Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Behavioral abnormality (HP:0000708)

Parent Node:
Impairment in personality functioning (HP:0031466)

..Starting node
..Hostility (HP:0031473)

Term ID:

31473

Name:

Hostility

Synonym:

Definition:

Persistent or frequent angry feelings; anger or irritability in response to minor slights and insults.

Comments:

Reference:

HP:0031473

Genes and Diseases:

Child Nodes:

Sister Nodes:

Abnormal fear/anxiety-related behavior (HP:0100852)

Anhedonia (HP:0012154)

Bipolar affective disorder (HP:0007302)

Depression (HP:0000716)

Disinhibition (HP:0000734)

Emotional lability (HP:0000712)

Inappropriate behavior (HP:0000719)

Low self esteem (HP:0031469)

Negative affectivity (HP:0031467)

Personality disorder (HP:0012075)

Separation insecurity (HP:0031468)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031473	HP:0031473	Hostility	0	HTT CL E G H	3064	4851	ORPHA:399	Huntington disease	HP:0040282 - Frequent	12
HP:0031473	HP:0031473	Hostility	0	MECP2 CL E G H	4204	6990	OMIM:300260	Mental retardation, x-linked syndromic, Lubs type	.	950
HP:0031473	HP:0031473	Hostility	0	SLC2A3 CL E G H	6515	11007	ORPHA:399	Huntington disease	HP:0040282 - Frequent	1

Genes (3) :HTT MECP2 SLC2A3

Diseases (2) :ORPHA:399 OMIM:300260

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.