Human Phenotype Ontology 
Grandparent Node:
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Neurodevelopmental abnormality (HP:0012759)help
Parent Node:
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Specific learning disability (HP:0001328)help
..Starting node
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Dyscalculia (HP:0002442)help
Term ID: 2442
Name: Dyscalculia
Synonym: Difficulty making arithmetical calculations
Definition: A specific learning disability involving mathematics and arithmetic.
Comments:
Reference: HP:0002442
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandDyslexia (HP:0010522) help
..expandImpaired visuospatial constructive cognition (HP:0010794) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002442HP:0002442Dyscalculia0APC2 CL E G H1029724036ORPHA:821Sotos syndromeHP:0040283 - Occasional1
HP:0002442HP:0002442Dyscalculia0C9ORF72 CL E G H20322828337OMIM:105550Amyotrophic lateral sclerosis and/or frontotemporal dementia 1.56
HP:0002442HP:0002442Dyscalculia0C9ORF72 CL E G H20322828337ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent56
HP:0002442HP:0002442Dyscalculia0C9ORF72 CL E G H20322828337ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent56
HP:0002442HP:0002442Dyscalculia0CACNA1A CL E G H7731388OMIM:141500Migraine, familial hemiplegic, 1.449
HP:0002442HP:0002442Dyscalculia0CHCHD10 CL E G H40091615559ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent11
HP:0002442HP:0002442Dyscalculia0CHMP2B CL E G H2597824537ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent42
HP:0002442HP:0002442Dyscalculia0CHMP2B CL E G H2597824537OMIM:600795Frontotemporal dementia and/or amytrophic lateral sclerosis 7.42
HP:0002442HP:0002442Dyscalculia0CYLD CL E G H15402584OMIM:619132FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 8; FTDALS8126
HP:0002442HP:0002442Dyscalculia0FMR1 CL E G H23323775ORPHA:449291Symptomatic form of fragile X syndrome in female carriersHP:0040283 - Occasional30
HP:0002442HP:0002442Dyscalculia0FUS CL E G H25214010ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent105
HP:0002442HP:0002442Dyscalculia0GRN CL E G H28964601ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent126
HP:0002442HP:0002442Dyscalculia0HNRNPA1 CL E G H31785031ORPHA:52430Inclusion body myopathy with Paget disease of bone and frontotemporal dementiaHP:0040283 - Occasional31
HP:0002442HP:0002442Dyscalculia0HNRNPA2B1 CL E G H31815033ORPHA:52430Inclusion body myopathy with Paget disease of bone and frontotemporal dementiaHP:0040283 - Occasional5
HP:0002442HP:0002442Dyscalculia0MAP1B CL E G H41316836OMIM:618918PERIVENTRICULAR NODULAR HETEROTOPIA 9; PVNH9
HP:0002442HP:0002442Dyscalculia0MAPT CL E G H41376893ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent140
HP:0002442HP:0002442Dyscalculia0NSD1 CL E G H6432414234ORPHA:821Sotos syndromeHP:0040283 - Occasional544
HP:0002442HP:0002442Dyscalculia0PNKP CL E G H112849154ORPHA:459033Ataxia-oculomotor apraxia type 4HP:0040283 - Occasional244
HP:0002442HP:0002442Dyscalculia0PSEN1 CL E G H56639508ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent241
HP:0002442HP:0002442Dyscalculia0SETD2 CL E G H2907218420ORPHA:821Sotos syndromeHP:0040283 - Occasional60
HP:0002442HP:0002442Dyscalculia0SQSTM1 CL E G H887811280ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent62
HP:0002442HP:0002442Dyscalculia0SQSTM1 CL E G H887811280ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent62
HP:0002442HP:0002442Dyscalculia0SRY CL E G H673611311ORPHA:177245,X/46,XY mixed gonadal dysgenesisHP:0040283 - Occasional23
HP:0002442HP:0002442Dyscalculia0TARDBP CL E G H2343511571ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent65
HP:0002442HP:0002442Dyscalculia0TBK1 CL E G H2911011584ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent20
HP:0002442HP:0002442Dyscalculia0TMEM106B CL E G H5466422407ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent
HP:0002442HP:0002442Dyscalculia0TREM2 CL E G H5420917761ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent31
HP:0002442HP:0002442Dyscalculia0VCP CL E G H741512666ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent63
HP:0002442HP:0002442Dyscalculia0VCP CL E G H741512666ORPHA:275872Frontotemporal dementia with motor neuron diseaseHP:0040282 - Frequent63
HP:0002442HP:0002442Dyscalculia0VCP CL E G H741512666ORPHA:52430Inclusion body myopathy with Paget disease of bone and frontotemporal dementiaHP:0040283 - Occasional63


Genes (24) :APC2 C9ORF72 CACNA1A CHCHD10 CHMP2B CYLD FMR1 FUS GRN HNRNPA1 HNRNPA2B1 MAP1B MAPT NSD1 PNKP PSEN1 SETD2 SQSTM1 SRY TARDBP TBK1 TMEM106B TREM2 VCP

Diseases (12) :ORPHA:821 OMIM:105550 ORPHA:275864 ORPHA:275872 OMIM:141500 OMIM:600795 OMIM:619132 ORPHA:449291 ORPHA:52430 OMIM:618918 ORPHA:459033 ORPHA:1772
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.