Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Behavioral abnormality (HP:0000708)

Parent Node:
Abnormal temper tantrums (HP:0025160)

..Starting node
..Severe temper tantrums (HP:0025162)

Term ID:

25162

Name:

Severe temper tantrums

Synonym:

Definition:

Temper tantrums whose severity is more severe than usual. For instance, a temper tantrum might be considered to be severe if a child loses control so completely that the child cannot control the tantrum on its own, continuing until it becomes exhausted or a parent intervenes.

Comments:

Reference:

HP:0025162

Genes and Diseases:

Child Nodes:

Sister Nodes:

Frequent temper tantrums (HP:0025161)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0025162	HP:0025162	Severe temper tantrums	0	DPF2 CL E G H	5977	9964	OMIM:618027	Coffin-Siris syndrome 7
HP:0025162	HP:0025162	Severe temper tantrums	0	GNAI1 CL E G H	2770	4384	OMIM:619854
HP:0025162	HP:0025162	Severe temper tantrums	0	RSRC1 CL E G H	51319	24152	OMIM:618402	Intellectual developmental disorder, autosomal recessive 70	2
HP:0025162	HP:0025162	Severe temper tantrums	0	SCN8A CL E G H	6334	10596	OMIM:614306	Cognitive impairment with or without cerebellar ataxia	357
HP:0025162	HP:0025162	Severe temper tantrums	0	TACO1 CL E G H	51204	24316	OMIM:619052	MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 8; MC4DN8	23
HP:0025162	HP:0025162	Severe temper tantrums	0	WARS2 CL E G H	10352	12730	OMIM:617710	Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	2

Genes (6) :DPF2 GNAI1 RSRC1 SCN8A TACO1 WARS2

Diseases (6) :OMIM:618027 OMIM:619854 OMIM:618402 OMIM:614306 OMIM:619052 OMIM:617710

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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