Human Phenotype Ontology 
Grandparent Node:
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Abnormal respiratory system morphology (HP:0012252)help
Parent Node:
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Abnormal lung morphology (HP:0002088)help
..Starting node
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Pulmonary opacity (HP:0031457)help
Term ID: 31457
Name: Pulmonary opacity
Synonym:
Definition: Opacity refers to any area that preferentially attenuates the x-ray beam and therefore appears more opaque than the surrounding area. It is a nonspecific term that does not indicate the size or pathologic nature of the abnormality.
Comments:
Reference: HP:0031457
Genes and Diseases:
 
       Child Nodes:
........expandGround-glass opacification on pulmonary HRCT (HP:0025179) help
................... HP:0025180 Centrilobular ground-glass opacification on pulmonary HRCT

 Sister Nodes: 
..expandAbnormal lung lobation (HP:0002101) help
..expandAbnormal pleura morphology (HP:0002103) help
..expandAbnormal pulmonary interstitial morphology (HP:0006530) help
..expandAbnormal pulmonary lymphatics (HP:0006529) help
..expandAbnormal subpleural morphology (HP:0031630) help
..expandAbnormality of the pulmonary vasculature (HP:0004930) help
..expandAplasia/Hypoplasia of the lungs (HP:0006703) help
..expandAtelectasis (HP:0100750) help
..expandBronchogenic cyst (HP:0100730) help
..expandBronchopulmonary sequestration (HP:0010960) help
..expandChronic lung disease (HP:0006528) help
..expandEmphysema (HP:0002097) help
..expandHemoptysis (HP:0002105) help
..expandHypersensitivity pneumonitis (HP:0006516) help
..expandIntraalveolar nodular calcifications (HP:0006514) help
..expandIntraalveolar phospholipid accumulation (HP:0006517) help
..expandLung abscess (HP:0025044) help
..expandMultiple pulmonary cysts (HP:0005948) help
..expandNeoplasm of the lung (HP:0100526) help
..expandPneumothorax (HP:0002107) help
..expandPulmonary edema (HP:0100598) help
..expandPulmonary fibrosis (HP:0002206) help
..expandPulmonary granulomatosis (HP:0030250) help
..expandPulmonary hemorrhage (HP:0040223) help
..expandPulmonary infiltrates (HP:0002113) help
..expandPulmonary pneumatocele (HP:0025419) help
..expandRespiratory tract infection (HP:0011947) help
..expandUnilateral primary pulmonary dysgenesis (HP:0006549) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031457HP:0031457Pulmonary opacity0ABCA3 CL E G H2133ORPHA:2032Idiopathic pulmonary fibrosis147
HP:0031457HP:0031457Pulmonary opacity0ABCA3 CL E G H2133OMIM:610921Surfactant metabolism dysfunction, pulmonary, 3147
HP:0031457HP:0031457Pulmonary opacity0ATP11A CL E G H2325013552ORPHA:2032Idiopathic pulmonary fibrosis
HP:0031457HP:0031457Pulmonary opacity0BMPR2 CL E G H6591078OMIM:265450PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT; PVOD1525
HP:0031457HP:0031457Pulmonary opacity0COL3A1 CL E G H12812201OMIM:130050Ehlers-Danlos syndrome, Vascular type749
HP:0031457HP:0031457Pulmonary opacity0CSF2RA CL E G H14382435OMIM:300770SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 4; SMDP415
HP:0031457HP:0031457Pulmonary opacity0CSF2RB CL E G H14392436OMIM:614370SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 5; SMDP517
HP:0031457HP:0031457Pulmonary opacity0DPP9 CL E G H9103918648ORPHA:2032Idiopathic pulmonary fibrosis
HP:0031457HP:0031457Pulmonary opacity0DSP CL E G H18323052ORPHA:2032Idiopathic pulmonary fibrosis747
HP:0031457HP:0031457Pulmonary opacity0EIF2AK4 CL E G H44027519687ORPHA:199241Pulmonary capillary hemangiomatosis40
HP:0031457HP:0031457Pulmonary opacity0EIF2AK4 CL E G H44027519687OMIM:234810PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE; PVOD240
HP:0031457HP:0031457Pulmonary opacity0FAM13A CL E G H1014419367ORPHA:2032Idiopathic pulmonary fibrosis
HP:0031457HP:0031457Pulmonary opacity0HLA-DPB1 CL E G H31154940ORPHA:133Chronic beryllium disease1
HP:0031457HP:0031457Pulmonary opacity0IFIH1 CL E G H6413518873OMIM:619773IMMUNODEFICIENCY 95; IMD9528
HP:0031457HP:0031457Pulmonary opacity0MUC5B CL E G H7278977516ORPHA:2032Idiopathic pulmonary fibrosis133
HP:0031457HP:0031457Pulmonary opacity0NKX2-1 CL E G H708011825OMIM:610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress51
HP:0031457HP:0031457Pulmonary opacity0PARN CL E G H50738609ORPHA:2032Idiopathic pulmonary fibrosis26
HP:0031457HP:0031457Pulmonary opacity0RTEL1 CL E G H5175015888ORPHA:2032Idiopathic pulmonary fibrosis77
HP:0031457HP:0031457Pulmonary opacity0SFTPA1 CL E G H65350910798ORPHA:2032Idiopathic pulmonary fibrosis19
HP:0031457HP:0031457Pulmonary opacity0SFTPA1 CL E G H65350910798OMIM:619611INTERSTITIAL LUNG DISEASE 1; ILD119
HP:0031457HP:0031457Pulmonary opacity0SFTPA2 CL E G H72923810799ORPHA:2032Idiopathic pulmonary fibrosis10
HP:0031457HP:0031457Pulmonary opacity0SFTPB CL E G H643910801ORPHA:217563Neonatal acute respiratory distress due to SP-B deficiencyHP:0040282 - Frequent51
HP:0031457HP:0031457Pulmonary opacity0SFTPB CL E G H643910801OMIM:265120Surfactant metabolism dysfunction, pulmonary, 151
HP:0031457HP:0031457Pulmonary opacity0SFTPC CL E G H644010802ORPHA:2032Idiopathic pulmonary fibrosis33
HP:0031457HP:0031457Pulmonary opacity0SFTPC CL E G H644010802OMIM:610913Surfactant metabolism dysfunction, pulmonary, 233
HP:0031457HP:0031457Pulmonary opacity0SLC34A2 CL E G H1056811020ORPHA:60025Pulmonary alveolar microlithiasis7
HP:0031457HP:0031457Pulmonary opacity0STN1 CL E G H7999126200ORPHA:2032Idiopathic pulmonary fibrosis2
HP:0031457HP:0031457Pulmonary opacity0TERC CL E G H701211727ORPHA:2032Idiopathic pulmonary fibrosis48
HP:0031457HP:0031457Pulmonary opacity0TERT CL E G H701511730ORPHA:2032Idiopathic pulmonary fibrosis238
HP:0031457HP:0033702Subpleural curvilinear line1 CL E G H
HP:0031457HP:0033656Juxtaphrenic peak1 CL E G H
HP:0031457HP:0033650Pulmonary parenchymal band1 CL E G H
HP:0031457HP:0025179Ground-glass opacification1ABCA3 CL E G H2133ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent147
HP:0031457HP:0025179Ground-glass opacification1ABCA3 CL E G H2133OMIM:610921Surfactant metabolism dysfunction, pulmonary, 3147
HP:0031457HP:0025179Ground-glass opacification1ATP11A CL E G H2325013552ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent
HP:0031457HP:0025179Ground-glass opacification1BMPR2 CL E G H6591078OMIM:265450PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT; PVOD1525
HP:0031457HP:0025395Combined cystic and ground-glass pattern on pulmonary HRCT1COL3A1 CL E G H12812201OMIM:130050Ehlers-Danlos syndrome, Vascular type749
HP:0031457HP:0025179Ground-glass opacification1CSF2RA CL E G H14382435OMIM:300770SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 4; SMDP415
HP:0031457HP:0025179Ground-glass opacification1CSF2RB CL E G H14392436OMIM:614370SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 5; SMDP517
HP:0031457HP:0025179Ground-glass opacification1DPP9 CL E G H9103918648ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent
HP:0031457HP:0025179Ground-glass opacification1DSP CL E G H18323052ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent747
HP:0031457HP:0025179Ground-glass opacification1EIF2AK4 CL E G H44027519687ORPHA:199241Pulmonary capillary hemangiomatosisHP:0040281 - Very frequent40
HP:0031457HP:0025179Ground-glass opacification1EIF2AK4 CL E G H44027519687OMIM:234810PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE; PVOD240
HP:0031457HP:0025179Ground-glass opacification1FAM13A CL E G H1014419367ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent
HP:0031457HP:0025179Ground-glass opacification1HLA-DPB1 CL E G H31154940ORPHA:133Chronic beryllium diseaseHP:0040282 - Frequent1
HP:0031457HP:0025179Ground-glass opacification1IFIH1 CL E G H6413518873OMIM:619773IMMUNODEFICIENCY 95; IMD9528
HP:0031457HP:0025179Ground-glass opacification1MUC5B CL E G H7278977516ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent133
HP:0031457HP:0025179Ground-glass opacification1NKX2-1 CL E G H708011825OMIM:610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress51
HP:0031457HP:0032177Parenchymal consolidation1NKX2-1 CL E G H708011825OMIM:610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress51
HP:0031457HP:0025179Ground-glass opacification1PARN CL E G H50738609ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent26
HP:0031457HP:0025179Ground-glass opacification1RTEL1 CL E G H5175015888ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent77
HP:0031457HP:0025179Ground-glass opacification1SFTPA1 CL E G H65350910798ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent19
HP:0031457HP:0025179Ground-glass opacification1SFTPA1 CL E G H65350910798OMIM:619611INTERSTITIAL LUNG DISEASE 1; ILD119
HP:0031457HP:0025179Ground-glass opacification1SFTPA2 CL E G H72923810799ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent10
HP:0031457HP:0025179Ground-glass opacification1SFTPB CL E G H643910801OMIM:265120Surfactant metabolism dysfunction, pulmonary, 151
HP:0031457HP:0025179Ground-glass opacification1SFTPC CL E G H644010802ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent33
HP:0031457HP:0025179Ground-glass opacification1SFTPC CL E G H644010802OMIM:610913Surfactant metabolism dysfunction, pulmonary, 233
HP:0031457HP:0025179Ground-glass opacification1SLC34A2 CL E G H1056811020ORPHA:60025Pulmonary alveolar microlithiasisHP:0040284 - Very rare7
HP:0031457HP:0025179Ground-glass opacification1STN1 CL E G H7999126200ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent2
HP:0031457HP:0025179Ground-glass opacification1TERC CL E G H701211727ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent48
HP:0031457HP:0025179Ground-glass opacification1TERT CL E G H701511730ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent238
HP:0031457HP:0032983Atoll sign2 CL E G H
HP:0031457HP:0032971Computed tomographic halo sign2 CL E G H
HP:0031457HP:0025180Centrilobular ground-glass opacification on pulmonary HRCT2BMPR2 CL E G H6591078OMIM:265450PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT; PVOD1525
HP:0031457HP:0025180Centrilobular ground-glass opacification on pulmonary HRCT2EIF2AK4 CL E G H44027519687ORPHA:199241Pulmonary capillary hemangiomatosisHP:0040282 - Frequent40
HP:0031457HP:0025180Centrilobular ground-glass opacification on pulmonary HRCT2EIF2AK4 CL E G H44027519687OMIM:234810PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE; PVOD240


Genes (24) :ABCA3 ATP11A BMPR2 COL3A1 CSF2RA CSF2RB DPP9 DSP EIF2AK4 FAM13A HLA-DPB1 IFIH1 MUC5B NKX2-1 PARN RTEL1 SFTPA1 SFTPA2 SFTPB SFTPC SLC34A2 STN1 TERC TERT

Diseases (16) :ORPHA:2032 OMIM:610921 OMIM:265450 OMIM:130050 OMIM:300770 OMIM:614370 ORPHA:199241 OMIM:234810 ORPHA:133 OMIM:619773 OMIM:610978 OMIM:619611 ORPHA:217563 OMIM:265120 OMIM:610913 ORPHA:60025
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.