Human Phenotype Ontology 
Grandparent Node:
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Anemia due to reduced life span of red cells (HP:0011895)help
Parent Node:
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Hemolytic anemia (HP:0001878)help
..Starting node
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Coombs-positive hemolytic anemia (HP:0004844)help
Term ID: 4844
Name: Coombs-positive hemolytic anemia
Synonym: Coombs-positive hemolytic anaemia; Direct Coombs positive
Definition: A type of hemolytic anemia in which the Coombs test is positive.
Comments:
Reference: HP:0004844
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAutoimmune hemolytic anemia (HP:0001890) help
..expandChronic hemolytic anemia (HP:0004870) help
..expandCold-induced hemolysis (HP:0031484) help
..expandCompensated hemolytic anemia (HP:0004863) help
..expandCongenital hemolytic anemia (HP:0004804) help
..expandDrug-sensitive hemolytic anemia (HP:0004817) help
..expandEpisodic hemolytic anemia (HP:0004802) help
..expandExercise-induced hemolysis (HP:0005535) help
..expandFava bean-induced hemolytic anemia (HP:0004814) help
..expandHeinz body anemia (HP:0005511) help
..expandIncreased red cell hemolysis by shear stress (HP:0008269) help
..expandMacrocytic hemolytic disease (HP:0005524) help
..expandMicroangiopathic hemolytic anemia (HP:0001937) help
..expandNonspherocytic hemolytic anemia (HP:0001930) help
..expandSpontaneous hemolytic crises (HP:0005525) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0004844HP:0004844Coombs-positive hemolytic anemia0CASP10 CL E G H8431500ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional87
HP:0004844HP:0004844Coombs-positive hemolytic anemia0CASP10 CL E G H8431500OMIM:603909Autoimmune lymphoproliferative syndrome, type IIA87
HP:0004844HP:0004844Coombs-positive hemolytic anemia0FAS CL E G H35511920ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional59
HP:0004844HP:0004844Coombs-positive hemolytic anemia0FAS CL E G H35511920OMIM:601859Autoimmune lymphoproliferative syndrome.59
HP:0004844HP:0004844Coombs-positive hemolytic anemia0FASLG CL E G H35611936OMIM:601859Autoimmune lymphoproliferative syndrome.37
HP:0004844HP:0004844Coombs-positive hemolytic anemia0FASLG CL E G H35611936ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional37
HP:0004844HP:0004844Coombs-positive hemolytic anemia0FOXP3 CL E G H509436106OMIM:304790Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked32
HP:0004844HP:0004844Coombs-positive hemolytic anemia0HMOX1 CL E G H31625013OMIM:614034HEME OXYGENASE 1 DEFICIENCY; HMOX1D3
HP:0004844HP:0004844Coombs-positive hemolytic anemia0LAT CL E G H2704018874OMIM:617514Immunodeficiency 522
HP:0004844HP:0004844Coombs-positive hemolytic anemia0PRKCD CL E G H55809399ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional10
HP:0004844HP:0004844Coombs-positive hemolytic anemia0RASGRP1 CL E G H101259878ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional
HP:0004844HP:0004844Coombs-positive hemolytic anemia0SOCS1 CL E G H865119383OMIM:619375AUTOINFLAMMATORY SYNDROME, FAMILIAL, WITH OR WITHOUT IMMUNODEFICIENCY; AISIMD6
HP:0004844HP:0004844Coombs-positive hemolytic anemia0TNFRSF4 CL E G H729311918OMIM:615593Immunodeficiency 162


Genes (10) :CASP10 FAS FASLG FOXP3 HMOX1 LAT PRKCD RASGRP1 SOCS1 TNFRSF4

Diseases (8) :ORPHA:3261 OMIM:603909 OMIM:601859 OMIM:304790 OMIM:614034 OMIM:617514 OMIM:619375 OMIM:615593
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.