HFE CL E G H30774886ORPHA:586Cystic fibrosis38
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1HMOX1 CL E G H31625013ORPHA:586Cystic fibrosis3
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1HMOX1 CL E G H31625013ORPHA:586Cystic fibrosis3
HP:0005420HP:0002742Recurrent Klebsiella infections1IL12RB1 CL E G H35945971ORPHA:319552Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiencyHP:0040284 - Very rare46
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1IL2RG CL E G H35616010ORPHA:276T-B+ severe combined immunodeficiency due to gamma chain deficiencyHP:0040283 - Occasional48
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1KCNN4 CL E G H37836293ORPHA:586Cystic fibrosis3
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1KCNN4 CL E G H37836293ORPHA:586Cystic fibrosis3
HP:0005420HP:0002742Recurrent Klebsiella infections1MBL2 CL E G H41536922OMIM:614372Mannose-Binding lectin deficiency54
HP:0005420HP:0005430Recurrent Neisserial infections1MBL2 CL E G H41536922OMIM:614372Mannose-Binding lectin deficiency54
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1MIF CL E G H42827097ORPHA:586Cystic fibrosis1
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1MIF CL E G H42827097ORPHA:586Cystic fibrosis1
HP:0005420HP:0002742Recurrent Klebsiella infections1NCF1 CL E G H6533617660OMIM:233700Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I.13
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1NCF1 CL E G H6533617660OMIM:233700Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I.13
HP:0005420HP:0002740Recurrent E. coli infections1NCF1 CL E G H6533617660OMIM:233700Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I.13
HP:0005420HP:0002741Recurrent Serratia marcescens infections1NCF1 CL E G H6533617660OMIM:233700Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type I.13
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1NCF2 CL E G H46887661OMIM:233710Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II.67
HP:0005420HP:0002741Recurrent Serratia marcescens infections1NCF2 CL E G H46887661OMIM:233710Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II.67
HP:0005420HP:0002742Recurrent Klebsiella infections1NCF2 CL E G H46887661OMIM:233710Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II.67
HP:0005420HP:0002740Recurrent E. coli infections1NCF2 CL E G H46887661OMIM:233710Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II.67
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1RPGR CL E G H610310295OMIM:300455RETINITIS PIGMENTOSA, X-LINKED, AND SINORESPIRATORY INFECTIONS, WITH OR WITHOUT DEAFNESS200
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SCNN1A CL E G H633710599ORPHA:60033Idiopathic bronchiectasisHP:0040282 - Frequent67
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SCNN1B CL E G H633810600ORPHA:60033Idiopathic bronchiectasisHP:0040282 - Frequent61
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SCNN1G CL E G H634010602ORPHA:60033Idiopathic bronchiectasisHP:0040282 - Frequent57
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SERPINA1 CL E G H52658941ORPHA:586Cystic fibrosis131
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1SERPINA1 CL E G H52658941ORPHA:586Cystic fibrosis131
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SLC11A1 CL E G H655610907ORPHA:586Cystic fibrosis2
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1SLC11A1 CL E G H655610907ORPHA:586Cystic fibrosis2
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SLC26A9 CL E G H11501914469ORPHA:586Cystic fibrosis5
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1SLC26A9 CL E G H11501914469ORPHA:586Cystic fibrosis5
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SLC6A14 CL E G H1125411047ORPHA:586Cystic fibrosis
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1SLC6A14 CL E G H1125411047ORPHA:586Cystic fibrosis
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1SLC9A3 CL E G H655011073ORPHA:586Cystic fibrosis7
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1SLC9A3 CL E G H655011073ORPHA:586Cystic fibrosis7
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1STX1A CL E G H680411433ORPHA:586Cystic fibrosis
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1STX1A CL E G H680411433ORPHA:586Cystic fibrosis
HP:0005420HP:0002842Recurrent Burkholderia cepacia infections1TGFB1 CL E G H704011766ORPHA:586Cystic fibrosis13
HP:0005420HP:0005376Recurrent Haemophilus influenzae infections1TGFB1 CL E G H704011766ORPHA:586Cystic fibrosis13
HP:0005420HP:0005381Recurrent meningococcal disease2C5 CL E G H7271331OMIM:609536C5 deficiency16
HP:0005420HP:0005381Recurrent meningococcal disease2C6 CL E G H7291339OMIM:612446COMPLEMENT COMPONENT 6 DEFICIENCY; C6D12
HP:0005420HP:0005381Recurrent meningococcal disease2C7 CL E G H7301346OMIM:610102COMPLEMENT COMPONENT 7 DEFICIENCY; C7D14
HP:0005420HP:0005381Recurrent meningococcal disease2CFB CL E G H6291037OMIM:615561COMPLEMENT FACTOR B DEFICIENCY; CFBD30
HP:0005420HP:0005381Recurrent meningococcal disease2CFI CL E G H34265394OMIM:610984Complement factor I deficiency.57
HP:0005420HP:0005381Recurrent meningococcal disease2MBL2 CL E G H41536922OMIM:614372Mannose-Binding lectin deficiency54


Genes (37) :C5 C6 C7 C8B CEACAM3 CEACAM6 CFB CFI CFTR CLCA4 CYBA CYBB DCTN4 EDNRA GCLC GSTM3 HFE HMOX1 IL12RB1 IL2RG ITGB2 KCNN4 MBL2 MIF NCF1 NCF2 RPGR SCNN1A SCNN1B SCNN1G SERPINA1 SLC11A1 SLC26A9 SLC6A14 SLC9A3 STX1A TGFB1

Diseases (17) :OMIM:609536 OMIM:612446 OMIM:610102 OMIM:613789 ORPHA:586 OMIM:615561 OMIM:610984 ORPHA:60033 OMIM:233690 OMIM:306400 ORPHA:319552 ORPHA:276 OMIM:116920 OMIM:614372 OMIM:233700 OMIM:233710 OMIM:300455
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.