Human Phenotype Ontology 
Grandparent Node:
expand
Abnormal nerve conduction velocity (HP:0040129)help
Parent Node:
expand
Abnormal motor nerve conduction velocity (HP:0040131)help
Parent Node:
expand
Decreased nerve conduction velocity (HP:0000762)help
..Starting node
..expand
Decreased motor nerve conduction velocity (HP:0003431)help
Term ID: 3431
Name: Decreased motor nerve conduction velocity
Synonym: Decreased motor NCV; Decreased motor nerve conduction velocities; Reduced motor nerve conduction velocity
Definition: A type of decreased nerve conduction velocity that affects the motor neuron.
Comments:
Reference: HP:0003431
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandDecreased sensory nerve conduction velocity (HP:0003448) help
..expandMotor conduction block (HP:0012078) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003431HP:0003431Decreased motor nerve conduction velocity0AARS1 CL E G H1620OMIM:613287Charcot-Marie-Tooth disease, axonal, type 2N.
HP:0003431HP:0003431Decreased motor nerve conduction velocity0ATP11A CL E G H2325013552OMIM:619851LEUKODYSTROPHY, HYPOMYELINATING, 24; HLD24
HP:0003431HP:0003431Decreased motor nerve conduction velocity0ATXN1 CL E G H631010548OMIM:164400Spinocerebellar ataxia 119
HP:0003431HP:0003431Decreased motor nerve conduction velocity0BSCL2 CL E G H2658015832OMIM:270685Spastic paraplegia 17105
HP:0003431HP:0003431Decreased motor nerve conduction velocity0CCT5 CL E G H229481618ORPHA:139578Mutilating hereditary sensory neuropathy with spastic paraplegiaHP:0040282 - Frequent56
HP:0003431HP:0003431Decreased motor nerve conduction velocity0CCT5 CL E G H229481618OMIM:256840Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive.56
HP:0003431HP:0003431Decreased motor nerve conduction velocity0CTDP1 CL E G H91502498OMIM:604168Congenital cataracts, facial dysmorphism, and neuropathy.17
HP:0003431HP:0003431Decreased motor nerve conduction velocity0DCAF8 CL E G H5071724891OMIM:610100Giant axonal neuropathy, autosomal dominant.2
HP:0003431HP:0003431Decreased motor nerve conduction velocity0DNAJC3 CL E G H56119439OMIM:616192Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus3
HP:0003431HP:0003431Decreased motor nerve conduction velocity0EGR2 CL E G H19593239OMIM:607678Charcot-Marie-Tooth disease, demyelinating, type 1D.58
HP:0003431HP:0003431Decreased motor nerve conduction velocity0EGR2 CL E G H19593239OMIM:145900Hypertrophic neuropathy of dejerine-sottas.58
HP:0003431HP:0003431Decreased motor nerve conduction velocity0EGR2 CL E G H19593239OMIM:605253Neuropathy, congenital hypomyelinating, 1, autosomal recessive.58
HP:0003431HP:0003431Decreased motor nerve conduction velocity0FBXO38 CL E G H8154528844OMIM:615575Neuronopathy, distal hereditary motor, type IID1
HP:0003431HP:0003431Decreased motor nerve conduction velocity0FGD4 CL E G H12151219125OMIM:609311Charcot-marie-tooth disease, type 4H158
HP:0003431HP:0003431Decreased motor nerve conduction velocity0FIG4 CL E G H989616873OMIM:611228Charcot-Marie-Tooth disease, type 4J.111
HP:0003431HP:0003431Decreased motor nerve conduction velocity0FXN CL E G H23953951ORPHA:95Friedreich ataxiaHP:0040283 - Occasional18
HP:0003431HP:0003431Decreased motor nerve conduction velocity0GDAP1 CL E G H5433215968OMIM:607831Charcot-Marie-Tooth disease, axonal, type 2K.108
HP:0003431HP:0003431Decreased motor nerve conduction velocity0GDAP1 CL E G H5433215968OMIM:607706Charcot-Marie-Tooth disease, axonal, with vocal cord paresis, autosomalrecessive.108
HP:0003431HP:0003431Decreased motor nerve conduction velocity0GDAP1 CL E G H5433215968OMIM:214400Charcot-Marie-Tooth disease, type 4A.108
HP:0003431HP:0003431Decreased motor nerve conduction velocity0GJB1 CL E G H27054283OMIM:302800Charcot-Marie-Tooth neuropathy, X-linked dominant, 1107
HP:0003431HP:0003431Decreased motor nerve conduction velocity0GJC2 CL E G H5716517494OMIM:608804Leukodystrophy, hypomyelinating, 2.37
HP:0003431HP:0003431Decreased motor nerve conduction velocity0HK1 CL E G H30984922ORPHA:99953Charcot-Marie-Tooth disease type 4GHP:0040281 - Very frequent11
HP:0003431HP:0003431Decreased motor nerve conduction velocity0HK1 CL E G H30984922OMIM:605285Neuropathy, hereditary motor and sensory, Russe type.11
HP:0003431HP:0003431Decreased motor nerve conduction velocity0HPDL CL E G H8484228242OMIM:619026NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE SPASTICITY AND BRAIN WHITE MATTER ABNORMALITIES; NEDSWMA
HP:0003431HP:0003431Decreased motor nerve conduction velocity0HSPB1 CL E G H33155246OMIM:606595Charcot-Marie-Tooth disease, axonal, type 2F.47
HP:0003431HP:0003431Decreased motor nerve conduction velocity0HYCC1 CL E G H8466824587OMIM:610532Leukodystrophy, hypomyelinating, 5.
HP:0003431HP:0003431Decreased motor nerve conduction velocity0JPH1 CL E G H5670414201OMIM:607831Charcot-Marie-Tooth disease, axonal, type 2K.1
HP:0003431HP:0003431Decreased motor nerve conduction velocity0KIF1B CL E G H2309516636OMIM:118210Charcot-Marie-Tooth disease, axonal, type 2A1.202
HP:0003431HP:0003431Decreased motor nerve conduction velocity0LIG3 CL E G H39806600ORPHA:298Mitochondrial neurogastrointestinal encephalomyopathyHP:0040282 - Frequent1
HP:0003431HP:0003431Decreased motor nerve conduction velocity0LITAF CL E G H951616841OMIM:601098Charcot-Marie-Tooth disease, demyelinating, type 1C.74
HP:0003431HP:0003431Decreased motor nerve conduction velocity0LMNA CL E G H40006636ORPHA:98856Charcot-Marie-Tooth disease type 2B1645
HP:0003431HP:0003431Decreased motor nerve conduction velocity0LMNA CL E G H40006636OMIM:605588Charcot-Marie-Tooth disease, axonal, type 2B1.645
HP:0003431HP:0003431Decreased motor nerve conduction velocity0LRSAM1 CL E G H9067825135OMIM:614436Charcot-Marie-Tooth disease, axonal, type 2P.102
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MED25 CL E G H8185728845OMIM:605589Charcot-Marie-Tooth disease, axonal, type 2B2.43
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MFN2 CL E G H992716877OMIM:609260Charcot-marie-tooth disease, axonal, type 2A2A203
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MFN2 CL E G H992716877OMIM:601152Hereditary motor and sensory neuropathy VI.203
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MORC2 CL E G H2288023573OMIM:616688Charcot-Marie-Tooth disease, axonal, type 2Z8
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MPZ CL E G H43597225OMIM:118200Charcot-Marie-Tooth disease, demyelinating, type 1B.134
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MPZ CL E G H43597225OMIM:145900Hypertrophic neuropathy of dejerine-sottas.134
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MPZ CL E G H43597225OMIM:618184Neuropathy, congenital hypomyelinating, 2.134
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MPZ CL E G H43597225ORPHA:3115Roussy-Lévy syndromeHP:0040282 - Frequent134
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MPZ CL E G H43597225OMIM:180800Roussy-Levy hereditary areflexic dystasia.134
HP:0003431HP:0003431Decreased motor nerve conduction velocity0MTMR2 CL E G H88987450OMIM:601382Charcot-Marie-Tooth disease, type 4B1.88
HP:0003431HP:0003431Decreased motor nerve conduction velocity0NALCN CL E G H25923219082OMIM:615419Hypotonia, infantile, with psychomotor retardation and characteristic facies 1.48
HP:0003431HP:0003431Decreased motor nerve conduction velocity0NDRG1 CL E G H103977679ORPHA:99950Charcot-Marie-Tooth disease type 4DHP:0040281 - Very frequent82
HP:0003431HP:0003431Decreased motor nerve conduction velocity0NEFL CL E G H47477739OMIM:607684Charcot-Marie-Tooth disease, axonal, type 2E.118
HP:0003431HP:0003431Decreased motor nerve conduction velocity0NEFL CL E G H47477739OMIM:607734Charcot-Marie-Tooth disease, demyelinating, type 1F.118
HP:0003431HP:0003431Decreased motor nerve conduction velocity0NOTCH2NLC CL E G H10099671753924OMIM:603472NEURONAL INTRANUCLEAR INCLUSION DISEASE
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PLEKHG5 CL E G H5744929105OMIM:615376Charcot-Marie-Tooth disease, recessive intermediate C.186
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118OMIM:118300Charcot-Marie-Tooth disease and deafness.79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118ORPHA:101081Charcot-Marie-Tooth disease type 1AHP:0040282 - Frequent79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118OMIM:118220Charcot-Marie-Tooth disease, demyelinating, type 1A.79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118ORPHA:640Hereditary neuropathy with liability to pressure palsiesHP:0040281 - Very frequent79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118OMIM:145900Hypertrophic neuropathy of dejerine-sottas.79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118OMIM:162500Neuropathy, hereditary, with liability to pressure palsies.79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118ORPHA:3115Roussy-Lévy syndromeHP:0040282 - Frequent79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PMP22 CL E G H53769118OMIM:180800Roussy-Levy hereditary areflexic dystasia.79
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PNKP CL E G H112849154OMIM:605589Charcot-Marie-Tooth disease, axonal, type 2B2.244
HP:0003431HP:0003431Decreased motor nerve conduction velocity0POLG CL E G H54289179ORPHA:298Mitochondrial neurogastrointestinal encephalomyopathyHP:0040282 - Frequent464
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PRPS1 CL E G H56319462ORPHA:1187Lethal ataxia with deafness and optic atrophyHP:0040281 - Very frequent49
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PRX CL E G H5771613797OMIM:614895Charcot-Marie-Tooth disease, demyelinating, type 4F.170
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PRX CL E G H5771613797OMIM:145900Hypertrophic neuropathy of dejerine-sottas.170
HP:0003431HP:0003431Decreased motor nerve conduction velocity0PTRH2 CL E G H5165124265ORPHA:456312Infantile multisystem neurologic-endocrine-pancreatic diseaseHP:0040283 - Occasional6
HP:0003431HP:0003431Decreased motor nerve conduction velocity0RAB7A CL E G H78799788OMIM:600882Charcot-Marie-Tooth disease, axonal, type 2B.50
HP:0003431HP:0003431Decreased motor nerve conduction velocity0REEP1 CL E G H6505525786OMIM:614751Neuronopathy, distal hereditary motor, type VB.87
HP:0003431HP:0003431Decreased motor nerve conduction velocity0RRM2B CL E G H5048417296ORPHA:298Mitochondrial neurogastrointestinal encephalomyopathyHP:0040282 - Frequent125
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SACS CL E G H2627810519OMIM:270550Spastic ataxia, Charlevoix-Saguenay type309
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SBF2 CL E G H818462135OMIM:604563Charcot-Marie-Tooth disease, type 4B2.180
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SETX CL E G H23064445OMIM:606002Spinocerebellar ataxia, autosomal recessive 1.162
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SH3TC2 CL E G H7962829427ORPHA:99949Charcot-Marie-Tooth disease type 4C493
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SH3TC2 CL E G H7962829427OMIM:601596Charcot-Marie-Tooth disease, type 4C.493
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SIGMAR1 CL E G H102808157OMIM:605726Spinal muscular atrophy, distal, autosomal recessive, 2.6
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SLC12A6 CL E G H999010914OMIM:620068163
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SLC12A6 CL E G H999010914OMIM:218000Agenesis of the corpus callosum with peripheral neuropathy.163
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SORD CL E G H665211184OMIM:618912SORBITOL DEHYDROGENASE DEFICIENCY WITH PERIPHERAL NEUROPATHY; SORDD
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SPTLC1 CL E G H1055811277OMIM:162400Neuropathy, hereditary sensory and autonomic, type IA54
HP:0003431HP:0003431Decreased motor nerve conduction velocity0SPTLC2 CL E G H951711278OMIM:613640Neuropathy, hereditary sensory and autonomic, type IC149
HP:0003431HP:0003431Decreased motor nerve conduction velocity0TBC1D20 CL E G H12863716133OMIM:615663Warburg micro syndrome 415
HP:0003431HP:0003431Decreased motor nerve conduction velocity0TYMP CL E G H18903148ORPHA:298Mitochondrial neurogastrointestinal encephalomyopathyHP:0040282 - Frequent138
HP:0003431HP:0003431Decreased motor nerve conduction velocity0UQCRC1 CL E G H738412585OMIM:619279PARKINSONISM WITH POLYNEUROPATHY; PKNPY
HP:0003431HP:0003431Decreased motor nerve conduction velocity0YARS1 CL E G H856512840OMIM:608323Charcot-Marie-Tooth disease, dominant intermediate C


Genes (58) :AARS1 ATP11A ATXN1 BSCL2 CCT5 CTDP1 DCAF8 DNAJC3 EGR2 FBXO38 FGD4 FIG4 FXN GDAP1 GJB1 GJC2 HK1 HPDL HSPB1 HYCC1 JPH1 KIF1B LIG3 LITAF LMNA LRSAM1 MED25 MFN2 MORC2 MPZ MTMR2 NALCN NDRG1 NEFL NOTCH2NLC PLEKHG5 PMP22 PNKP POLG PRPS1 PRX PTRH2 RAB7A REEP1 RRM2B SACS SBF2 SETX SH3TC2 SIGMAR1 SLC12A6 SORD SPTLC1 SPTLC2 TBC1D20 TYMP UQCRC1 YARS1

Diseases (71) :OMIM:613287 OMIM:619851 OMIM:164400 OMIM:270685 ORPHA:139578 OMIM:256840 OMIM:604168 OMIM:610100 OMIM:616192 OMIM:607678 OMIM:145900 OMIM:605253 OMIM:615575 OMIM:609311 OMIM:611228 ORPHA:95 OMIM:607831 OMIM:607706 OMIM:214400 OMIM:302800 OMIM:608804 ORPHA:99953 OMIM:605285 OMIM:619026 OMIM:606595 OMIM:610532 OMIM:118210 ORPHA:298 OMIM:601098 ORPHA:98856 OMIM:605588 OMIM:614436 OMIM:605589 OMIM:609260 OMIM:601152 OMIM:616688 OMIM:118200 OMIM:618184 ORPHA:3115 OMIM:180800 OMIM:601382 OMIM:615419 ORPHA:99950 OMIM:607684 OMIM:607734 OMIM:603472 OMIM:615376 OMIM:118300 ORPHA:101081 OMIM:118220 ORPHA:640 OMIM:162500 ORPHA:1187 OMIM:614895 ORPHA:456312 OMIM:600882 OMIM:614751 OMIM:270550 OMIM:604563 OMIM:606002 ORPHA:99949 OMIM:601596 OMIM:605726 OMIM:620068 OMIM:218000 OMIM:618912 OMIM:162400 OMIM:613640 OMIM:615663 OMIM:619279 OMIM:608323
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.