Human Phenotype Ontology 
Grandparent Node:
expand
Abnormal QT interval (HP:0031547)help
Parent Node:
expand
Prolonged QT interval (HP:0001657)help
..Starting node
..expand
Prolonged QTc interval (HP:0005184)help
Term ID: 5184
Name: Prolonged QTc interval
Synonym:
Definition: A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.
Comments:
Reference: HP:0005184
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0005184HP:0005184Prolonged QTc interval0AKAP9 CL E G H10142379OMIM:611820Long QT syndrome 11289
HP:0005184HP:0005184Prolonged QTc interval0AKAP9 CL E G H10142379ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate289
HP:0005184HP:0005184Prolonged QTc interval0ALG10B CL E G H14424531088OMIM:613688Long QT syndrome 23
HP:0005184HP:0005184Prolonged QTc interval0ANK2 CL E G H287493ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate539
HP:0005184HP:0005184Prolonged QTc interval0CACNA1C CL E G H7751390OMIM:618447LONG QT SYNDROME 8; LQT8572
HP:0005184HP:0005184Prolonged QTc interval0CACNA1C CL E G H7751390ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate572
HP:0005184HP:0005184Prolonged QTc interval0CALM1 CL E G H8011442OMIM:616247Long QT syndrome 1418
HP:0005184HP:0005184Prolonged QTc interval0CALM1 CL E G H8011442ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate18
HP:0005184HP:0005184Prolonged QTc interval0CALM2 CL E G H8051445OMIM:616249Long QT syndrome 15.13
HP:0005184HP:0005184Prolonged QTc interval0CALM2 CL E G H8051445ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate13
HP:0005184HP:0005184Prolonged QTc interval0CALM3 CL E G H8081449OMIM:618782LONG QT SYNDROME 16; LQT1616
HP:0005184HP:0005184Prolonged QTc interval0CALM3 CL E G H8081449ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate16
HP:0005184HP:0005184Prolonged QTc interval0CAV3 CL E G H8591529ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate148
HP:0005184HP:0005184Prolonged QTc interval0FLNC CL E G H23183756OMIM:617047Cardiomyopathy, familial hypertrophic, 26197
HP:0005184HP:0005184Prolonged QTc interval0HCN4 CL E G H1002116882OMIM:163800Sick sinus syndrome 2185
HP:0005184HP:0005184Prolonged QTc interval0KCNA5 CL E G H37416224OMIM:612240Atrial fibrillation, familial, 7HP:0040283 - Occasional38
HP:0005184HP:0005184Prolonged QTc interval0KCNE1 CL E G H37536240ORPHA:90647Jervell and Lange-Nielsen syndromeHP:0040281 - Very frequent148
HP:0005184HP:0005184Prolonged QTc interval0KCNE1 CL E G H37536240OMIM:613695Long QT syndrome 5148
HP:0005184HP:0005184Prolonged QTc interval0KCNE1 CL E G H37536240ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate148
HP:0005184HP:0005184Prolonged QTc interval0KCNE2 CL E G H99926242OMIM:613693Long QT syndrome 643
HP:0005184HP:0005184Prolonged QTc interval0KCNE2 CL E G H99926242ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate43
HP:0005184HP:0005184Prolonged QTc interval0KCNH2 CL E G H37576251OMIM:613688Long QT syndrome 2901
HP:0005184HP:0005184Prolonged QTc interval0KCNH2 CL E G H37576251ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate901
HP:0005184HP:0005184Prolonged QTc interval0KCNJ2 CL E G H37596263OMIM:170390Andersen cardiodysrhythmic periodic paralysis193
HP:0005184HP:0005184Prolonged QTc interval0KCNJ2 CL E G H37596263ORPHA:37553Andersen-Tawil syndromeHP:0040283 - Occasional193
HP:0005184HP:0005184Prolonged QTc interval0KCNJ5 CL E G H37626266ORPHA:37553Andersen-Tawil syndromeHP:0040283 - Occasional128
HP:0005184HP:0005184Prolonged QTc interval0KCNJ5 CL E G H37626266OMIM:613485Long QT syndrome 13128
HP:0005184HP:0005184Prolonged QTc interval0KCNJ5 CL E G H37626266ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate128
HP:0005184HP:0005184Prolonged QTc interval0KCNQ1 CL E G H37846294OMIM:607554Atrial fibrillation, familial, 3730
HP:0005184HP:0005184Prolonged QTc interval0KCNQ1 CL E G H37846294ORPHA:90647Jervell and Lange-Nielsen syndromeHP:0040281 - Very frequent730
HP:0005184HP:0005184Prolonged QTc interval0KCNQ1 CL E G H37846294OMIM:220400Jervell and lange-nielsen syndrome 1730
HP:0005184HP:0005184Prolonged QTc interval0KCNQ1 CL E G H37846294OMIM:192500LONG QT SYNDROME 1; LQT1730
HP:0005184HP:0005184Prolonged QTc interval0KCNQ1 CL E G H37846294ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate730
HP:0005184HP:0005184Prolonged QTc interval0MECP2 CL E G H42046990OMIM:312750Rett syndrome.950
HP:0005184HP:0005184Prolonged QTc interval0NOS1AP CL E G H972216859ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate4
HP:0005184HP:0005184Prolonged QTc interval0SCN10A CL E G H633610582ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate146
HP:0005184HP:0005184Prolonged QTc interval0SCN4B CL E G H633010592ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate110
HP:0005184HP:0005184Prolonged QTc interval0SCN5A CL E G H633110593OMIM:603830Long QT syndrome 31134
HP:0005184HP:0005184Prolonged QTc interval0SCN5A CL E G H633110593ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate1134
HP:0005184HP:0005184Prolonged QTc interval0SNTA1 CL E G H664011167OMIM:612955Long QT syndrome 12118
HP:0005184HP:0005184Prolonged QTc interval0SNTA1 CL E G H664011167ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate118
HP:0005184HP:0005184Prolonged QTc interval0SVIL CL E G H684011480OMIM:619040MYOFIBRILLAR MYOPATHY 10; MFM101
HP:0005184HP:0005184Prolonged QTc interval0TANGO2 CL E G H12898925439OMIM:616878Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration12
HP:0005184HP:0005184Prolonged QTc interval0TBX5 CL E G H691011604ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate123
HP:0005184HP:0005184Prolonged QTc interval0TNNI3K CL E G H5108619661OMIM:616117Cardiac conduction disease with or without dilated cardiomyopathy.1
HP:0005184HP:0005184Prolonged QTc interval0TRDN CL E G H1034512261ORPHA:101016Romano-Ward syndromeHP:0040280 - Obligate145


Genes (28) :AKAP9 ALG10B ANK2 CACNA1C CALM1 CALM2 CALM3 CAV3 FLNC HCN4 KCNA5 KCNE1 KCNE2 KCNH2 KCNJ2 KCNJ5 KCNQ1 MECP2 NOS1AP SCN10A SCN4B SCN5A SNTA1 SVIL TANGO2 TBX5 TNNI3K TRDN

Diseases (25) :OMIM:611820 ORPHA:101016 OMIM:613688 OMIM:618447 OMIM:616247 OMIM:616249 OMIM:618782 OMIM:617047 OMIM:163800 OMIM:612240 ORPHA:90647 OMIM:613695 OMIM:613693 OMIM:170390 ORPHA:37553 OMIM:613485 OMIM:607554 OMIM:220400 OMIM:192500 OMIM:312750 OMIM:603830 OMIM:612955 OMIM:619040 OMIM:616878 OMIM:616117
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.