Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Peripheral neuropathy (HP:0009830)

Parent Node:
Somatic sensory dysfunction (HP:0003474)

..Starting node
..Impaired vibratory sensation (HP:0002495)

Term ID:

2495

Name:

Impaired vibratory sensation

Synonym:

Decreased vibration sense; Decreased vibratory sense; Diminished vibratory sense; Hypopallesthesia; Impaired vibratory sensation; Impaired vibratory sense

Definition:

A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.

Comments:

Reference:

HP:0002495

Genes and Diseases:

Child Nodes:

........

Impaired vibration sensation in the lower limbs (HP:0002166)

................... HP:0006938 Impaired vibration sensation at ankles

........

Impaired distal vibration sensation (HP:0006886)

................... HP:0006938 Impaired vibration sensation at ankles

........

Abolished vibration sense (HP:0006944)

Sister Nodes:

Abnormality of pain sensation (HP:0010832)

Dissociated sensory loss (HP:0010835)

Distal sensory impairment (HP:0002936)

Impaired proprioception (HP:0010831)

Impaired tactile sensation (HP:0010830)

Impaired temperature sensation (HP:0010829)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	DiseaseId	DiseaseName	DiseaseMIM	ConceptID	Source	Typical association	ClinVar variants	HGNC ID	GeneMIM
HPO disease - gene - phenotype typical associations:
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ATXN1 CL E G H	6310	164400	Spinocerebellar ataxia 1	164400	C0752120	OMIM	1	86	10548	601556
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ATXN2 CL E G H	6311	183090	Spinocerebellar ataxia 2	183090	C0752121	OMIM	1	53	10555	601517
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ATXN3 CL E G H	4287	109150	Azorean disease	109150	C0024408	OMIM	1	46	7106	607047
HP:0002495	HP:0002495	Impaired vibratory sensation	0	BSCL2 CL E G H	26580	139536				ORPHA	1	435	15832	606158
HP:0002495	HP:0002495	Impaired vibratory sensation	0	C19orf12 CL E G H	83636	320370				ORPHA	1	276	25443	614297
HP:0002495	HP:0002495	Impaired vibratory sensation	0	CYP7B1 CL E G H	9420	100986				ORPHA	1	333	2652	603711
HP:0002495	HP:0002495	Impaired vibratory sensation	0	FXN CL E G H	2395	229300	Friedreich ataxia 1	229300	C1856689	OMIM	1	143	3951	606829
HP:0002495	HP:0002495	Impaired vibratory sensation	0	GARS CL E G H	2617	139536				ORPHA	1		4162	600287
HP:0002495	HP:0002495	Impaired vibratory sensation	0	MAG CL E G H	4099	459056				ORPHA	1	171	6783	159460
HP:0002495	HP:0002495	Impaired vibratory sensation	0	MFN2 CL E G H	9927	99947				ORPHA	1	1063	16877	608507
HP:0002495	HP:0002495	Impaired vibratory sensation	0	NIPA1 CL E G H	123606	100988				ORPHA	1	576	17043	608145
HP:0002495	HP:0002495	Impaired vibratory sensation	0	PLEKHG4 CL E G H	25894	98765				ORPHA	1	41	24501	609526
HP:0002495	HP:0002495	Impaired vibratory sensation	0	POLG CL E G H	5428	70595				ORPHA	1	1917	9179	174763
HP:0002495	HP:0002495	Impaired vibratory sensation	0	POLG CL E G H	5428	94125	Recessive mitochondrial ataxia syndrome		CN206743	ORPHA	1	1917	9179	174763
HP:0002495	HP:0002495	Impaired vibratory sensation	0	REEP1 CL E G H	65055	139536				ORPHA	1	377	25786	609139
HP:0002495	HP:0002495	Impaired vibratory sensation	0	SAR1B CL E G H	51128	246700	Chylomicron retention disease	246700	C0795956	OMIM	1	102	10535	607690
HP:0002495	HP:0002495	Impaired vibratory sensation	0	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	343	10985	603861
HP:0002495	HP:0002495	Impaired vibratory sensation	0	SPART CL E G H	23111	101000				ORPHA	1	274	18514	607111
HP:0002495	HP:0002495	Impaired vibratory sensation	0	SPTBN2 CL E G H	6712	600224	Spinocerebellar ataxia 5	600224	C0752123	OMIM	1	716	11276	604985
HP:0002495	HP:0002495	Impaired vibratory sensation	0	TPP1 CL E G H	1200	284324				ORPHA	1	849	2073	607998
HP:0002495	HP:0002495	Impaired vibratory sensation	0	TPP1 CL E G H	1200	609270	Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia	609270	C1836474	OMIM	1	849	2073	607998
HP:0002495	HP:0002495	Impaired vibratory sensation	0	TWNK CL E G H	56652	70595				ORPHA	1	308	1160	606075
HP:0002495	HP:0006944	Abolished vibration sense	1	ATXN1 CL E G H	6310	164400	Spinocerebellar ataxia 1	164400	C0752120	OMIM	1	86	10548	601556
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ATXN1 CL E G H	6310	164400	Spinocerebellar ataxia 1	164400	C0752120	OMIM	1	86	10548	601556
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ATXN1 CL E G H	6310	164400	Spinocerebellar ataxia 1	164400	C0752120	OMIM	1	86	10548	601556
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ATXN2 CL E G H	6311	183090	Spinocerebellar ataxia 2	183090	C0752121	OMIM	1	53	10555	601517
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ATXN2 CL E G H	6311	183090	Spinocerebellar ataxia 2	183090	C0752121	OMIM	1	53	10555	601517
HP:0002495	HP:0006944	Abolished vibration sense	1	ATXN2 CL E G H	6311	183090	Spinocerebellar ataxia 2	183090	C0752121	OMIM	1	53	10555	601517
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ATXN3 CL E G H	4287	109150	Azorean disease	109150	C0024408	OMIM	1	46	7106	607047
HP:0002495	HP:0006944	Abolished vibration sense	1	ATXN3 CL E G H	4287	109150	Azorean disease	109150	C0024408	OMIM	1	46	7106	607047
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ATXN3 CL E G H	4287	109150	Azorean disease	109150	C0024408	OMIM	1	46	7106	607047
HP:0002495	HP:0006944	Abolished vibration sense	1	BSCL2 CL E G H	26580	139536				ORPHA	1	435	15832	606158
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	BSCL2 CL E G H	26580	139536				ORPHA	1	435	15832	606158
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	BSCL2 CL E G H	26580	139536				ORPHA	1	435	15832	606158
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	C19orf12 CL E G H	83636	320370				ORPHA	1	276	25443	614297
HP:0002495	HP:0006944	Abolished vibration sense	1	C19orf12 CL E G H	83636	320370				ORPHA	1	276	25443	614297
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	C19orf12 CL E G H	83636	320370				ORPHA	1	276	25443	614297
HP:0002495	HP:0006944	Abolished vibration sense	1	CYP7B1 CL E G H	9420	100986				ORPHA	1	333	2652	603711
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	CYP7B1 CL E G H	9420	100986				ORPHA	1	333	2652	603711
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	CYP7B1 CL E G H	9420	100986				ORPHA	1	333	2652	603711
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	FXN CL E G H	2395	229300	Friedreich ataxia 1	229300	C1856689	OMIM	1	143	3951	606829
HP:0002495	HP:0006944	Abolished vibration sense	1	FXN CL E G H	2395	229300	Friedreich ataxia 1	229300	C1856689	OMIM	1	143	3951	606829
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	FXN CL E G H	2395	229300	Friedreich ataxia 1	229300	C1856689	OMIM	1	143	3951	606829
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	GARS CL E G H	2617	139536				ORPHA	1		4162	600287
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	GARS CL E G H	2617	139536				ORPHA	1		4162	600287
HP:0002495	HP:0006944	Abolished vibration sense	1	GARS CL E G H	2617	139536				ORPHA	1		4162	600287
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	MAG CL E G H	4099	459056				ORPHA	1	171	6783	159460
HP:0002495	HP:0006944	Abolished vibration sense	1	MAG CL E G H	4099	459056				ORPHA	1	171	6783	159460
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	MAG CL E G H	4099	459056				ORPHA	1	171	6783	159460
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	MFN2 CL E G H	9927	99947				ORPHA	1	1063	16877	608507
HP:0002495	HP:0006944	Abolished vibration sense	1	MFN2 CL E G H	9927	99947				ORPHA	1	1063	16877	608507
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	MFN2 CL E G H	9927	99947				ORPHA	1	1063	16877	608507
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	NIPA1 CL E G H	123606	100988				ORPHA	1	576	17043	608145
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	NIPA1 CL E G H	123606	100988				ORPHA	1	576	17043	608145
HP:0002495	HP:0006944	Abolished vibration sense	1	NIPA1 CL E G H	123606	100988				ORPHA	1	576	17043	608145
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	PLEKHG4 CL E G H	25894	98765				ORPHA	1	41	24501	609526
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	PLEKHG4 CL E G H	25894	98765				ORPHA	1	41	24501	609526
HP:0002495	HP:0006944	Abolished vibration sense	1	PLEKHG4 CL E G H	25894	98765				ORPHA	1	41	24501	609526
HP:0002495	HP:0006944	Abolished vibration sense	1	POLG CL E G H	5428	70595				ORPHA	1	1917	9179	174763
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	POLG CL E G H	5428	70595				ORPHA	1	1917	9179	174763
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	POLG CL E G H	5428	70595				ORPHA	1	1917	9179	174763
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	POLG CL E G H	5428	94125	Recessive mitochondrial ataxia syndrome		CN206743	ORPHA	1	1917	9179	174763
HP:0002495	HP:0006944	Abolished vibration sense	1	POLG CL E G H	5428	94125	Recessive mitochondrial ataxia syndrome		CN206743	ORPHA	1	1917	9179	174763
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	POLG CL E G H	5428	94125	Recessive mitochondrial ataxia syndrome		CN206743	ORPHA	1	1917	9179	174763
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	REEP1 CL E G H	65055	139536				ORPHA	1	377	25786	609139
HP:0002495	HP:0006944	Abolished vibration sense	1	REEP1 CL E G H	65055	139536				ORPHA	1	377	25786	609139
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	REEP1 CL E G H	65055	139536				ORPHA	1	377	25786	609139
HP:0002495	HP:0006944	Abolished vibration sense	1	SAR1B CL E G H	51128	246700	Chylomicron retention disease	246700	C0795956	OMIM	1	102	10535	607690
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	SAR1B CL E G H	51128	246700	Chylomicron retention disease	246700	C0795956	OMIM	1	102	10535	607690
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	SAR1B CL E G H	51128	246700	Chylomicron retention disease	246700	C0795956	OMIM	1	102	10535	607690
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	343	10985	603861
HP:0002495	HP:0006944	Abolished vibration sense	1	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	343	10985	603861
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	343	10985	603861
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	SPART CL E G H	23111	101000				ORPHA	1	274	18514	607111
HP:0002495	HP:0006944	Abolished vibration sense	1	SPART CL E G H	23111	101000				ORPHA	1	274	18514	607111
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	SPART CL E G H	23111	101000				ORPHA	1	274	18514	607111
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	SPTBN2 CL E G H	6712	600224	Spinocerebellar ataxia 5	600224	C0752123	OMIM	1	716	11276	604985
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	SPTBN2 CL E G H	6712	600224	Spinocerebellar ataxia 5	600224	C0752123	OMIM	1	716	11276	604985
HP:0002495	HP:0006944	Abolished vibration sense	1	SPTBN2 CL E G H	6712	600224	Spinocerebellar ataxia 5	600224	C0752123	OMIM	1	716	11276	604985
HP:0002495	HP:0006944	Abolished vibration sense	1	TPP1 CL E G H	1200	284324				ORPHA	1	849	2073	607998
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	TPP1 CL E G H	1200	284324				ORPHA	1	849	2073	607998
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	TPP1 CL E G H	1200	284324				ORPHA	1	849	2073	607998
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	TPP1 CL E G H	1200	609270	Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia	609270	C1836474	OMIM	1	849	2073	607998
HP:0002495	HP:0006944	Abolished vibration sense	1	TPP1 CL E G H	1200	609270	Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia	609270	C1836474	OMIM	1	849	2073	607998
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	TPP1 CL E G H	1200	609270	Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia	609270	C1836474	OMIM	1	849	2073	607998
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	TWNK CL E G H	56652	70595				ORPHA	1	308	1160	606075
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	TWNK CL E G H	56652	70595				ORPHA	1	308	1160	606075
HP:0002495	HP:0006944	Abolished vibration sense	1	TWNK CL E G H	56652	70595				ORPHA	1	308	1160	606075
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ATXN1 CL E G H	6310	164400	Spinocerebellar ataxia 1	164400	C0752120	OMIM	1	86	10548	601556
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ATXN2 CL E G H	6311	183090	Spinocerebellar ataxia 2	183090	C0752121	OMIM	1	53	10555	601517
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ATXN3 CL E G H	4287	109150	Azorean disease	109150	C0024408	OMIM	1	46	7106	607047
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	BSCL2 CL E G H	26580	139536				ORPHA	1	435	15832	606158
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	C19orf12 CL E G H	83636	320370				ORPHA	1	276	25443	614297
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	CYP7B1 CL E G H	9420	100986				ORPHA	1	333	2652	603711
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	FXN CL E G H	2395	229300	Friedreich ataxia 1	229300	C1856689	OMIM	1	143	3951	606829
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	GARS CL E G H	2617	139536				ORPHA	1		4162	600287
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	MAG CL E G H	4099	459056				ORPHA	1	171	6783	159460
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	MFN2 CL E G H	9927	99947				ORPHA	1	1063	16877	608507
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	NIPA1 CL E G H	123606	100988				ORPHA	1	576	17043	608145
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	PLEKHG4 CL E G H	25894	98765				ORPHA	1	41	24501	609526
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	POLG CL E G H	5428	70595				ORPHA	1	1917	9179	174763
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	POLG CL E G H	5428	94125	Recessive mitochondrial ataxia syndrome		CN206743	ORPHA	1	1917	9179	174763
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	REEP1 CL E G H	65055	139536				ORPHA	1	377	25786	609139
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	SAR1B CL E G H	51128	246700	Chylomicron retention disease	246700	C0795956	OMIM	1	102	10535	607690
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	SLC25A15 CL E G H	10166	238970	Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome	238970	C0268540	OMIM	1	343	10985	603861
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	SPART CL E G H	23111	101000				ORPHA	1	274	18514	607111
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	SPTBN2 CL E G H	6712	600224	Spinocerebellar ataxia 5	600224	C0752123	OMIM	1	716	11276	604985
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	TPP1 CL E G H	1200	284324				ORPHA	1	849	2073	607998
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	TPP1 CL E G H	1200	609270	Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia	609270	C1836474	OMIM	1	849	2073	607998
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	TWNK CL E G H	56652	70595				ORPHA	1	308	1160	606075
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ALDH18A1 CL E G H	5832	601162	Spastic paraplegia 9	601162	C1832669	OMIM	0	437	9722	138250
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ATL1 CL E G H	51062	100984				ORPHA	0	408	11231	606439
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ATXN8 CL E G H	724066	98760				ORPHA	0	2	32925	613289
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ATXN8OS CL E G H	6315	98760				ORPHA	0	79	10561	603680
HP:0002495	HP:0002495	Impaired vibratory sensation	0	BEAN1 CL E G H	146227	217012				ORPHA	0	35	24160	612051
HP:0002495	HP:0002495	Impaired vibratory sensation	0	FGF14 CL E G H	2259	609307	Spinocerebellar ataxia 27	609307	C1836383	OMIM	0	208	3671	601515
HP:0002495	HP:0002495	Impaired vibratory sensation	0	MT-TE CL E G H	4556	2596	Hantavirosis			ORPHA	0		7479	590025
HP:0002495	HP:0002495	Impaired vibratory sensation	0	NEFH CL E G H	4744	616924	Charcot-Marie-Tooth disease, axonal, type 2CC	616924	C4310790	OMIM	0	465	7737	162230
HP:0002495	HP:0002495	Impaired vibratory sensation	0	SACS CL E G H	26278	98				ORPHA	0	2506	10519	604490
HP:0002495	HP:0002495	Impaired vibratory sensation	0	VPS37A CL E G H	137492	319199				ORPHA	0	198	24928	609927
HP:0002495	HP:0002495	Impaired vibratory sensation	0	ZFYVE26 CL E G H	23503	100996				ORPHA	0	1894	20761	612012
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ALDH18A1 CL E G H	5832	601162	Spastic paraplegia 9	601162	C1832669	OMIM	0	437	9722	138250
HP:0002495	HP:0006944	Abolished vibration sense	1	ALDH18A1 CL E G H	5832	601162	Spastic paraplegia 9	601162	C1832669	OMIM	0	437	9722	138250
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ALDH18A1 CL E G H	5832	601162	Spastic paraplegia 9	601162	C1832669	OMIM	0	437	9722	138250
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ATL1 CL E G H	51062	100984				ORPHA	0	408	11231	606439
HP:0002495	HP:0006944	Abolished vibration sense	1	ATL1 CL E G H	51062	100984				ORPHA	0	408	11231	606439
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ATL1 CL E G H	51062	100984				ORPHA	0	408	11231	606439
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ATXN8 CL E G H	724066	98760				ORPHA	0	2	32925	613289
HP:0002495	HP:0006944	Abolished vibration sense	1	ATXN8 CL E G H	724066	98760				ORPHA	0	2	32925	613289
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ATXN8 CL E G H	724066	98760				ORPHA	0	2	32925	613289
HP:0002495	HP:0006944	Abolished vibration sense	1	ATXN8OS CL E G H	6315	98760				ORPHA	0	79	10561	603680
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ATXN8OS CL E G H	6315	98760				ORPHA	0	79	10561	603680
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ATXN8OS CL E G H	6315	98760				ORPHA	0	79	10561	603680
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	BEAN1 CL E G H	146227	217012				ORPHA	0	35	24160	612051
HP:0002495	HP:0006944	Abolished vibration sense	1	BEAN1 CL E G H	146227	217012				ORPHA	0	35	24160	612051
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	BEAN1 CL E G H	146227	217012				ORPHA	0	35	24160	612051
HP:0002495	HP:0006944	Abolished vibration sense	1	FGF14 CL E G H	2259	609307	Spinocerebellar ataxia 27	609307	C1836383	OMIM	0	208	3671	601515
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	FGF14 CL E G H	2259	609307	Spinocerebellar ataxia 27	609307	C1836383	OMIM	0	208	3671	601515
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	FGF14 CL E G H	2259	609307	Spinocerebellar ataxia 27	609307	C1836383	OMIM	0	208	3671	601515
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	MT-TE CL E G H	4556	2596	Hantavirosis			ORPHA	0		7479	590025
HP:0002495	HP:0006944	Abolished vibration sense	1	MT-TE CL E G H	4556	2596	Hantavirosis			ORPHA	0		7479	590025
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	MT-TE CL E G H	4556	2596	Hantavirosis			ORPHA	0		7479	590025
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	NEFH CL E G H	4744	616924	Charcot-Marie-Tooth disease, axonal, type 2CC	616924	C4310790	OMIM	0	465	7737	162230
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	NEFH CL E G H	4744	616924	Charcot-Marie-Tooth disease, axonal, type 2CC	616924	C4310790	OMIM	0	465	7737	162230
HP:0002495	HP:0006944	Abolished vibration sense	1	NEFH CL E G H	4744	616924	Charcot-Marie-Tooth disease, axonal, type 2CC	616924	C4310790	OMIM	0	465	7737	162230
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	SACS CL E G H	26278	98				ORPHA	0	2506	10519	604490
HP:0002495	HP:0006944	Abolished vibration sense	1	SACS CL E G H	26278	98				ORPHA	0	2506	10519	604490
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	SACS CL E G H	26278	98				ORPHA	0	2506	10519	604490
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	VPS37A CL E G H	137492	319199				ORPHA	0	198	24928	609927
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	VPS37A CL E G H	137492	319199				ORPHA	0	198	24928	609927
HP:0002495	HP:0006944	Abolished vibration sense	1	VPS37A CL E G H	137492	319199				ORPHA	0	198	24928	609927
HP:0002495	HP:0006886	Impaired distal vibration sensation	1	ZFYVE26 CL E G H	23503	100996				ORPHA	0	1894	20761	612012
HP:0002495	HP:0006944	Abolished vibration sense	1	ZFYVE26 CL E G H	23503	100996				ORPHA	0	1894	20761	612012
HP:0002495	HP:0002166	Impaired vibration sensation in the lower limbs	1	ZFYVE26 CL E G H	23503	100996				ORPHA	0	1894	20761	612012
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ALDH18A1 CL E G H	5832	601162	Spastic paraplegia 9	601162	C1832669	OMIM	0	437	9722	138250
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ATL1 CL E G H	51062	100984				ORPHA	0	408	11231	606439
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ATXN8 CL E G H	724066	98760				ORPHA	0	2	32925	613289
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ATXN8OS CL E G H	6315	98760				ORPHA	0	79	10561	603680
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	BEAN1 CL E G H	146227	217012				ORPHA	0	35	24160	612051
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	FGF14 CL E G H	2259	609307	Spinocerebellar ataxia 27	609307	C1836383	OMIM	0	208	3671	601515
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	MT-TE CL E G H	4556	2596	Hantavirosis			ORPHA	0		7479	590025
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	NEFH CL E G H	4744	616924	Charcot-Marie-Tooth disease, axonal, type 2CC	616924	C4310790	OMIM	0	465	7737	162230
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	SACS CL E G H	26278	98				ORPHA	0	2506	10519	604490
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	VPS37A CL E G H	137492	319199				ORPHA	0	198	24928	609927
HP:0002495	HP:0006938	Impaired vibration sensation at ankles	2	ZFYVE26 CL E G H	23503	100996				ORPHA	0	1894	20761	612012

Genes (72) :ALDH18A1 ARSI ATL1 ATP6 ATXN1 ATXN2 ATXN3 ATXN8 ATXN8OS B4GALNT1 BEAN1 BSCL2 C19ORF12 C19orf12 CACNA1G CPT1C CYP7B1 DCAF8 DDHD1 FGF14 FLRT1 FLVCR1 FMR1 FXN GARS GBA2 GCH1 HARS HINT1 HSPD1 KCNC3 KCND3 KIF5A KLC2 KLHL9 LRSAM1 MAG MFN2 NEFH NIPA1 PDYN PEX6 PLEKHG4 POLG POLR3A PRKCG REEP1 REEP2 RTN2 SACS SAMD9L SAR1B SCO2 SETX SLC25A15 SLC33A1 SLC52A2 SPART SPAST SPG11 SPG7 SPTBN2 TDP1 TPP1 TRNE TWNK VAMP1 VCP VPS37A WASHC5 WDR48 ZFYVE26

Diseases (87) :601162 100984 164400 183090 109150 98760 217012 139536 320370 100986 609307 229300 459056 99947 616924 100988 98765 70595 94125 98 246700 238970 101000 600224 284324 609270 2596 319199 100996 447753 401815 182600 320360 270685 444099 270800 610100 101008 320406 88628 609033 300623 352641 614409 98808 488333 324442 100994 605280 98768 604187 399081 614436 600363 101108 610245 95433 157640 258450 607459 447896 100993 604805 270550 159550 521411 606002 171863 182601 604360 99013 607259 94124 251282 435387 100989 603563 401800 447760 101006 458803 616795 320391 98772 605361 401849 100985

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.

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