Human Phenotype Ontology 
Grandparent Node:
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Abnormal immunoglobulin level (HP:0010701)help
Parent Node:
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Increased circulating antibody level (HP:0010702)help
..Starting node
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Increased circulating IgA level (HP:0003261)help
Term ID: 3261
Name: Increased circulating IgA level
Synonym: Elevated IgA; Elevated serum IgA; IgA hypergammaglobulinemia; Increased levels of IgA; Increased serum IgA
Definition: An abnormally increased level of immunoglobulin A in blood.
Comments:
Reference: HP:0003261
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandIncreased alpha-globulin (HP:0005413) help
..expandIncreased circulating IgE level (HP:0003212) help
..expandIncreased circulating IgG level (HP:0003237) help
..expandIncreased circulating IgM level (HP:0003496) help
..expandParaproteinemia (HP:0031047) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003261HP:0003261Increased circulating IgA level0CARD10 CL E G H2977516422OMIM:619632IMMUNODEFICIENCY 89 AND AUTOIMMUNITY; IMD895
HP:0003261HP:0003261Increased circulating IgA level0CASP10 CL E G H8431500ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional87
HP:0003261HP:0003261Increased circulating IgA level0CASP10 CL E G H8431500OMIM:603909Autoimmune lymphoproliferative syndrome, type IIA.87
HP:0003261HP:0003261Increased circulating IgA level0CCND1 CL E G H5951582ORPHA:29073Multiple myelomaHP:0040283 - Occasional1
HP:0003261HP:0003261Increased circulating IgA level0CD247 CL E G H9191677OMIM:610163IMMUNODEFICIENCY 25; IMD258
HP:0003261HP:0003261Increased circulating IgA level0CD40LG CL E G H95911935OMIM:308230Immunodeficiency, X-linked, with hyper-IgM33
HP:0003261HP:0003261Increased circulating IgA level0FAS CL E G H35511920OMIM:601859Autoimmune lymphoproliferative syndrome.59
HP:0003261HP:0003261Increased circulating IgA level0FAS CL E G H35511920ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional59
HP:0003261HP:0003261Increased circulating IgA level0FASLG CL E G H35611936ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional37
HP:0003261HP:0003261Increased circulating IgA level0FASLG CL E G H35611936OMIM:601859Autoimmune lymphoproliferative syndrome.37
HP:0003261HP:0003261Increased circulating IgA level0GTF2H5 CL E G H40467221157OMIM:616395Trichothiodystrophy 3, photosensitive3
HP:0003261HP:0003261Increased circulating IgA level0IKBKG CL E G H85175961OMIM:300291ECTODERMAL DYSPLASIA AND IMMUNODEFICIENCY 1; EDAID152
HP:0003261HP:0003261Increased circulating IgA level0IKBKG CL E G H85175961OMIM:300636Immunodeficiency 3352
HP:0003261HP:0003261Increased circulating IgA level0IL12A CL E G H35925969ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional
HP:0003261HP:0003261Increased circulating IgA level0IL12RB1 CL E G H35945971ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional46
HP:0003261HP:0003261Increased circulating IgA level0IL7R CL E G H35756024ORPHA:169154T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiencyHP:0040283 - Occasional94
HP:0003261HP:0003261Increased circulating IgA level0IRF5 CL E G H36636120ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional4
HP:0003261HP:0003261Increased circulating IgA level0MMEL1 CL E G H7925814668ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional
HP:0003261HP:0003261Increased circulating IgA level0MVK CL E G H45987530OMIM:260920Hyper-Igd syndrome150
HP:0003261HP:0003261Increased circulating IgA level0MVK CL E G H45987530ORPHA:343Hyperimmunoglobulinemia D with periodic feverHP:0040281 - Very frequent150
HP:0003261HP:0003261Increased circulating IgA level0NLRP1 CL E G H2286114374OMIM:617388AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSIS; AIADK37
HP:0003261HP:0003261Increased circulating IgA level0OTULIN CL E G H9026825118OMIM:617099AUTOINFLAMMATION, PANNICULITIS, AND DERMATOSIS SYNDROME; AIPDS3
HP:0003261HP:0003261Increased circulating IgA level0PGM3 CL E G H52388907ORPHA:443811PGM3-CDGHP:0040283 - Occasional15
HP:0003261HP:0003261Increased circulating IgA level0POMP CL E G H5137120330OMIM:618048Proteasome-Associated autoinflammatory syndrome 22
HP:0003261HP:0003261Increased circulating IgA level0POU2AF1 CL E G H54509211ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional
HP:0003261HP:0003261Increased circulating IgA level0PRKCD CL E G H55809399ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional10
HP:0003261HP:0003261Increased circulating IgA level0PSMB8 CL E G H56969545OMIM:256040Proteasome-associated autoinflammatory syndrome 1 and digenic forms20
HP:0003261HP:0003261Increased circulating IgA level0RASGRP1 CL E G H101259878ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040283 - Occasional
HP:0003261HP:0003261Increased circulating IgA level0RASGRP1 CL E G H101259878OMIM:618534IMMUNODEFICIENCY 64; IMD64
HP:0003261HP:0003261Increased circulating IgA level0SPIB CL E G H668911242ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional
HP:0003261HP:0003261Increased circulating IgA level0STING1 CL E G H34006127962OMIM:615934STING-associated vasculopathy, infantile-onset
HP:0003261HP:0003261Increased circulating IgA level0TNFSF15 CL E G H996611931ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional
HP:0003261HP:0003261Increased circulating IgA level0TNPO3 CL E G H2353417103ORPHA:186Primary biliary cholangitisHP:0040283 - Occasional71
HP:0003261HP:0003261Increased circulating IgA level0WAS CL E G H745412731OMIM:313900Thrombocytopenia 1.65
HP:0003261HP:0003261Increased circulating IgA level0WAS CL E G H745412731OMIM:301000Wiskott-Aldrich syndrome.65
HP:0003261HP:0032335Monoclonal elevation of circulating IgA1 CL E G H
HP:0003261HP:0032334Oligoclonal elevation of circulating IgA1 CL E G H
HP:0003261HP:0032333Polyclonal elevation of circulating IgA1 CL E G H


Genes (28) :CARD10 CASP10 CCND1 CD247 CD40LG FAS FASLG GTF2H5 IKBKG IL12A IL12RB1 IL7R IRF5 MMEL1 MVK NLRP1 OTULIN PGM3 POMP POU2AF1 PRKCD PSMB8 RASGRP1 SPIB STING1 TNFSF15 TNPO3 WAS

Diseases (23) :OMIM:619632 ORPHA:3261 OMIM:603909 ORPHA:29073 OMIM:610163 OMIM:308230 OMIM:601859 OMIM:616395 OMIM:300291 OMIM:300636 ORPHA:186 ORPHA:169154 OMIM:260920 ORPHA:343 OMIM:617388 OMIM:617099 ORPHA:443811 OMIM:618048 OMIM:256040 OMIM:618534 OMIM:615934 OMIM:313900 OMIM:301000
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.