Human Phenotype Ontology 
Grandparent Node:
All (HP:0000001)help
Parent Node:
Clinical modifier (HP:0012823)help
..Starting node
Aggravated by (HP:0025285)help
Term ID: 25285
Name: Aggravated by
Synonym: Exacerbated by
Definition: An aggravating factor is defined as an external factor that leads to a sign or symptom that is already present getting worse or becoming more severe.
Reference: HP:0025285
Genes and Diseases:
       Child Nodes:
........expandAggravated by activity (HP:0025286) help
........expandExacerbated by head trauma (HP:0025315) help

 Sister Nodes: 
..expandAmeliorated by (HP:0025254) help
..expandPain characteristic (HP:0025280) help
..expandPhenotypic variability (HP:0003812) help
..expandPosition (HP:0012830) help
..expandRefractory (HP:0031375) help
..expandSeverity (HP:0012824) help
..expandTriggered by (HP:0025204) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025285HP:0025285Aggravated by0 CL E G H
HP:0025285HP:0025286Aggravated by activity1 CL E G H
HP:0025285HP:0025315Exacerbated by head trauma1 CL E G H
HP:0025285HP:0032500Exacerbated by tobacco use1 CL E G H
HP:0025285HP:0032525Aggravated by acetylcholinesterase inhibitor1 CL E G H
HP:0025285HP:0032501Exacerbated by contraceptive medication1 CL E G H
HP:0025285HP:0032502Exacerbated by barbiturate medication1 CL E G H
HP:0025285HP:0032542Exacerbated by pregnancy1 CL E G H
HP:0025285HP:0032365Exacerbated by aspirin ingestion1 CL E G H
HP:0025285HP:0032534Exacerbated by methylxanthine ingestion1 CL E G H

Genes (0) :

Diseases (0) :

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.