Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of the skin (HP:0000951)

Grandparent Node:
Neoplasm by anatomical site (HP:0011793)

Parent Node:
Neoplasm of the skin (HP:0008069)

..Starting node
..Seborrheic keratosis (HP:0031287)

Term ID:

31287

Name:

Seborrheic keratosis

Synonym:

Basal cell papilloma; Seborrheic verruca; Senile wart

Definition:

A raised growth on the skin of older individuals. The lesion usually is initially light tan and may darken to dark brown or nearly black. The consistent feature of seborrheic keratoses is their waxy, pasted-on or stuck-on look.

Comments:

Reference:

HP:0031287

Genes and Diseases:

Child Nodes:

Sister Nodes:

Acanthoma (HP:0025432)

Actinic keratosis (HP:0025127)

Adenoma sebaceum (HP:0009720)

Basal cell carcinoma (HP:0002671)

Cutaneous angiolipomas (HP:0006773)

Cutaneous leiomyoma (HP:0007620)

Cutaneous leiomyosarcoma (HP:0006755)

Cutaneous mastocytosis (HP:0200151)

Cutaneous melanoma (HP:0012056)

Cutaneous myxoma (HP:0030428)

Eccrine syringofibroadenoma (HP:0031018)

Fibrofolliculoma (HP:0030436)

Frontal cutaneous lipoma (HP:0007541)

Kaposi's sarcoma (HP:0100726)

Keratoacanthoma (HP:0031525)

Lymphocytoma cutis (HP:0031549)

Merkel cell skin cancer (HP:0030447)

Multiple cutaneous leiomyomas (HP:0007437)

Multiple cutaneous malignancies (HP:0007606)

Myxoid subcutaneous tumors (HP:0006769)

Neurofibromas (HP:0001067)

Papilloma (HP:0012740)

Peripheral Schwannoma (HP:0009593)

Skin appendage neoplasm (HP:0012842)

Squamous cell carcinoma (HP:0002860)

Steatocystoma multiplex (HP:0012035)

Subcutaneous lipoma (HP:0001031)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0031287	HP:0031287	Seborrheic keratosis	0	ERCC4 CL E G H	2072	3436	OMIM:278760	Xeroderma pigmentosum, complementation group F	.	158
HP:0031287	HP:0031287	Seborrheic keratosis	0	NTHL1 CL E G H	4913	8028	ORPHA:454840	NTHL1-related attenuated familial adenomatous polyposis	HP:0040283 - Occasional	2
HP:0031287	HP:0031287	Seborrheic keratosis	0	PIK3CA CL E G H	5290	8975	OMIM:182000	KERATOSIS, SEBORRHEIC		162

Genes (3) :ERCC4 NTHL1 PIK3CA

Diseases (3) :OMIM:278760 ORPHA:454840 OMIM:182000

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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