Human Phenotype Ontology 
Grandparent Node:
expandAbnormal respiratory system physiology (HP:0002795)help
Parent Node:
expandAbnormal mucociliary clearance (HP:0031602)help
..Starting node
..expandImpaired nasal mucociliary clearance (HP:0031603)help
Term ID: 31603
Name: Impaired nasal mucociliary clearance
Synonym: Abnormal saccharine test
Definition: An abnormally increased amount of time required to clear mucus (and substances contained in the mucus) from the nasal mucosa. The nasal mucociliary clearance (NMC) system functions to transport the mucous layer lining the nasal epithelium towards the naso pharynx by ciliary beating in a metachronous fashion at a frequency of 7-16 Hz. NMC depends upon two principal components: physicochemical qualities and quantities of mucus and the properties of cilia that propel it. NMC is considered to be representative of pulmonary clearance. normal NMC time is determined to be up to 20 minutes. Duration of 30 minutes is considered as the cutoff point that discriminates normal subjects from subjects with impaired NMC. NMC can be measured by determination of the transport time of markers that are placed on the nasal mucosa including saccharine, radioactive markers, and dyes.
Comments:
Reference: HP:0031603
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031603HP:0031603Impaired nasal mucociliary clearance0GAS2L2 CL E G H24617624846OMIM:618449Ciliary dyskinesia, primary, 411


Genes (1) :GAS2L2

Diseases (1) :OMIM:618449
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.