Human Phenotype Ontology 
Grandparent Node:
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Abnormality of nervous system physiology (HP:0012638)help
Parent Node:
expand
Behavioral abnormality (HP:0000708)help
..Starting node
..expand
Sleep disturbance (HP:0002360)help
Term ID: 2360
Name: Sleep disturbance
Synonym: Difficulty sleeping; Sleep disturbances; Sleep dysfunction; Trouble sleeping
Definition: An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness.
Comments:
Reference: HP:0002360
Genes and Diseases:
 
       Child Nodes:
........expandExcessive daytime somnolence (HP:0001262) help
........expandExcessive daytime sleepiness (HP:0002189) help
........expandAbnormal rapid eye movement sleep (HP:0002494) help
........expandBruxism (HP:0003763) help
........expandSleep-wake cycle disturbance (HP:0006979) help
................... HP:0031849 Sleep-wake inversion
................... HP:0031873 Early chronotype
................... HP:0031874 Late chronotype
........expandSleep apnea (HP:0010535) help
................... HP:0002870 Obstructive sleep apnea
................... HP:0010536 Central sleep apnea
........expandRestless legs (HP:0012452) help
........expandSleep paralysis (HP:0025233) help
........expandParasomnia (HP:0025234) help
................... HP:0025235 Non-rapid eye movement parasomnia
........expandSnoring (HP:0025267) help
................... HP:0025372 Loud snoring
........expandNarcolepsy (HP:0030050) help
........expandInsomnia (HP:0100785) help
................... HP:0031354 Sleep onset Insomnia
................... HP:0031355 Maintenance insomnia
................... HP:0031356 Terminal insomnia
........expandHypersomnia (HP:0100786) help
................... HP:0007200 Episodic hypersomnia

 Sister Nodes: 
..expandAbnormal consumption behavior (HP:0040202) help
..expandAbnormal emotion/affect behavior (HP:0100851) help
..expandAbnormal social behavior (HP:0012433) help
..expandAbnormal temper tantrums (HP:0025160) help
..expandAddictive behavior (HP:0030858) help
..expandAutistic behavior (HP:0000729) help
..expandDelusions (HP:0000746) help
..expandDrooling (HP:0002307) help
..expandEcholalia (HP:0010529) help
..expandHallucinations (HP:0000738) help
..expandHyperorality (HP:0000710) help
..expandImpairment in personality functioning (HP:0031466) help
..expandInflexible adherence to routines or rituals (HP:0000732) help
..expandLack of insight (HP:0000757) help
..expandLack of spontaneous play (HP:0000721) help
..expandLow frustration tolerance (HP:0000744) help
..expandMania (HP:0100754) help
..expandMutism (HP:0002300) help
..expandObsessive-compulsive behavior (HP:0000722) help
..expandOppositional defiant disorder (HP:0010865) help
..expandPerseveration (HP:0030223) help
..expandPersonality changes (HP:0000751) help
..expandPhotophobia (HP:0000613) help
..expandPseudobulbar behavioral symptoms (HP:0002193) help
..expandPsychomotor retardation (HP:0025356) help
..expandPsychosis (HP:0000709) help
..expandRestlessness (HP:0000711) help
..expandSchizophrenia (HP:0100753) help
..expandSelf-neglect (HP:0025479) help
..expandShort attention span (HP:0000736) help
..expandSound sensitivity (HP:0025112) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0002360HP:0002360Sleep disturbance0ASPA CL E G H443314911ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance0ASPA CL E G H443314918ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance0ATAD1 CL E G H848963197Lateral body wall defectORPHA132625903614452
HP:0002360HP:0002360Sleep disturbance0BSCL2 CL E G H26580363400ORPHA15026315832606158
HP:0002360HP:0002360Sleep disturbance0DCTN1 CL E G H1639178509ORPHA1574212711601143
HP:0002360HP:0002360Sleep disturbance0DCTN1 CL E G H1639168605Perry syndrome168605C1868594OMIM1574212711601143
HP:0002360HP:0002360Sleep disturbance0DDC CL E G H1644608643Deficiency of aromatic-L-amino-acid decarboxylase608643C1291564OMIM1591162719107930
HP:0002360HP:0002360Sleep disturbance0DEAF1 CL E G H10522819ORPHA11712914677602635
HP:0002360HP:0002360Sleep disturbance0DEAF1 CL E G H10522617171Dyskinesia, seizures, and intellectual developmental disorder617171C4310683OMIM11712914677602635
HP:0002360HP:0002360Sleep disturbance0EHMT1 CL E G H79813610253Chromosome 9q deletion syndrome610253C0795833OMIM19474624650607001
HP:0002360HP:0002360Sleep disturbance0EML1 CL E G H2009600348Band heterotopia600348C1838239OMIM17663330602033
HP:0002360HP:0002360Sleep disturbance0FBXO7 CL E G H25793171695ORPHA11710913586605648
HP:0002360HP:0002360Sleep disturbance0FLII CL E G H2314819ORPHA121533750600362
HP:0002360HP:0002360Sleep disturbance0GABBR2 CL E G H9568617904Early infantile epileptic encephalopathy 59617904CN870853OMIM182094507607340
HP:0002360HP:0002360Sleep disturbance0GCH1 CL E G H264398808ORPHA12522084193600225
HP:0002360HP:0002360Sleep disturbance0GLRA1 CL E G H27413197Lateral body wall defectORPHA1721994326138491
HP:0002360HP:0002360Sleep disturbance0GLRB CL E G H27433197Lateral body wall defectORPHA1191254329138492
HP:0002360HP:0002360Sleep disturbance0GNS CL E G H2799252940Mucopolysaccharidosis, MPS-III-D252940C0086650OMIM1251464422607664
HP:0002360HP:0002360Sleep disturbance0GPHN CL E G H102433197Lateral body wall defectORPHA12015515465603930
HP:0002360HP:0002360Sleep disturbance0HDAC8 CL E G H55869199Cardiac hydatid cysts with intracavitary expansionORPHA15622713315300269
HP:0002360HP:0002360Sleep disturbance0HESX1 CL E G H8820226307ORPHA127464877601802
HP:0002360HP:0002360Sleep disturbance0HGSNAT CL E G H138050252930Mucopolysaccharidosis, MPS-III-C252930C0086649OMIM17237126527610453
HP:0002360HP:0002360Sleep disturbance0IDUA CL E G H342593473ORPHA12916225391252800
HP:0002360HP:0002360Sleep disturbance0IQSEC2 CL E G H23096819ORPHA15753929059300522
HP:0002360HP:0002360Sleep disturbance0KMT2A CL E G H4297199Cardiac hydatid cysts with intracavitary expansionORPHA11273797132159555
HP:0002360HP:0002360Sleep disturbance0LHX3 CL E G H8022226307ORPHA1181756595600577
HP:0002360HP:0002360Sleep disturbance0LHX4 CL E G H89884226307ORPHA12311621734602146
HP:0002360HP:0002360Sleep disturbance0LIAS CL E G H11019614462Pyruvate dehydrogenase lipoic acid synthetase deficiency614462C3280887OMIM1817916429607031
HP:0002360HP:0002360Sleep disturbance0MBD5 CL E G H55777228402ORPHA19166420444611472
HP:0002360HP:0002360Sleep disturbance0MFSD8 CL E G H256471610951Ceroid lipofuscinosis neuronal 7610951C1838571OMIM14935028486611124
HP:0002360HP:0002360Sleep disturbance0NAGLU CL E G H4669252920Mucopolysaccharidosis, MPS-III-B252920C0086648OMIM11762847632609701
HP:0002360HP:0002360Sleep disturbance0NDST1 CL E G H3340616116Mental retardation, autosomal recessive 46616116C4015283OMIM17847680600853
HP:0002360HP:0002360Sleep disturbance0NIPBL CL E G H25836199Cardiac hydatid cysts with intracavitary expansionORPHA143780928862608667
HP:0002360HP:0002360Sleep disturbance0NR4A2 CL E G H4929168600Parkinson disease, late-onset168600C3160718OMIM123797981601828
HP:0002360HP:0002360Sleep disturbance0NSDHL CL E G H50814300831NSDHL-Related Disorders300831C3151781OMIM13125613398300275
HP:0002360HP:0002360Sleep disturbance0POU1F1 CL E G H5449226307ORPHA146729210173110
HP:0002360HP:0002360Sleep disturbance0PPT1 CL E G H5538256730Ceroid lipofuscinosis neuronal 1256730C1850451OMIM1773299325600722
HP:0002360HP:0002360Sleep disturbance0PRNP CL E G H5621280397ORPHA11091269449176640
HP:0002360HP:0002360Sleep disturbance0PROP1 CL E G H5626226307ORPHA1421509455601538
HP:0002360HP:0002360Sleep disturbance0RAD21 CL E G H5885199Cardiac hydatid cysts with intracavitary expansionORPHA1131499811606462
HP:0002360HP:0002360Sleep disturbance0RAI1 CL E G H10743819ORPHA11164049834607642
HP:0002360HP:0002360Sleep disturbance0RAI1 CL E G H10743182290Smith-Magenis syndrome182290C0795864OMIM11164049834607642
HP:0002360HP:0002360Sleep disturbance0SEPSECS CL E G H51091613811Pontocerebellar hypoplasia type 2D613811C3151140OMIM11617430605613009
HP:0002360HP:0002360Sleep disturbance0SETD5 CL E G H55209199Cardiac hydatid cysts with intracavitary expansionORPHA13823625566615743
HP:0002360HP:0002360Sleep disturbance0SGSH CL E G H6448252900Mucopolysaccharidosis, MPS-III-A252900C0086647OMIM114840810818605270
HP:0002360HP:0002360Sleep disturbance0SIN3A CL E G H25942613406Witteveen-kolk syndrome613406C3150674OMIM11611619353607776
HP:0002360HP:0002360Sleep disturbance0SLC18A2 CL E G H6571352649ORPHA185110935193001
HP:0002360HP:0002360Sleep disturbance0SLC2A1 CL E G H6513606777GLUT1 deficiency syndrome 1606777CN030711OMIM128151611005138140
HP:0002360HP:0002360Sleep disturbance0SLC6A5 CL E G H91523197Lateral body wall defectORPHA13314311051604159
HP:0002360HP:0002360Sleep disturbance0SLC9A6 CL E G H10479300243Christianson syndrome300243C2678194OMIM12835111079300231
HP:0002360HP:0002360Sleep disturbance0SLITRK1 CL E G H114798137580Tourette Syndrome137580C0040517OMIM11116920297609678
HP:0002360HP:0002360Sleep disturbance0SMC1A CL E G H8243199Cardiac hydatid cysts with intracavitary expansionORPHA110048411111300040
HP:0002360HP:0002360Sleep disturbance0SMC3 CL E G H9126199Cardiac hydatid cysts with intracavitary expansionORPHA1282132468606062
HP:0002360HP:0002360Sleep disturbance0SNCA CL E G H6622171695ORPHA13713011138163890
HP:0002360HP:0002360Sleep disturbance0SNCA CL E G H6622168601Parkinson disease 1168601C1868595OMIM13713011138163890
HP:0002360HP:0002360Sleep disturbance0SNCAIP CL E G H9627168600Parkinson disease, late-onset168600C3160718OMIM1611511139603779
HP:0002360HP:0002360Sleep disturbance0SPR CL E G H669770594ORPHA12510011257182125
HP:0002360HP:0002360Sleep disturbance0SPR CL E G H6697612716Sepiapterin reductase deficiency612716C0268468OMIM12510011257182125
HP:0002360HP:0002360Sleep disturbance0THRA CL E G H706797927ORPHA1143411796190120
HP:0002360HP:0002360Sleep disturbance0THRB CL E G H706897927ORPHA117129511799190160
HP:0002360HP:0002360Sleep disturbance0TNXB CL E G H7148285Impossible syndromeORPHA13824411976600985
HP:0002360HP:0002360Sleep disturbance0TRHR CL E G H720199832ORPHA174912299188545
HP:0002360HP:0002360Sleep disturbance0TSHB CL E G H725290674ORPHA1142512372188540
HP:0002360HP:0002360Sleep disturbance0TSHR CL E G H725399819ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance0TSHR CL E G H725390673ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance0TSHR CL E G H7253424ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance0WDR45 CL E G H11152329284ORPHA17834928912300526
HP:0002360HP:0002360Sleep disturbance1ASPA CL E G H443314911ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance1ASPA CL E G H443314918ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance1ATAD1 CL E G H848963197Lateral body wall defectORPHA132625903614452
HP:0002360HP:0002360Sleep disturbance1BSCL2 CL E G H26580363400ORPHA15026315832606158
HP:0002360HP:0002360Sleep disturbance1DCTN1 CL E G H1639178509ORPHA1574212711601143
HP:0002360HP:0002360Sleep disturbance1DCTN1 CL E G H1639168605Perry syndrome168605C1868594OMIM1574212711601143
HP:0002360HP:0002360Sleep disturbance1DDC CL E G H1644608643Deficiency of aromatic-L-amino-acid decarboxylase608643C1291564OMIM1591162719107930
HP:0002360HP:0002360Sleep disturbance1DEAF1 CL E G H10522819ORPHA11712914677602635
HP:0002360HP:0002360Sleep disturbance1DEAF1 CL E G H10522617171Dyskinesia, seizures, and intellectual developmental disorder617171C4310683OMIM11712914677602635
HP:0002360HP:0002360Sleep disturbance1EHMT1 CL E G H79813610253Chromosome 9q deletion syndrome610253C0795833OMIM19474624650607001
HP:0002360HP:0002360Sleep disturbance1EML1 CL E G H2009600348Band heterotopia600348C1838239OMIM17663330602033
HP:0002360HP:0002360Sleep disturbance1FBXO7 CL E G H25793171695ORPHA11710913586605648
HP:0002360HP:0002360Sleep disturbance1FLII CL E G H2314819ORPHA121533750600362
HP:0002360HP:0002360Sleep disturbance1GABBR2 CL E G H9568617904Early infantile epileptic encephalopathy 59617904CN870853OMIM182094507607340
HP:0002360HP:0002360Sleep disturbance1GCH1 CL E G H264398808ORPHA12522084193600225
HP:0002360HP:0002360Sleep disturbance1GLRA1 CL E G H27413197Lateral body wall defectORPHA1721994326138491
HP:0002360HP:0002360Sleep disturbance1GLRB CL E G H27433197Lateral body wall defectORPHA1191254329138492
HP:0002360HP:0002360Sleep disturbance1GNS CL E G H2799252940Mucopolysaccharidosis, MPS-III-D252940C0086650OMIM1251464422607664
HP:0002360HP:0002360Sleep disturbance1GPHN CL E G H102433197Lateral body wall defectORPHA12015515465603930
HP:0002360HP:0002360Sleep disturbance1HDAC8 CL E G H55869199Cardiac hydatid cysts with intracavitary expansionORPHA15622713315300269
HP:0002360HP:0002360Sleep disturbance1HESX1 CL E G H8820226307ORPHA127464877601802
HP:0002360HP:0002360Sleep disturbance1HGSNAT CL E G H138050252930Mucopolysaccharidosis, MPS-III-C252930C0086649OMIM17237126527610453
HP:0002360HP:0002360Sleep disturbance1IDUA CL E G H342593473ORPHA12916225391252800
HP:0002360HP:0002360Sleep disturbance1IQSEC2 CL E G H23096819ORPHA15753929059300522
HP:0002360HP:0002360Sleep disturbance1KMT2A CL E G H4297199Cardiac hydatid cysts with intracavitary expansionORPHA11273797132159555
HP:0002360HP:0002360Sleep disturbance1LHX3 CL E G H8022226307ORPHA1181756595600577
HP:0002360HP:0002360Sleep disturbance1LHX4 CL E G H89884226307ORPHA12311621734602146
HP:0002360HP:0002360Sleep disturbance1LIAS CL E G H11019614462Pyruvate dehydrogenase lipoic acid synthetase deficiency614462C3280887OMIM1817916429607031
HP:0002360HP:0002360Sleep disturbance1MBD5 CL E G H55777228402ORPHA19166420444611472
HP:0002360HP:0002360Sleep disturbance1MFSD8 CL E G H256471610951Ceroid lipofuscinosis neuronal 7610951C1838571OMIM14935028486611124
HP:0002360HP:0002360Sleep disturbance1NAGLU CL E G H4669252920Mucopolysaccharidosis, MPS-III-B252920C0086648OMIM11762847632609701
HP:0002360HP:0002360Sleep disturbance1NDST1 CL E G H3340616116Mental retardation, autosomal recessive 46616116C4015283OMIM17847680600853
HP:0002360HP:0002360Sleep disturbance1NIPBL CL E G H25836199Cardiac hydatid cysts with intracavitary expansionORPHA143780928862608667
HP:0002360HP:0002360Sleep disturbance1NR4A2 CL E G H4929168600Parkinson disease, late-onset168600C3160718OMIM123797981601828
HP:0002360HP:0002360Sleep disturbance1NSDHL CL E G H50814300831NSDHL-Related Disorders300831C3151781OMIM13125613398300275
HP:0002360HP:0002360Sleep disturbance1POU1F1 CL E G H5449226307ORPHA146729210173110
HP:0002360HP:0002360Sleep disturbance1PPT1 CL E G H5538256730Ceroid lipofuscinosis neuronal 1256730C1850451OMIM1773299325600722
HP:0002360HP:0002360Sleep disturbance1PRNP CL E G H5621280397ORPHA11091269449176640
HP:0002360HP:0002360Sleep disturbance1PROP1 CL E G H5626226307ORPHA1421509455601538
HP:0002360HP:0002360Sleep disturbance1RAD21 CL E G H5885199Cardiac hydatid cysts with intracavitary expansionORPHA1131499811606462
HP:0002360HP:0002360Sleep disturbance1RAI1 CL E G H10743819ORPHA11164049834607642
HP:0002360HP:0002360Sleep disturbance1RAI1 CL E G H10743182290Smith-Magenis syndrome182290C0795864OMIM11164049834607642
HP:0002360HP:0002360Sleep disturbance1SEPSECS CL E G H51091613811Pontocerebellar hypoplasia type 2D613811C3151140OMIM11617430605613009
HP:0002360HP:0002360Sleep disturbance1SETD5 CL E G H55209199Cardiac hydatid cysts with intracavitary expansionORPHA13823625566615743
HP:0002360HP:0002360Sleep disturbance1SGSH CL E G H6448252900Mucopolysaccharidosis, MPS-III-A252900C0086647OMIM114840810818605270
HP:0002360HP:0002360Sleep disturbance1SIN3A CL E G H25942613406Witteveen-kolk syndrome613406C3150674OMIM11611619353607776
HP:0002360HP:0002360Sleep disturbance1SLC18A2 CL E G H6571352649ORPHA185110935193001
HP:0002360HP:0002360Sleep disturbance1SLC2A1 CL E G H6513606777GLUT1 deficiency syndrome 1606777CN030711OMIM128151611005138140
HP:0002360HP:0002360Sleep disturbance1SLC6A5 CL E G H91523197Lateral body wall defectORPHA13314311051604159
HP:0002360HP:0002360Sleep disturbance1SLC9A6 CL E G H10479300243Christianson syndrome300243C2678194OMIM12835111079300231
HP:0002360HP:0002360Sleep disturbance1SLITRK1 CL E G H114798137580Tourette Syndrome137580C0040517OMIM11116920297609678
HP:0002360HP:0002360Sleep disturbance1SMC1A CL E G H8243199Cardiac hydatid cysts with intracavitary expansionORPHA110048411111300040
HP:0002360HP:0002360Sleep disturbance1SMC3 CL E G H9126199Cardiac hydatid cysts with intracavitary expansionORPHA1282132468606062
HP:0002360HP:0002360Sleep disturbance1SNCA CL E G H6622171695ORPHA13713011138163890
HP:0002360HP:0002360Sleep disturbance1SNCA CL E G H6622168601Parkinson disease 1168601C1868595OMIM13713011138163890
HP:0002360HP:0002360Sleep disturbance1SNCAIP CL E G H9627168600Parkinson disease, late-onset168600C3160718OMIM1611511139603779
HP:0002360HP:0002360Sleep disturbance1SPR CL E G H669770594ORPHA12510011257182125
HP:0002360HP:0002360Sleep disturbance1SPR CL E G H6697612716Sepiapterin reductase deficiency612716C0268468OMIM12510011257182125
HP:0002360HP:0002360Sleep disturbance1THRA CL E G H706797927ORPHA1143411796190120
HP:0002360HP:0002360Sleep disturbance1THRB CL E G H706897927ORPHA117129511799190160
HP:0002360HP:0002360Sleep disturbance1TNXB CL E G H7148285Impossible syndromeORPHA13824411976600985
HP:0002360HP:0002360Sleep disturbance1TRHR CL E G H720199832ORPHA174912299188545
HP:0002360HP:0002360Sleep disturbance1TSHB CL E G H725290674ORPHA1142512372188540
HP:0002360HP:0002360Sleep disturbance1TSHR CL E G H725390673ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance1TSHR CL E G H7253424ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance1TSHR CL E G H725399819ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance1WDR45 CL E G H11152329284ORPHA17834928912300526
HP:0002360HP:0002360Sleep disturbance2ASPA CL E G H443314911ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance2ASPA CL E G H443314918ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance2ATAD1 CL E G H848963197Lateral body wall defectORPHA132625903614452
HP:0002360HP:0002360Sleep disturbance2BSCL2 CL E G H26580363400ORPHA15026315832606158
HP:0002360HP:0002360Sleep disturbance2DCTN1 CL E G H1639178509ORPHA1574212711601143
HP:0002360HP:0002360Sleep disturbance2DCTN1 CL E G H1639168605Perry syndrome168605C1868594OMIM1574212711601143
HP:0002360HP:0002360Sleep disturbance2DDC CL E G H1644608643Deficiency of aromatic-L-amino-acid decarboxylase608643C1291564OMIM1591162719107930
HP:0002360HP:0002360Sleep disturbance2DEAF1 CL E G H10522819ORPHA11712914677602635
HP:0002360HP:0002360Sleep disturbance2DEAF1 CL E G H10522617171Dyskinesia, seizures, and intellectual developmental disorder617171C4310683OMIM11712914677602635
HP:0002360HP:0002360Sleep disturbance2EHMT1 CL E G H79813610253Chromosome 9q deletion syndrome610253C0795833OMIM19474624650607001
HP:0002360HP:0002360Sleep disturbance2EML1 CL E G H2009600348Band heterotopia600348C1838239OMIM17663330602033
HP:0002360HP:0002360Sleep disturbance2FBXO7 CL E G H25793171695ORPHA11710913586605648
HP:0002360HP:0002360Sleep disturbance2FLII CL E G H2314819ORPHA121533750600362
HP:0002360HP:0002360Sleep disturbance2GABBR2 CL E G H9568617904Early infantile epileptic encephalopathy 59617904CN870853OMIM182094507607340
HP:0002360HP:0002360Sleep disturbance2GCH1 CL E G H264398808ORPHA12522084193600225
HP:0002360HP:0002360Sleep disturbance2GLRA1 CL E G H27413197Lateral body wall defectORPHA1721994326138491
HP:0002360HP:0002360Sleep disturbance2GLRB CL E G H27433197Lateral body wall defectORPHA1191254329138492
HP:0002360HP:0002360Sleep disturbance2GNS CL E G H2799252940Mucopolysaccharidosis, MPS-III-D252940C0086650OMIM1251464422607664
HP:0002360HP:0002360Sleep disturbance2GPHN CL E G H102433197Lateral body wall defectORPHA12015515465603930
HP:0002360HP:0002360Sleep disturbance2HDAC8 CL E G H55869199Cardiac hydatid cysts with intracavitary expansionORPHA15622713315300269
HP:0002360HP:0002360Sleep disturbance2HESX1 CL E G H8820226307ORPHA127464877601802
HP:0002360HP:0002360Sleep disturbance2HGSNAT CL E G H138050252930Mucopolysaccharidosis, MPS-III-C252930C0086649OMIM17237126527610453
HP:0002360HP:0002360Sleep disturbance2IDUA CL E G H342593473ORPHA12916225391252800
HP:0002360HP:0002360Sleep disturbance2IQSEC2 CL E G H23096819ORPHA15753929059300522
HP:0002360HP:0002360Sleep disturbance2KMT2A CL E G H4297199Cardiac hydatid cysts with intracavitary expansionORPHA11273797132159555
HP:0002360HP:0002360Sleep disturbance2LHX3 CL E G H8022226307ORPHA1181756595600577
HP:0002360HP:0002360Sleep disturbance2LHX4 CL E G H89884226307ORPHA12311621734602146
HP:0002360HP:0002360Sleep disturbance2LIAS CL E G H11019614462Pyruvate dehydrogenase lipoic acid synthetase deficiency614462C3280887OMIM1817916429607031
HP:0002360HP:0002360Sleep disturbance2MBD5 CL E G H55777228402ORPHA19166420444611472
HP:0002360HP:0002360Sleep disturbance2MFSD8 CL E G H256471610951Ceroid lipofuscinosis neuronal 7610951C1838571OMIM14935028486611124
HP:0002360HP:0002360Sleep disturbance2NAGLU CL E G H4669252920Mucopolysaccharidosis, MPS-III-B252920C0086648OMIM11762847632609701
HP:0002360HP:0002360Sleep disturbance2NDST1 CL E G H3340616116Mental retardation, autosomal recessive 46616116C4015283OMIM17847680600853
HP:0002360HP:0002360Sleep disturbance2NIPBL CL E G H25836199Cardiac hydatid cysts with intracavitary expansionORPHA143780928862608667
HP:0002360HP:0002360Sleep disturbance2NR4A2 CL E G H4929168600Parkinson disease, late-onset168600C3160718OMIM123797981601828
HP:0002360HP:0002360Sleep disturbance2NSDHL CL E G H50814300831NSDHL-Related Disorders300831C3151781OMIM13125613398300275
HP:0002360HP:0002360Sleep disturbance2POU1F1 CL E G H5449226307ORPHA146729210173110
HP:0002360HP:0002360Sleep disturbance2PPT1 CL E G H5538256730Ceroid lipofuscinosis neuronal 1256730C1850451OMIM1773299325600722
HP:0002360HP:0002360Sleep disturbance2PRNP CL E G H5621280397ORPHA11091269449176640
HP:0002360HP:0002360Sleep disturbance2PROP1 CL E G H5626226307ORPHA1421509455601538
HP:0002360HP:0002360Sleep disturbance2RAD21 CL E G H5885199Cardiac hydatid cysts with intracavitary expansionORPHA1131499811606462
HP:0002360HP:0002360Sleep disturbance2RAI1 CL E G H10743819ORPHA11164049834607642
HP:0002360HP:0002360Sleep disturbance2RAI1 CL E G H10743182290Smith-Magenis syndrome182290C0795864OMIM11164049834607642
HP:0002360HP:0002360Sleep disturbance2SEPSECS CL E G H51091613811Pontocerebellar hypoplasia type 2D613811C3151140OMIM11617430605613009
HP:0002360HP:0002360Sleep disturbance2SETD5 CL E G H55209199Cardiac hydatid cysts with intracavitary expansionORPHA13823625566615743
HP:0002360HP:0002360Sleep disturbance2SGSH CL E G H6448252900Mucopolysaccharidosis, MPS-III-A252900C0086647OMIM114840810818605270
HP:0002360HP:0002360Sleep disturbance2SIN3A CL E G H25942613406Witteveen-kolk syndrome613406C3150674OMIM11611619353607776
HP:0002360HP:0002360Sleep disturbance2SLC18A2 CL E G H6571352649ORPHA185110935193001
HP:0002360HP:0002360Sleep disturbance2SLC2A1 CL E G H6513606777GLUT1 deficiency syndrome 1606777CN030711OMIM128151611005138140
HP:0002360HP:0002360Sleep disturbance2SLC6A5 CL E G H91523197Lateral body wall defectORPHA13314311051604159
HP:0002360HP:0002360Sleep disturbance2SLC9A6 CL E G H10479300243Christianson syndrome300243C2678194OMIM12835111079300231
HP:0002360HP:0002360Sleep disturbance2SLITRK1 CL E G H114798137580Tourette Syndrome137580C0040517OMIM11116920297609678
HP:0002360HP:0002360Sleep disturbance2SMC1A CL E G H8243199Cardiac hydatid cysts with intracavitary expansionORPHA110048411111300040
HP:0002360HP:0002360Sleep disturbance2SMC3 CL E G H9126199Cardiac hydatid cysts with intracavitary expansionORPHA1282132468606062
HP:0002360HP:0002360Sleep disturbance2SNCA CL E G H6622171695ORPHA13713011138163890
HP:0002360HP:0002360Sleep disturbance2SNCA CL E G H6622168601Parkinson disease 1168601C1868595OMIM13713011138163890
HP:0002360HP:0002360Sleep disturbance2SNCAIP CL E G H9627168600Parkinson disease, late-onset168600C3160718OMIM1611511139603779
HP:0002360HP:0002360Sleep disturbance2SPR CL E G H669770594ORPHA12510011257182125
HP:0002360HP:0002360Sleep disturbance2SPR CL E G H6697612716Sepiapterin reductase deficiency612716C0268468OMIM12510011257182125
HP:0002360HP:0002360Sleep disturbance2THRA CL E G H706797927ORPHA1143411796190120
HP:0002360HP:0002360Sleep disturbance2THRB CL E G H706897927ORPHA117129511799190160
HP:0002360HP:0002360Sleep disturbance2TNXB CL E G H7148285Impossible syndromeORPHA13824411976600985
HP:0002360HP:0002360Sleep disturbance2TRHR CL E G H720199832ORPHA174912299188545
HP:0002360HP:0002360Sleep disturbance2TSHB CL E G H725290674ORPHA1142512372188540
HP:0002360HP:0002360Sleep disturbance2TSHR CL E G H725390673ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance2TSHR CL E G H7253424ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance2TSHR CL E G H725399819ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance2WDR45 CL E G H11152329284ORPHA17834928912300526
HP:0002360HP:0002360Sleep disturbance3ASPA CL E G H443314918ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance3ASPA CL E G H443314911ORPHA1102177756608034
HP:0002360HP:0002360Sleep disturbance3ATAD1 CL E G H848963197Lateral body wall defectORPHA132625903614452
HP:0002360HP:0002360Sleep disturbance3BSCL2 CL E G H26580363400ORPHA15026315832606158
HP:0002360HP:0002360Sleep disturbance3DCTN1 CL E G H1639178509ORPHA1574212711601143
HP:0002360HP:0002360Sleep disturbance3DCTN1 CL E G H1639168605Perry syndrome168605C1868594OMIM1574212711601143
HP:0002360HP:0002360Sleep disturbance3DDC CL E G H1644608643Deficiency of aromatic-L-amino-acid decarboxylase608643C1291564OMIM1591162719107930
HP:0002360HP:0002360Sleep disturbance3DEAF1 CL E G H10522819ORPHA11712914677602635
HP:0002360HP:0002360Sleep disturbance3DEAF1 CL E G H10522617171Dyskinesia, seizures, and intellectual developmental disorder617171C4310683OMIM11712914677602635
HP:0002360HP:0002360Sleep disturbance3EHMT1 CL E G H79813610253Chromosome 9q deletion syndrome610253C0795833OMIM19474624650607001
HP:0002360HP:0002360Sleep disturbance3EML1 CL E G H2009600348Band heterotopia600348C1838239OMIM17663330602033
HP:0002360HP:0002360Sleep disturbance3FBXO7 CL E G H25793171695ORPHA11710913586605648
HP:0002360HP:0002360Sleep disturbance3FLII CL E G H2314819ORPHA121533750600362
HP:0002360HP:0002360Sleep disturbance3GABBR2 CL E G H9568617904Early infantile epileptic encephalopathy 59617904CN870853OMIM182094507607340
HP:0002360HP:0002360Sleep disturbance3GCH1 CL E G H264398808ORPHA12522084193600225
HP:0002360HP:0002360Sleep disturbance3GLRA1 CL E G H27413197Lateral body wall defectORPHA1721994326138491
HP:0002360HP:0002360Sleep disturbance3GLRB CL E G H27433197Lateral body wall defectORPHA1191254329138492
HP:0002360HP:0002360Sleep disturbance3GNS CL E G H2799252940Mucopolysaccharidosis, MPS-III-D252940C0086650OMIM1251464422607664
HP:0002360HP:0002360Sleep disturbance3GPHN CL E G H102433197Lateral body wall defectORPHA12015515465603930
HP:0002360HP:0002360Sleep disturbance3HDAC8 CL E G H55869199Cardiac hydatid cysts with intracavitary expansionORPHA15622713315300269
HP:0002360HP:0002360Sleep disturbance3HESX1 CL E G H8820226307ORPHA127464877601802
HP:0002360HP:0002360Sleep disturbance3HGSNAT CL E G H138050252930Mucopolysaccharidosis, MPS-III-C252930C0086649OMIM17237126527610453
HP:0002360HP:0002360Sleep disturbance3IDUA CL E G H342593473ORPHA12916225391252800
HP:0002360HP:0002360Sleep disturbance3IQSEC2 CL E G H23096819ORPHA15753929059300522
HP:0002360HP:0002360Sleep disturbance3KMT2A CL E G H4297199Cardiac hydatid cysts with intracavitary expansionORPHA11273797132159555
HP:0002360HP:0002360Sleep disturbance3LHX3 CL E G H8022226307ORPHA1181756595600577
HP:0002360HP:0002360Sleep disturbance3LHX4 CL E G H89884226307ORPHA12311621734602146
HP:0002360HP:0002360Sleep disturbance3LIAS CL E G H11019614462Pyruvate dehydrogenase lipoic acid synthetase deficiency614462C3280887OMIM1817916429607031
HP:0002360HP:0002360Sleep disturbance3MBD5 CL E G H55777228402ORPHA19166420444611472
HP:0002360HP:0002360Sleep disturbance3MFSD8 CL E G H256471610951Ceroid lipofuscinosis neuronal 7610951C1838571OMIM14935028486611124
HP:0002360HP:0002360Sleep disturbance3NAGLU CL E G H4669252920Mucopolysaccharidosis, MPS-III-B252920C0086648OMIM11762847632609701
HP:0002360HP:0002360Sleep disturbance3NDST1 CL E G H3340616116Mental retardation, autosomal recessive 46616116C4015283OMIM17847680600853
HP:0002360HP:0002360Sleep disturbance3NIPBL CL E G H25836199Cardiac hydatid cysts with intracavitary expansionORPHA143780928862608667
HP:0002360HP:0002360Sleep disturbance3NR4A2 CL E G H4929168600Parkinson disease, late-onset168600C3160718OMIM123797981601828
HP:0002360HP:0002360Sleep disturbance3NSDHL CL E G H50814300831NSDHL-Related Disorders300831C3151781OMIM13125613398300275
HP:0002360HP:0002360Sleep disturbance3POU1F1 CL E G H5449226307ORPHA146729210173110
HP:0002360HP:0002360Sleep disturbance3PPT1 CL E G H5538256730Ceroid lipofuscinosis neuronal 1256730C1850451OMIM1773299325600722
HP:0002360HP:0002360Sleep disturbance3PRNP CL E G H5621280397ORPHA11091269449176640
HP:0002360HP:0002360Sleep disturbance3PROP1 CL E G H5626226307ORPHA1421509455601538
HP:0002360HP:0002360Sleep disturbance3RAD21 CL E G H5885199Cardiac hydatid cysts with intracavitary expansionORPHA1131499811606462
HP:0002360HP:0002360Sleep disturbance3RAI1 CL E G H10743819ORPHA11164049834607642
HP:0002360HP:0002360Sleep disturbance3RAI1 CL E G H10743182290Smith-Magenis syndrome182290C0795864OMIM11164049834607642
HP:0002360HP:0002360Sleep disturbance3SEPSECS CL E G H51091613811Pontocerebellar hypoplasia type 2D613811C3151140OMIM11617430605613009
HP:0002360HP:0002360Sleep disturbance3SETD5 CL E G H55209199Cardiac hydatid cysts with intracavitary expansionORPHA13823625566615743
HP:0002360HP:0002360Sleep disturbance3SGSH CL E G H6448252900Mucopolysaccharidosis, MPS-III-A252900C0086647OMIM114840810818605270
HP:0002360HP:0002360Sleep disturbance3SIN3A CL E G H25942613406Witteveen-kolk syndrome613406C3150674OMIM11611619353607776
HP:0002360HP:0002360Sleep disturbance3SLC18A2 CL E G H6571352649ORPHA185110935193001
HP:0002360HP:0002360Sleep disturbance3SLC2A1 CL E G H6513606777GLUT1 deficiency syndrome 1606777CN030711OMIM128151611005138140
HP:0002360HP:0002360Sleep disturbance3SLC6A5 CL E G H91523197Lateral body wall defectORPHA13314311051604159
HP:0002360HP:0002360Sleep disturbance3SLC9A6 CL E G H10479300243Christianson syndrome300243C2678194OMIM12835111079300231
HP:0002360HP:0002360Sleep disturbance3SLITRK1 CL E G H114798137580Tourette Syndrome137580C0040517OMIM11116920297609678
HP:0002360HP:0002360Sleep disturbance3SMC1A CL E G H8243199Cardiac hydatid cysts with intracavitary expansionORPHA110048411111300040
HP:0002360HP:0002360Sleep disturbance3SMC3 CL E G H9126199Cardiac hydatid cysts with intracavitary expansionORPHA1282132468606062
HP:0002360HP:0002360Sleep disturbance3SNCA CL E G H6622171695ORPHA13713011138163890
HP:0002360HP:0002360Sleep disturbance3SNCA CL E G H6622168601Parkinson disease 1168601C1868595OMIM13713011138163890
HP:0002360HP:0002360Sleep disturbance3SNCAIP CL E G H9627168600Parkinson disease, late-onset168600C3160718OMIM1611511139603779
HP:0002360HP:0002360Sleep disturbance3SPR CL E G H669770594ORPHA12510011257182125
HP:0002360HP:0002360Sleep disturbance3SPR CL E G H6697612716Sepiapterin reductase deficiency612716C0268468OMIM12510011257182125
HP:0002360HP:0002360Sleep disturbance3THRA CL E G H706797927ORPHA1143411796190120
HP:0002360HP:0002360Sleep disturbance3THRB CL E G H706897927ORPHA117129511799190160
HP:0002360HP:0002360Sleep disturbance3TNXB CL E G H7148285Impossible syndromeORPHA13824411976600985
HP:0002360HP:0002360Sleep disturbance3TRHR CL E G H720199832ORPHA174912299188545
HP:0002360HP:0002360Sleep disturbance3TSHB CL E G H725290674ORPHA1142512372188540
HP:0002360HP:0002360Sleep disturbance3TSHR CL E G H725399819ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance3TSHR CL E G H725390673ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance3TSHR CL E G H7253424ORPHA116117812373603372
HP:0002360HP:0002360Sleep disturbance3WDR45 CL E G H11152329284ORPHA17834928912300526
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002360HP:0002360Sleep disturbance0AGA CL E G H17593ORPHA038239318613228
HP:0002360HP:0002360Sleep disturbance0AIFM1 CL E G H9131101078ORPHA0333438768300169
HP:0002360HP:0002360Sleep disturbance0ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA064916876606036
HP:0002360HP:0002360Sleep disturbance0ATAD3A CL E G H55210496790ORPHA01718625567612316
HP:0002360HP:0002360Sleep disturbance0ATXN10 CL E G H2581498761ORPHA047710549611150
HP:0002360HP:0002360Sleep disturbance0ATXN3 CL E G H4287276238ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance0ATXN3 CL E G H4287276241ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance0ATXN3 CL E G H4287276244ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance0CDH23 CL E G H6407296253ORPHA0361143713733605516
HP:0002360HP:0002360Sleep disturbance0CISD2 CL E G H4938563463ORPHA042324212611507
HP:0002360HP:0002360Sleep disturbance0DNAJC13 CL E G H23317411602ORPHA0165130343614334
HP:0002360HP:0002360Sleep disturbance0EHMT1 CL E G H7981396147ORPHA09474624650607001
HP:0002360HP:0002360Sleep disturbance0EIF4G1 CL E G H1981411602ORPHA020523296600495
HP:0002360HP:0002360Sleep disturbance0ELN CL E G H2006194050Williams syndrome194050C0175702OMIM01275233327130160
HP:0002360HP:0002360Sleep disturbance0EPG5 CL E G H577241493Congenital mesoblastic nephromaORPHA06849529331615068
HP:0002360HP:0002360Sleep disturbance0FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA02653883688136350
HP:0002360HP:0002360Sleep disturbance0GBA CL E G H2629411602ORPHA04942064177606463
HP:0002360HP:0002360Sleep disturbance0GIGYF2 CL E G H26058411602ORPHA03612611960612003
HP:0002360HP:0002360Sleep disturbance0HDAC4 CL E G H97591001Branchial arch defectsORPHA01622314063605314
HP:0002360HP:0002360Sleep disturbance0HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA027464877601802
HP:0002360HP:0002360Sleep disturbance0KIF11 CL E G H3832152950Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation152950C1835265OMIM0701726388148760
HP:0002360HP:0002360Sleep disturbance0LRRK2 CL E G H120892411602ORPHA013838818618609007
HP:0002360HP:0002360Sleep disturbance0MLXIPL CL E G H51085194050Williams syndrome194050C0175702OMIM0619712744605678
HP:0002360HP:0002360Sleep disturbance0NDP CL E G H4693649ORPHA01672077678300658
HP:0002360HP:0002360Sleep disturbance0NKX2-1 CL E G H7080610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress610978C1970269OMIM014313611825600635
HP:0002360HP:0002360Sleep disturbance0OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA078988522600037
HP:0002360HP:0002360Sleep disturbance0PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA0839815836607123
HP:0002360HP:0002360Sleep disturbance0SATB2 CL E G H23314251019ORPHA010627421637608148
HP:0002360HP:0002360Sleep disturbance0SEPT9 CL E G H108012901Hypogonadotropic hypogonadism-anosmia, X-linkedORPHA01987323604061
HP:0002360HP:0002360Sleep disturbance0SLC2A1 CL E G H651371277ORPHA028151611005138140
HP:0002360HP:0002360Sleep disturbance0SNCA CL E G H6622411602ORPHA03713011138163890
HP:0002360HP:0002360Sleep disturbance0SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA010510511195184429
HP:0002360HP:0002360Sleep disturbance0SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA02821811199313430
HP:0002360HP:0002360Sleep disturbance0SPART CL E G H23111101000ORPHA0718318514607111
HP:0002360HP:0002360Sleep disturbance0TFAP2B CL E G H702146627ORPHA0155711743601601
HP:0002360HP:0002360Sleep disturbance0USP8 CL E G H910196253ORPHA018512631603158
HP:0002360HP:0002360Sleep disturbance0VPS13A CL E G H232302388ORPHA01165061908605978
HP:0002360HP:0002360Sleep disturbance0VPS35 CL E G H55737411602ORPHA02311713487601501
HP:0002360HP:0002360Sleep disturbance0WAC CL E G H51322616708Desanto-shinawi syndrome616708C4225239OMIM0257717327615049
HP:0002360HP:0002360Sleep disturbance0WDR73 CL E G H84942251300Galloway-Mowat syndrome 1251300CN031715OMIM0129525928616144
HP:0002360HP:0002360Sleep disturbance0WFS1 CL E G H74663463ORPHA039371412762606201
HP:0002360HP:0002360Sleep disturbance1AGA CL E G H17593ORPHA038239318613228
HP:0002360HP:0002360Sleep disturbance1AIFM1 CL E G H9131101078ORPHA0333438768300169
HP:0002360HP:0002360Sleep disturbance1ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA064916876606036
HP:0002360HP:0002360Sleep disturbance1ATAD3A CL E G H55210496790ORPHA01718625567612316
HP:0002360HP:0002360Sleep disturbance1ATXN10 CL E G H2581498761ORPHA047710549611150
HP:0002360HP:0002360Sleep disturbance1ATXN3 CL E G H4287276241ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance1ATXN3 CL E G H4287276244ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance1ATXN3 CL E G H4287276238ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance1CDH23 CL E G H6407296253ORPHA0361143713733605516
HP:0002360HP:0002360Sleep disturbance1CISD2 CL E G H4938563463ORPHA042324212611507
HP:0002360HP:0002360Sleep disturbance1DNAJC13 CL E G H23317411602ORPHA0165130343614334
HP:0002360HP:0002360Sleep disturbance1EHMT1 CL E G H7981396147ORPHA09474624650607001
HP:0002360HP:0002360Sleep disturbance1EIF4G1 CL E G H1981411602ORPHA020523296600495
HP:0002360HP:0002360Sleep disturbance1ELN CL E G H2006194050Williams syndrome194050C0175702OMIM01275233327130160
HP:0002360HP:0002360Sleep disturbance1EPG5 CL E G H577241493Congenital mesoblastic nephromaORPHA06849529331615068
HP:0002360HP:0002360Sleep disturbance1FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA02653883688136350
HP:0002360HP:0002360Sleep disturbance1GBA CL E G H2629411602ORPHA04942064177606463
HP:0002360HP:0002360Sleep disturbance1GIGYF2 CL E G H26058411602ORPHA03612611960612003
HP:0002360HP:0002360Sleep disturbance1HDAC4 CL E G H97591001Branchial arch defectsORPHA01622314063605314
HP:0002360HP:0002360Sleep disturbance1HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA027464877601802
HP:0002360HP:0002360Sleep disturbance1KIF11 CL E G H3832152950Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation152950C1835265OMIM0701726388148760
HP:0002360HP:0002360Sleep disturbance1LRRK2 CL E G H120892411602ORPHA013838818618609007
HP:0002360HP:0002360Sleep disturbance1MLXIPL CL E G H51085194050Williams syndrome194050C0175702OMIM0619712744605678
HP:0002360HP:0002360Sleep disturbance1NDP CL E G H4693649ORPHA01672077678300658
HP:0002360HP:0002360Sleep disturbance1NKX2-1 CL E G H7080610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress610978C1970269OMIM014313611825600635
HP:0002360HP:0002360Sleep disturbance1OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA078988522600037
HP:0002360HP:0002360Sleep disturbance1PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA0839815836607123
HP:0002360HP:0002360Sleep disturbance1SATB2 CL E G H23314251019ORPHA010627421637608148
HP:0002360HP:0002360Sleep disturbance1SEPT9 CL E G H108012901Hypogonadotropic hypogonadism-anosmia, X-linkedORPHA01987323604061
HP:0002360HP:0002360Sleep disturbance1SLC2A1 CL E G H651371277ORPHA028151611005138140
HP:0002360HP:0002360Sleep disturbance1SNCA CL E G H6622411602ORPHA03713011138163890
HP:0002360HP:0002360Sleep disturbance1SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA010510511195184429
HP:0002360HP:0002360Sleep disturbance1SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA02821811199313430
HP:0002360HP:0002360Sleep disturbance1SPART CL E G H23111101000ORPHA0718318514607111
HP:0002360HP:0002360Sleep disturbance1TFAP2B CL E G H702146627ORPHA0155711743601601
HP:0002360HP:0002360Sleep disturbance1USP8 CL E G H910196253ORPHA018512631603158
HP:0002360HP:0002360Sleep disturbance1VPS13A CL E G H232302388ORPHA01165061908605978
HP:0002360HP:0002360Sleep disturbance1VPS35 CL E G H55737411602ORPHA02311713487601501
HP:0002360HP:0002360Sleep disturbance1WAC CL E G H51322616708Desanto-shinawi syndrome616708C4225239OMIM0257717327615049
HP:0002360HP:0002360Sleep disturbance1WDR73 CL E G H84942251300Galloway-Mowat syndrome 1251300CN031715OMIM0129525928616144
HP:0002360HP:0002360Sleep disturbance1WFS1 CL E G H74663463ORPHA039371412762606201
HP:0002360HP:0002360Sleep disturbance2AGA CL E G H17593ORPHA038239318613228
HP:0002360HP:0002360Sleep disturbance2AIFM1 CL E G H9131101078ORPHA0333438768300169
HP:0002360HP:0002360Sleep disturbance2ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA064916876606036
HP:0002360HP:0002360Sleep disturbance2ATAD3A CL E G H55210496790ORPHA01718625567612316
HP:0002360HP:0002360Sleep disturbance2ATXN10 CL E G H2581498761ORPHA047710549611150
HP:0002360HP:0002360Sleep disturbance2ATXN3 CL E G H4287276238ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance2ATXN3 CL E G H4287276241ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance2ATXN3 CL E G H4287276244ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance2CDH23 CL E G H6407296253ORPHA0361143713733605516
HP:0002360HP:0002360Sleep disturbance2CISD2 CL E G H4938563463ORPHA042324212611507
HP:0002360HP:0002360Sleep disturbance2DNAJC13 CL E G H23317411602ORPHA0165130343614334
HP:0002360HP:0002360Sleep disturbance2EHMT1 CL E G H7981396147ORPHA09474624650607001
HP:0002360HP:0002360Sleep disturbance2EIF4G1 CL E G H1981411602ORPHA020523296600495
HP:0002360HP:0002360Sleep disturbance2ELN CL E G H2006194050Williams syndrome194050C0175702OMIM01275233327130160
HP:0002360HP:0002360Sleep disturbance2EPG5 CL E G H577241493Congenital mesoblastic nephromaORPHA06849529331615068
HP:0002360HP:0002360Sleep disturbance2FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA02653883688136350
HP:0002360HP:0002360Sleep disturbance2GBA CL E G H2629411602ORPHA04942064177606463
HP:0002360HP:0002360Sleep disturbance2GIGYF2 CL E G H26058411602ORPHA03612611960612003
HP:0002360HP:0002360Sleep disturbance2HDAC4 CL E G H97591001Branchial arch defectsORPHA01622314063605314
HP:0002360HP:0002360Sleep disturbance2HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA027464877601802
HP:0002360HP:0002360Sleep disturbance2KIF11 CL E G H3832152950Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation152950C1835265OMIM0701726388148760
HP:0002360HP:0002360Sleep disturbance2LRRK2 CL E G H120892411602ORPHA013838818618609007
HP:0002360HP:0002360Sleep disturbance2MLXIPL CL E G H51085194050Williams syndrome194050C0175702OMIM0619712744605678
HP:0002360HP:0002360Sleep disturbance2NDP CL E G H4693649ORPHA01672077678300658
HP:0002360HP:0002360Sleep disturbance2NKX2-1 CL E G H7080610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress610978C1970269OMIM014313611825600635
HP:0002360HP:0002360Sleep disturbance2OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA078988522600037
HP:0002360HP:0002360Sleep disturbance2PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA0839815836607123
HP:0002360HP:0002360Sleep disturbance2SATB2 CL E G H23314251019ORPHA010627421637608148
HP:0002360HP:0002360Sleep disturbance2SEPT9 CL E G H108012901Hypogonadotropic hypogonadism-anosmia, X-linkedORPHA01987323604061
HP:0002360HP:0002360Sleep disturbance2SLC2A1 CL E G H651371277ORPHA028151611005138140
HP:0002360HP:0002360Sleep disturbance2SNCA CL E G H6622411602ORPHA03713011138163890
HP:0002360HP:0002360Sleep disturbance2SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA010510511195184429
HP:0002360HP:0002360Sleep disturbance2SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA02821811199313430
HP:0002360HP:0002360Sleep disturbance2SPART CL E G H23111101000ORPHA0718318514607111
HP:0002360HP:0002360Sleep disturbance2TFAP2B CL E G H702146627ORPHA0155711743601601
HP:0002360HP:0002360Sleep disturbance2USP8 CL E G H910196253ORPHA018512631603158
HP:0002360HP:0002360Sleep disturbance2VPS13A CL E G H232302388ORPHA01165061908605978
HP:0002360HP:0002360Sleep disturbance2VPS35 CL E G H55737411602ORPHA02311713487601501
HP:0002360HP:0002360Sleep disturbance2WAC CL E G H51322616708Desanto-shinawi syndrome616708C4225239OMIM0257717327615049
HP:0002360HP:0002360Sleep disturbance2WDR73 CL E G H84942251300Galloway-Mowat syndrome 1251300CN031715OMIM0129525928616144
HP:0002360HP:0002360Sleep disturbance2WFS1 CL E G H74663463ORPHA039371412762606201
HP:0002360HP:0002360Sleep disturbance3AGA CL E G H17593ORPHA038239318613228
HP:0002360HP:0002360Sleep disturbance3AIFM1 CL E G H9131101078ORPHA0333438768300169
HP:0002360HP:0002360Sleep disturbance3ARNT2 CL E G H99153157Lachiewicz Sibley syndromeORPHA064916876606036
HP:0002360HP:0002360Sleep disturbance3ATAD3A CL E G H55210496790ORPHA01718625567612316
HP:0002360HP:0002360Sleep disturbance3ATXN10 CL E G H2581498761ORPHA047710549611150
HP:0002360HP:0002360Sleep disturbance3ATXN3 CL E G H4287276238ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance3ATXN3 CL E G H4287276241ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance3ATXN3 CL E G H4287276244ORPHA03347106607047
HP:0002360HP:0002360Sleep disturbance3CDH23 CL E G H6407296253ORPHA0361143713733605516
HP:0002360HP:0002360Sleep disturbance3CISD2 CL E G H4938563463ORPHA042324212611507
HP:0002360HP:0002360Sleep disturbance3DNAJC13 CL E G H23317411602ORPHA0165130343614334
HP:0002360HP:0002360Sleep disturbance3EHMT1 CL E G H7981396147ORPHA09474624650607001
HP:0002360HP:0002360Sleep disturbance3EIF4G1 CL E G H1981411602ORPHA020523296600495
HP:0002360HP:0002360Sleep disturbance3ELN CL E G H2006194050Williams syndrome194050C0175702OMIM01275233327130160
HP:0002360HP:0002360Sleep disturbance3EPG5 CL E G H577241493Congenital mesoblastic nephromaORPHA06849529331615068
HP:0002360HP:0002360Sleep disturbance3FGFR1 CL E G H22603157Lachiewicz Sibley syndromeORPHA02653883688136350
HP:0002360HP:0002360Sleep disturbance3GBA CL E G H2629411602ORPHA04942064177606463
HP:0002360HP:0002360Sleep disturbance3GIGYF2 CL E G H26058411602ORPHA03612611960612003
HP:0002360HP:0002360Sleep disturbance3HDAC4 CL E G H97591001Branchial arch defectsORPHA01622314063605314
HP:0002360HP:0002360Sleep disturbance3HESX1 CL E G H88203157Lachiewicz Sibley syndromeORPHA027464877601802
HP:0002360HP:0002360Sleep disturbance3KIF11 CL E G H3832152950Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation152950C1835265OMIM0701726388148760
HP:0002360HP:0002360Sleep disturbance3LRRK2 CL E G H120892411602ORPHA013838818618609007
HP:0002360HP:0002360Sleep disturbance3MLXIPL CL E G H51085194050Williams syndrome194050C0175702OMIM0619712744605678
HP:0002360HP:0002360Sleep disturbance3NDP CL E G H4693649ORPHA01672077678300658
HP:0002360HP:0002360Sleep disturbance3NKX2-1 CL E G H7080610978Choreoathetosis, hypothyroidism, and neonatal respiratory distress610978C1970269OMIM014313611825600635
HP:0002360HP:0002360Sleep disturbance3OTX2 CL E G H50153157Lachiewicz Sibley syndromeORPHA078988522600037
HP:0002360HP:0002360Sleep disturbance3PROKR2 CL E G H1286743157Lachiewicz Sibley syndromeORPHA0839815836607123
HP:0002360HP:0002360Sleep disturbance3SATB2 CL E G H23314251019ORPHA010627421637608148
HP:0002360HP:0002360Sleep disturbance3SEPT9 CL E G H108012901Hypogonadotropic hypogonadism-anosmia, X-linkedORPHA01987323604061
HP:0002360HP:0002360Sleep disturbance3SLC2A1 CL E G H651371277ORPHA028151611005138140
HP:0002360HP:0002360Sleep disturbance3SNCA CL E G H6622411602ORPHA03713011138163890
HP:0002360HP:0002360Sleep disturbance3SOX2 CL E G H66573157Lachiewicz Sibley syndromeORPHA010510511195184429
HP:0002360HP:0002360Sleep disturbance3SOX3 CL E G H66583157Lachiewicz Sibley syndromeORPHA02821811199313430
HP:0002360HP:0002360Sleep disturbance3SPART CL E G H23111101000ORPHA0718318514607111
HP:0002360HP:0002360Sleep disturbance3TFAP2B CL E G H702146627ORPHA0155711743601601
HP:0002360HP:0002360Sleep disturbance3USP8 CL E G H910196253ORPHA018512631603158
HP:0002360HP:0002360Sleep disturbance3VPS13A CL E G H232302388ORPHA01165061908605978
HP:0002360HP:0002360Sleep disturbance3VPS35 CL E G H55737411602ORPHA02311713487601501
HP:0002360HP:0002360Sleep disturbance3WAC CL E G H51322616708Desanto-shinawi syndrome616708C4225239OMIM0257717327615049
HP:0002360HP:0002360Sleep disturbance3WDR73 CL E G H84942251300Galloway-Mowat syndrome 1251300CN031715OMIM0129525928616144
HP:0002360HP:0002360Sleep disturbance3WFS1 CL E G H74663463ORPHA039371412762606201


Genes (235) :AGA AGRN AHDC1 AIFM1 AIP ANK3 APOE ARCN1 ARNT2 ASCL1 ASPA ATAD1 ATAD3A ATXN10 ATXN3 ATXN7 BAZ1B BRAF BSCL2 CCDC47 CDH23 CEP57 CHAT CISD2 CLIP2 COA8 COL13A1 COL3A1 COL4A3BP COL5A1 COLQ COQ2 CPOX CREBBP CSNK1D CTNNB1 CTSH DCTN1 DDC DEAF1 DHCR7 DHX30 DKK1 DMPK DNA2 DNAJC13 DNMT1 DOK7 DPYS DUOX2 DUOXA2 EDN1 EHMT1 EIF4G1 ELN EML1 EP300 EPG5 FBXO7 FGFR1 FGFR2 FGFR3 FKRP FKTN FLCN FLII FOXE1 FOXG1 GABBR2 GBA GCH1 GIGYF2 GJB1 GLRA1 GLRB GNAI3 GNE GNS GPHN GPR101 GTF2I GTF2IRD1 HCRT HDAC4 HDAC8 HERC2 HESX1 HGSNAT HLA-DQB1 HLA-DRB1 HMBS HMGCL HRAS IDS IDUA IL12A IL12RB1 IPW IQSEC2 IRF5 IYD KIF11 KMT2A LAMB2 LARGE1 LHX3 LHX4 LIAS LIMK1 LRRK2 MAGEL2 MBD5 MECP2 MEN1 MFN2 MFSD8 MKRN3 MKRN3-AS1 MLXIPL MMEL1 MOG MUSK MYO9A MYOD1 NAA10 NADK2 NAGLU NDN NDP NDST1 NFIX NGLY1 NIPBL NKX2-1 NKX2-5 NPAP1 NR4A2 NSDHL OTX2 P2RY11 PAX8 PER2 PER3 PGAP3 PHOX2B PLCB4 POMT1 POMT2 POU1F1 POU2AF1 PPT1 PRNP PROKR2 PROP1 PRPS1 PSEN2 PTS PWAR1 PWRN1 RAD21 RAI1 RAPSN RET RFC2 RPS6KA3 RUNX2 SATB2 SEPSECS SEPTIN9 SETD5 SGSH SH3BP2 SHANK3 SHROOM4 SIN3A SKI SLC18A2 SLC18A3 SLC22A5 SLC25A1 SLC26A4 SLC2A1 SLC52A2 SLC52A3 SLC5A5 SLC5A7 SLC6A5 SLC9A6 SLITRK1 SMC1A SMC3 SNAP25 SNCA SNCAIP SNORD115-1 SNORD116-1 SNRPN SOD1 SOX2 SOX3 SPART SPIB SPR SYT2 TAF1 TBC1D24 TBL2 TCF4 TFAP2B TG THRA THRB TNFSF15 TNFSF4 TNPO3 TNXB TPO TRHR TRPV4 TSHB TSHR TSPYL1 TUBB3 TWIST1 TWNK UBE3A USP8 VAMP1 VPS13A VPS35 WAC WDR45 WDR73 WFS1 ZNF365

Diseases (175) :93 101078 3157 314918 314911 3197 496790 98761 276238 276244 276241 363400 96253 3463 178509 168605 608643 819 617171 411602 96147 610253 194050 600348 1493 171695 617904 98808 252940 1001 199 226307 252930 93473 152950 614462 228402 610951 252920 649 616116 610978 168600 300831 256730 280397 182290 251019 613811 2901 252900 613406 352649 71277 606777 300243 137580 168601 101000 70594 612716 46627 97927 285 99832 90674 424 90673 99819 2388 616708 329284 251300 615829 963 615493 606889 94147 904 54595 614114 436271 286 616351 98915 98933 227510 121300 615224 2073 818 270400 617804 160900 314404 604121 614116 994 222748 95716 137888 794 123500 429 616482 236670 610883 95713 613454 617903 101075 602483 3166 269921 300942 83465 161400 176270 79276 246450 186 615547 300260 300055 312750 97279 99947 614250 276432 95712 604348 615716 614669 282166 600072 99014 261640 1713 192 1452 48652 606232 300434 94065 212140 97229 105400 300966 352596 2896 169100 168593 300570 271245 105830 98914 617164 99803 618268 180849 268882 352470 615156 15 218040 309900 607015 607016 431361 602535 615273 616882 184 182212 606071
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.