Human Phenotype Ontology

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	AIFM1 CL E G H	9131	8768	OMIM:300816	Combined oxidative phosphorylation deficiency 6	.	60
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ALG14 CL E G H	199857	28287	ORPHA:353327	Congenital myasthenic syndromes with glycosylation defect	HP:0040283 - Occasional	12
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ALG2 CL E G H	85365	23159	ORPHA:353327	Congenital myasthenic syndromes with glycosylation defect	HP:0040283 - Occasional	46
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ALG2 CL E G H	85365	23159	OMIM:616228	Myasthenic syndrome, congenital, 14	HP:0040283 - Occasional	46
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ATP6 CL E G H	4508	7414	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ATP8 CL E G H	4509	7415	ORPHA:480	Kearns-Sayre syndrome	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	BCS1L CL E G H	617	1020	OMIM:124000	Mitochondrial complex III deficiency, nuclear type 1	.	72
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	CARS2 CL E G H	79587	25695	ORPHA:477774	Combined oxidative phosphorylation defect type 27	HP:0040282 - Frequent	35
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	CHCHD10 CL E G H	400916	15559	ORPHA:457050	Autosomal dominant mitochondrial myopathy with exercise intolerance	HP:0040282 - Frequent	11
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	CHCHD10 CL E G H	400916	15559	ORPHA:276435	Lower motor neuron syndrome with late-adult onset	HP:0040283 - Occasional	11
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	CHCHD10 CL E G H	400916	15559	OMIM:616209	Myopathy, isolated mitochondrial, autosomal dominant		11
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COQ2 CL E G H	27235	25223	OMIM:607426	Coenzyme Q10 deficiency, primary, 1	.	54
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COX1 CL E G H	4512	7419	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COX1 CL E G H	4512	7419	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COX2 CL E G H	4513	7421	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COX2 CL E G H	4513	7421	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COX3 CL E G H	4514	7422	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	COX3 CL E G H	4514	7422	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	CYTB CL E G H	4519	7427	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	DGUOK CL E G H	1716	2858	OMIM:617070	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4	.	57
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	DPAGT1 CL E G H	1798	2995	ORPHA:353327	Congenital myasthenic syndromes with glycosylation defect	HP:0040283 - Occasional	38
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	EARS2 CL E G H	124454	29419	OMIM:614924	Combined oxidative phosphorylation deficiency 12	.	80
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	GFPT1 CL E G H	2673	4241	ORPHA:353327	Congenital myasthenic syndromes with glycosylation defect	HP:0040283 - Occasional	128
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	GMPPB CL E G H	29925	22932	ORPHA:353327	Congenital myasthenic syndromes with glycosylation defect	HP:0040283 - Occasional	34
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	LIG3 CL E G H	3980	6600	ORPHA:298	Mitochondrial neurogastrointestinal encephalomyopathy	HP:0040282 - Frequent	1
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	MGME1 CL E G H	92667	16205	OMIM:615084	Mitochondrial DNA depletion syndrome 11		11
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	MGME1 CL E G H	92667	16205	ORPHA:352447	Progressive external ophthalmoplegia-myopathy-emaciation syndrome	HP:0040282 - Frequent	11
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	MIEF2 CL E G H	125170	17920	OMIM:619024	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 49; COXPD49
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	MYH7 CL E G H	4625	7577	OMIM:160500	Myopathy, distal, 1	.	1269
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND1 CL E G H	4535	7455	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND1 CL E G H	4535	7455	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND1 CL E G H	4535	7455	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND2 CL E G H	4536	7456	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND3 CL E G H	4537	7458	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND4 CL E G H	4538	7459	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND4 CL E G H	4538	7459	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND5 CL E G H	4540	7461	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND5 CL E G H	4540	7461	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND5 CL E G H	4540	7461	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND5 CL E G H	4540	7461	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND6 CL E G H	4541	7462	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND6 CL E G H	4541	7462	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	ND6 CL E G H	4541	7462	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	NDUFS4 CL E G H	4724	7711	OMIM:252010	Mitochondrial complex I deficiency, nuclear type 1		27
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	NEFH CL E G H	4744	7737	OMIM:616924	Charcot-Marie-Tooth disease, axonal, type 2CC		24
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	NUBPL CL E G H	80224	20278	OMIM:618242	Mitochondrial complex I deficiency, nuclear type 21		89
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	PABPN1 CL E G H	8106	8565	ORPHA:270	Oculopharyngeal muscular dystrophy	HP:0040281 - Very frequent	10
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	ORPHA:254892	Autosomal dominant progressive external ophthalmoplegia	HP:0040282 - Frequent	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	ORPHA:254886	Autosomal recessive progressive external ophthalmoplegia	HP:0040282 - Frequent	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	OMIM:603041	Mitochondrial DNA depletion syndrome 1 (mngie type)	.	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	OMIM:613662	Mitochondrial DNA depletion syndrome 4B (mngie type)		464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	ORPHA:298	Mitochondrial neurogastrointestinal encephalomyopathy	HP:0040282 - Frequent	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	OMIM:157640	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1	.	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	OMIM:258450	Progressive external ophthalmoplegia with mitochondrial DNA deletions,autosomal recessive	.	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	OMIM:607459	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	.	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG CL E G H	5428	9179	ORPHA:70595	Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome	HP:0040282 - Frequent	464
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	POLG2 CL E G H	11232	9180	ORPHA:254892	Autosomal dominant progressive external ophthalmoplegia	HP:0040282 - Frequent	45
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	RNR1 CL E G H	4549	7470	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	RRM2B CL E G H	50484	17296	ORPHA:254892	Autosomal dominant progressive external ophthalmoplegia	HP:0040282 - Frequent	125
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	RRM2B CL E G H	50484	17296	ORPHA:480	Kearns-Sayre syndrome	HP:0040282 - Frequent	125
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	RRM2B CL E G H	50484	17296	ORPHA:298	Mitochondrial neurogastrointestinal encephalomyopathy	HP:0040282 - Frequent	125
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SDHA CL E G H	6389	10680	OMIM:252011	Mitochondrial complex II deficiency	.	304
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SLC25A26 CL E G H	115286	20661	OMIM:616794	Combined oxidative phosphorylation deficiency 28		5
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SLC25A32 CL E G H	81034	29683	OMIM:616839	EXERCISE INTOLERANCE, RIBOFLAVIN-RESPONSIVE; RREI		3
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SLC25A4 CL E G H	291	10990	ORPHA:254892	Autosomal dominant progressive external ophthalmoplegia	HP:0040282 - Frequent	68
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SLC25A4 CL E G H	291	10990	OMIM:615418	Mitochondrial DNA depletion syndrome 12 (cardiomyopathic type)		68
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SLC25A4 CL E G H	291	10990	OMIM:609283	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2	.	68
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SPG7 CL E G H	6687	11237	ORPHA:99013	Spastic paraplegia type 7	HP:0040282 - Frequent	171
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	SUCLG1 CL E G H	8802	11449	ORPHA:17	Fatal infantile lactic acidosis with methylmalonic aciduria	HP:0040283 - Occasional	60
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TK2 CL E G H	7084	11831	ORPHA:254886	Autosomal recessive progressive external ophthalmoplegia	HP:0040282 - Frequent	103
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TK2 CL E G H	7084	11831	OMIM:609560	Mitochondrial DNA depletion syndrome 2 (myopathic type)	.	103
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRMU CL E G H	55687	25481	ORPHA:254864	Mitochondrial myopathy with reversible cytochrome C oxidase deficiency	HP:0040281 - Very frequent	101
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNC CL E G H	4511	7477	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNE CL E G H	4556	7479	ORPHA:254864	Mitochondrial myopathy with reversible cytochrome C oxidase deficiency	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNF CL E G H	4558	7481	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNF CL E G H	4558	7481	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNF CL E G H	4558	7481	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNF CL E G H	4558	7481	OMIM:545000	Myoclonic epilepsy associated with ragged-red fibers	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNH CL E G H	4564	7487	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNH CL E G H	4564	7487	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNI CL E G H	4565	7488	OMIM:545000	Myoclonic epilepsy associated with ragged-red fibers	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNK CL E G H	4566	7489	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNK CL E G H	4566	7489	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNK CL E G H	4566	7489	ORPHA:1349	Mitochondrial DNA-related cardiomyopathy and hearing loss	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNK CL E G H	4566	7489	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNK CL E G H	4566	7489	OMIM:545000	Myoclonic epilepsy associated with ragged-red fibers	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	ORPHA:480	Kearns-Sayre syndrome	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	ORPHA:663	Mitochondrial DNA-related progressive external ophthalmoplegia	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL1 CL E G H	4567	7490	OMIM:545000	Myoclonic epilepsy associated with ragged-red fibers	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNL2 CL E G H	4568	7491	ORPHA:663	Mitochondrial DNA-related progressive external ophthalmoplegia	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNN CL E G H	4570	7493	ORPHA:663	Mitochondrial DNA-related progressive external ophthalmoplegia	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNP CL E G H	4571	7494	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNP CL E G H	4571	7494	OMIM:545000	Myoclonic epilepsy associated with ragged-red fibers	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNQ CL E G H	4572	7495	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNQ CL E G H	4572	7495	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNQ CL E G H	4572	7495	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS1 CL E G H	4574	7497	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS1 CL E G H	4574	7497	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS1 CL E G H	4574	7497	ORPHA:663	Mitochondrial DNA-related progressive external ophthalmoplegia	HP:0040282 - Frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS1 CL E G H	4574	7497	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS2 CL E G H	4575	7498	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS2 CL E G H	4575	7498	ORPHA:551	MERRF	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNS2 CL E G H	4575	7498	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNV CL E G H	4577	7500	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNV CL E G H	4577	7500	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNW CL E G H	4578	7501	ORPHA:550	MELAS	HP:0040281 - Very frequent
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNW CL E G H	4578	7501	ORPHA:255210	Mitochondrial DNA-associated Leigh syndrome	HP:0040284 - Very rare
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TRNW CL E G H	4578	7501	OMIM:540000	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	.
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TWNK CL E G H	56652	1160	ORPHA:254892	Autosomal dominant progressive external ophthalmoplegia	HP:0040282 - Frequent	113
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TWNK CL E G H	56652	1160	OMIM:609286	Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 3	.	113
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TWNK CL E G H	56652	1160	OMIM:607459	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	.	113
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TWNK CL E G H	56652	1160	ORPHA:70595	Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome	HP:0040282 - Frequent	113
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TYMP CL E G H	1890	3148	OMIM:603041	Mitochondrial DNA depletion syndrome 1 (mngie type)	.	138
HP:0003200	HP:0003200	Ragged-red muscle fibers	0	TYMP CL E G H	1890	3148	ORPHA:298	Mitochondrial neurogastrointestinal encephalomyopathy	HP:0040282 - Frequent	138