Human Phenotype Ontology 
Grandparent Node:
Abnormal nervous system physiology (HP:0012638)help
Parent Node:
Behavioral abnormality (HP:0000708)help
..Starting node
Perseveration (HP:0030223)help
Term ID: 30223
Name: Perseveration
Synonym: Perseverative behavior; Perseverative behaviour
Definition: Perseveration can be defined as the contextually inappropriate and unintentional repetition of a response or behavioral unit. In other words, the observed repetitiveness does not meet the demands of the situation, is not the product of deliberation, and may even unfold despite counterintention. Perseveration can therefore be differentiated from goal-directed and intentional forms of repetition, such as linguistic redundancies designed to enhance communicative or poetic impact.
Reference: HP:0030223
Genes and Diseases:
       Child Nodes:
........expandPersistent repetition of words (HP:0031431) help
........expandPersistent repetition of actions (HP:0031432) help

 Sister Nodes: 
..expandAbnormal consumption behavior (HP:0040202) help
..expandAbnormal emotion/affect behavior (HP:0100851) help
..expandAbnormal social behavior (HP:0012433) help
..expandAbnormal temper tantrums (HP:0025160) help
..expandAddictive behavior (HP:0030858) help
..expandAutistic behavior (HP:0000729) help
..expandDelusions (HP:0000746) help
..expandDrooling (HP:0002307) help
..expandEcholalia (HP:0010529) help
..expandHallucinations (HP:0000738) help
..expandHyperorality (HP:0000710) help
..expandImpairment in personality functioning (HP:0031466) help
..expandInflexible adherence to routines or rituals (HP:0000732) help
..expandLack of insight (HP:0000757) help
..expandLack of spontaneous play (HP:0000721) help
..expandLow frustration tolerance (HP:0000744) help
..expandMania (HP:0100754) help
..expandMutism (HP:0002300) help
..expandObsessive-compulsive behavior (HP:0000722) help
..expandobsolete Psychomotor retardation (HP:0025356) help
..expandOppositional defiant disorder (HP:0010865) help
..expandPersonality changes (HP:0000751) help
..expandPhotophobia (HP:0000613) help
..expandPseudobulbar behavioral symptoms (HP:0002193) help
..expandPsychosis (HP:0000709) help
..expandRestlessness (HP:0000711) help
..expandSchizophrenia (HP:0100753) help
..expandSelf-neglect (HP:0025479) help
..expandShort attention span (HP:0000736) help
..expandSleep disturbance (HP:0002360) help
..expandSound sensitivity (HP:0025112) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0030223HP:0030223Perseveration0C9ORF72 CL E G H20322828337ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent56
HP:0030223HP:0030223Perseveration0C9ORF72 CL E G H20322828337ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional56
HP:0030223HP:0030223Perseveration0C9ORF72 CL E G H20322828337ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional56
HP:0030223HP:0030223Perseveration0CHCHD10 CL E G H40091615559ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional11
HP:0030223HP:0030223Perseveration0CHMP2B CL E G H2597824537ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent42
HP:0030223HP:0030223Perseveration0CHMP2B CL E G H2597824537ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional42
HP:0030223HP:0030223Perseveration0CIC CL E G H2315214214OMIM:617600Mental retardation, autosomal dominant 4539
HP:0030223HP:0030223Perseveration0FUS CL E G H25214010ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional105
HP:0030223HP:0030223Perseveration0GRN CL E G H28964601ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent126
HP:0030223HP:0030223Perseveration0GRN CL E G H28964601OMIM:607485Frontotemporal lobar degeneration with TDP43 inclusions.126
HP:0030223HP:0030223Perseveration0GRN CL E G H28964601ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional126
HP:0030223HP:0030223Perseveration0MAPT CL E G H41376893ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent140
HP:0030223HP:0030223Perseveration0MAPT CL E G H41376893OMIM:172700Pick disease of brain.140
HP:0030223HP:0030223Perseveration0MAPT CL E G H41376893ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional140
HP:0030223HP:0030223Perseveration0NONO CL E G H48417871OMIM:300967MENTAL RETARDATION, X-LINKED, SYNDROMIC 34; MRXS3410
HP:0030223HP:0030223Perseveration0NOTCH3 CL E G H48547883OMIM:125310Cerebral arteriopathy, autosomal dominant, with subcortical infarctsand leukoencephalopathy144
HP:0030223HP:0030223Perseveration0NPC2 CL E G H1057714537OMIM:607625Niemann-pick disease, type C2.33
HP:0030223HP:0030223Perseveration0PRNP CL E G H56219449ORPHA:280397Familial Alzheimer-like prion diseaseHP:0040281 - Very frequent69
HP:0030223HP:0030223Perseveration0PRNP CL E G H56219449OMIM:137440Gerstmann-Straussler disease.69
HP:0030223HP:0030223Perseveration0PSEN1 CL E G H56639508ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent241
HP:0030223HP:0030223Perseveration0PSEN1 CL E G H56639508OMIM:172700Pick disease of brain.241
HP:0030223HP:0030223Perseveration0PSEN1 CL E G H56639508ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional241
HP:0030223HP:0030223Perseveration0SQSTM1 CL E G H887811280ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent62
HP:0030223HP:0030223Perseveration0SQSTM1 CL E G H887811280ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional62
HP:0030223HP:0030223Perseveration0TACO1 CL E G H5120424316OMIM:619052MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 8; MC4DN823
HP:0030223HP:0030223Perseveration0TARDBP CL E G H2343511571OMIM:612069Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia.65
HP:0030223HP:0030223Perseveration0TARDBP CL E G H2343511571ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional65
HP:0030223HP:0030223Perseveration0TBK1 CL E G H2911011584ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional20
HP:0030223HP:0030223Perseveration0TMEM106B CL E G H5466422407ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent
HP:0030223HP:0030223Perseveration0TMEM106B CL E G H5466422407ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional
HP:0030223HP:0030223Perseveration0TREM2 CL E G H5420917761ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent31
HP:0030223HP:0030223Perseveration0TREM2 CL E G H5420917761ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional31
HP:0030223HP:0030223Perseveration0TTPA CL E G H727412404OMIM:277460VITAMIN E, FAMILIAL ISOLATED DEFICIENCY OF62
HP:0030223HP:0030223Perseveration0USP7 CL E G H787412630OMIM:616863Chromosome 16p13.2 deletion syndrome2
HP:0030223HP:0030223Perseveration0VCP CL E G H741512666ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent63
HP:0030223HP:0030223Perseveration0VCP CL E G H741512666ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040283 - Occasional63
HP:0030223HP:0030223Perseveration0VCP CL E G H741512666ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional63
HP:0030223HP:0031432Persistent repetition of actions1 CL E G H
HP:0030223HP:0031431Persistent repetition of words1 CL E G H


Diseases (15) :ORPHA:275864 ORPHA:275872 ORPHA:100070 OMIM:617600 OMIM:607485 OMIM:172700 OMIM:300967 OMIM:125310 OMIM:607625 ORPHA:280397 OMIM:137440 OMIM:619052 OMIM:612069 OMIM:277460 OMIM:616863

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.