Human Phenotype Ontology 
Grandparent Node:
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Neoplasm of the gastrointestinal tract (HP:0007378)help
Parent Node:
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Adenocarcinoma of the intestines (HP:0040273)help
Parent Node:
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Neoplasm of the small intestine (HP:0100833)help
..Starting node
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Adenocarcinoma of the small intestine (HP:0040274)help
Term ID: 40274
Name: Adenocarcinoma of the small intestine
Synonym:
Definition: A malignant epithelial tumor with a glandular organization that originates in the small intestine.
Comments:
Reference: HP:0040274
Genes and Diseases:
 
       Child Nodes:
........expandDuodenal adenocarcinoma (HP:0006771) help
........expandJejunal adenocarcinoma (HP:0030411) help
........expandIleal adenocarcinoma (HP:0030412) help

 Sister Nodes: 
..expandSmall intestinal polyp (HP:0012737) help
..expandSmall intestine carcinoid (HP:0006722) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0040274HP:0040274Adenocarcinoma of the small intestine0AAGAB CL E G H7971925662ORPHA:79501Punctate palmoplantar keratoderma type 1HP:0040284 - Very rare7
HP:0040274HP:0040274Adenocarcinoma of the small intestine0APC CL E G H324583OMIM:175100Adenomatous polyposis coli3179
HP:0040274HP:0040274Adenocarcinoma of the small intestine0APC CL E G H324583ORPHA:247806APC-related attenuated familial adenomatous polyposis3179
HP:0040274HP:0040274Adenocarcinoma of the small intestine0BMPR1A CL E G H6571076ORPHA:157794Hereditary mixed polyposis syndrome385
HP:0040274HP:0040274Adenocarcinoma of the small intestine0BMPR1A CL E G H6571076OMIM:174900Juvenile polyposis syndrome385
HP:0040274HP:0040274Adenocarcinoma of the small intestine0COL14A1 CL E G H73732191ORPHA:79501Punctate palmoplantar keratoderma type 1HP:0040284 - Very rare2
HP:0040274HP:0040274Adenocarcinoma of the small intestine0GREM1 CL E G H265852001ORPHA:157794Hereditary mixed polyposis syndrome9
HP:0040274HP:0040274Adenocarcinoma of the small intestine0MLH1 CL E G H42927127OMIM:276300Mismatch repair cancer syndrome 11819
HP:0040274HP:0040274Adenocarcinoma of the small intestine0MLH1 CL E G H42927127OMIM:158320Muir-Torre syndrome1819
HP:0040274HP:0040274Adenocarcinoma of the small intestine0MSH2 CL E G H44367325OMIM:158320Muir-Torre syndrome2162
HP:0040274HP:0040274Adenocarcinoma of the small intestine0NTHL1 CL E G H49138028OMIM:616415Familial adenomatous polyposis 32
HP:0040274HP:0040274Adenocarcinoma of the small intestine0NTHL1 CL E G H49138028ORPHA:454840NTHL1-related attenuated familial adenomatous polyposis2
HP:0040274HP:0040274Adenocarcinoma of the small intestine0SMAD4 CL E G H40896770OMIM:174900Juvenile polyposis syndrome504
HP:0040274HP:0030412Ileal adenocarcinoma1 CL E G H
HP:0040274HP:0030411Jejunal adenocarcinoma1 CL E G H
HP:0040274HP:0006771Duodenal adenocarcinoma1APC CL E G H324583OMIM:175100Adenomatous polyposis coli3179
HP:0040274HP:0006771Duodenal adenocarcinoma1APC CL E G H324583ORPHA:247806APC-related attenuated familial adenomatous polyposisHP:0040284 - Very rare3179
HP:0040274HP:0006771Duodenal adenocarcinoma1BMPR1A CL E G H6571076ORPHA:157794Hereditary mixed polyposis syndromeHP:0040284 - Very rare385
HP:0040274HP:0006771Duodenal adenocarcinoma1BMPR1A CL E G H6571076OMIM:174900Juvenile polyposis syndrome385
HP:0040274HP:0006771Duodenal adenocarcinoma1GREM1 CL E G H265852001ORPHA:157794Hereditary mixed polyposis syndromeHP:0040284 - Very rare9
HP:0040274HP:0006771Duodenal adenocarcinoma1MLH1 CL E G H42927127OMIM:158320Muir-Torre syndrome.1819
HP:0040274HP:0006771Duodenal adenocarcinoma1MSH2 CL E G H44367325OMIM:158320Muir-Torre syndrome.2162
HP:0040274HP:0006771Duodenal adenocarcinoma1NTHL1 CL E G H49138028OMIM:616415Familial adenomatous polyposis 32
HP:0040274HP:0006771Duodenal adenocarcinoma1NTHL1 CL E G H49138028ORPHA:454840NTHL1-related attenuated familial adenomatous polyposisHP:0040283 - Occasional2
HP:0040274HP:0006771Duodenal adenocarcinoma1SMAD4 CL E G H40896770OMIM:174900Juvenile polyposis syndrome504


Genes (9) :AAGAB APC BMPR1A COL14A1 GREM1 MLH1 MSH2 NTHL1 SMAD4

Diseases (9) :ORPHA:79501 OMIM:175100 ORPHA:247806 ORPHA:157794 OMIM:174900 OMIM:276300 OMIM:158320 OMIM:616415 ORPHA:454840
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.