Human Phenotype Ontology 
Grandparent Node:
expandAbnormality of metabolism/homeostasis (HP:0001939)help
Grandparent Node:
expandAbnormality of the urinary system physiology (HP:0011277)help
Parent Node:
expandAbnormality of urine homeostasis (HP:0003110)help
..Starting node
..expandHyposthenuria (HP:0003158)help
Term ID: 3158
Name: Hyposthenuria
Synonym: Reduced urinary osmolality
Definition: An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine.
Comments:
Reference: HP:0003158
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal urinary acylglycine profile (HP:0012073) help
..expandAbnormal urinary color (HP:0012086) help
..expandAbnormal urinary electrolyte concentration (HP:0012591) help
..expandAbnormal urinary odor (HP:0012088) help
..expandAbnormal urinary sulfate concentration (HP:0012612) help
..expandAbnormal urine alpha-ketoglutarate concentration (HP:0012401) help
..expandAbnormal urine citrate concentration (HP:0012404) help
..expandAbnormal urine cytology (HP:0012614) help
..expandAbnormality of urinary uric acid level (HP:0012610) help
..expandAbnormality of urine bicarbonate level (HP:0011279) help
..expandAbnormality of urine catecholamine level (HP:0011281) help
..expandAbsent urinary urothione (HP:0003606) help
..expandAciduria (HP:0012072) help
..expandBacteriuria (HP:0012461) help
..expandBilirubinuria (HP:0031811) help
..expandElevated urine pyrophosphate (HP:0003491) help
..expandFoamy urine (HP:0031504) help
..expandHemoglobinuria (HP:0003641) help
..expandHemosiderinuria (HP:0012543) help
..expandHyperuricosuria (HP:0003149) help
..expandIncreased urinary glycerol (HP:0040301) help
..expandIncreased urinary sulfite (HP:0011942) help
..expandIncreased urinary thiosulfate (HP:0011943) help
..expandIncreased urine urobilinogen (HP:0031890) help
..expandKetonuria (HP:0002919) help
..expandLow urinary cyclic AMP response to PTH administration (HP:0003456) help
..expandMyoglobinuria (HP:0002913) help
..expandNitrituria (HP:0031812) help
..expandobsolete Abnormality of urine glucose concentration (HP:0011016) help
..expandParathormone-independent increased renal tubular calcium reabsorption (HP:0003529) help
..expandProteinuria (HP:0000093) help
..expandTrimethylaminuria (HP:0003614) help
..expandUrinary glycosaminoglycan excretion (HP:0003541) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0003158HP:0003158Hyposthenuria0AQP2 CL E G H359634ORPHA:223Nephrogenic diabetes insipidusHP:0040281 - Very frequent75
HP:0003158HP:0003158Hyposthenuria0AVPR2 CL E G H554897ORPHA:223Nephrogenic diabetes insipidusHP:0040281 - Very frequent67
HP:0003158HP:0003158Hyposthenuria0CLCN5 CL E G H11842023OMIM:308990Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis112
HP:0003158HP:0003158Hyposthenuria0KCNJ1 CL E G H37586255OMIM:241200Bartter syndrome, antenatal, type 2.51
HP:0003158HP:0003158Hyposthenuria0NPHP1 CL E G H48677905OMIM:256100Nephronophthisis 1.85
HP:0003158HP:0003158Hyposthenuria0SLC12A1 CL E G H655710910OMIM:601678Bartter syndrome, type 1, antenatal.75


Genes (6) :AQP2 AVPR2 CLCN5 KCNJ1 NPHP1 SLC12A1

Diseases (5) :ORPHA:223 OMIM:308990 OMIM:241200 OMIM:256100 OMIM:601678
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.