Human Phenotype Ontology 
Grandparent Node:
expandAbnormality of skin morphology (HP:0011121)help
Parent Node:
expandLocalized skin lesion (HP:0011355)help
..Starting node
..expandComedo (HP:0025249)help
Term ID: 25249
Name: Comedo
Synonym:
Definition: A clogged cutaneous sebaceous follicle, which is a cutaneous gland that secretes sebum (usually into a hair follicle).
Comments:
Reference: HP:0025249
Genes and Diseases:
 
       Child Nodes:
........expandClosed comedo (HP:0025250) help
........expandOpen comedo (HP:0025251) help

 Sister Nodes: 
..expandAbnormal perifollicular morphology (HP:0031285) help
..expandAnnular cutaneous lesion (HP:0025528) help
..expandAplasia/Hypoplasia of the skin (HP:0008065) help
..expandAtypical scarring of skin (HP:0000987) help
..expandCafe-au-lait spot (HP:0000957) help
..expandCapillary malformation (HP:0025104) help
..expandCutaneous cyst (HP:0025245) help
..expandHypopigmented skin patches (HP:0001053) help
..expandLichenoid skin lesion (HP:0031452) help
..expandMacule (HP:0012733) help
..expandMilia (HP:0001056) help
..expandMolluscoid pseudotumors (HP:0000993) help
..expandNevus (HP:0003764) help
..expandPapule (HP:0200034) help
..expandSerpiginous cutaneous lesion (HP:0025527) help
..expandSkin dimple (HP:0010781) help
..expandSkin erosion (HP:0200041) help
..expandSkin fissure (HP:0031057) help
..expandSkin nodule (HP:0200036) help
..expandSkin pit (HP:0100276) help
..expandSkin plaque (HP:0200035) help
..expandSkin tags (HP:0010609) help
..expandSkin ulcer (HP:0200042) help
..expandSkin vesicle (HP:0200037) help
..expandXanthomatosis (HP:0000991) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025249HP:0025249Comedo0LIPH CL E G H20087918483OMIM:604379Hypotrichosis 7.12
HP:0025249HP:0025249Comedo0LPAR6 CL E G H1016115520OMIM:278150Hypotrichosis 8.8
HP:0025249HP:0025249Comedo0LRP1 CL E G H40356692OMIM:604093Keratosis pilaris atrophicans.4
HP:0025249HP:0025249Comedo0NEK9 CL E G H9175418591ORPHA:64754Nevus comedonicus syndromeHP:0040281 - Very frequent9
HP:0025249HP:0025251Open comedo1 CL E G H
HP:0025249HP:0025250Closed comedo1 CL E G H


Genes (4) :LIPH LPAR6 LRP1 NEK9

Diseases (4) :OMIM:604379 OMIM:278150 OMIM:604093 ORPHA:64754
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.