Human Phenotype Ontology 
Grandparent Node:
expandAbnormal biliary tract morphology (HP:0012440)help
Grandparent Node:
expandIncreased inflammatory response (HP:0012649)help
Parent Node:
expandCholangitis (HP:0030151)help
..Starting node
..expandGranulomatous cholangitis (HP:0030988)help
Term ID: 30988
Name: Granulomatous cholangitis
Synonym:
Definition: Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts.
Comments:
Reference: HP:0030988
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandLymphoid cholangitis (HP:0030989) help
..expandPleomorphic cholangitis (HP:0030990) help
..expandSclerosing cholangitis (HP:0030991) help
..expandSuppurative cholangitis (HP:0030987) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0030988HP:0030988Granulomatous cholangitis0 CL E G H


Genes (0) :

Diseases (0) :
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.