Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the face (HP:0000271)help
Parent Node:
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Abnormality of the forehead (HP:0000290)help
..Starting node
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Narrow forehead (HP:0000341)help
Term ID: 341
Name: Narrow forehead
Synonym: Bitemporal narrowing; Bitemporal narrowness; Bitemporal skull narrowing; Decreased width of the forehead; Intertemporal narrowing; Narrow bitemporal diameter; Narrow bitemporal width; Narrow forehead; Temporal narrowness
Definition: Width of the forehead or distance between the frontotemporales is more than two standard deviations below the mean (objective); or apparently narrow intertemporal region (subjective).
Comments:
Reference: HP:0000341
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormality of frontalis muscle belly (HP:3000004) help
..expandAbnormality of the frontal hairline (HP:0000599) help
..expandAbnormality of the glabella (HP:0002056) help
..expandAbnormality of the metopic suture (HP:0005556) help
..expandBroad forehead (HP:0000337) help
..expandFlat forehead (HP:0004425) help
..expandForehead hyperpigmentation (HP:0005336) help
..expandFrontal bossing (HP:0002007) help
..expandFrontal hirsutism (HP:0011335) help
..expandHigh forehead (HP:0000348) help
..expandLarge forehead (HP:0002003) help
..expandProminent forehead (HP:0011220) help
..expandSloping forehead (HP:0000340) help
..expandSmall forehead (HP:0000350) help
..expandVertical forehead creases (HP:0011221) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0000341HP:0000341Narrow forehead0AMER1 CL E G H139285300373Osteopathia striata with cranial sclerosis300373C0432268OMIM14121926837300647
HP:0000341HP:0000341Narrow forehead0AMPD2 CL E G H271615809Pontocerebellar hypoplasia, type 9615809C4014354OMIM11898469102771
HP:0000341HP:0000341Narrow forehead0AP4B1 CL E G H10717614066Spastic paraplegia 47, autosomal recessive614066C3279738OMIM121140572607245
HP:0000341HP:0000341Narrow forehead0AP4E1 CL E G H23431613744Spastic paraplegia 51, autosomal recessive613744C3151056OMIM118178573607244
HP:0000341HP:0000341Narrow forehead0AP4M1 CL E G H9179612936Spastic paraplegia 50, autosomal recessive612936C2752008OMIM115150574602296
HP:0000341HP:0000341Narrow forehead0ASPM CL E G H259266608716Primary autosomal recessive microcephaly 5608716C1837501OMIM121379019048605481
HP:0000341HP:0000341Narrow forehead0ASXL1 CL E G H171023605039C-like syndrome605039C0796232OMIM14119918318612990
HP:0000341HP:0000341Narrow forehead0ATRX CL E G H546309580Mental retardation-hypotonic facies syndrome X-linked, 1309580C0796003OMIM1170663886300032
HP:0000341HP:0000341Narrow forehead0BMP2 CL E G H650617877SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIES617877CN807949OMIM137691069112261
HP:0000341HP:0000341Narrow forehead0BRAF CL E G H673115150Cardiofaciocutaneous syndrome 1115150CN029449OMIM1684901097164757
HP:0000341HP:0000341Narrow forehead0BRAF CL E G H673613706Noonan syndrome 7613706C3150970OMIM1684901097164757
HP:0000341HP:0000341Narrow forehead0CCDC47 CL E G H57003618268618268618268OMIM1520248560
HP:0000341HP:0000341Narrow forehead0CCDC88A CL E G H55704617507PEHO-like syndrome617507C1850056OMIM145625523609736
HP:0000341HP:0000341Narrow forehead0CDC42 CL E G H998616737Takenouchi-Kosaki syndrome616737C4225222OMIM111331736116952
HP:0000341HP:0000341Narrow forehead0CDH11 CL E G H1009211380Brachioskeletogenital syndrome211380C0809936OMIM110401750600023
HP:0000341HP:0000341Narrow forehead0COG7 CL E G H91949608779COG7 congenital disorder of glycosylation608779C2931010OMIM1515918622606978
HP:0000341HP:0000341Narrow forehead0CTU2 CL E G H348180618142MICROCEPHALY, FACIAL DYSMORPHISM, RENAL AGENESIS, AND AMBIGUOUS GENITALIA SYNDROME618142OMIM1410328005617057
HP:0000341HP:0000341Narrow forehead0DCHS1 CL E G H8642601390601390601390OMIM12418013681603057
HP:0000341HP:0000341Narrow forehead0DHCR7 CL E G H1717270400Smith-Lemli-Opitz syndrome270400C0175694OMIM12183762860602858
HP:0000341HP:0000341Narrow forehead0DOCK7 CL E G H85440615859Epileptic encephalopathy, early infantile, 23615859C4014492OMIM1744619190615730
HP:0000341HP:0000341Narrow forehead0DYRK1A CL E G H1859614104Mental retardation, autosomal dominant 7614104C3279839OMIM1774373091600855
HP:0000341HP:0000341Narrow forehead0ELN CL E G H2006194050Williams syndrome194050C0175702OMIM11275233327130160
HP:0000341HP:0000341Narrow forehead0FAT4 CL E G H79633615546Van Maldergem syndrome 2615546C3809875OMIM13731723109612411
HP:0000341HP:0000341Narrow forehead0FRMD4A CL E G H55691466688ORPHA125325491616305
HP:0000341HP:0000341Narrow forehead0FRMD4A CL E G H55691616819Corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia616819C4225193OMIM125325491616305
HP:0000341HP:0000341Narrow forehead0FUT8 CL E G H2530618005CONGENITAL DISORDER OF GLYCOSYLATION WITH DEFECTIVE FUCOSYLATION618005CN248517OMIM15284019602589
HP:0000341HP:0000341Narrow forehead0GNPTAB CL E G H79158252500I cell disease252500C2673377OMIM118846229670607840
HP:0000341HP:0000341Narrow forehead0GPAA1 CL E G H8733617810GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 15617810C4540520OMIM111774446603048
HP:0000341HP:0000341Narrow forehead0GTPBP2 CL E G H54676617988JABERI-ELAHI SYNDROME617988CN244943OMIM15214670607434
HP:0000341HP:0000341Narrow forehead0HERC2 CL E G H8924176270Prader-Willi syndrome176270C0032897OMIM164824868605837
HP:0000341HP:0000341Narrow forehead0IER3IP1 CL E G H51124614231Microcephaly, epilepsy, and diabetes syndrome614231C3280240OMIM148318550609382
HP:0000341HP:0000341Narrow forehead0IFT140 CL E G H9742266920Renal dysplasia, retinal pigmentary dystrophy, cerebellar ataxia and skeletal dysplasia266920C1849437OMIM17253029077614620
HP:0000341HP:0000341Narrow forehead0IPW CL E G H3653176270Prader-Willi syndrome176270C0032897OMIM13116109601491
HP:0000341HP:0000341Narrow forehead0KAT6A CL E G H7994457193ORPHA12921913013601408
HP:0000341HP:0000341Narrow forehead0KAT6A CL E G H7994616268Mental retardation, autosomal dominant 32616268C4225396OMIM12921913013601408
HP:0000341HP:0000341Narrow forehead0KCNK9 CL E G H51305612292Birk Barel mental retardation dysmorphism syndrome612292C2676770OMIM12656283605874
HP:0000341HP:0000341Narrow forehead0LAGE3 CL E G H8270301006GALLOWAY-MOWAT SYNDROME 2, X-LINKED301006C4538784OMIM1321926058300060
HP:0000341HP:0000341Narrow forehead0LGI4 CL E G H163175617468Arthrogryposis multiplex congenita, neurogenic, with myelin defect617468C4479539OMIM194818712608303
HP:0000341HP:0000341Narrow forehead0MAGEL2 CL E G H54551176270Prader-Willi syndrome176270C0032897OMIM1204536814605283
HP:0000341HP:0000341Narrow forehead0MAGEL2 CL E G H54551615547Schaaf-yang syndrome615547C3809877OMIM1204536814605283
HP:0000341HP:0000341Narrow forehead0MAP2K2 CL E G H5605615280Cardiofaciocutaneous syndrome 4615280C3809007OMIM1353386842601263
HP:0000341HP:0000341Narrow forehead0MED13L CL E G H23389616789Mental retardation and distinctive facial features with or without cardiac defects616789C4225208OMIM18135022962608771
HP:0000341HP:0000341Narrow forehead0MEIS2 CL E G H4212261190ORPHA123577001601740
HP:0000341HP:0000341Narrow forehead0MEIS2 CL E G H4212600987Cleft palate, cardiac defects, and mental retardation600987C1832950OMIM123577001601740
HP:0000341HP:0000341Narrow forehead0MKRN3 CL E G H7681176270Prader-Willi syndrome176270C0032897OMIM1323317114603856
HP:0000341HP:0000341Narrow forehead0MKRN3-AS1 CL E G H10108176270Prader-Willi syndrome176270C0032897OMIM112910603857
HP:0000341HP:0000341Narrow forehead0MLXIPL CL E G H51085194050Williams syndrome194050C0175702OMIM1619712744605678
HP:0000341HP:0000341Narrow forehead0NBAS CL E G H51594614800Short stature, optic nerve atrophy, and Pelger-Huet anomaly614800C3541319OMIM14415615625608025
HP:0000341HP:0000341Narrow forehead0NDN CL E G H4692176270Prader-Willi syndrome176270C0032897OMIM123147675602117
HP:0000341HP:0000341Narrow forehead0NEXMIF CL E G H340533300912Mental retardation, X-linked 98300912C3806730OMIM14146829433300524
HP:0000341HP:0000341Narrow forehead0NPAP1 CL E G H23742176270Prader-Willi syndrome176270C0032897OMIM13431190610922
HP:0000341HP:0000341Narrow forehead0NUP107 CL E G H57122616730Nephrotic syndrome, type 11616730C4225228OMIM1124029914607617
HP:0000341HP:0000341Narrow forehead0OSGEP CL E G H55644617729GALLOWAY-MOWAT SYNDROME 3617729C4540266OMIM1174618028610107
HP:0000341HP:0000341Narrow forehead0PIGN CL E G H23556614080Multiple congenital anomalies-hypotonia-seizures syndrome 1614080C3279775OMIM1344168967606097
HP:0000341HP:0000341Narrow forehead0PIGT CL E G H51604615398Multiple congenital anomalies-hypotonia-seizures syndrome 3615398C3809356OMIM1127214938610272
HP:0000341HP:0000341Narrow forehead0PIGY CL E G H84992616809Hyperphosphatasia with mental retardation syndrome 6616809C4225201OMIM122328213610662
HP:0000341HP:0000341Narrow forehead0PPP2R5D CL E G H5528616355Mental retardation, autosomal dominant 35616355C4225354OMIM111419312601646
HP:0000341HP:0000341Narrow forehead0PUF60 CL E G H22827615583Verheij syndrome615583C3810023OMIM13212917042604819
HP:0000341HP:0000341Narrow forehead0PUM1 CL E G H9698617931SPINOCEREBELLAR ATAXIA 47617931CN244564OMIM1123214957607204
HP:0000341HP:0000341Narrow forehead0PWAR1 CL E G H145624176270Prader-Willi syndrome176270C0032897OMIM131130089600161
HP:0000341HP:0000341Narrow forehead0PWRN1 CL E G H791114176270Prader-Willi syndrome176270C0032897OMIM132233235611215
HP:0000341HP:0000341Narrow forehead0PYCR2 CL E G H29920616420Leukodystrophy, hypomyelinating, 10616420C4225332OMIM1136330262616406
HP:0000341HP:0000341Narrow forehead0QARS CL E G H5859615760Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy615760C4014239OMIM1109751603727
HP:0000341HP:0000341Narrow forehead0RARS2 CL E G H57038611523Pontocerebellar hypoplasia type 6611523C1969084OMIM13721621406611524
HP:0000341HP:0000341Narrow forehead0RBBP8 CL E G H5932606744Seckel syndrome 2606744C1847572OMIM161089891604124
HP:0000341HP:0000341Narrow forehead0RYR1 CL E G H6261324581ORPHA1688309410483180901
HP:0000341HP:0000341Narrow forehead0SC5D CL E G H630946059ORPHA1618210547602286
HP:0000341HP:0000341Narrow forehead0SERPINH1 CL E G H871613848Osteogenesis imperfecta type 10613848C3151211OMIM181031546600943
HP:0000341HP:0000341Narrow forehead0SETBP1 CL E G H26040798ORPHA14721215573611060
HP:0000341HP:0000341Narrow forehead0SLC12A6 CL E G H9990218000Andermann syndrome218000C0795950OMIM12038710914604878
HP:0000341HP:0000341Narrow forehead0SLC16A2 CL E G H6567300523Allan-Herndon-Dudley syndrome300523C0795889OMIM18825710923300095
HP:0000341HP:0000341Narrow forehead0SLC25A46 CL E G H91137616505NEUROPATHY, HEREDITARY MOTOR AND SENSORY, TYPE VIB616505C4225302OMIM11717425198610826
HP:0000341HP:0000341Narrow forehead0SMC1A CL E G H8243300590Congenital muscular hypertrophy-cerebral syndrome300590C1802395OMIM110048411111300040
HP:0000341HP:0000341Narrow forehead0SMG9 CL E G H56006616920Heart and brain malformation syndrome616920C4310793OMIM122925763613176
HP:0000341HP:0000341Narrow forehead0SNORD115-1 CL E G H338433176270Prader-Willi syndrome176270C0032897OMIM131333020609837
HP:0000341HP:0000341Narrow forehead0SNORD116-1 CL E G H100033413176270Prader-Willi syndrome176270C0032897OMIM131433067605436
HP:0000341HP:0000341Narrow forehead0SNRPN CL E G H6638176270Prader-Willi syndrome176270C0032897OMIM12538511164182279
HP:0000341HP:0000341Narrow forehead0TBCK CL E G H93627616900Hypotonia, infantile, with psychomotor retardation and characteristic facies 3616900C4225161OMIM1169628261616899
HP:0000341HP:0000341Narrow forehead0TCF4 CL E G H69252896Hypogonadism retinitis pigmentosaORPHA114862411634602272
HP:0000341HP:0000341Narrow forehead0TCF4 CL E G H6925610954Pitt-Hopkins syndrome610954C1970431OMIM114862411634602272
HP:0000341HP:0000341Narrow forehead0TMCO1 CL E G H54499213980Craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome213980C1859252OMIM153318188614123
HP:0000341HP:0000341Narrow forehead0TRAPPC9 CL E G H83696352530ORPHA11829830832611966
HP:0000341HP:0000341Narrow forehead0USP9X CL E G H8239300968Mental retardation, X-linked 99, syndromic, female-restricted300968C4225416OMIM12826912632300072
HP:0000341HP:0000341Narrow forehead0WDR35 CL E G H57539613610Cranioectodermal dysplasia 2613610C3150874OMIM13129229250613602
HP:0000341HP:0000341Narrow forehead0ZNHIT3 CL E G H9326260565PEHO syndrome260565C1850055OMIM119912309604500
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000341HP:0000341Narrow forehead0AP4B1 CL E G H10717280763ORPHA021140572607245
HP:0000341HP:0000341Narrow forehead0AP4E1 CL E G H23431280763ORPHA018178573607244
HP:0000341HP:0000341Narrow forehead0AP4M1 CL E G H9179280763ORPHA015150574602296
HP:0000341HP:0000341Narrow forehead0AP4S1 CL E G H11154280763ORPHA0859575607243
HP:0000341HP:0000341Narrow forehead0GPT2 CL E G H84706477673ANO5-Related DisordersCN239193ORPHA0105818062138210
HP:0000341HP:0000341Narrow forehead0NAA10 CL E G H8260276432ORPHA01029618704300013
HP:0000341HP:0000341Narrow forehead0PSPH CL E G H572379350ORPHA091099577172480
HP:0000341HP:0000341Narrow forehead0PUF60 CL E G H22827508488ORPHA03212917042604819
HP:0000341HP:0000341Narrow forehead0SC5D CL E G H6309607330Lathosterolosis607330C1846421OMIM0618210547602286
HP:0000341HP:0000341Narrow forehead0SON CL E G H6651500150ORPHA02822411183182465
HP:0000341HP:0000341Narrow forehead0ZIC2 CL E G H7546609637Holoprosencephaly 5609637C1864827OMIM012315412873603073


Genes (85) :AMER1 AMPD2 AP4B1 AP4E1 AP4M1 AP4S1 ASPM ASXL1 ATRX BMP2 BRAF CCDC47 CCDC88A CDC42 CDH11 COG7 CTU2 DCHS1 DHCR7 DOCK7 DYRK1A ELN FAT4 FRMD4A FUT8 GNPTAB GPAA1 GPT2 GTPBP2 HERC2 IER3IP1 IFT140 IPW KAT6A KCNK9 LAGE3 LGI4 MAGEL2 MAP2K2 MED13L MEIS2 MKRN3 MKRN3-AS1 MLXIPL NAA10 NBAS NDN NEXMIF NPAP1 NUP107 OSGEP PIGN PIGT PIGY PPP2R5D PSPH PUF60 PUM1 PWAR1 PWRN1 PYCR2 QARS RARS2 RBBP8 RYR1 SC5D SERPINH1 SETBP1 SLC12A6 SLC16A2 SLC25A46 SMC1A SMG9 SNORD115-1 SNORD116-1 SNRPN SON TBCK TCF4 TMCO1 TRAPPC9 USP9X WDR35 ZIC2 ZNHIT3

Diseases (81) :300373 615809 280763 614066 613744 612936 608716 605039 309580 617877 115150 613706 618268 617507 616737 211380 608779 618142 601390 270400 615859 614104 194050 615546 466688 616819 618005 252500 617810 477673 617988 176270 614231 266920 457193 616268 612292 301006 617468 615547 615280 616789 261190 600987 276432 614800 300912 616730 617729 614080 615398 616809 616355 79350 508488 615583 617931 616420 615760 611523 606744 324581 46059 607330 613848 798 218000 300523 616505 300590 616920 500150 616900 2896 610954 213980 352530 300968 613610 609637 260565
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.