Human Phenotype Ontology 
Grandparent Node:
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Abnormal cellular physiology (HP:0011017)help
Grandparent Node:
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Abnormal lymphocyte physiology (HP:0031409)help
Parent Node:
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Abnormal lymphocyte proliferation (HP:0031378)help
Parent Node:
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Abnormality of T cell physiology (HP:0011840)help
..Starting node
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Abnormal T cell proliferation (HP:0031379)help
Term ID: 31379
Name: Abnormal T cell proliferation
Synonym:
Definition: Any abnormality in the multiplication or reproduction of T cells, which results in the expansion of a cell population.
Comments:
Reference: HP:0031379
Genes and Diseases:
 
       Child Nodes:
........expandDefective T cell proliferation (HP:0030253) help
........expandReduced antigen-specific T cell proliferation (HP:0031402) help

 Sister Nodes: 
..expandAbnormal delayed hypersensitivity skin test (HP:0002963) help
..expandAbnormal T cell activation (HP:0410035) help
..expandImpaired T cell function (HP:0005435) help
..expandLack of T cell function (HP:0005354) help
..expandobsolete Exaggerated cellular immune processes (HP:0005397) help
..expandOligoclonal T cell expansion (HP:0031430) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031379HP:0031379Abnormal T cell proliferation0CARD11 CL E G H8443316393OMIM:615206Card11 immunodeficiency45
HP:0031379HP:0031379Abnormal T cell proliferation0CD3E CL E G H9161674OMIM:615615Immunodeficiency 1824
HP:0031379HP:0031379Abnormal T cell proliferation0CTPS1 CL E G H15032519OMIM:615897IMMUNODEFICIENCY 24; IMD242
HP:0031379HP:0031379Abnormal T cell proliferation0DOCK2 CL E G H17942988OMIM:616433Immunodeficiency 406
HP:0031379HP:0031379Abnormal T cell proliferation0LCP2 CL E G H39376529OMIM:619374IMMUNODEFICIENCY 81; IMD81
HP:0031379HP:0031379Abnormal T cell proliferation0LIG1 CL E G H39786598OMIM:619774IMMUNODEFICIENCY 96; IMD969
HP:0031379HP:0031379Abnormal T cell proliferation0MRTFA CL E G H5759114334OMIM:618847IMMUNODEFICIENCY 66; IMD66
HP:0031379HP:0031379Abnormal T cell proliferation0NSMCE3 CL E G H561607677OMIM:617241LUNG DISEASE, IMMUNODEFICIENCY, AND CHROMOSOME BREAKAGE SYNDROME; LICS2
HP:0031379HP:0031379Abnormal T cell proliferation0PGM3 CL E G H52388907ORPHA:443811PGM3-CDG15
HP:0031379HP:0031379Abnormal T cell proliferation0RAG1 CL E G H58969831ORPHA:331206Severe combined immunodeficiency due to complete RAG1/2 deficiency127
HP:0031379HP:0031379Abnormal T cell proliferation0RAG2 CL E G H58979832ORPHA:331206Severe combined immunodeficiency due to complete RAG1/2 deficiency50
HP:0031379HP:0031379Abnormal T cell proliferation0RASGRP1 CL E G H101259878OMIM:618534IMMUNODEFICIENCY 64; IMD64
HP:0031379HP:0031379Abnormal T cell proliferation0TGFB1 CL E G H704011766OMIM:618213INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY; IBDIMDE13
HP:0031379HP:0031379Abnormal T cell proliferation0WIPF1 CL E G H745612736OMIM:614493WISKOTT-ALDRICH SYNDROME 2; WAS26
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1CARD11 CL E G H8443316393OMIM:615206Card11 immunodeficiency45
HP:0031379HP:0030253Defective T cell proliferation1CD3E CL E G H9161674OMIM:615615Immunodeficiency 18HP:0040283 - Occasional24
HP:0031379HP:0030253Defective T cell proliferation1CTPS1 CL E G H15032519OMIM:615897IMMUNODEFICIENCY 24; IMD242
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1CTPS1 CL E G H15032519OMIM:615897IMMUNODEFICIENCY 24; IMD242
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1DOCK2 CL E G H17942988OMIM:616433Immunodeficiency 406
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1LCP2 CL E G H39376529OMIM:619374IMMUNODEFICIENCY 81; IMD81
HP:0031379HP:0030253Defective T cell proliferation1LIG1 CL E G H39786598OMIM:619774IMMUNODEFICIENCY 96; IMD969
HP:0031379HP:0030253Defective T cell proliferation1MRTFA CL E G H5759114334OMIM:618847IMMUNODEFICIENCY 66; IMD66
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1NSMCE3 CL E G H561607677OMIM:617241LUNG DISEASE, IMMUNODEFICIENCY, AND CHROMOSOME BREAKAGE SYNDROME; LICS2
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1PGM3 CL E G H52388907ORPHA:443811PGM3-CDGHP:0040282 - Frequent15
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1RAG1 CL E G H58969831ORPHA:331206Severe combined immunodeficiency due to complete RAG1/2 deficiencyHP:0040282 - Frequent127
HP:0031379HP:0031402Reduced antigen-specific T cell proliferation1RAG2 CL E G H58979832ORPHA:331206Severe combined immunodeficiency due to complete RAG1/2 deficiencyHP:0040282 - Frequent50
HP:0031379HP:0030253Defective T cell proliferation1RASGRP1 CL E G H101259878OMIM:618534IMMUNODEFICIENCY 64; IMD64
HP:0031379HP:0030253Defective T cell proliferation1TGFB1 CL E G H704011766OMIM:618213INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY; IBDIMDE13
HP:0031379HP:0030253Defective T cell proliferation1WIPF1 CL E G H745612736OMIM:614493WISKOTT-ALDRICH SYNDROME 2; WAS26


Genes (14) :CARD11 CD3E CTPS1 DOCK2 LCP2 LIG1 MRTFA NSMCE3 PGM3 RAG1 RAG2 RASGRP1 TGFB1 WIPF1

Diseases (13) :OMIM:615206 OMIM:615615 OMIM:615897 OMIM:616433 OMIM:619374 OMIM:619774 OMIM:618847 OMIM:617241 ORPHA:443811 ORPHA:331206 OMIM:618534 OMIM:618213 OMIM:614493
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.