Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Behavioral abnormality (HP:0000708)

Parent Node:
Impairment in personality functioning (HP:0031466)

..Starting node
..Low self esteem (HP:0031469)

Term ID:

31469

Name:

Low self esteem

Synonym:

Definition:

Negative opinion about oneself characterized by low self-confidence and exaggeratedly critical feelings about oneself.

Comments:

Reference:

HP:0031469

Genes and Diseases:

Child Nodes:

Sister Nodes:

Abnormal fear/anxiety-related behavior (HP:0100852)

Anhedonia (HP:0012154)

Bipolar affective disorder (HP:0007302)

Depression (HP:0000716)

Disinhibition (HP:0000734)

Emotional lability (HP:0000712)

Hostility (HP:0031473)

Inappropriate behavior (HP:0000719)

Negative affectivity (HP:0031467)

Personality disorder (HP:0012075)

Separation insecurity (HP:0031468)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031469	HP:0031469	Low self esteem	0	CACNA1H CL E G H	8912	1395	ORPHA:64280	Childhood absence epilepsy	HP:0040283 - Occasional	75
HP:0031469	HP:0031469	Low self esteem	0	FMO3 CL E G H	2328	3771	ORPHA:468726	Severe primary trimethylaminuria	HP:0040282 - Frequent	55
HP:0031469	HP:0031469	Low self esteem	0	GABRA1 CL E G H	2554	4075	ORPHA:64280	Childhood absence epilepsy	HP:0040283 - Occasional	134
HP:0031469	HP:0031469	Low self esteem	0	GABRB3 CL E G H	2562	4083	ORPHA:64280	Childhood absence epilepsy	HP:0040283 - Occasional	57
HP:0031469	HP:0031469	Low self esteem	0	GABRG2 CL E G H	2566	4087	ORPHA:64280	Childhood absence epilepsy	HP:0040283 - Occasional	139
HP:0031469	HP:0031469	Low self esteem	0	IRF6 CL E G H	3664	6121	ORPHA:199302	Isolated cleft lip	HP:0040283 - Occasional	99
HP:0031469	HP:0031469	Low self esteem	0	JRK CL E G H	8629	6199	ORPHA:64280	Childhood absence epilepsy	HP:0040283 - Occasional
HP:0031469	HP:0031469	Low self esteem	0	MSX1 CL E G H	4487	7391	ORPHA:199302	Isolated cleft lip	HP:0040283 - Occasional	12
HP:0031469	HP:0031469	Low self esteem	0	NECTIN1 CL E G H	5818	9706	ORPHA:199302	Isolated cleft lip	HP:0040283 - Occasional	4
HP:0031469	HP:0031469	Low self esteem	0	SLC2A1 CL E G H	6513	11005	ORPHA:64280	Childhood absence epilepsy	HP:0040283 - Occasional	255
HP:0031469	HP:0031469	Low self esteem	0	TP63 CL E G H	8626	15979	ORPHA:199302	Isolated cleft lip	HP:0040283 - Occasional	140

Genes (11) :CACNA1H FMO3 GABRA1 GABRB3 GABRG2 IRF6 JRK MSX1 NECTIN1 SLC2A1 TP63

Diseases (3) :ORPHA:64280 ORPHA:468726 ORPHA:199302

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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